Aliases for DENND11 Gene

Aliases for DENND11 Gene

  • DENN Domain Containing 11 2 3 5
  • KIAA1147 2 3 4
  • LCHN 2 3 4
  • DENN Domain-Containing Protein 11 3 4
  • Protein LCHN 3 4
  • Predicted Protein Of HQ2561 3
  • PRO2561 3
  • DENND11 5

External Ids for DENND11 Gene

Previous HGNC Symbols for DENND11 Gene

  • KIAA1147

Summaries for DENND11 Gene

GeneCards Summary for DENND11 Gene

DENND11 (DENN Domain Containing 11) is a Protein Coding gene. Diseases associated with DENND11 include Infant Botulism and Foodborne Botulism.

UniProtKB/Swiss-Prot Summary for DENND11 Gene

  • Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity).

Additional gene information for DENND11 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DENND11 Gene

Genomics for DENND11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DENND11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DENND11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DENND11

Genomic Locations for DENND11 Gene

Genomic Locations for DENND11 Gene
chr7:141,652,381-141,702,188
(GRCh38/hg38)
Size:
49,808 bases
Orientation:
Minus strand
chr7:141,356,528-141,401,953
(GRCh37/hg19)
Size:
45,426 bases
Orientation:
Minus strand

Genomic View for DENND11 Gene

Genes around DENND11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DENND11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DENND11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND11 Gene

Proteins for DENND11 Gene

  • Protein details for DENND11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D1U4-DEN11_HUMAN
    Recommended name:
    DENN domain-containing protein 11
    Protein Accession:
    A4D1U4
    Secondary Accessions:
    • Q9ULS3

    Protein attributes for DENND11 Gene

    Size:
    455 amino acids
    Molecular mass:
    51446 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DENND11 Gene

Post-translational modifications for DENND11 Gene

  • Ubiquitination at Lys152
  • Modification sites at PhosphoSitePlus

Other Protein References for DENND11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DENND11 Gene

Domains & Families for DENND11 Gene

Gene Families for DENND11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DENND11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DENND11 Gene

GenScript: Design optimal peptide antigens:
  • Protein LCHN (LCHN_HUMAN)
  • PRO2561 (Q9P1C9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A4D1U4

UniProtKB/Swiss-Prot:

DEN11_HUMAN :
  • Belongs to the DENND11 family.
Family:
  • Belongs to the DENND11 family.
genes like me logo Genes that share domains with DENND11: view

Function for DENND11 Gene

Molecular function for DENND11 Gene

UniProtKB/Swiss-Prot Function:
Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity).

Phenotypes From GWAS Catalog for DENND11 Gene

Gene Ontology (GO) - Molecular Function for DENND11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with DENND11: view
genes like me logo Genes that share phenotypes with DENND11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DENND11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DENND11 Gene

Localization for DENND11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DENND11 gene
Compartment Confidence
plasma membrane 1
endosome 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DENND11 Gene

Pathways & Interactions for DENND11 Gene

PathCards logo

SuperPathways for DENND11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DENND11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DENND11 Gene

Drugs & Compounds for DENND11 Gene

No Compound Related Data Available

Transcripts for DENND11 Gene

mRNA/cDNA for DENND11 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DENND11

Alternative Splicing Database (ASD) splice patterns (SP) for DENND11 Gene

No ASD Table

Relevant External Links for DENND11 Gene

GeneLoc Exon Structure for
DENND11

Expression for DENND11 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DENND11

SOURCE GeneReport for Unigene cluster for DENND11 Gene:

Hs.521240

Evidence on tissue expression from TISSUES for DENND11 Gene

  • Nervous system(4.2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DENND11 Gene

Orthologs for DENND11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DENND11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KIAA1147 30 31
  • 99.85 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KIAA1147 30 31
  • 92.12 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KIAA1147 30 31
  • 91.53 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia E330009J07Rik 30 31
  • 89.94 (n)
OneToOne
Dennd11 17
Rat
(Rattus norvegicus)
Mammalia RGD1563986 30
  • 89.89 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1147 31
  • 85 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia KIAA1147 31
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves KIAA1147 30 31
  • 80.33 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KIAA1147 31
  • 84 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-238n5.4 30 31
  • 65 (a)
OneToOne
Species where no ortholog for DENND11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DENND11 Gene

ENSEMBL:
Gene Tree for DENND11 (if available)
TreeFam:
Gene Tree for DENND11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DENND11: view image

Paralogs for DENND11 Gene

No data available for Paralogs for DENND11 Gene

Variants for DENND11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DENND11 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
617460 Likely Pathogenic: Sengers syndrome 141,652,869(-) A/AG FRAMESHIFT_VARIANT
744244 Likely Benign: not provided 141,652,852(-) G/A SYNONYMOUS_VARIANT
909035 Likely Benign: Sengers syndrome; Cataract, autosomal recessive congenital 5 141,652,982(-) G/A THREE_PRIME_UTR_VARIANT
909036 Uncertain Significance: Sengers syndrome; Cataract, autosomal recessive congenital 5 141,653,021(-) G/T THREE_PRIME_UTR_VARIANT
909037 Uncertain Significance: Sengers syndrome; Cataract, autosomal recessive congenital 5 141,653,049(-) C/T THREE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for DENND11 Gene

Structural Variations from Database of Genomic Variants (DGV) for DENND11 Gene

Variant ID Type Subtype PubMed ID
esv34135 CNV loss 18971310
nsv475452 CNV novel sequence insertion 20440878
nsv5973 CNV insertion 18451855

Variation tolerance for DENND11 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 25.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DENND11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DENND11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENND11 Gene

Disorders for DENND11 Gene

MalaCards: The human disease database

(8) MalaCards diseases for DENND11 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
infant botulism
  • infant intestinal botulism
foodborne botulism
  • wound botulism
transient cerebral ischemia
  • tia
sengers syndrome
  • mitochondrial dna depletion syndrome 10 ; mtdps10
alternating hemiplegia of childhood
  • ahc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DENND11

genes like me logo Genes that share disorders with DENND11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DENND11 Gene

Publications for DENND11 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4
  2. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects. (PMID: 25489052) Myklebust LM … Arnesen T (Human molecular genetics 2015) 4
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for DENND11 Gene

Sources for DENND11 Gene