Aliases for DEFB4B Gene
External Ids for DEFB4B Gene
Previous HGNC Symbols for DEFB4B Gene
Previous GeneCards Identifiers for DEFB4B Gene
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Oct 2014]
GeneCards Summary for DEFB4B Gene
DEFB4B (Defensin Beta 4B) is a Protein Coding gene. Diseases associated with DEFB4B include Marginal Corneal Ulcer and Erythrasma. Among its related pathways are Innate Immune System and Defensins. An important paralog of this gene is DEFB4A.
UniProtKB/Swiss-Prot Summary for DEFB4B Gene
Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells (PubMed:20068036).