Aliases for DEDD2 Gene
External Ids for DEDD2 Gene
Previous GeneCards Identifiers for DEDD2 Gene
This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
GeneCards Summary for DEDD2 Gene
DEDD2 (Death Effector Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include receptor signaling complex scaffold activity. An important paralog of this gene is DEDD.
UniProtKB/Swiss-Prot Summary for DEDD2 Gene
May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.