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Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. [provided by RefSeq, Oct 2014]
DEFB115 (Defensin Beta 115) is a Protein Coding gene. Among its related pathways are Defensins and Innate Immune System. An important paralog of this gene is DEFB129.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH20J031245 | Enhancer | 0.3 | FANTOM5 | 0.4 | -11.8 | -11816 | 0.4 | SREBF1 | LINC01597 DEFB116 DEFB121 DEFB115 lnc-DEFB115-2 LOC107985433 | |
GH20J031228 | Enhancer | 0.2 | FANTOM5 | 0.3 | -28.9 | -28854 | 0 | DEFB116 lnc-DEFB115-2 DEFB115 LOC107985433 | ||
GH20J031226 | Enhancer | 0.2 | FANTOM5 | 0.3 | -31.4 | -31421 | 0.3 | DEFB116 lnc-DEFB115-2 DEFB115 LOC107985433 | ||
GH20J030376 | Promoter/Enhancer | 1.7 | Ensembl ENCODE CraniofacialAtlas | 0 | -880.3 | -880263 | 4 | SP1 GATAD2A CTCF ZBTB33 TFE3 ZNF7 TARDBP JUND RBFOX2 ZNF24 | FRG1BP lnc-DEFB115-5 LINC01597 RF00951-087 LOC107985433 DEFB115 | |
GH20J031167 | Enhancer | 0.2 | Ensembl | 0.2 | -89.6 | -89563 | 0.2 | lnc-DEFB115-2 DEFB115 piR-59769-359 LOC107985433 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Defensins |
.81
.81
|
|
2 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006952 | defense response | IEA | -- |
GO:0042742 | defense response to bacterium | IEA | -- |
GO:0045087 | innate immune response | IEA | -- |
This gene was present in the common ancestor of human and mouse.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DEFB115 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Defb28 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4298n100 | CNV | gain | 25217958 |
dgv4299n100 | CNV | gain | 25217958 |
dgv4300n100 | CNV | gain | 25217958 |
esv2763228 | CNV | gain | 21179565 |
esv3645643 | CNV | gain | 21293372 |
esv3645644 | CNV | loss | 21293372 |
esv3645645 | CNV | gain | 21293372 |
nsv458960 | CNV | gain | 19166990 |
nsv470546 | CNV | gain | 18288195 |
nsv585909 | CNV | gain | 21841781 |
nsv833951 | CNV | gain+loss | 17160897 |
nsv964448 | CNV | duplication | 23825009 |
No disorders were found for DEFB115 Gene.