Aliases for DEFB103A Gene
External Ids for DEFB103A Gene
Previous HGNC Symbols for DEFB103A Gene
Previous GeneCards Identifiers for DEFB103A Gene
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103, an antibiotic peptide which is induced by bacteria and interferon gamma, and which displays antimicrobial activity against S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. [provided by RefSeq, Oct 2014]
GeneCards Summary for DEFB103A Gene
DEFB103A (Defensin Beta 103A) is a Protein Coding gene. Diseases associated with DEFB103A include Cardiomyopathy, Familial Hypertrophic, 12 and Ileitis. Among its related pathways are Defensins and Innate Immune System. An important paralog of this gene is DEFB103B.
UniProtKB/Swiss-Prot Summary for DEFB103A Gene
Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed.