Aliases for DECR1 Gene
Aliases for DECR1 Gene
External Ids for DECR1 Gene
- HGNC: 2753
- Entrez Gene: 1666
- Ensembl: ENSG00000104325
- OMIM: 222745
- UniProtKB: Q16698
Previous HGNC Symbols for DECR1 Gene
- DECR
Previous GeneCards Identifiers for DECR1 Gene
- GC08P089445
- GC08P090745
- GC08P090970
- GC08P091082
- GC08P086223
Summaries for DECR1 Gene
-
This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters. [provided by RefSeq, Jul 2008]
GeneCards Summary for DECR1 Gene
DECR1 (2,4-Dienoyl-CoA Reductase 1) is a Protein Coding gene. Diseases associated with DECR1 include 2,4-Dienoyl-Coa Reductase Deficiency and Chronic Granulomatous Disease. Among its related pathways are Mitochondrial Fatty Acid Beta-Oxidation and Metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NADPH binding. An important paralog of this gene is PECR.
UniProtKB/Swiss-Prot for DECR1 Gene
-
Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
Additional gene information for DECR1 Gene
- Monarch Initiative
- Search for DECR1 at DataMed
- Search for DECR1 at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DECR1 Gene
Genomics for DECR1 Gene
GeneHancer (GH) Regulatory Elements for DECR1 Gene
Promoters and enhancers for DECR1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH08J089999 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE dbSUPER | 650.7 | +0.2 | 168 | 3.8 | HDGF FOXA2 SMAD1 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 YY1 | NBN DECR1 LOC101929709 | |
| GH08J090004 | Enhancer | 1.1 | Ensembl ENCODE dbSUPER | 18.7 | +4.6 | 4593 | 2.3 | HDGF CTCF BCOR EBF1 IRF4 GATA2 EGR1 POLR2A EED ATF7 | DECR1 NBN PIR41949 | |
| GH08J089725 | Enhancer | 1.5 | FANTOM5 Ensembl ENCODE | 10.9 | -273.1 | -273148 | 5.7 | HDGF PKNOX1 ATF1 SIN3A IRF4 YY1 POLR2B ZNF766 ZNF143 ATF7 | LOC101929709 RIPK2 DECR1 NBN OSGIN2 PIR62642 | |
| GH08J090082 | Promoter/Enhancer | 1.5 | EPDnew Ensembl ENCODE | 10.6 | +81.5 | 81492 | 0.7 | HDAC1 RB1 SIN3A ZBTB40 ZBTB7B ZNF48 CHAMP1 ZNF766 ARID2 SCRT2 | CALB1 NBN DECR1 PIR41949 | |
| GH08J089841 | Enhancer | 1.1 | FANTOM5 Ensembl ENCODE dbSUPER | 10.7 | -159.9 | -159851 | 1 | ATF4 CEBPB CEBPG | RIPK2 DECR1 NBN LOC101929709 OSGIN2 ENSG00000275103 GC08M089901 RNU6-925P |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DECR1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DECR1 gene promoter:
Regulatory Element Products
Genomic Locations for DECR1 Gene
Genomic Locations for DECR1 Gene
- chr8:90,001,352-90,052,092
- (GRCh38/hg38)
- Size:
- 50,741 bases
- Orientation:
- Plus strand
- chr8:91,013,580-91,064,320
- (GRCh37/hg19)
Genomic View for DECR1 Gene
Genes around DECR1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q21.3 by Entrez Gene
- 8q21.3 by HGNC
- 8q21.3 by Ensembl
DECR1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DECR1 Gene
Proteins for DECR1 Gene
-
Protein details for DECR1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16698-DECR_HUMAN
- Recommended name:
- 2,4-dienoyl-CoA reductase, mitochondrial
- Protein Accession:
- Q16698
- B7Z6B8
- Q2M304
- Q93085
Protein attributes for DECR1 Gene
- Size:
- 335 amino acids
- Molecular mass:
- 36068 Da
- Quaternary structure:
-
- Homotetramer.
Protein Expression for DECR1 Gene
Post-translational modifications for DECR1 Gene
Other Protein References for DECR1 Gene
Antibody Products
- R&D Systems Antibodies for DECR1 (DECR1)
- Novus Biologicals Antibodies for DECR1
- Invitrogen Antibodies for DECR1
- GeneTex DECR1 Antibody for DECR1
-
Boster Bio Antibodies for DECR1
-
Santa Cruz Biotechnology (SCBT) Antibodies for DECR1
Protein Products
-
OriGene Purified Proteins for DECR1
- Search Origene for MassSpec and Protein Over-expression Lysates for DECR1
- Origene Custom Protein Services for DECR1
- ProSpec Recombinant Proteins for DECR1
- GeneTex Proteins for DECR1
Assay Products
- antibodies-online: Search results for 29 available NADPH Elisa Kits ranked by validation data
- Compare Top NADPH Elisa Kits
-
Recommended
- 2 Chicken ELISA Kits
- 1 Cow (Bovine) ELISA Kit
- 1 Dog (Canine) ELISA Kit
- 1 General ELISA Kit
- 2 Guinea Pig ELISA Kits
- 3 Human ELISA Kits
- 2 Monkey ELISA Kits
- 6 Mouse (Murine) ELISA Kits
- 2 Pig (Porcine) ELISA Kits
- 1 Rabbit ELISA Kit
- 7 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 2 Chicken ELISA Kits
- 1 Cow (Bovine) ELISA Kit
- 1 Dog (Canine) ELISA Kit
- 1 General ELISA Kit
- 2 Guinea Pig ELISA Kits
- 3 Human ELISA Kits
- 2 Monkey ELISA Kits
- 6 Mouse (Murine) ELISA Kits
- 2 Pig (Porcine) ELISA Kits
- 1 Rabbit ELISA Kit
- 7 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
No data available for DME Specific Peptides for DECR1 Gene
Domains & Families for DECR1 Gene
Gene Families for DECR1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for DECR1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for DECR1 Gene
Graphical View of Domain Structure for InterPro Entry
Q16698UniProtKB/Swiss-Prot:
DECR_HUMAN :- Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
- Family:
-
- Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
Function for DECR1 Gene
Molecular function for DECR1 Gene
- UniProtKB/Swiss-Prot Function:
- Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Trans-2,3-didehydroacyl-CoA + NADP(+) = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=7.7 uM for NADPH {ECO:0000269 PubMed:15531764}; KM=14.3 uM for trans-2,trans-4-hexadienoyl-CoA {ECO:0000269 PubMed:15531764}; Vmax=30.3 umol/min/mg enzyme {ECO:0000269 PubMed:15531764};
- GENATLAS Biochemistry:
- 2-4-dienoyl-CoA reductase,mitochondrial,auxiliary enzyme of beta oxidation participating in the metabolism of (poly) unsaturated fatty enoyl-CoA esters
Enzyme Numbers (IUBMB) for DECR1 Gene
Phenotypes From GWAS Catalog for DECR1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008670 | 2,4-dienoyl-CoA reductase (NADPH) activity | IDA,IEA | 15531764 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0016651 | oxidoreductase activity, acting on NAD(P)H | TAS | -- |
| GO:0070402 | NADPH binding | IDA | 15531764 |
Phenotypes for DECR1 Gene
- MGI mutant phenotypes for DECR1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DECR1:
Animal Models for DECR1 Gene
- MGI Knock Outs for DECR1:
-
- Decr1 Decr1<tm1Jkh>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DECR1
-
CRISPR Products
-
OriGene CRISPR knockouts for DECR1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DECR1
- genomics-online: gRNA clones - Search results for 108 available NADPH gene related products
- Overview of 108 available NADPH gene related products
- Applied Biological Materials CRISPR for DECR1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DECR1
- GenScript: Design CRISPR guide RNA sequences for DECR1
miRNA for DECR1 Gene
- miRTarBase miRNAs that target DECR1
-
- hsa-mir-374b-3p (MIRT545666)
- hsa-mir-511-5p (MIRT545667)
- hsa-mir-4524b-5p (MIRT545668)
- hsa-mir-6830-3p (MIRT545669)
- hsa-mir-4524a-5p (MIRT545670)
- hsa-mir-107 (MIRT545671)
- hsa-mir-103a-3p (MIRT545672)
- hsa-mir-7153-5p (MIRT545673)
- hsa-mir-146b-5p (MIRT545674)
- hsa-mir-146a-5p (MIRT545675)
- hsa-mir-589-5p (MIRT545676)
- hsa-mir-654-3p (MIRT545677)
- hsa-mir-646 (MIRT545678)
- hsa-mir-503-5p (MIRT545679)
- hsa-mir-6838-5p (MIRT545680)
- hsa-mir-497-5p (MIRT545681)
- hsa-mir-424-5p (MIRT545682)
- hsa-mir-195-5p (MIRT545683)
- hsa-mir-16-5p (MIRT545684)
- hsa-mir-15b-5p (MIRT545685)
- hsa-mir-15a-5p (MIRT545686)
- hsa-mir-4773 (MIRT545687)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for DECR1
- Browse OriGene Inhibitory RNA Products For DECR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DECR1
- genomics-online: shRNA clones - Search results for 108 available NADPH gene related products
- Overview of 108 available NADPH gene related products
Clone Products
- Sino Biological Human cDNA Clone for DECR1
- VectorBuilder custom plasmid, inducible vectors for DECR1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DECR1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DECR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DECR1
- Applied Biological Materials Clones for DECR1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DECR1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DECR1 Gene
Localization for DECR1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DECR1 Gene
- Mitochondrion.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 3 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| golgi apparatus | 1 |
- Mitochondria (3)
- Cytosol (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | HDA | 21630459 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005739 | mitochondrion | NAS | 7818482 |
| GO:0005759 | mitochondrial matrix | TAS | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for DECR1 Gene
Pathways by source for DECR1 Gene
2 BioSystems pathways for DECR1 Gene
Interacting Proteins for DECR1 Gene
GPS-Prot Interaction Network for DECR1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006631 | fatty acid metabolic process | IEA | -- |
| GO:0006635 | fatty acid beta-oxidation | IDA,TAS | -- |
| GO:0051289 | protein homotetramerization | IDA | 15531764 |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for SIGNOR curated interactions for DECR1 Gene
Drugs & Compounds for DECR1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| NADP |
|
53-59-8 |
|
|||
| nadph |
|
53-57-6 |
|
|||
| trans-3-Hexenoyl-CoA |
|
6599-65-1 |
|
Transcripts for DECR1 Gene
mRNA/cDNA for DECR1 Gene
- (277) Selected AceView cDNA sequences:
- (6) Additional mRNA sequences :
- (5) REFSEQ mRNAs :
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000220764 1207 bps (uc003yek.2)
- ENST00000517301 464 bps (uc064oiq.1)
- ENST00000517314 654 bps (uc064oid.1)
- ENST00000517597 897 bps (uc064oih.1)
- ENST00000517761 774 bps (uc064oim.1)
Unigene Clusters for DECR1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DECR1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DECR1
- genomics-online: gRNA clones - Search results for 108 available NADPH gene related products
- Overview of 108 available NADPH gene related products
- Applied Biological Materials CRISPR for DECR1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DECR1
- GenScript: Design CRISPR guide RNA sequences for DECR1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for DECR1
- Browse OriGene Inhibitory RNA Products For DECR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DECR1
- genomics-online: shRNA clones - Search results for 108 available NADPH gene related products
- Overview of 108 available NADPH gene related products
Clone Products
- Sino Biological Human cDNA Clone for DECR1
- VectorBuilder custom plasmid, inducible vectors for DECR1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DECR1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DECR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DECR1
- Applied Biological Materials Clones for DECR1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||
| SP5: | - |
Expression for DECR1 Gene
mRNA differential expression in normal tissues according to GTEx for DECR1 Gene
This gene is overexpressed in Heart - Left Ventricle (x5.8) and Liver (x4.5).
This gene is overexpressed in Heart (10.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DECR1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DECR1 Gene:
DECR1SOURCE GeneReport for Unigene cluster for DECR1 Gene:
Hs.492212mRNA Expression by UniProt/SwissProt for DECR1 Gene:
Q16698-DECR_HUMAN
Tissue specificity:
Heart = liver = pancreas > kidney >> skeletal muscle = lung.
Evidence on tissue expression from TISSUES for DECR1 Gene
- Liver(4.9)
- Nervous system(4.7)
- Heart(3.6)
- Kidney(3.6)
- Muscle(3.5)
- Blood(3.3)
- Lung(3.3)
- Adrenal gland(3.2)
- Intestine(3.1)
- Skin(2.9)
- Stomach(2.8)
- Eye(2.6)
- Pancreas(2.6)
- Thyroid gland(2.6)
- Spleen(2.5)
- Bone marrow(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for DECR1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- nervous
- respiratory
- skeletal muscle
Regions:
Head and neck:
- brain
Thorax:
- lung
General:
- blood
- peripheral nerve
- peripheral nervous system
- spinal cord
Primer Products
-
OriGene qPCR primer pairs and template standards for DECR1
-
OriGene qPCR primer pairs for DECR1
- genomics-online: primer clones - Search results for 108 available NADPH gene related products
- Overview of 108 available NADPH gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DECR1 Gene
Orthologs for DECR1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DECR1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | DECR1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | DECR1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Decr1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Decr1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DECR1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | DECR1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DECR1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | DECR1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | decr1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.22226 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | decr1 34 33 |
|
OneToOne | |
| wufe38b07 33 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | F53C11.3 34 35 |
|
OneToMany | |
| decr-1.3 34 |
|
OneToMany | |||
| T05C12.3 35 |
|
|
|||
| W01C9.4 35 |
|
|
|||
| decr-1.2 34 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SPS19 34 |
|
OneToMany |
- Species where no ortholog for DECR1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for DECR1 Gene
- ENSEMBL:
- Gene Tree for DECR1 (if available)
- TreeFam:
- Gene Tree for DECR1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DECR1: view image
Paralogs for DECR1 Gene
Variants for DECR1 Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000075698 | -- | 90,037,904(+) | A/G | intron_variant | |
| rs1000170335 | -- | 90,028,774(+) | C/G/T | intron_variant | |
| rs1000203172 | -- | 90,028,533(+) | T/A | intron_variant | |
| rs1000350821 | -- | 90,025,846(+) | T/C | intron_variant | |
| rs1000418327 | -- | 90,018,470(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759628 | CNV | gain+loss | 17122850 |
| nsv8365 | CNV | gain | 18304495 |
Residual Variation Intolerance Score:
44.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.11;
22.62% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DECR1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DECR1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DECR1 Gene
Disorders for DECR1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| 2,4-dienoyl-coa reductase deficiency |
|
|
| chronic granulomatous disease |
|
|
| hyperlysinemia, type i |
|
|
| retinitis pigmentosa 47 |
|
|
| suppurative lymphadenitis |
|
|
Search DECR1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
DECR_HUMAN- 2,4-dienoyl-CoA reductase deficiency (DECRD) [MIM:616034]: A rare, autosomal recessive, inborn error of polyunsaturated fatty acids and lysine metabolism, resulting in mitochondrial dysfunction. Affected individuals have a severe encephalopathy with neurologic and metabolic abnormalities beginning in early infancy. Laboratory studies show increased C10:2 carnitine levels and hyperlysinemia. {ECO:0000269 PubMed:24847004}. Note=The protein represented in this entry is involved in disease pathogenesis. A selective decrease in mitochondrial NADP(H) levels due to NADK2 mutations causes a deficiency of NADPH-dependent mitochondrial enzymes, such as DECR1 and AASS. {ECO:0000269 PubMed:24847004}.
Additional Disease Information for DECR1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for DECR1 Gene
Publications for DECR1 Gene
- Molecular cloning and characterization of the human mitochondrial 2,4-dienoyl-CoA reductase gene (DECR). (PMID: 9403065) Helander HM … Hiltunen JK (Genomics 1997) 3 4 22 58
- Isolation and characterization of cDNA for human 120 kDa mitochondrial 2,4-dienoyl-coenzyme A reductase. (PMID: 7818482) Koivuranta KT … Hiltunen JK (The Biochemical journal 1994) 2 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
- Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 44 58
Products for DECR1 Gene
- R&D Systems Antibodies for DECR1 (DECR1)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for DECR1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for DECR1
- Search Origene for MassSpec and Protein Over-expression Lysates for DECR1
- Origene Custom Protein Services for DECR1
- Origene sirna, shrna, and RNAi products in human, mouse, rat for DECR1
- Browse OriGene Inhibitory RNA Products For DECR1
- OriGene qPCR primer pairs and template standards for DECR1
- OriGene qPCR primer pairs for DECR1
- OriGene CRISPR knockouts for DECR1
- OriGene ORF clones in human for DECR1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DECR1
- GenScript: Next-day shipping of latest version cDNA ORF clones for DECR1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for DECR1
- GenScript Custom Assay Services for DECR1
- GenScript Custom overexpressing Cell Line Services for DECR1
- GenScript: Design CRISPR guide RNA sequences for DECR1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for DECR1
- Sino Biological Human cDNA Clone for DECR1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
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- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
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- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for DECR1
- Novus Biologicals proteins and lysates for DECR1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- ProSpec Recombinant Proteins for DECR1
- VectorBuilder custom plasmid, inducible vectors for DECR1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DECR1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DECR1
- antibodies-online: Search results for 4 available NADPH Antibodies ranked by validation data
- Compare Top NADPH Antibodies
- antibodies-online: Search results for 29 available NADPH Elisa Kits ranked by validation data
- Compare Top NADPH Elisa Kits
- Recommended
- 2 Chicken ELISA Kits
- 1 Cow (Bovine) ELISA Kit
- 1 Dog (Canine) ELISA Kit
- 1 General ELISA Kit
- 2 Guinea Pig ELISA Kits
- 3 Human ELISA Kits
- 2 Monkey ELISA Kits
- 6 Mouse (Murine) ELISA Kits
- 2 Pig (Porcine) ELISA Kits
- 1 Rabbit ELISA Kit
- 7 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 2 Chicken ELISA Kits
- 1 Cow (Bovine) ELISA Kit
- 1 Dog (Canine) ELISA Kit
- 1 General ELISA Kit
- 2 Guinea Pig ELISA Kits
- 3 Human ELISA Kits
- 2 Monkey ELISA Kits
- 6 Mouse (Murine) ELISA Kits
- 2 Pig (Porcine) ELISA Kits
- 1 Rabbit ELISA Kit
- 7 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- antibodies-online: Search results for 10 available NADPH Proteins ranked by validation data
- Compare Top NADPH Proteins
- GeneTex DECR1 Antibody for DECR1
- GeneTex Proteins for DECR1
- Santa Cruz Biotechnology (SCBT) Antibodies for DECR1
- Search Santa Cruz Biotechnology (SCBT) for DECR1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DECR1
- Horizon Cell Lines for DECR1
- genomics-online: cdna clones - Search results for 108 available NADPH gene related products
- Overview of 108 available NADPH gene related products
- orf clones - Search results for 108 available NADPH gene related products
- Overview of 108 available NADPH gene related products
- genomics-online: gRNA clones - Search results for 108 available NADPH gene related products
- Overview of 108 available NADPH gene related products
- genomics-online: primer clones - Search results for 108 available NADPH gene related products
- Overview of 108 available NADPH gene related products
- genomics-online: shRNA clones - Search results for 108 available NADPH gene related products
- Overview of 108 available NADPH gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DECR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DECR1
- GeneCopoeia miRNA 3'UTR Target clone products for DECR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DECR1
- Boster Bio Antibodies for DECR1
- Browse Boster Bio ELISA Kits
Sources for DECR1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio