Aliases for DEFB105B Gene
Aliases for DEFB105B Gene
External Ids for DEFB105B Gene
- HGNC: 29930
- Entrez Gene: 504180
- Ensembl: ENSG00000186599
- UniProtKB: Q8NG35
Previous GeneCards Identifiers for DEFB105B Gene
- GC08U900546
- GC08P007334
Summaries for DEFB105B Gene
-
Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105B, represents the more telomeric copy. [provided by RefSeq, Oct 2014]
GeneCards Summary for DEFB105B Gene
DEFB105B (Defensin Beta 105B) is a Protein Coding gene. Among its related pathways are Defensins and Innate Immune System. An important paralog of this gene is DEFB105A.
UniProtKB/Swiss-Prot for DEFB105B Gene
-
Has antibacterial activity.
Additional gene information for DEFB105B Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEFB105B Gene
Genomics for DEFB105B Gene
GeneHancer (GH) Regulatory Elements for DEFB105B Gene
Promoters and enhancers for DEFB105B Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH08I007486 | Promoter | 0.5 | EPDnew | 550.8 | -1.2 | -1229 | 0.1 | DEFB106B DEFB105B | ||
| GH08I007487 | Promoter | 0.5 | EPDnew | 550.8 | 0.0 | -8 | 0.1 | DEFB105B DEFB106B |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DEFB105B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for DEFB105B Gene
Genomic Locations for DEFB105B Gene
- chr8:7,487,668-7,490,779
- (GRCh38/hg38)
- Size:
- 3,112 bases
- Orientation:
- Plus strand
- chr8:7,345,191-7,347,115
- (GRCh37/hg19)
Genomic View for DEFB105B Gene
Genes around DEFB105B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p23.1 by Ensembl
- 8p23.1 by Entrez Gene
- 8p23.1 by HGNC
DEFB105B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DEFB105B Gene
Proteins for DEFB105B Gene
-
Protein details for DEFB105B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NG35-D105A_HUMAN
- Recommended name:
- Beta-defensin 105
- Protein Accession:
- Q8NG35
- A1A581
- Q8IZN8
Protein attributes for DEFB105B Gene
- Size:
- 78 amino acids
- Molecular mass:
- 8923 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for DEFB105B Gene
No Post-translational modifications
Other Protein References for DEFB105B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for DEFB105B
Protein Products
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Assay Products
No data available for DME Specific Peptides for DEFB105B Gene
Domains & Families for DEFB105B Gene
Gene Families for DEFB105B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for DEFB105B Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DEFB105B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8NG35- Family:
-
- Belongs to the beta-defensin family.
Function for DEFB105B Gene
Molecular function for DEFB105B Gene
- UniProtKB/Swiss-Prot Function:
- Has antibacterial activity.
Phenotypes for DEFB105B Gene
- GenomeRNAi human phenotypes for DEFB105B:
Animal Model Products
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-
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miRNA for DEFB105B Gene
- miRTarBase miRNAs that target DEFB105B
-
- hsa-mir-7850-5p (MIRT619811)
- hsa-mir-6515-5p (MIRT619812)
- hsa-mir-4443 (MIRT619813)
- hsa-mir-7977 (MIRT619814)
- hsa-mir-650 (MIRT619815)
- hsa-mir-3612 (MIRT619816)
- hsa-mir-6847-3p (MIRT619817)
- hsa-mir-383-3p (MIRT619818)
- hsa-mir-7703 (MIRT637458)
- hsa-mir-6864-3p (MIRT637459)
- hsa-mir-3672 (MIRT637460)
- hsa-mir-514b-5p (MIRT637461)
- hsa-mir-513c-5p (MIRT637462)
- hsa-mir-6868-3p (MIRT637463)
- hsa-mir-6720-5p (MIRT637464)
- hsa-mir-6512-3p (MIRT637465)
- hsa-mir-6729-5p (MIRT637466)
- hsa-mir-4649-5p (MIRT637467)
- hsa-mir-1273a (MIRT637468)
- hsa-mir-661 (MIRT637469)
- hsa-mir-4252 (MIRT637470)
- hsa-mir-873-3p (MIRT637471)
- hsa-mir-4486 (MIRT637472)
- hsa-mir-4793-3p (MIRT637473)
- hsa-mir-766-3p (MIRT637474)
- hsa-mir-372-5p (MIRT637475)
- hsa-mir-371a-5p (MIRT637476)
- hsa-mir-616-5p (MIRT637477)
- hsa-mir-373-5p (MIRT637478)
- hsa-mir-371b-5p (MIRT637479)
- hsa-mir-1248 (MIRT637480)
- hsa-mir-1237-3p (MIRT637481)
- hsa-mir-939-3p (MIRT637482)
- hsa-mir-6849-3p (MIRT637483)
- hsa-mir-1273g-3p (MIRT637484)
- hsa-mir-759 (MIRT637485)
- hsa-mir-3613-3p (MIRT637486)
- hsa-mir-5586-3p (MIRT637487)
- hsa-mir-508-5p (MIRT637488)
- hsa-mir-4797-5p (MIRT637489)
- hsa-mir-1468-3p (MIRT718222)
- hsa-mir-4729 (MIRT718223)
- hsa-mir-4524b-3p (MIRT718224)
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-
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- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 65 available DEFB105B gene related products
- Overview of 65 available DEFB105B gene related products
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Recommended
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Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DEFB105B Gene
Localization for DEFB105B Gene
Subcellular locations from UniProtKB/Swiss-Prot for DEFB105B Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0009986 | cell surface | IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for DEFB105B Gene
Pathways & Interactions for DEFB105B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Defensins |
.83
.83
|
|
| 2 | Innate Immune System |
.61
|
|
Pathways by source for DEFB105B Gene
5 Reactome pathways for DEFB105B Gene
Interacting Proteins for DEFB105B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006952 | defense response | IEA | -- |
| GO:0042742 | defense response to bacterium | IBA,IEA | -- |
| GO:0045087 | innate immune response | IBA | -- |
No data available for SIGNOR curated interactions for DEFB105B Gene
Transcripts for DEFB105B Gene
mRNA/cDNA for DEFB105B Gene
- (1) REFSEQ mRNAs :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for DEFB105B
- genomics-online: gRNA clones - Search results for 65 available DEFB105B gene related products
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Recommended
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DEFB105B
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miRNA Products
- Search ViGene Biosciences for DEFB105B
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for DEFB105B
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- genomics-online: shRNA clones - Search results for 65 available DEFB105B gene related products
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Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for DEFB105B gene
Clone Products
-
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for DEFB105B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DEFB105B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 65 available DEFB105B gene related products
- Overview of 65 available DEFB105B gene related products
-
Recommended
- orf clones - Search results for 65 available DEFB105B gene related products
- Overview of 65 available DEFB105B gene related products
-
Recommended
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for DEFB105B Gene
NURSA nuclear receptor signaling pathways regulating expression of DEFB105B Gene:
DEFB105BSOURCE GeneReport for Unigene cluster for DEFB105B Gene:
Hs.381378mRNA Expression by UniProt/SwissProt for DEFB105B Gene:
Q8NG35-D105A_HUMAN
Tissue specificity:
Specifically expressed in testis.
Primer Products
-
OriGene qPCR primer pairs for DEFB105B
- genomics-online: primer clones - Search results for 65 available DEFB105B gene related products
- Overview of 65 available DEFB105B gene related products
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Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DEFB105B Gene
Orthologs for DEFB105B Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DEFB105A 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | DEFB105A 33 |
|
||
| CBD105 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Defb12 33 |
|
||
| cow (Bos Taurus) |
Mammalia | LOC100296624 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Defb12 33 16 34 |
|
||
| Defb35 34 |
|
ManyToMany |
- Species where no ortholog for DEFB105B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for DEFB105B Gene
(1) SIMAP similar genes for DEFB105B Gene using alignment to 2 proteins:
Variants for DEFB105B Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1004007523 | -- | 7,486,741(+) | A/T | upstream_transcript_variant | |
| rs1016606954 | -- | 7,486,762(+) | G/T | upstream_transcript_variant | |
| rs1021627976 | -- | 7,489,958(+) | T/A | downstream_transcript_variant | |
| rs1028016386 | -- | 7,488,046(+) | C/T | intron_variant | |
| rs1045969933 | -- | 7,486,712(+) | G/T | upstream_transcript_variant |
Additional Variant Information for DEFB105B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DEFB105B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for DEFB105B Gene
Disorders for DEFB105B Gene
Additional Disease Information for DEFB105B
No disorders were found for DEFB105B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DEFB105B Gene
Publications for DEFB105B Gene
- Duplication and selection in the evolution of primate beta-defensin genes. (PMID: 12734011) Semple CA … Dorin JR (Genome biology 2003) 3 4 58
- Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice. (PMID: 12193721) Yamaguchi Y … Ouchi Y (Journal of immunology (Baltimore, Md. : 1950) 2002) 3 4 58
- Human defensin 5 disulfide array mutants: disulfide bond deletion attenuates antibacterial activity against Staphylococcus aureus. (PMID: 21861459) Wanniarachchi YA … Nolan EM (Biochemistry 2011) 3 58
- Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. (PMID: 16033865) Patil AA … Zhang G (Physiological genomics 2005) 3 58
- Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence. (PMID: 15588320) Taudien S … Platzer M (BMC genomics 2004) 3 58
Products for DEFB105B Gene
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DEFB105B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for DEFB105B
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- ViGene Biosciences adenoviral particle packaged cDNA for DEFB105B gene
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- genomics-online: cdna clones - Search results for 65 available DEFB105A gene related products
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Sources for DEFB105B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
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