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Aliases for DELE1 Gene

Aliases for DELE1 Gene

  • DAP3 Binding Cell Death Enhancer 1 2 3
  • KIAA0141 2 3 5 5
  • Death Ligand Signal Enhancer 2 3
  • DELE 3 4

External Ids for DELE1 Gene

Previous HGNC Symbols for DELE1 Gene

  • KIAA0141

Summaries for DELE1 Gene

GeneCards Summary for DELE1 Gene

DELE1 (DAP3 Binding Cell Death Enhancer 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DELE1 Gene

  • Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

Additional gene information for DELE1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DELE1 Gene

Genomics for DELE1 Gene

GeneHancer (GH) Regulatory Elements for DELE1 Gene

Promoters and enhancers for DELE1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J141922 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 657.5 0.0 -16 2.1 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B DELE1 GC05M141922 LOC102723915 HDAC3 GC05M141915
GH05J141968 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.8 +45.8 45782 3 CLOCK DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC GLIS1 RNF14 PCDH12 LOC102723915 HDAC3 PCDHB18P PCDHGA6 PCDHGA7 DELE1 PCDHGA5 ENSG00000271871
GH05J141679 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 20.2 -242.0 -241974 4.7 HDGF ARNT SIN3A ZNF2 YY1 CBX5 ZNF213 FOS SP3 REST ARAP3 PCDHB19P HARS2 DELE1 PCDHB18P PCDHGA7 PCDH1 PCDH12 RNF14 HDAC3
GH05J141957 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 26.9 +35.6 35575 4.5 HDGF ARNT ARID4B ZNF2 ETS1 ZNF766 E2F8 ELK1 ARID2 ZNF143 RNF14 GC05M141957 PCDH12 LOC102723915 HDAC3 DELE1 FCHSD1 ARAP3 ENSG00000271871 PCDH1
GH05J142815 Enhancer 1.4 Ensembl ENCODE dbSUPER 24.5 +900.5 900493 17.2 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF548 FOS DELE1 ENSG00000271871 ARHGAP26-AS1 GC05P142827 GC05P142826 ARHGAP26
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DELE1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for DELE1 Gene

Genomic Locations for DELE1 Gene
chr5:141,923,785-141,951,465
(GRCh38/hg38)
Size:
27,681 bases
Orientation:
Plus strand
chr5:141,303,373-141,321,612
(GRCh37/hg19)
Size:
18,240 bases
Orientation:
Plus strand

Genomic View for DELE1 Gene

Genes around DELE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DELE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DELE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DELE1 Gene

Proteins for DELE1 Gene

  • Protein details for DELE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14154-DELE_HUMAN
    Recommended name:
    Death ligand signal enhancer
    Protein Accession:
    Q14154
    Secondary Accessions:
    • Q969R4
    • Q96EU9

    Protein attributes for DELE1 Gene

    Size:
    515 amino acids
    Molecular mass:
    55920 Da
    Quaternary structure:
    • Interacts with DAP3.
    SequenceCaution:
    • Sequence=BAA09490.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for DELE1 Gene

Post-translational modifications for DELE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DELE1 Gene

Domains & Families for DELE1 Gene

Gene Families for DELE1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DELE1 Gene

Suggested Antigen Peptide Sequences for DELE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DELE1: view

No data available for UniProtKB/Swiss-Prot for DELE1 Gene

Function for DELE1 Gene

Molecular function for DELE1 Gene

UniProtKB/Swiss-Prot Function:
Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

Phenotypes From GWAS Catalog for DELE1 Gene

Gene Ontology (GO) - Molecular Function for DELE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20563667
genes like me logo Genes that share ontologies with DELE1: view
genes like me logo Genes that share phenotypes with DELE1: view

Animal Model Products

CRISPR Products

miRNA for DELE1 Gene

miRTarBase miRNAs that target DELE1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DELE1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DELE1 Gene

Localization for DELE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DELE1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DELE1 gene
Compartment Confidence
mitochondrion 5
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DELE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,IEA 10942595
genes like me logo Genes that share ontologies with DELE1: view

Pathways & Interactions for DELE1 Gene

SuperPathways for DELE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DELE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IDA 20563667
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA 20563667
genes like me logo Genes that share ontologies with DELE1: view

No data available for Pathways by source and SIGNOR curated interactions for DELE1 Gene

Drugs & Compounds for DELE1 Gene

No Compound Related Data Available

Transcripts for DELE1 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DELE1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DELE1 Gene

No ASD Table

Relevant External Links for DELE1 Gene

GeneLoc Exon Structure for
DELE1
ECgene alternative splicing isoforms for
DELE1

Expression for DELE1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DELE1 Gene:

DELE1

mRNA Expression by UniProt/SwissProt for DELE1 Gene:

Q14154-DELE_HUMAN
Tissue specificity: Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Evidence on tissue expression from TISSUES for DELE1 Gene

  • Nervous system(4.8)
  • Bone marrow(4.3)
  • Lung(2.5)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DELE1 Gene

Orthologs for DELE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DELE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA0141 34 33
  • 99.35 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA0141 34 33
  • 86.8 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA0141 34 33
  • 84.92 (n)
OneToOne
mouse
(Mus musculus)
Mammalia 0610009O20Rik 34 33
  • 79.29 (n)
OneToOne
Dele1 16
rat
(Rattus norvegicus)
Mammalia RGD735029 33
  • 78.96 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA0141 34
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA0141 34
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA0141 33
  • 67.05 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0141 33
  • 49.55 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:158257 34 33
  • 47.12 (n)
OneToOne
Species where no ortholog for DELE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DELE1 Gene

ENSEMBL:
Gene Tree for DELE1 (if available)
TreeFam:
Gene Tree for DELE1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DELE1: view image

Paralogs for DELE1 Gene

No data available for Paralogs for DELE1 Gene

Variants for DELE1 Gene

Sequence variations from dbSNP and Humsavar for DELE1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000284609 -- 141,927,042(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000465484 -- 141,922,030(+) C/A upstream_transcript_variant
rs1000649715 -- 141,922,859(+) A/G upstream_transcript_variant
rs1000840304 -- 141,937,998(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000894208 -- 141,937,598(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DELE1 Gene

Variant ID Type Subtype PubMed ID
esv2667575 CNV deletion 23128226
nsv1117586 CNV deletion 24896259
nsv1154058 CNV deletion 26484159
nsv599924 CNV gain 21841781

Variation tolerance for DELE1 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.85; 89.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DELE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DELE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DELE1 Gene

Disorders for DELE1 Gene

Additional Disease Information for DELE1

No disorders were found for DELE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DELE1 Gene

Publications for DELE1 Gene

  1. Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction. (PMID: 20563667) Harada T … Miyazaki T (Apoptosis : an international journal on programmed cell death 2010) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1995) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for DELE1 Gene

Sources for DELE1 Gene

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