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This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters. [provided by RefSeq, Jul 2008]
DECR1 (2,4-Dienoyl-CoA Reductase 1) is a Protein Coding gene. Diseases associated with DECR1 include 2,4-Dienoyl-Coa Reductase Deficiency and Hyperlysinemia, Type I. Among its related pathways are Mitochondrial Fatty Acid Beta-Oxidation and Fatty Acid Biosynthesis (WikiPathways). Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NADPH binding. An important paralog of this gene is DECR2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008670 | 2,4-dienoyl-CoA reductase (NADPH) activity | IEA,IDA | 15531764 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0042802 | identical protein binding | IPI | 15531764 |
GO:0070402 | NADPH binding | IDA | 15531764 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | HDA | 21630459 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005739 | mitochondrion | NAS | 7818482 |
GO:0005759 | mitochondrial matrix | TAS | -- |
GO:0005829 | cytosol | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006631 | fatty acid metabolic process | IEA | -- |
GO:0006635 | fatty acid beta-oxidation | TAS | -- |
GO:0055114 | oxidation-reduction process | IEA | -- |
GO:0120162 | positive regulation of cold-induced thermogenesis | ISS | 19578400 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
trans-3-Hexenoyl-CoA |
|
6599-65-1 |
|
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||
SP2: | |||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||
SP5: | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DECR1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DECR1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DECR1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Decr1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Decr1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | DECR1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | DECR1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DECR1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DECR1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | decr1 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.22226 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | decr1 30 31 |
|
OneToOne | |
wufe38b07 30 |
|
||||
Worm (Caenorhabditis elegans) |
Secernentea | F53C11.3 31 32 |
|
OneToMany | |
decr-1.3 31 |
|
OneToMany | |||
T05C12.3 32 |
|
|
|||
W01C9.4 32 |
|
|
|||
decr-1.2 31 |
|
OneToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SPS19 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs137904244 | Benign: not provided | 90,020,923(+) |
T/C NM_001359.2(DECR1):c.432T>C (p.Asn144=) |
SYNONYMOUS | |
rs138725804 | Benign: not provided | 90,019,121(+) |
T/C NM_001359.2(DECR1):c.366T>C (p.Asp122=) |
SYNONYMOUS | |
rs1451324144 | Uncertain Significance: 2,4-Dienoyl-CoA reductase deficiency | 90,017,256(+) |
G/A NM_001359.2(DECR1):c.202G>A (p.Gly68Ser) |
MISSENSE | |
rs145323335 | Likely Benign: 2,4-Dienoyl-CoA reductase deficiency | 90,017,131(+) |
G/A NM_001359.2(DECR1):c.77G>A (p.Ser26Asn) |
MISSENSE | |
rs147668665 | Benign: not provided | 90,045,002(+) |
GT/G NM_001359.2(DECR1):c.885+9del |
INTRON |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759628 | CNV | gain+loss | 17122850 |
nsv8365 | CNV | gain | 18304495 |
Disorder | Aliases | PubMed IDs |
---|---|---|
2,4-dienoyl-coa reductase deficiency |
|
|
hyperlysinemia, type i |
|
|
hyperprolinemia, type i |
|
|
hyperprolinemia, type ii |
|
|
carnitine deficiency, systemic primary |
|
|