Aliases for DEFB4A Gene
External Ids for DEFB4A Gene
Previous HGNC Symbols for DEFB4A Gene
Previous GeneCards Identifiers for DEFB4A Gene
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Jul 2008]
GeneCards Summary for DEFB4A Gene
DEFB4A (Defensin Beta 4A) is a Protein Coding gene. Diseases associated with DEFB4A include Oral Candidiasis and Anal Fistula. Among its related pathways are Bacterial infections in CF airways and NOD-like receptor signaling pathway. An important paralog of this gene is DEFB4B.
UniProtKB/Swiss-Prot Summary for DEFB4A Gene
Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells (PubMed:20068036).