This gene encodes a member of the DExD/H-box helicase family of proteins, a subset of the super family 2 helicases. Members of the DExD/H-box helicase family share a conserved functional core comprised of two RecA-like globular domains. These domains contain conserved motifs that mediate ATP binding, ATP hydrolysis, nucleic acid binding, and RNA unwinding. In addition to functi... See more...

Aliases for DDX60L Gene

Aliases for DDX60L Gene

  • DExD/H-Box 60 Like 2 3 5
  • Probable ATP-Dependent RNA Helicase DDX60-Like 3 4
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 60-Like 2 3
  • DEAD Box Protein 60-Like 3 4
  • Putative ATP-Dependent RNA Helicase DDX60 3
  • DEAD-Box Helicase 60 Like 3
  • EC 4

External Ids for DDX60L Gene

Previous GeneCards Identifiers for DDX60L Gene

  • GC04M169515
  • GC04M169277
  • GC04M165030

Summaries for DDX60L Gene

Entrez Gene Summary for DDX60L Gene

  • This gene encodes a member of the DExD/H-box helicase family of proteins, a subset of the super family 2 helicases. Members of the DExD/H-box helicase family share a conserved functional core comprised of two RecA-like globular domains. These domains contain conserved motifs that mediate ATP binding, ATP hydrolysis, nucleic acid binding, and RNA unwinding. In addition to functions in RNA metabolism, members of this family are involved in anti-viral immunity and act as cytosolic sensors of viral nucleic acids. The protein encoded by this gene has been shown to inhibit hepatitis C virus replication in response to interferon stimulation in cell culture. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

GeneCards Summary for DDX60L Gene

DDX60L (DExD/H-Box 60 Like) is a Protein Coding gene. Diseases associated with DDX60L include Hepatitis C Virus. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is DDX60.

Additional gene information for DDX60L Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DDX60L Gene

Genomics for DDX60L Gene

GeneHancer (GH) Regulatory Elements for DDX60L Gene

Promoters and enhancers for DDX60L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J168536 Promoter/Enhancer 0.9 Ensembl dbSUPER 757 +1.4 1385 0.8 L3MBTL2 ATF7 MGA EHMT2 POLR2A CEBPG CEBPB ATF2 ZEB2 TAF7 DDX60L lnc-DDX60L-3 PALLD
GH04J168479 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 60.9 +53.7 53657 12.7 SIN3A ZBTB40 ZBTB6 POLR2A CREB1 ZNF362 ETV6 ELF1 L3MBTL2 RAD21 DDX60L DDX60 ENSG00000207171 PALLD lnc-DDX60L-3
GH04J168501 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 62.3 +30.9 30886 11.8 ZBTB40 GATA3 FOXA1 TCF7L2 ZNF217 ZNF133 HLF RERE SP1 NCOA3 DDX60L DDX60 ENSG00000207171 ENSG00000249623 PALLD lnc-DDX60L-3
GH04J168449 Enhancer 1.3 FANTOM5 Ensembl ENCODE 20 +85.6 85586 6 SMARCE1 CTBP1 USF2 BCL6B ZNF148 CBFA2T2 BACH1 SP7 ZSCAN21 PRDM1 DDX60L DDX60 ENSG00000207171 piR-42491-169
GH04J168557 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 17.1 -22.8 -22808 6 ZNF362 ZNF384 SP7 PRDM1 ZIC2 POLR2A PRDM10 ZNF639 CTBP1 ZSCAN4 DDX60L RNU6-1336P PALLD ENSG00000249623 DDX60 lnc-ANXA10-1 lnc-DDX60L-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DDX60L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DDX60L gene promoter:
  • AML1a
  • C/EBPalpha
  • GATA-1
  • GR
  • GR-beta
  • NF-kappaB
  • NF-kappaB1
  • Pax-2
  • Pax-2a
  • RelA

Genomic Locations for DDX60L Gene

Genomic Locations for DDX60L Gene
181,052 bases
Minus strand
181,052 bases
Minus strand

Genomic View for DDX60L Gene

Genes around DDX60L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX60L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX60L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX60L Gene

Proteins for DDX60L Gene

  • Protein details for DDX60L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DDX60-like
    Protein Accession:
    Secondary Accessions:
    • Q96ND6

    Protein attributes for DDX60L Gene

    1706 amino acids
    Molecular mass:
    197674 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB70966.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DDX60L Gene


neXtProt entry for DDX60L Gene

Post-translational modifications for DDX60L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DDX60L Gene

Domains & Families for DDX60L Gene

Gene Families for DDX60L Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DDX60L Gene

Suggested Antigen Peptide Sequences for DDX60L Gene

GenScript: Design optimal peptide antigens:
  • DEAD box protein 60-like (DDX6L_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the helicase family.
  • Belongs to the helicase family.
genes like me logo Genes that share domains with DDX60L: view

Function for DDX60L Gene

Molecular function for DDX60L Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=;.

Enzyme Numbers (IUBMB) for DDX60L Gene

Phenotypes From GWAS Catalog for DDX60L Gene

Gene Ontology (GO) - Molecular Function for DDX60L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0003724 RNA helicase activity IEA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX60L: view
genes like me logo Genes that share phenotypes with DDX60L: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DDX60L Gene

Localization for DDX60L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX60L gene
Compartment Confidence
plasma membrane 2
nucleus 2
cytosol 2
peroxisome 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DDX60L Gene

Pathways & Interactions for DDX60L Gene

PathCards logo

SuperPathways for DDX60L Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX60L Gene


No data available for Pathways by source and SIGNOR curated interactions for DDX60L Gene

Drugs & Compounds for DDX60L Gene

(3) Drugs for DDX60L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for DDX60L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with DDX60L: view

Transcripts for DDX60L Gene

mRNA/cDNA for DDX60L Gene

(3) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX60L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP2: - -
SP3: -

Relevant External Links for DDX60L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX60L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX60L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DDX60L Gene

This gene is overexpressed in Whole Blood (x10.9).

Protein differential expression in normal tissues from HIPED for DDX60L Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (33.3), Tlymphocyte (23.4), and Blymphocyte (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX60L Gene

NURSA nuclear receptor signaling pathways regulating expression of DDX60L Gene:


SOURCE GeneReport for Unigene cluster for DDX60L Gene:

genes like me logo Genes that share expression patterns with DDX60L: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX60L Gene

Orthologs for DDX60L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDX60L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DDX60L 33 32
  • 99.1 (n)
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 57 (a)
(Monodelphis domestica)
Mammalia -- 33
  • 56 (a)
-- 33
  • 54 (a)
-- 33
  • 16 (a)
-- 33
  • 14 (a)
(Caenorhabditis elegans)
Secernentea C28H8.3 33
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTR4 33
  • 15 (a)
Species where no ortholog for DDX60L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for DDX60L Gene

Gene Tree for DDX60L (if available)
Gene Tree for DDX60L (if available)
Evolutionary constrained regions (ECRs) for DDX60L: view image

Paralogs for DDX60L Gene

Paralogs for DDX60L Gene

(2) SIMAP similar genes for DDX60L Gene using alignment to 6 proteins:

  • D6RB62_HUMAN
  • H0Y8H0_HUMAN
  • H0Y939_HUMAN
genes like me logo Genes that share paralogs with DDX60L: view

Variants for DDX60L Gene

Sequence variations from dbSNP and Humsavar for DDX60L Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs201155959 uncertain-significance, Malignant tumor of prostate 168,430,522(-) G/A/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant, synonymous_variant
rs1000094871 -- 168,432,086(-) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000108977 -- 168,419,628(-) A/G intron_variant
rs1000115492 -- 168,388,006(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000124713 -- 168,467,861(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DDX60L Gene

Variant ID Type Subtype PubMed ID
nsv474731 CNV novel sequence insertion 20440878

Variation tolerance for DDX60L Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.96; 98.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DDX60L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX60L Gene

Disorders for DDX60L Gene

MalaCards: The human disease database

(1) MalaCards diseases for DDX60L Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitis c virus, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DDX60L

genes like me logo Genes that share disorders with DDX60L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DDX60L Gene

Publications for DDX60L Gene

  1. DDX60L Is an Interferon-Stimulated Gene Product Restricting Hepatitis C Virus Replication in Cell Culture. (PMID: 26269178) Grünvogel O … Lohmann V (Journal of virology 2015) 2 3 56
  2. Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. (PMID: 20708005) Chalasani N … Nonalcoholic Steatohepatitis Clinical Research Network (Gastroenterology 2010) 3 43 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. (PMID: 29467282) Heidelberger JB … Beli P (EMBO reports 2018) 3 56
  5. Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS. (PMID: 30471916) Lum KK … Cristea IM (Cell systems 2018) 3 56

Products for DDX60L Gene

Sources for DDX60L Gene