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Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation. This gene, DEFB106B, represents the more telomeric copy. [provided by RefSeq, Oct 2014]
DEFB106B (Defensin Beta 106B) is a Protein Coding gene. Among its related pathways are Defensins and Innate Immune System. An important paralog of this gene is DEFB106A.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH08J007487 | Promoter | 0.3 | EPDnew | 600.7 | -1.3 | -1260 | 0.1 | DEFB105B DEFB106B | ||
GH08J007481 | Promoter | 0.3 | EPDnew | 0.4 | +5.1 | 5076 | 0.1 | lnc-DEFB104B-1 DEFB104B DEFB106B |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001530 | lipopolysaccharide binding | IDA | 24189797 |
GO:0005515 | protein binding | IPI | 23938203 |
GO:0008201 | heparin binding | IDA | 24189797 |
GO:0031727 | CCR2 chemokine receptor binding | IDA | 23938203 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005634 | nucleus | IDA | 24189797 |
GO:0016020 | membrane | IEA | -- |
GO:0019898 | extrinsic component of membrane | IDA | 23938203 |
GO:1990742 | microvesicle | IDA | 23938203 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Defensins |
.81
.81
|
|
2 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006952 | defense response | IEA | -- |
GO:0042742 | defense response to bacterium | IEA | -- |
GO:0045087 | innate immune response | IDA | 24189797 |
GO:0050829 | defense response to Gram-negative bacterium | IDA | 24189797 |
GO:0050830 | defense response to Gram-positive bacterium | IDA | 24189797 |
This gene was present in the common ancestor of human and mouse.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DEFB106A 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Defb34 31 |
|
ManyToMany |
No disorders were found for DEFB106B Gene.