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Aliases for DEFB108B Gene

Aliases for DEFB108B Gene

  • Defensin Beta 108B 2 3 5
  • Defensin, Beta 108B 2 4
  • Beta-Defensin 8 3 4
  • DEFB-8 3 4
  • HBD-8 3 4
  • Beta-Defensin 108B 3
  • Defensin, Beta 108 4
  • Defensin, Beta 8 3
  • DEFB108 4
  • DEFB8 4
  • BD-8 4

External Ids for DEFB108B Gene

Previous GeneCards Identifiers for DEFB108B Gene

  • GC11P071222
  • GC11U900687
  • GC11P071545
  • GC11P067838

Summaries for DEFB108B Gene

Entrez Gene Summary for DEFB108B Gene

  • Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. A pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Oct 2014]

GeneCards Summary for DEFB108B Gene

DEFB108B (Defensin Beta 108B) is a Protein Coding gene. Among its related pathways are Defensins and Innate Immune System.

UniProtKB/Swiss-Prot for DEFB108B Gene

  • Has antibacterial activity.

Additional gene information for DEFB108B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEFB108B Gene

Genomics for DEFB108B Gene

GeneHancer (GH) Regulatory Elements for DEFB108B Gene

Promoters and enhancers for DEFB108B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I071833 Promoter 0.5 EPDnew 550.8 -0.1 -101 0.1 DEFB108B ZNF705E
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DEFB108B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DEFB108B gene promoter:

Genomic Locations for DEFB108B Gene

Genomic Locations for DEFB108B Gene
4,511 bases
Plus strand

Genomic View for DEFB108B Gene

Genes around DEFB108B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEFB108B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEFB108B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEFB108B Gene

Proteins for DEFB108B Gene

  • Protein details for DEFB108B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Beta-defensin 108B
    Protein Accession:

    Protein attributes for DEFB108B Gene

    73 amino acids
    Molecular mass:
    8326 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEFB108B Gene

Post-translational modifications for DEFB108B Gene

No Post-translational modifications

Other Protein References for DEFB108B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DEFB108B Gene

Domains & Families for DEFB108B Gene

Gene Families for DEFB108B Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for DEFB108B Gene


Suggested Antigen Peptide Sequences for DEFB108B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the beta-defensin family.
  • Belongs to the beta-defensin family.
genes like me logo Genes that share domains with DEFB108B: view

Function for DEFB108B Gene

Molecular function for DEFB108B Gene

UniProtKB/Swiss-Prot Function:
Has antibacterial activity.

Phenotypes for DEFB108B Gene

GenomeRNAi human phenotypes for DEFB108B:
genes like me logo Genes that share phenotypes with DEFB108B: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DEFB108B Gene

Localization for DEFB108B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEFB108B Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DEFB108B gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for DEFB108B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0009986 cell surface IBA --
genes like me logo Genes that share ontologies with DEFB108B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DEFB108B Gene

Pathways & Interactions for DEFB108B Gene

genes like me logo Genes that share pathways with DEFB108B: view

Pathways by source for DEFB108B Gene

Interacting Proteins for DEFB108B Gene

Gene Ontology (GO) - Biological Process for DEFB108B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response IEA --
GO:0042742 defense response to bacterium IEA,IBA --
GO:0045087 innate immune response IBA --
genes like me logo Genes that share ontologies with DEFB108B: view

No data available for SIGNOR curated interactions for DEFB108B Gene

Drugs & Compounds for DEFB108B Gene

No Compound Related Data Available

Transcripts for DEFB108B Gene

mRNA/cDNA for DEFB108B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DEFB108B Gene

Defensin, beta 108B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEFB108B Gene

No ASD Table

Relevant External Links for DEFB108B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DEFB108B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DEFB108B Gene

NURSA nuclear receptor signaling pathways regulating expression of DEFB108B Gene:


SOURCE GeneReport for Unigene cluster for DEFB108B Gene:


mRNA Expression by UniProt/SwissProt for DEFB108B Gene:

Tissue specificity: Specifically expressed in testis. Low expression is detected also in liver.
genes like me logo Genes that share expression patterns with DEFB108B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DEFB108B Gene

Orthologs for DEFB108B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DEFB108B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DEFB108B 33 34
  • 84.8 (n)
Species where no ortholog for DEFB108B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DEFB108B Gene

Gene Tree for DEFB108B (if available)
Gene Tree for DEFB108B (if available)

Paralogs for DEFB108B Gene

(8) SIMAP similar genes for DEFB108B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DEFB108B: view

No data available for Paralogs for DEFB108B Gene

Variants for DEFB108B Gene

Sequence variations from dbSNP and Humsavar for DEFB108B Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000071359 -- 71,831,870(+) A/G upstream_transcript_variant
rs1001282811 -- 71,836,678(+) T/A intron_variant
rs1001879450 -- 71,835,437(+) A/G intron_variant
rs1001945727 -- 71,834,430(+) A/G intron_variant
rs1002248466 -- 71,835,676(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DEFB108B Gene

Variant ID Type Subtype PubMed ID
dgv223e199 CNV deletion 23128226
esv25167 CNV gain 19812545
esv2744758 CNV deletion 23290073
esv2759836 CNV gain+loss 17122850
esv2760190 CNV loss 21179565
esv2761682 CNV gain 21179565
esv3892025 CNV gain 25118596
nsv428262 CNV gain+loss 18775914
nsv8837 CNV gain+loss 18304495
nsv972041 CNV duplication 23825009

Variation tolerance for DEFB108B Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.76; 89.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DEFB108B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEFB108B Gene

Disorders for DEFB108B Gene

Additional Disease Information for DEFB108B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DEFB108B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DEFB108B Gene

Publications for DEFB108B Gene

  1. Copy number variation of defensin genes and HIV infection in Brazilian children. (PMID: 19194307) Milanese M … Crovella S (Journal of acquired immune deficiency syndromes (1999) 2009) 3 44 58
  2. ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes. (PMID: 12600824) Kao CY … Wu R (American journal of respiratory cell and molecular biology 2003) 3 4 58
  3. Duplication and selection in the evolution of primate beta-defensin genes. (PMID: 12734011) Semple CA … Dorin JR (Genome biology 2003) 3 4 58
  4. Discovery of five conserved beta -defensin gene clusters using a computational search strategy. (PMID: 11854508) Schutte BC … McCray PB (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 4 58

Products for DEFB108B Gene

Sources for DEFB108B Gene

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