Aliases for DEFB105A Gene
External Ids for DEFB105A Gene
Previous HGNC Symbols for DEFB105A Gene
Previous GeneCards Identifiers for DEFB105A Gene
Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105A, represents the more centromeric copy. [provided by RefSeq, Oct 2014]
GeneCards Summary for DEFB105A Gene
DEFB105A (Defensin Beta 105A) is a Protein Coding gene. Diseases associated with DEFB105A include Cardiomyopathy, Familial Hypertrophic, 12 and Osteopetrosis, Autosomal Recessive 2. Among its related pathways are Defensins and Innate Immune System. An important paralog of this gene is DEFB105B.
UniProtKB/Swiss-Prot Summary for DEFB105A Gene
Has antibacterial activity.