Aliases for DEFB114 Gene
External Ids for DEFB114 Gene
Previous GeneCards Identifiers for DEFB114 Gene
Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. The protein encoded by this gene is a beta-defensin with antimicrobial activity against E. coli, S. aureus, and C. albicans. The encoded protein also binds and neutralizes lipopolysaccharide (LPS), a factor involved in inflammatory diseases and male reproductive issues. [provided by RefSeq, Nov 2014]
GeneCards Summary for DEFB114 Gene
DEFB114 (Defensin Beta 114) is a Protein Coding gene. Diseases associated with DEFB114 include Salpingo-Oophoritis. Among its related pathways are Defensins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include lipopolysaccharide binding.
UniProtKB/Swiss-Prot Summary for DEFB114 Gene
Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality.