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Aliases for DEFB130B Gene

Aliases for DEFB130B Gene

  • Defensin Beta 130B 2 3 5
  • Defensin, Beta 130-Like 3
  • Beta-Defensin 130-Like 3
  • Beta-Defensin 130B 3

External Ids for DEFB130B Gene

Summaries for DEFB130B Gene

GeneCards Summary for DEFB130B Gene

DEFB130B (Defensin Beta 130B) is a Protein Coding gene. An important paralog of this gene is DEFB130A.

UniProtKB/Swiss-Prot for DEFB130B Gene

  • Antimicrobial host-defense peptide. Has an antiplasmodial activity.

Additional gene information for DEFB130B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEFB130B Gene

Genomics for DEFB130B Gene

Genomic Locations for DEFB130B Gene

Genomic Locations for DEFB130B Gene
chr8:12,064,389-12,071,747
(GRCh38/hg38)
Size:
7,359 bases
Orientation:
Minus strand
chr8:11,921,898-11,929,256
(GRCh37/hg19)

Genomic View for DEFB130B Gene

Genes around DEFB130B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEFB130B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEFB130B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEFB130B Gene

No data available for GeneHancer (GH) Regulatory Elements for DEFB130B Gene

Proteins for DEFB130B Gene

  • Protein details for DEFB130B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DP73-D130B_HUMAN
    Recommended name:
    Beta-defensin 130B
    Protein Accession:
    P0DP73
    Secondary Accessions:
    • Q30KQ2

    Protein attributes for DEFB130B Gene

    Size:
    79 amino acids
    Molecular mass:
    8736 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEFB130B Gene

Post-translational modifications for DEFB130B Gene

No Post-translational modifications

Other Protein References for DEFB130B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DEFB130B Gene

Domains & Families for DEFB130B Gene

Gene Families for DEFB130B Gene

Protein Domains for DEFB130B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P0DP73

UniProtKB/Swiss-Prot:

D130B_HUMAN :
  • Belongs to the beta-defensin family.
Family:
  • Belongs to the beta-defensin family.
genes like me logo Genes that share domains with DEFB130B: view

No data available for Suggested Antigen Peptide Sequences for DEFB130B Gene

Function for DEFB130B Gene

Molecular function for DEFB130B Gene

UniProtKB/Swiss-Prot Function:
Antimicrobial host-defense peptide. Has an antiplasmodial activity.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DEFB130B Gene

Localization for DEFB130B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEFB130B Gene

Secreted.

Gene Ontology (GO) - Cellular Components for DEFB130B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with DEFB130B: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for DEFB130B Gene

Pathways & Interactions for DEFB130B Gene

SuperPathways for DEFB130B Gene

No Data Available

Interacting Proteins for DEFB130B Gene

Gene Ontology (GO) - Biological Process for DEFB130B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response IEA --
GO:0042742 defense response to bacterium IEA --
genes like me logo Genes that share ontologies with DEFB130B: view

No data available for Pathways by source and SIGNOR curated interactions for DEFB130B Gene

Drugs & Compounds for DEFB130B Gene

No Compound Related Data Available

Transcripts for DEFB130B Gene

mRNA/cDNA for DEFB130B Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for DEFB130B Gene

No ASD Table

Relevant External Links for DEFB130B Gene

GeneLoc Exon Structure for
DEFB130B
ECgene alternative splicing isoforms for
DEFB130B

Expression for DEFB130B Gene

mRNA Expression by UniProt/SwissProt for DEFB130B Gene:

P0DP73-D130B_HUMAN
Tissue specificity: Expressed on differentiated macrophage phagocytizing plasmodium falciparum-parasitized erythrocytes.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DEFB130B Gene

Orthologs for DEFB130B Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for DEFB130B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DEFB130 34 33
  • 99.58 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Defb41 33
  • 74.26 (n)
mouse
(Mus musculus)
Mammalia Defb47 16 34 33
  • 72.57 (n)
Species where no ortholog for DEFB130B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DEFB130B Gene

ENSEMBL:
Gene Tree for DEFB130B (if available)
TreeFam:
Gene Tree for DEFB130B (if available)

Paralogs for DEFB130B Gene

Paralogs for DEFB130B Gene

genes like me logo Genes that share paralogs with DEFB130B: view

Variants for DEFB130B Gene

Sequence variations from dbSNP and Humsavar for DEFB130B Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1002440634 -- 12,064,894(-) A/ intron_variant
rs1002650972 -- 12,064,675(-) T/C intron_variant
rs1003241928 -- 12,066,649(-) G/T intron_variant
rs1004208916 -- 12,071,185(-) C/A intron_variant
rs1004455692 -- 12,072,870(-) C/A upstream_transcript_variant

Additional Variant Information for DEFB130B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DEFB130B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for DEFB130B Gene

Disorders for DEFB130B Gene

Additional Disease Information for DEFB130B

No disorders were found for DEFB130B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DEFB130B Gene

Publications for DEFB130B Gene

  1. Involvement of β-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum. (PMID: 28181499) Terkawi MA … Kato K (Scientific reports 2017) 2 3 4 58
  2. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 58

Products for DEFB130B Gene

Sources for DEFB130B Gene

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