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Aliases for DEK Gene

Aliases for DEK Gene

  • DEK Proto-Oncogene 2 3 5
  • DEK Oncogene (DNA Binding) 2 3
  • DEK Oncogene 2
  • Protein DEK 3
  • D6S231E 3

External Ids for DEK Gene

Previous GeneCards Identifiers for DEK Gene

  • GC06M018280
  • GC06M018332

Summaries for DEK Gene

Entrez Gene Summary for DEK Gene

  • This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for DEK Gene

DEK (DEK Proto-Oncogene) is a Protein Coding gene. Diseases associated with DEK include Acute Myeloid Leukemia With T(6;9)(P23;Q34) and Iridocyclitis. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and histone binding.

UniProtKB/Swiss-Prot for DEK Gene

  • Involved in chromatin organization.

Gene Wiki entry for DEK Gene

Additional gene information for DEK Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEK Gene

Genomics for DEK Gene

GeneHancer (GH) Regulatory Elements for DEK Gene

Promoters and enhancers for DEK Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J018259 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 675.6 +2.1 2059 6.2 HDGF PKNOX1 SMAD1 FOXA2 ARNT SIN3A FEZF1 DMAP1 ZNF2 IRF4 DEK NUP153 LOC105374952 IMPDH1P9 RNF144B GC06M018248 KDM1B
GH06J018265 Promoter 0.9 EPDnew 650.7 -1.2 -1194 0.1 ZNF280A CBX5 GABPB1 TRIM24 ZBTB33 TRIM28 SETDB1 SPI1 DEK ENSG00000199715 GC06M018248
GH06J017903 Enhancer 1.4 Ensembl ENCODE dbSUPER 13.7 +358.0 358023 6.4 HDGF PKNOX1 FOXA2 ARNT SIN3A YBX1 YY1 POLR2B ZNF766 CBX5 NUP153 KIF13A LOC105374952 DEK NHLRC1 GC06P017893 RPS12P12
GH06J018386 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.4 -123.9 -123933 5.5 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SP3 SP5 ZHX2 RNF144B RNU6-263P DEK IMPDH1P9 KDM1B KIF13A PIR43810
GH06J018327 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.6 -64.5 -64468 4.3 TEAD4 JUNB OSR2 HIC1 SP1 CTBP1 PRDM6 GATA3 ZNF629 SCRT2 RNF144B DEK KDM1B KIF13A PIR61433 GC06P018364 PIR39754
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DEK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DEK gene promoter:
  • AML1a
  • Tal-1beta

Genomic Locations for DEK Gene

Genomic Locations for DEK Gene
40,956 bases
Minus strand
40,956 bases
Minus strand

Genomic View for DEK Gene

Genes around DEK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEK Gene

Proteins for DEK Gene

  • Protein details for DEK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein DEK
    Protein Accession:
    Secondary Accessions:
    • B2R6K6
    • B4DN37
    • Q5TGV4
    • Q5TGV5

    Protein attributes for DEK Gene

    375 amino acids
    Molecular mass:
    42674 Da
    Quaternary structure:
    • Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA.

    Three dimensional structures from OCA and Proteopedia for DEK Gene

    Alternative splice isoforms for DEK Gene


neXtProt entry for DEK Gene

Post-translational modifications for DEK Gene

  • Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase, and weakens the binding of DEK to DNA.
  • Ubiquitination at posLast=349349, Lys331, Lys137, posLast=125125, and Lys111
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for DEK
  • Boster Bio Antibodies for DEK
  • Santa Cruz Biotechnology (SCBT) Antibodies for DEK

No data available for DME Specific Peptides for DEK Gene

Domains & Families for DEK Gene

Gene Families for DEK Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DEK Gene


Suggested Antigen Peptide Sequences for DEK Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DEK: view

No data available for UniProtKB/Swiss-Prot for DEK Gene

Function for DEK Gene

Molecular function for DEK Gene

UniProtKB/Swiss-Prot Function:
Involved in chromatin organization.
GENATLAS Biochemistry:
nuclear protein of unknown function,likely associated to chromatin

Phenotypes From GWAS Catalog for DEK Gene

Gene Ontology (GO) - Molecular Function for DEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IBA --
GO:0003723 RNA binding HDA 22658674
GO:0042393 histone binding IDA 12140263
genes like me logo Genes that share ontologies with DEK: view
genes like me logo Genes that share phenotypes with DEK: view

Animal Models for DEK Gene

MGI Knock Outs for DEK:
  • Dek Dek<tm1Siwe>

Animal Model Products

miRNA for DEK Gene

miRTarBase miRNAs that target DEK

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DEK Gene

Localization for DEK Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEK Gene

Nucleus. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DEK gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS 21653549
GO:0005654 nucleoplasm TAS --
GO:0043292 contractile fiber IEA --
genes like me logo Genes that share ontologies with DEK: view

Pathways & Interactions for DEK Gene

genes like me logo Genes that share pathways with DEK: view

SIGNOR curated interactions for DEK Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006338 chromatin remodeling IBA --
GO:0006357 regulation of transcription by RNA polymerase II TAS --
GO:0006366 transcription by RNA polymerase II TAS 9050861
GO:0007165 signal transduction TAS 9050861
genes like me logo Genes that share ontologies with DEK: view

Drugs & Compounds for DEK Gene

(1) Additional Compounds for DEK Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DEK: view

Transcripts for DEK Gene

Unigene Clusters for DEK Gene

DEK oncogene:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEK Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: -
SP3: - - -

Relevant External Links for DEK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DEK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DEK Gene

Protein differential expression in normal tissues from HIPED for DEK Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.7) and Tlymphocyte (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DEK Gene

Protein tissue co-expression partners for DEK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DEK Gene:


SOURCE GeneReport for Unigene cluster for DEK Gene:


mRNA Expression by UniProt/SwissProt for DEK Gene:

Tissue specificity: Ubiquitous. Expressed at relatively high levels.

Evidence on tissue expression from TISSUES for DEK Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Bone marrow(2.8)
  • Skin(2.3)
  • Blood(2.2)
  • Lymph node(2.2)
  • Spleen(2.2)
  • Heart(2.1)
  • Intestine(2.1)
  • Lung(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with DEK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DEK Gene

Orthologs for DEK Gene

This gene was present in the common ancestor of animals.

Orthologs for DEK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DEK 34 33
  • 98.84 (n)
(Canis familiaris)
Mammalia DEK 34 33
  • 94.05 (n)
(Bos Taurus)
Mammalia DEK 34 33
  • 92.27 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 88 (a)
-- 34
  • 72 (a)
-- 34
  • 52 (a)
(Rattus norvegicus)
Mammalia Dek 33
  • 87.08 (n)
(Mus musculus)
Mammalia Dek 16 34 33
  • 86.36 (n)
(Ornithorhynchus anatinus)
Mammalia DEK 34
  • 84 (a)
(Gallus gallus)
Aves DEK 34 33
  • 79.44 (n)
(Anolis carolinensis)
Reptilia DEK 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dek 33
  • 66.56 (n)
Str.6224 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398543 33
(Danio rerio)
Actinopterygii dek 34
  • 29 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dek 34
  • 17 (a)
Species where no ortholog for DEK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEK Gene

Gene Tree for DEK (if available)
Gene Tree for DEK (if available)
Evolutionary constrained regions (ECRs) for DEK: view image

Paralogs for DEK Gene

(1) SIMAP similar genes for DEK Gene using alignment to 7 proteins:

  • D6R9L5_HUMAN
  • H0Y8X0_HUMAN
  • H0Y993_HUMAN
  • L8EA44_HUMAN
genes like me logo Genes that share paralogs with DEK: view

No data available for Paralogs for DEK Gene

Variants for DEK Gene

Sequence variations from dbSNP and Humsavar for DEK Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000016996 -- 18,243,732(-) G/A intron_variant
rs1000036179 -- 18,224,186(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000097076 -- 18,228,898(-) C/G intron_variant
rs1000190947 -- 18,264,721(-) G/A/T upstream_transcript_variant
rs1000205166 -- 18,259,061(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DEK Gene

Variant ID Type Subtype PubMed ID
esv3307418 CNV mobile element insertion 20981092
esv3335295 CNV insertion 20981092
esv3424290 CNV insertion 20981092
esv3567344 CNV deletion 23714750
esv3567345 CNV deletion 23714750
nsv1144134 CNV deletion 24896259

Variation tolerance for DEK Gene

Residual Variation Intolerance Score: 24.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DEK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEK Gene

Disorders for DEK Gene

MalaCards: The human disease database

(4) MalaCards diseases for DEK Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute myeloid leukemia with t(6;9)(p23;q34)
  • aml with t(6;9)(p23;q34)
  • primary iridocyclitis
juvenile rheumatoid arthritis
  • rheumatoid arthritis, systemic juvenile
leukemia, acute myeloid
  • aml
- elite association - COSMIC cancer census association via MalaCards
Search DEK in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK-NUP214 fusion gene (PubMed:1549122). {ECO:0000269 PubMed:1549122}.

Genatlas disease for DEK Gene

myelodysplastic syndrome,refractory anemia with excess of blasts in transformation (MDS/RAEBT),acute myeloid leukemia of poor prognosis (AML),with t(6;9)(p23;q34) translocation

Additional Disease Information for DEK

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DEK: view

Publications for DEK Gene

  1. The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. (PMID: 1549122) von Lindern M … Grosveld G (Molecular and cellular biology 1992) 2 3 4 22 58
  2. Solution NMR structure of the N-terminal domain of the human DEK protein. (PMID: 18227428) Devany M … Matsuo H (Protein science : a publication of the Protein Society 2008) 3 4 22 58
  3. The distribution of the DEK protein in mammalian chromatin. (PMID: 17524367) Hu HG … Knippers R (Biochemical and biophysical research communications 2007) 3 4 22 58
  4. Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK. (PMID: 15199154) Kappes F … Gruss C (Molecular and cellular biology 2004) 3 4 22 58
  5. Solution NMR structure of the C-terminal domain of the human protein DEK. (PMID: 15238633) Devany M … Matsuo H (Protein science : a publication of the Protein Society 2004) 3 4 22 58

Products for DEK Gene

Sources for DEK Gene

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