Aliases for DEFB106B Gene
Aliases for DEFB106B Gene
External Ids for DEFB106B Gene
- HGNC: 28879
- Entrez Gene: 503841
- Ensembl: ENSG00000187082
- UniProtKB: Q8N104
Previous GeneCards Identifiers for DEFB106B Gene
- GC08U900536
- GC08M007329
- GC08M007340
Summaries for DEFB106B Gene
-
Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation. This gene, DEFB106B, represents the more telomeric copy. [provided by RefSeq, Oct 2014]
GeneCards Summary for DEFB106B Gene
DEFB106B (Defensin Beta 106B) is a Protein Coding gene. Among its related pathways are Defensins and Innate Immune System. An important paralog of this gene is DEFB106A.
UniProtKB/Swiss-Prot for DEFB106B Gene
-
Has antibacterial activity (PubMed:12600824). Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:23938203).
Additional gene information for DEFB106B Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEFB106B Gene
Genomics for DEFB106B Gene
GeneHancer (GH) Regulatory Elements for DEFB106B Gene
Promoters and enhancers for DEFB106B Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH08J007487 | Promoter | 0.5 | EPDnew | 650.7 | -1.3 | -1260 | 0.1 | DEFB105B DEFB106B | ||
| GH08J007481 | Promoter | 0.5 | EPDnew | 0.4 | +5.1 | 5076 | 0.1 | DEFB104B DEFB106B |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DEFB106B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for DEFB106B Gene
Genomic Locations for DEFB106B Gene
- chr8:7,482,504-7,486,400
- (GRCh38/hg38)
- Size:
- 3,897 bases
- Orientation:
- Minus strand
- chr8:7,340,026-7,343,922
- (GRCh37/hg19)
Genomic View for DEFB106B Gene
Genes around DEFB106B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p23.1 by Entrez Gene
- 8p23.1 by HGNC
- 8p23.1 by Ensembl
DEFB106B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DEFB106B Gene
Proteins for DEFB106B Gene
-
Protein details for DEFB106B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N104-D106A_HUMAN
- Recommended name:
- Beta-defensin 106
- Protein Accession:
- Q8N104
- Q2NKR0
- Q496I8
- Q2NKR0
- Q496I8
Protein attributes for DEFB106B Gene
- Size:
- 65 amino acids
- Molecular mass:
- 7369 Da
- Quaternary structure:
-
- Monomer (PubMed:23938203). Interacts with CCR2 (via extracellular N-terminal region); this interaction may preferentially require specific tyrosine sulfation on CCR2 (PubMed:23938203).
- Monomer (PubMed:23938203). Interacts with CCR2 (via extracellular N-terminal region); this interaction may preferentially require specific tyrosine sulfation on CCR2 (PubMed:23938203).
Post-translational modifications for DEFB106B Gene
No Post-translational modifications
Other Protein References for DEFB106B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for DEFB106B
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Protein Products
-
OriGene Purified Proteins for DEFB106B
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Assay Products
No data available for DME Specific Peptides for DEFB106B Gene
Domains & Families for DEFB106B Gene
Gene Families for DEFB106B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for DEFB106B Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DEFB106B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8N104- Family:
-
- Belongs to the beta-defensin family.
Function for DEFB106B Gene
Molecular function for DEFB106B Gene
- UniProtKB/Swiss-Prot Function:
- Has antibacterial activity (PubMed:12600824). Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:23938203).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001530 | lipopolysaccharide binding | IDA | 24189797 |
| GO:0005515 | protein binding | IPI | 23938203 |
| GO:0008201 | heparin binding | IDA | 24189797 |
| GO:0031727 | CCR2 chemokine receptor binding | IDA | 23938203 |
Phenotypes for DEFB106B Gene
- GenomeRNAi human phenotypes for DEFB106B:
Animal Model Products
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-
CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for DEFB106B Gene
- miRTarBase miRNAs that target DEFB106B
miRNA Products
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-
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DEFB106B
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DEFB106B
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DEFB106B Gene
Localization for DEFB106B Gene
Subcellular locations from UniProtKB/Swiss-Prot for DEFB106B Gene
- Secreted. Membrane. Note=Associates with tumor cell membrane-derived microvesicles (PubMed:23938203). {ECO:0000269 PubMed:23938203}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005634 | nucleus | IDA | 24189797 |
| GO:0009986 | cell surface | IBA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0019898 | extrinsic component of membrane | IDA | 23938203 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for DEFB106B Gene
Pathways & Interactions for DEFB106B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Defensins |
.82
.82
|
|
| 2 | Innate Immune System |
.61
|
|
Pathways by source for DEFB106B Gene
5 Reactome pathways for DEFB106B Gene
Interacting Proteins for DEFB106B Gene
GPS-Prot Interaction Network for DEFB106B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006952 | defense response | IEA | -- |
| GO:0042742 | defense response to bacterium | IEA,IBA | -- |
| GO:0045087 | innate immune response | IBA,IDA | 24189797 |
| GO:0050829 | defense response to Gram-negative bacterium | IDA | 24189797 |
| GO:0050830 | defense response to Gram-positive bacterium | IDA | 24189797 |
No data available for SIGNOR curated interactions for DEFB106B Gene
Transcripts for DEFB106B Gene
mRNA/cDNA for DEFB106B Gene
- (10) Additional mRNA sequences :
- (1) REFSEQ mRNAs :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000335479 316 bps (uc003wro.2)
Unigene Clusters for DEFB106B Gene
- Defensin, beta 106B:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for DEFB106B
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- Applied Biological Materials CRISPR for DEFB106B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DEFB106B
- GenScript: Design CRISPR guide RNA sequences for DEFB106B
miRNA Products
Inhibitory RNA Products
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Clone Products
-
OriGene ORF clones in human for DEFB106B
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- Sino Biological Human cDNA Clone for DEFB106B
- VectorBuilder custom plasmid, inducible vectors for DEFB106B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DEFB106B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DEFB106B
- genomics-online: cdna clones - Search results for available DEFB106B gene related products
- orf clones - Search results for available DEFB106B gene related products
- Applied Biological Materials Clones for DEFB106B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for DEFB106B Gene
NURSA nuclear receptor signaling pathways regulating expression of DEFB106B Gene:
DEFB106BSOURCE GeneReport for Unigene cluster for DEFB106B Gene:
Hs.511958mRNA Expression by UniProt/SwissProt for DEFB106B Gene:
Q8N104-D106A_HUMAN
Tissue specificity:
Expressed specifically in epididymis and lung.
Evidence on tissue expression from TISSUES for DEFB106B Gene
- Lung(4.2)
Primer Products
- genomics-online: primer clones - Search results for available DEFB106B gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DEFB106B Gene
Orthologs for DEFB106B Gene
This gene was present in the common ancestor of human and mouse.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DEFB106A 34 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Defb34 34 |
|
ManyToMany |
- Species where no ortholog for DEFB106B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for DEFB106B Gene
Variants for DEFB106B Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000147741 | -- | 7,483,974(-) | T/A | intron_variant | |
| rs1002207963 | -- | 7,484,600(-) | C/T | intron_variant | |
| rs1003955156 | -- | 7,485,136(-) | A/G | intron_variant | |
| rs1004007523 | -- | 7,486,741(-) | A/T | upstream_transcript_variant | |
| rs1009576230 | -- | 7,483,112(-) | G/T | intron_variant |
Residual Variation Intolerance Score:
64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.00;
0.03% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DEFB106B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DEFB106B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEFB106B Gene
Disorders for DEFB106B Gene
Additional Disease Information for DEFB106B
No disorders were found for DEFB106B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DEFB106B Gene
Publications for DEFB106B Gene
- Structural basis for the interaction of human β-defensin 6 and its putative chemokine receptor CCR2 and breast cancer microvesicles. (PMID: 23938203) De Paula VS … Valente AP (Journal of molecular biology 2013) 3 4 58
- Duplication and selection in the evolution of primate beta-defensin genes. (PMID: 12734011) Semple CA … Dorin JR (Genome biology 2003) 3 4 58
- Discovery of five conserved beta -defensin gene clusters using a computational search strategy. (PMID: 11854508) Schutte BC … McCray PB (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 4 58
- Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice. (PMID: 12193721) Yamaguchi Y … Ouchi Y (Journal of immunology (Baltimore, Md. : 1950) 2002) 3 4 58
- Soluble fusion expression, characterization and localization of human β-defensin 6. (PMID: 24189797) Xin A … Zhang Y (Molecular medicine reports 2014) 3 58
Products for DEFB106B Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for DEFB106B
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- genomics-online: cdna clones - Search results for available DEFB106B gene related products
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Sources for DEFB106B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
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- (60) TGDB
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- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
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- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
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- (114) diseasecard
- (115) NIH Rare Diseases
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