This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associat... See more...

Aliases for DEK Gene

Aliases for DEK Gene

  • DEK Proto-Oncogene 2 3 5
  • DEK Oncogene (DNA Binding) 2 3
  • Protein DEK 3 4
  • DEK Oncogene 2
  • D6S231E 3

External Ids for DEK Gene

Previous GeneCards Identifiers for DEK Gene

  • GC06M018280
  • GC06M018332

Summaries for DEK Gene

Entrez Gene Summary for DEK Gene

  • This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

CIViC Summary for DEK Gene

GeneCards Summary for DEK Gene

DEK (DEK Proto-Oncogene) is a Protein Coding gene. Diseases associated with DEK include Acute Myeloid Leukemia With T(6;9)(P23;Q34) and Iridocyclitis. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and histone binding.

UniProtKB/Swiss-Prot Summary for DEK Gene

Gene Wiki entry for DEK Gene

Additional gene information for DEK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DEK Gene

Genomics for DEK Gene

GeneHancer (GH) Regulatory Elements for DEK Gene

Promoters and enhancers for DEK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DEK on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DEK

Top Transcription factor binding sites by QIAGEN in the DEK gene promoter:
  • AML1a
  • Tal-1beta

Genomic Locations for DEK Gene

Genomic Locations for DEK Gene
chr6:18,223,860-18,264,568
(GRCh38/hg38)
Size:
40,709 bases
Orientation:
Minus strand
chr6:18,224,099-18,265,054
(GRCh37/hg19)
Size:
40,956 bases
Orientation:
Minus strand

Genomic View for DEK Gene

Genes around DEK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEK Gene

Proteins for DEK Gene

  • Protein details for DEK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35659-DEK_HUMAN
    Recommended name:
    Protein DEK
    Protein Accession:
    P35659
    Secondary Accessions:
    • B2R6K6
    • B4DN37
    • Q5TGV4
    • Q5TGV5

    Protein attributes for DEK Gene

    Size:
    375 amino acids
    Molecular mass:
    42674 Da
    Quaternary structure:
    • Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA.

    Three dimensional structures from OCA and Proteopedia for DEK Gene

    Alternative splice isoforms for DEK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DEK Gene

Post-translational modifications for DEK Gene

  • Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase, and weakens the binding of DEK to DNA.
  • Ubiquitination at Lys111, Lys125, Lys137, Lys331, and Lys349
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DEK Gene

Domains & Families for DEK Gene

Gene Families for DEK Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DEK Gene

Blocks:
  • DNA-binding SAP
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DEK Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53031, highly similar to Protein DEK (B4DFG0_HUMAN)
  • cDNA FLJ52337, highly similar to Protein DEK (B4DN37_HUMAN)
  • Protein DEK (DEK_HUMAN)
genes like me logo Genes that share domains with DEK: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DEK Gene

Function for DEK Gene

Molecular function for DEK Gene

UniProtKB/Swiss-Prot Function:
Involved in chromatin organization.
GENATLAS Biochemistry:
nuclear protein of unknown function,likely associated to chromatin

Phenotypes From GWAS Catalog for DEK Gene

Gene Ontology (GO) - Molecular Function for DEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0042393 histone binding IDA 12140263
genes like me logo Genes that share ontologies with DEK: view
genes like me logo Genes that share phenotypes with DEK: view

Animal Models for DEK Gene

MGI Knock Outs for DEK:
  • Dek Dek<tm1Siwe>

Animal Model Products

CRISPR Products

miRNA for DEK Gene

miRTarBase miRNAs that target DEK

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DEK Gene

Localization for DEK Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEK Gene

Nucleus. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DEK gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IDA 21653549
GO:0005654 nucleoplasm TAS --
GO:0043292 contractile fiber IEA --
genes like me logo Genes that share ontologies with DEK: view

Pathways & Interactions for DEK Gene

genes like me logo Genes that share pathways with DEK: view

Interacting Proteins for DEK Gene

;

SIGNOR curated interactions for DEK Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for DEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS --
GO:0006366 transcription by RNA polymerase II TAS 9050861
GO:0007165 signal transduction TAS 9050861
GO:0019079 viral genome replication TAS 9050861
genes like me logo Genes that share ontologies with DEK: view

Drugs & Compounds for DEK Gene

(1) Additional Compounds for DEK Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DEK: view

Transcripts for DEK Gene

mRNA/cDNA for DEK Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEK Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: -
SP2:
SP3: - - -

Relevant External Links for DEK Gene

GeneLoc Exon Structure for
DEK

Expression for DEK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DEK Gene

Protein differential expression in normal tissues from HIPED for DEK Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.7) and Tlymphocyte (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DEK Gene



Protein tissue co-expression partners for DEK Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DEK

SOURCE GeneReport for Unigene cluster for DEK Gene:

Hs.484813

mRNA Expression by UniProt/SwissProt for DEK Gene:

P35659-DEK_HUMAN
Tissue specificity: Ubiquitous. Expressed at relatively high levels.

Evidence on tissue expression from TISSUES for DEK Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Bone marrow(2.8)
  • Skin(2.3)
  • Blood(2.2)
  • Lymph node(2.2)
  • Spleen(2.2)
  • Heart(2.1)
  • Intestine(2.1)
  • Lung(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with DEK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DEK Gene

Orthologs for DEK Gene

This gene was present in the common ancestor of animals.

Orthologs for DEK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DEK 31 30
  • 98.84 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DEK 31 30
  • 94.05 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DEK 31 30
  • 92.27 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 88 (a)
OneToMany
-- 31
  • 72 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dek 30
  • 87.08 (n)
mouse
(Mus musculus)
Mammalia Dek 17 31 30
  • 86.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DEK 31
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves DEK 31 30
  • 79.44 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DEK 31
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dek 30
  • 66.56 (n)
Str.6224 30
African clawed frog
(Xenopus laevis)
Amphibia LOC398543 30
zebrafish
(Danio rerio)
Actinopterygii dek 31
  • 29 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dek 31
  • 17 (a)
OneToOne
Species where no ortholog for DEK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEK Gene

ENSEMBL:
Gene Tree for DEK (if available)
TreeFam:
Gene Tree for DEK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DEK: view image

Paralogs for DEK Gene

(1) SIMAP similar genes for DEK Gene using alignment to 7 proteins:

  • DEK_HUMAN
  • B4DFG0_HUMAN
  • D6R9L5_HUMAN
  • D6RDA2_HUMAN
  • H0Y8X0_HUMAN
  • H0Y993_HUMAN
  • L8EA44_HUMAN
genes like me logo Genes that share paralogs with DEK: view

No data available for Paralogs for DEK Gene

Variants for DEK Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DEK Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs17336208 - p.Val140Ala

Additional dbSNP identifiers (rs#s) for DEK Gene

Structural Variations from Database of Genomic Variants (DGV) for DEK Gene

Variant ID Type Subtype PubMed ID
esv3307418 CNV mobile element insertion 20981092
esv3335295 CNV insertion 20981092
esv3424290 CNV insertion 20981092
esv3567344 CNV deletion 23714750
esv3567345 CNV deletion 23714750
nsv1144134 CNV deletion 24896259

Variation tolerance for DEK Gene

Residual Variation Intolerance Score: 24.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DEK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DEK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEK Gene

Disorders for DEK Gene

MalaCards: The human disease database

(8) MalaCards diseases for DEK Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute myeloid leukemia with t(6;9)(p23;q34)
  • aml with t(6;9)(p23;q34)
iridocyclitis
  • primary iridocyclitis
juvenile rheumatoid arthritis
  • rheumatoid arthritis, systemic juvenile
serous surface papilloma
lymphocytic leukemia
  • lymphoblastic leukemia
- elite association - COSMIC cancer census association via MalaCards
Search DEK in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DEK_HUMAN
  • Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK-NUP214 fusion gene (PubMed:1549122). {ECO:0000269 PubMed:1549122}.

Genatlas disease for DEK Gene

myelodysplastic syndrome,refractory anemia with excess of blasts in transformation (MDS/RAEBT),acute myeloid leukemia of poor prognosis (AML),with t(6;9)(p23;q34) translocation

Additional Disease Information for DEK

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DEK: view

Publications for DEK Gene

  1. The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. (PMID: 1549122) von Lindern M … Grosveld G (Molecular and cellular biology 1992) 2 3 4 23 54
  2. Solution NMR structure of the N-terminal domain of the human DEK protein. (PMID: 18227428) Devany M … Matsuo H (Protein science : a publication of the Protein Society 2008) 3 4 23 54
  3. The distribution of the DEK protein in mammalian chromatin. (PMID: 17524367) Hu HG … Knippers R (Biochemical and biophysical research communications 2007) 3 4 23 54
  4. Solution NMR structure of the C-terminal domain of the human protein DEK. (PMID: 15238633) Devany M … Matsuo H (Protein science : a publication of the Protein Society 2004) 3 4 23 54
  5. Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK. (PMID: 15199154) Kappes F … Gruss C (Molecular and cellular biology 2004) 3 4 23 54

Products for DEK Gene

  • Signalway ELISA kits for DEK
  • Signalway Proteins for DEK

Sources for DEK Gene