Aliases for DEFA6 Gene
External Ids for DEFA6 Gene
Previous GeneCards Identifiers for DEFA6 Gene
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel. [provided by RefSeq, Oct 2014]
GeneCards Summary for DEFA6 Gene
DEFA6 (Defensin Alpha 6) is a Protein Coding gene. Diseases associated with DEFA6 include Acute Vascular Insufficiency Of Intestine. Among its related pathways are Innate Immune System and Defensins. An important paralog of this gene is DEFA4.
UniProtKB/Swiss-Prot Summary for DEFA6 Gene
Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1.