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Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105B, represents the more telomeric copy. [provided by RefSeq, Oct 2014]
DEFB105B (Defensin Beta 105B) is a Protein Coding gene. Diseases associated with DEFB105B include Cardiomyopathy, Familial Hypertrophic, 12 and Osteopetrosis, Autosomal Recessive 2. Among its related pathways are Defensins and Innate Immune System. An important paralog of this gene is DEFB105A.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH08J007487 | Promoter | 0.3 | EPDnew | 600.7 | 0.0 | -19 | 0.1 | DEFB105B DEFB106B | ||
GH08J007495 | Promoter | 0.3 | EPDnew | 0.4 | +8.2 | 8216 | 0.1 | DEFB107B DEFB105B |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Defensins |
.81
.81
|
|
2 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006952 | defense response | IEA | -- |
GO:0042742 | defense response to bacterium | IEA | -- |
GO:0045087 | innate immune response | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DEFB105A 30 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | DEFB105A 30 |
|
||
CBD105 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Defb12 30 |
|
||
Cow (Bos Taurus) |
Mammalia | LOC100296624 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Defb12 30 17 31 |
|
ManyToMany | |
Defb35 31 |
|
ManyToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
cardiomyopathy, familial hypertrophic, 12 |
|
|
osteopetrosis, autosomal recessive 2 |
|
|
cardiomyopathy, familial hypertrophic, 6 |
|
|
congenital bile acid synthesis defect |
|
|
west nile fever |
|
|