Aliases for DEFB1 Gene
External Ids for DEFB1 Gene
Previous GeneCards Identifiers for DEFB1 Gene
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for DEFB1 Gene
DEFB1 (Defensin Beta 1) is a Protein Coding gene. Diseases associated with DEFB1 include Tonsillitis and Cystic Fibrosis. Among its related pathways are Defensins and Regulation of activated PAK-2p34 by proteasome mediated degradation.
UniProtKB/Swiss-Prot Summary for DEFB1 Gene
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636).