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Aliases for DEC1 Gene

Aliases for DEC1 Gene

  • Deleted In Esophageal Cancer 1 2 3 3 5
  • Candidate Tumor Suppressor CTS9 3 4
  • CTS9 3 4

External Ids for DEC1 Gene

Previous GeneCards Identifiers for DEC1 Gene

  • GC09P108702
  • GC09P109636
  • GC09P111357
  • GC09P113280
  • GC09P114983
  • GC09P116943
  • GC09P117904
  • GC09P087508

Summaries for DEC1 Gene

Entrez Gene Summary for DEC1 Gene

  • The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for DEC1 Gene

DEC1 (Deleted In Esophageal Cancer 1) is a Protein Coding gene. Diseases associated with DEC1 include Esophageal Cancer. Among its related pathways are Circadian rhythm pathway.

UniProtKB/Swiss-Prot for DEC1 Gene

  • Candidate tumor suppressor.

Gene Wiki entry for DEC1 Gene

Additional gene information for DEC1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEC1 Gene

Genomics for DEC1 Gene

GeneHancer (GH) Regulatory Elements for DEC1 Gene

Promoters and enhancers for DEC1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J115202 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 668.8 +92.5 92517 5.5 PKNOX1 SMAD1 JUN EBF1 BATF IRF4 POLR2A EED RCOR1 FOSL2 DEC1 TNC TNFSF15 LOC105376233 LOC101928748
GH09J115141 Promoter 0.5 EPDnew 650.3 +29.2 29180 0.1 DEC1 LOC101928748 LOC105376233
GH09J114803 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 22.9 -307.3 -307283 4.5 FOXA2 RARA FOS IKZF2 RUNX3 ELK4 RXRA MIER2 REST NR2F2 TNFSF15 DEC1 WHRN ENSG00000274919
GH09J115169 Enhancer 0.8 ENCODE dbSUPER 26.8 +58.1 58080 1.8 JUND MAFF NANOG POU5F1 FOSL2 FOS MAFK TRIM28 DEC1 TNC LOC101928748 LOC105376233
GH09J115164 Enhancer 1.1 Ensembl ENCODE dbSUPER 19.1 +52.2 52246 1.3 ZNF362 ZFP37 ZNF398 FEZF1 ZEB2 ZBTB8A ZNF501 ZNF843 ZNF335 JUND DEC1 TNC LOC101928748 LOC105376233
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DEC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DEC1 gene promoter:
  • AP-1
  • STAT3
  • c-Jun
  • ATF-2
  • Sp1
  • Pbx1a
  • c-Fos

Genomic Locations for DEC1 Gene

Genomic Locations for DEC1 Gene
290,028 bases
Plus strand
260,827 bases
Plus strand

Genomic View for DEC1 Gene

Genes around DEC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEC1 Gene

Proteins for DEC1 Gene

  • Protein details for DEC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Deleted in esophageal cancer 1
    Protein Accession:

    Protein attributes for DEC1 Gene

    70 amino acids
    Molecular mass:
    7542 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEC1 Gene

Post-translational modifications for DEC1 Gene

No Post-translational modifications

Other Protein References for DEC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DEC1 Gene

Domains & Families for DEC1 Gene

Gene Families for DEC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DEC1 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DEC1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for DEC1 Gene

Function for DEC1 Gene

Molecular function for DEC1 Gene

UniProtKB/Swiss-Prot Function:
Candidate tumor suppressor.

Phenotypes From GWAS Catalog for DEC1 Gene

genes like me logo Genes that share phenotypes with DEC1: view

Human Phenotype Ontology for DEC1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

miRNA for DEC1 Gene

miRTarBase miRNAs that target DEC1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for DEC1 Gene

Localization for DEC1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DEC1 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DEC1 Gene

Pathways & Interactions for DEC1 Gene

SuperPathway Contained pathways
1 Circadian rhythm pathway
genes like me logo Genes that share pathways with DEC1: view

Pathways by source for DEC1 Gene

1 BioSystems pathway for DEC1 Gene

Gene Ontology (GO) - Biological Process for DEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation TAS 10612805
genes like me logo Genes that share ontologies with DEC1: view

No data available for SIGNOR curated interactions for DEC1 Gene

Drugs & Compounds for DEC1 Gene

No Compound Related Data Available

Transcripts for DEC1 Gene

mRNA/cDNA for DEC1 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DEC1 Gene

Deleted in esophageal cancer 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for DEC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DEC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DEC1 Gene

mRNA differential expression in normal tissues according to GTEx for DEC1 Gene

This gene is overexpressed in Nerve - Tibial (x6.3).

SOURCE GeneReport for Unigene cluster for DEC1 Gene:


mRNA Expression by UniProt/SwissProt for DEC1 Gene:

Tissue specificity: Expressed in many tissues, with highest expression in prostate and testis. Reduced expression in esophageal carcinomas.
genes like me logo Genes that share expression patterns with DEC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DEC1 Gene

Orthologs for DEC1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DEC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DEC1 34
  • 97 (a)
Species where no ortholog for DEC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DEC1 Gene

Gene Tree for DEC1 (if available)
Gene Tree for DEC1 (if available)
Evolutionary constrained regions (ECRs) for DEC1: view image

Paralogs for DEC1 Gene

No data available for Paralogs for DEC1 Gene

Variants for DEC1 Gene

Sequence variations from dbSNP and Humsavar for DEC1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000005571 -- 115,331,465(+) C/G/T intron_variant
rs1000009279 -- 115,197,957(+) C/G intron_variant
rs1000015522 -- 115,324,632(+) /T intron_variant
rs1000022979 -- 115,157,906(+) T/C intron_variant
rs1000032440 -- 115,389,598(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DEC1 Gene

Variant ID Type Subtype PubMed ID
dgv4131n106 CNV deletion 24896259
esv1089105 CNV deletion 17803354
esv1206387 CNV insertion 17803354
esv2068341 CNV deletion 18987734
esv2176591 CNV deletion 18987734
esv2494923 CNV deletion 19546169
esv2674932 CNV deletion 23128226
esv2677881 CNV deletion 23128226
esv2738968 CNV deletion 23290073
esv2738969 CNV deletion 23290073
esv2761245 CNV loss 21179565
esv2761552 CNV loss 21179565
esv3290 CNV loss 18987735
esv3399588 CNV insertion 20981092
esv3545361 CNV deletion 23714750
esv3573368 CNV loss 25503493
esv3573369 CNV loss 25503493
esv3573370 CNV loss 25503493
esv3621568 CNV loss 21293372
esv3621570 CNV loss 21293372
esv8511 CNV loss 19470904
nsv1075266 CNV deletion 25765185
nsv1147735 CNV deletion 26484159
nsv477372 CNV novel sequence insertion 20440878
nsv507528 OTHER sequence alteration 20534489
nsv512115 CNV loss 21212237
nsv519995 CNV loss 19592680
nsv525037 CNV loss 19592680
nsv527294 CNV loss 19592680
nsv615250 CNV loss 21841781
nsv615251 CNV gain 21841781
nsv6681 CNV deletion 18451855
nsv6682 CNV deletion 18451855
nsv7434 OTHER inversion 18451855
nsv831697 CNV loss 17160897
nsv957705 CNV deletion 24416366

Variation tolerance for DEC1 Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DEC1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEC1 Gene

Disorders for DEC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DEC1 Gene - From: HGMD, OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
esophageal cancer
  • esophageal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search DEC1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DEC1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DEC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DEC1 Gene

Publications for DEC1 Gene

  1. Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32. (PMID: 10612805) Nishiwaki T … Nakamura Y (Genes, chromosomes & cancer 2000) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. A novel functional DEC1 promoter polymorphism -249T>C reduces risk of squamous cell carcinoma of the head and neck. (PMID: 20935061) Huang YJ … Wei Q (Carcinogenesis 2010) 3 44 58
  4. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PMID: 19339270) Canova C … Brennan P (Cancer research 2009) 3 44 58
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58

Products for DEC1 Gene

Sources for DEC1 Gene

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