Aliases for DEFB105A Gene
External Ids for DEFB105A Gene
Previous HGNC Symbols for DEFB105A Gene
Previous GeneCards Identifiers for DEFB105A Gene
Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105A, represents the more centromeric copy. [provided by RefSeq, Oct 2014]
GeneCards Summary for DEFB105A Gene
DEFB105A (Defensin Beta 105A) is a Protein Coding gene. Diseases associated with DEFB105A include Osteopetrosis, Autosomal Recessive 2 and Congenital Bile Acid Synthesis Defect. Among its related pathways are Defensins and Innate Immune System. An important paralog of this gene is DEFB105B.
UniProtKB/Swiss-Prot Summary for DEFB105A Gene
Has antibacterial activity.