Aliases for DEFB133 Gene

Aliases for DEFB133 Gene

  • Defensin Beta 133 2 3 5
  • Defensin, Beta 133 2 4
  • Beta-Defensin 133 3 4
  • DEFB133 5

External Ids for DEFB133 Gene

Previous GeneCards Identifiers for DEFB133 Gene

  • GC12U900425
  • GC06M049914
  • GC06M049645

Summaries for DEFB133 Gene

GeneCards Summary for DEFB133 Gene

DEFB133 (Defensin Beta 133) is a Pseudogene. Among its related pathways are Defensins and Innate Immune System.

UniProtKB/Swiss-Prot Summary for DEFB133 Gene

Additional gene information for DEFB133 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DEFB133 Gene

Genomics for DEFB133 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DEFB133 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J049949 Promoter 1.2 EPDnew Ensembl 600.7 +0.3 264 1.2 HMBOX1 POLR2A TAF9B ZSCAN29 NFRKB NR2C2 MYC EP400 FOSL1 TBP DEFB133 DEFB114 lnc-DEFB133-1 CRISP1
GH06J049939 Enhancer 0.9 ENCODE 0.4 +10.2 10224 1.2 RFX1 SIX5 LEF1 IKZF1 JUND DDX20 PKNOX1 MTA1 REST NR2C1 DEFB113 lnc-DEFB133-1 DEFB133 DEFB114 CRISP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DEFB133 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DEFB133

Top Transcription factor binding sites by QIAGEN in the DEFB133 gene promoter:
  • Evi-1
  • FOXO3
  • FOXO3a
  • FOXO3b
  • Nkx2-5
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • SRY
  • TGIF

Genomic Locations for DEFB133 Gene

Genomic Locations for DEFB133 Gene
chr6:49,946,021-49,950,265
(GRCh38/hg38)
Size:
4,245 bases
Orientation:
Minus strand
chr6:49,913,814-49,917,157
(GRCh37/hg19)
Size:
3,344 bases
Orientation:
Minus strand

Genomic View for DEFB133 Gene

Genes around DEFB133 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEFB133 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEFB133 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEFB133 Gene

Proteins for DEFB133 Gene

  • Protein details for DEFB133 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q30KQ1-DB133_HUMAN
    Recommended name:
    Beta-defensin 133
    Protein Accession:
    Q30KQ1
    Secondary Accessions:
    • Q4QY39

    Protein attributes for DEFB133 Gene

    Size:
    61 amino acids
    Molecular mass:
    7213 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEFB133 Gene

Post-translational modifications for DEFB133 Gene

No Post-translational modifications

Other Protein References for DEFB133 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for DEFB133 Gene

Domains & Families for DEFB133 Gene

Gene Families for DEFB133 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for DEFB133 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DEFB133 Gene

GenScript: Design optimal peptide antigens:
  • Defensin, beta 133 (DB133_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q30KQ1

UniProtKB/Swiss-Prot:

DB133_HUMAN :
  • Belongs to the beta-defensin family.
Family:
  • Belongs to the beta-defensin family.
genes like me logo Genes that share domains with DEFB133: view

Function for DEFB133 Gene

Molecular function for DEFB133 Gene

UniProtKB/Swiss-Prot Function:
Has antibacterial activity.

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DEFB133

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DEFB133 Gene

Localization for DEFB133 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEFB133 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DEFB133 gene
Compartment Confidence
extracellular 4

Gene Ontology (GO) - Cellular Components for DEFB133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with DEFB133: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DEFB133 Gene

Pathways & Interactions for DEFB133 Gene

PathCards logo

SuperPathways for DEFB133 Gene

genes like me logo Genes that share pathways with DEFB133: view

Pathways by source for DEFB133 Gene

Interacting Proteins for DEFB133 Gene

Gene Ontology (GO) - Biological Process for DEFB133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response IEA --
GO:0042742 defense response to bacterium IEA --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with DEFB133: view

No data available for SIGNOR curated interactions for DEFB133 Gene

Drugs & Compounds for DEFB133 Gene

No Compound Related Data Available

Transcripts for DEFB133 Gene

mRNA/cDNA for DEFB133 Gene

1 REFSEQ mRNAs :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DEFB133

Alternative Splicing Database (ASD) splice patterns (SP) for DEFB133 Gene

No ASD Table

Relevant External Links for DEFB133 Gene

GeneLoc Exon Structure for
DEFB133

Expression for DEFB133 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DEFB133 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DEFB133

SOURCE GeneReport for Unigene cluster for DEFB133 Gene:

Hs.558270
genes like me logo Genes that share expression patterns with DEFB133: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DEFB133 Gene

Orthologs for DEFB133 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DEFB133 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DEFB133 31
  • 95 (a)
OneToOne
Species where no ortholog for DEFB133 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for DEFB133 Gene

ENSEMBL:
Gene Tree for DEFB133 (if available)
TreeFam:
Gene Tree for DEFB133 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DEFB133: view image

Paralogs for DEFB133 Gene

(1) SIMAP similar genes for DEFB133 Gene using alignment to 1 proteins:

  • DB133_HUMAN
genes like me logo Genes that share paralogs with DEFB133: view

No data available for Paralogs for DEFB133 Gene

Variants for DEFB133 Gene

Structural Variations from Database of Genomic Variants (DGV) for DEFB133 Gene

Variant ID Type Subtype PubMed ID
nsv603091 CNV loss 21841781

Variation tolerance for DEFB133 Gene

Gene Damage Index Score: 2.12; 38.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DEFB133 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DEFB133

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Additional dbSNP identifiers (rs#s) for DEFB133 Gene

Disorders for DEFB133 Gene

Additional Disease Information for DEFB133

No disorders were found for DEFB133 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DEFB133 Gene

Publications for DEFB133 Gene

  1. Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. (PMID: 16033865) Patil AA … Zhang G (Physiological genomics 2005) 3 4

Products for DEFB133 Gene

  • Signalway ELISA kits for DEFB133

Sources for DEFB133 Gene