Aliases for DDX60 Gene
External Ids for DDX60 Gene
Previous GeneCards Identifiers for DDX60 Gene
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular procsses involving RNA binding and alteration of RNA secondary structure. This gene encodes a DEXD/H box RNA helicase that functions as an antiviral factor and promotes RIG-I-like receptor-mediated signaling. [provided by RefSeq, Apr 2017]
GeneCards Summary for DDX60 Gene
DDX60 (DExD/H-Box Helicase 60) is a Protein Coding gene. Diseases associated with DDX60 include Autosomal Recessive Alport Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is DDX60L.
UniProtKB/Swiss-Prot Summary for DDX60 Gene
Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV).