The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas. [provided by RefSeq, Jul 2008] See more...

Aliases for DELEC1 Gene

Subcategory (RNA class) for DELEC1 Gene

lncRNA

Number of RNA Genes sources:

2 / 14

Aliases for DELEC1 Gene

  • Deleted In Esophageal Cancer 1 2 3 5
  • Candidate Tumor Suppressor 9 2 3
  • DEC1 3 5
  • Candidate Tumor Suppressor CTS9 3
  • Lnc-TMEM268-5 168
  • HSALNG0073943 167
  • DELEC1 2
  • CTS9 3

External Ids for DELEC1 Gene

Previous HGNC Symbols for DELEC1 Gene

  • DEC1

Summaries for DELEC1 Gene

Entrez Gene Summary for DELEC1 Gene

  • The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for DELEC1 Gene

DELEC1 (Deleted In Esophageal Cancer 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with DELEC1 include Esophageal Cancer. Among its related pathways are Circadian rhythm pathway.

Gene Wiki entry for DELEC1 Gene

Additional gene information for DELEC1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DELEC1 Gene

Genomics for DELEC1 Gene

GeneHancer (GH) Regulatory Elements for DELEC1 Gene

Promoters and enhancers for DELEC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J114849 Enhancer 0.4 ENCODE 500.7 -0.6 -574 2.7 CREB1 RFX5 SPI1 JUND PRDM10 DELEC1 TNFSF15 LOC645266 lnc-TMEM268-4
GH09J115202 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 21.9 +357.1 357133 13.4 JUND FOS EP300 REST ZNF623 TRIM28 MEF2C TRIM22 ATF2 BCL11A DELEC1 TNC TNFSF15 piR-57137-024 ENSG00000234692
GH09J115169 Enhancer 0.9 Ensembl ENCODE dbSUPER 26.6 +319.7 319729 1.8 TRIM28 MAFF FOS FOSL2 RFX5 MAFK JUND CTCF POU5F1 NANOG DELEC1 TNC piR-57137-024 LOC101928748
GH09J115166 Enhancer 0.8 Ensembl ENCODE dbSUPER 25.9 +316.5 316523 1.1 EP300 FOS JUND POLR2A STAT3 DELEC1 piR-57137-024 LOC101928748
GH09J115164 Enhancer 1 Ensembl ENCODE dbSUPER 19 +313.5 313534 2.2 JUND FOS REST ZNF184 NR3C1 FOSL2 KLF8 ZNF335 ZNF843 FEZF1 DELEC1 TNC piR-57137-024 LOC101928748
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DELEC1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DELEC1

Genomic Locations for DELEC1 Gene

Genomic Locations for DELEC1 Gene
chr9:114,850,968-115,402,644
(GRCh38/hg38)
Size:
551,677 bases
Orientation:
Plus strand
chr9:117,904,097-118,164,923
(GRCh37/hg19)
Size:
260,827 bases
Orientation:
Plus strand

Genomic View for DELEC1 Gene

Genes around DELEC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DELEC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DELEC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DELEC1 Gene

Proteins for DELEC1 Gene

Post-translational modifications for DELEC1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for DELEC1 Gene

Domains & Families for DELEC1 Gene

Gene Families for DELEC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
genes like me logo Genes that share domains with DELEC1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DELEC1 Gene

Function for DELEC1 Gene

Phenotypes From GWAS Catalog for DELEC1 Gene

genes like me logo Genes that share phenotypes with DELEC1: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DELEC1 Gene

Localization for DELEC1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DELEC1 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DELEC1 Gene

Pathways & Interactions for DELEC1 Gene

PathCards logo

SuperPathways for DELEC1 Gene

SuperPathway Contained pathways
1 Circadian rhythm pathway
genes like me logo Genes that share pathways with DELEC1: view

Pathways by source for DELEC1 Gene

1 BioSystems pathway for DELEC1 Gene
;

Gene Ontology (GO) - Biological Process for DELEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation TAS 10612805
genes like me logo Genes that share ontologies with DELEC1: view

No data available for Interacting Proteins and SIGNOR curated interactions for DELEC1 Gene

Drugs & Compounds for DELEC1 Gene

No Compound Related Data Available

Transcripts for DELEC1 Gene

mRNA/cDNA for DELEC1 Gene

11 RNACentral transcripts :
2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 LncBook transcripts :
2 LNCipedia transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DELEC1 Gene

No ASD Table

Relevant External Links for DELEC1 Gene

GeneLoc Exon Structure for
DELEC1

Expression for DELEC1 Gene

SOURCE GeneReport for Unigene cluster for DELEC1 Gene:

Hs.148841
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DELEC1 Gene

Orthologs for DELEC1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DELEC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DEC1 31
  • 97 (a)
OneToOne
Species where no ortholog for DELEC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DELEC1 Gene

ENSEMBL:
Gene Tree for DELEC1 (if available)
TreeFam:
Gene Tree for DELEC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DELEC1: view image

Paralogs for DELEC1 Gene

No data available for Paralogs for DELEC1 Gene

Variants for DELEC1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DELEC1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs2269700 - p.Ala60Val

Additional dbSNP identifiers (rs#s) for DELEC1 Gene

Structural Variations from Database of Genomic Variants (DGV) for DELEC1 Gene

Variant ID Type Subtype PubMed ID
dgv4131n106 CNV deletion 24896259
esv1089105 CNV deletion 17803354
esv1206387 CNV insertion 17803354
esv2068341 CNV deletion 18987734
esv2176591 CNV deletion 18987734
esv2494923 CNV deletion 19546169
esv2674932 CNV deletion 23128226
esv2677881 CNV deletion 23128226
esv2738968 CNV deletion 23290073
esv2738969 CNV deletion 23290073
esv2761245 CNV loss 21179565
esv2761552 CNV loss 21179565
esv3290 CNV loss 18987735
esv3399588 CNV insertion 20981092
esv3545361 CNV deletion 23714750
esv3573368 CNV loss 25503493
esv3573369 CNV loss 25503493
esv3573370 CNV loss 25503493
esv3621568 CNV loss 21293372
esv3621570 CNV loss 21293372
esv8511 CNV loss 19470904
nsv1075266 CNV deletion 25765185
nsv1147735 CNV deletion 26484159
nsv477372 CNV novel sequence insertion 20440878
nsv507528 OTHER sequence alteration 20534489
nsv512115 CNV loss 21212237
nsv519995 CNV loss 19592680
nsv525037 CNV loss 19592680
nsv527294 CNV loss 19592680
nsv615250 CNV loss 21841781
nsv615251 CNV gain 21841781
nsv6681 CNV deletion 18451855
nsv6682 CNV deletion 18451855
nsv7434 OTHER inversion 18451855
nsv831697 CNV loss 17160897
nsv957705 CNV deletion 24416366

Variation tolerance for DELEC1 Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DELEC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DELEC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DELEC1 Gene

Disorders for DELEC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DELEC1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
esophageal cancer
  • esophageal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with DELEC1: view

No data available for UniProtKB/Swiss-Prot , Genatlas and External Links for DELEC1 Gene

Publications for DELEC1 Gene

  1. Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32. (PMID: 10612805) Nishiwaki T … Nakamura Y (Genes, chromosomes & cancer 2000) 2 3 23 54
  2. Detailed deletion mapping in squamous cell carcinomas of the esophagus narrows a region containing a putative tumor suppressor gene to about 200 kilobases on distal chromosome 9q. (PMID: 8603412) Miura K … Nakamura Y (Cancer research 1996) 2 3 54
  3. Correlation between DEC1/DEC2 and epithelial‑mesenchymal transition in human prostate cancer PC‑3 cells. (PMID: 30106153) Liu Q … Kijima H (Molecular medicine reports 2018) 3 54
  4. Clusterin, a Novel DEC1 Target, Modulates DNA Damage-Mediated Cell Death. (PMID: 30002194) Ming X … Qian Y (Molecular cancer research : MCR 2018) 3 54
  5. DEC1 is required for anti-apoptotic activity of gastric cancer cells under hypoxia by promoting Survivin expression. (PMID: 29204860) Jia Y … Ma X (Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2018) 3 54

Products for DELEC1 Gene

Sources for DELEC1 Gene