This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012] See more...

Aliases for DDX6 Gene

Aliases for DDX6 Gene

  • DEAD-Box Helicase 6 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 6 (RNA Helicase, 54kD) 2 3
  • Probable ATP-Dependent RNA Helicase DDX6 3 4
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 6 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 6 2 3
  • ATP-Dependent RNA Helicase P54 3 4
  • DEAD Box Protein 6 3 4
  • Oncogene RCK 3 4
  • HLR2 3 4
  • RCK 3 4
  • EC 3.6.4.13 4
  • DEAD Box-6 3
  • EC 3.6.1 54
  • P54 3

External Ids for DDX6 Gene

Previous HGNC Symbols for DDX6 Gene

  • HLR2

Previous GeneCards Identifiers for DDX6 Gene

  • GC11M120959
  • GC11M120132
  • GC11M118654
  • GC11M118160
  • GC11M118162
  • GC11M118125
  • GC11M114556
  • GC11M118619

Summaries for DDX6 Gene

Entrez Gene Summary for DDX6 Gene

  • This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]

GeneCards Summary for DDX6 Gene

DDX6 (DEAD-Box Helicase 6) is a Protein Coding gene. Diseases associated with DDX6 include Nodal Marginal Zone Lymphoma and Embryonal Testis Carcinoma. Among its related pathways are Deadenylation-dependent mRNA decay and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein domain specific binding. An important paralog of this gene is DDX3X.

UniProtKB/Swiss-Prot Summary for DDX6 Gene

  • In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573).

Gene Wiki entry for DDX6 Gene

Additional gene information for DDX6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DDX6 Gene

Genomics for DDX6 Gene

GeneHancer (GH) Regulatory Elements for DDX6 Gene

Promoters and enhancers for DDX6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DDX6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DDX6 gene promoter:
  • AP-1
  • c-Fos
  • CREB
  • deltaCREB
  • FOXO3
  • FOXO3a
  • FOXO3b
  • MAZR
  • Pax-5
  • Pbx1a

Genomic Locations for DDX6 Gene

Genomic Locations for DDX6 Gene
chr11:118,747,763-118,791,263
(GRCh38/hg38)
Size:
43,501 bases
Orientation:
Minus strand
chr11:118,618,472-118,661,972
(GRCh37/hg19)
Size:
43,501 bases
Orientation:
Minus strand

Genomic View for DDX6 Gene

Genes around DDX6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX6 Gene

Proteins for DDX6 Gene

  • Protein details for DDX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26196-DDX6_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX6
    Protein Accession:
    P26196
    Secondary Accessions:
    • Q5D048

    Protein attributes for DDX6 Gene

    Size:
    483 amino acids
    Molecular mass:
    54417 Da
    Quaternary structure:
    • Forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS (PubMed:16364915, PubMed:19285948). Interacts with LIMD1, WTIP and AJUBA (PubMed:20616046). Interacts with APOBEC3G in an RNA-dependent manner (PubMed:16699599). Interacts with RC3H1 (By similarity). Interacts with ATXN2L (PubMed:23209657). Interacts with MCRIP1 (PubMed:26184334). Interacts with MCRIP2 (PubMed:26184334). Interacts with NUFIP2 (PubMed:26184334). Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (PubMed:23125361).

    Three dimensional structures from OCA and Proteopedia for DDX6 Gene

neXtProt entry for DDX6 Gene

Selected DME Specific Peptides for DDX6 Gene

P26196:
  • LLMGIFE
  • PSPIQEE
  • RNRVFHDFRNG
  • PYEINLM
  • GVTQYYA
  • IDKSLYV
  • LGYSCFYIHAKM
  • GAYLIPLLERLDLKKD
  • GRDILARAKNGTGK
  • TKGNEFEDY
  • DEADKLLS
  • QAVNVVINFDFP
  • HRIGRSGRFG
  • VPTRELA
  • GPGGGGTQ
  • NQSIIFCNS
  • VIATPGR
  • RVELLAKKI
  • YLHRIGR
  • TPGRILDL
  • TLPKNRQILLYSATFPLSVQKFM
  • EKPSPIQ
  • HCLNTLF
  • AETYLHR
  • LGTEIKPIP
  • TTGGTNLR
  • LYVAEYHSE
  • LRDDIMRL
  • GHLGLAINLI
  • SSQNGQLRGP
  • PTRELALQ

Post-translational modifications for DDX6 Gene

Domains & Families for DDX6 Gene

Gene Families for DDX6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DDX6 Gene

GenScript: Design optimal peptide antigens:
  • Oncogene RCK (DDX6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P26196

UniProtKB/Swiss-Prot:

DDX6_HUMAN :
  • Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
Family:
  • Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
genes like me logo Genes that share domains with DDX6: view

Function for DDX6 Gene

Molecular function for DDX6 Gene

UniProtKB/Swiss-Prot Function:
In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=. ;.
GENATLAS Biochemistry:
DEAD/H box protein 6,proliferation associated nuclear antigen p68,with homology to Drosophila oocyte specific helicase ME31,overexpressed in colorectal adenocarcinomas

Enzyme Numbers (IUBMB) for DDX6 Gene

Phenotypes From GWAS Catalog for DDX6 Gene

Gene Ontology (GO) - Molecular Function for DDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA,IEA 21873635
GO:0003724 RNA helicase activity IEA,TAS --
GO:0003729 mRNA binding IBA 21873635
GO:0004386 helicase activity TAS 1394235
genes like me logo Genes that share ontologies with DDX6: view
genes like me logo Genes that share phenotypes with DDX6: view

Animal Model Products

CRISPR Products

miRNA for DDX6 Gene

miRTarBase miRNAs that target DDX6

Clone Products

  • Addgene plasmids for DDX6

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX6 Gene

Localization for DDX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX6 Gene

Cytoplasm, P-body. Cytoplasm. Nucleus. Note=Upon cellular stress, relocalizes to stress granules (PubMed:26184334). {ECO:0000269 PubMed:26184334}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX6 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000792 heterochromatin IEA --
GO:0000932 P-body IMP 22022269
GO:0001520 outer dense fiber IEA --
GO:0005634 nucleus IEA,IDA 26184334
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with DDX6: view

Pathways & Interactions for DDX6 Gene

genes like me logo Genes that share pathways with DDX6: view

Pathways by source for DDX6 Gene

1 KEGG pathway for DDX6 Gene
1 Cell Signaling Technology pathway for DDX6 Gene

SIGNOR curated interactions for DDX6 Gene

Other effect:

Gene Ontology (GO) - Biological Process for DDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEA --
GO:0019074 viral RNA genome packaging IMP 22022269
GO:0019827 stem cell population maintenance IEA --
GO:0033962 cytoplasmic mRNA processing body assembly IDA 20826699
GO:0034063 stress granule assembly IBA 21873635
genes like me logo Genes that share ontologies with DDX6: view

Drugs & Compounds for DDX6 Gene

(4) Drugs for DDX6 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
D-tartaric acid Experimental Pharma Target 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for DDX6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with DDX6: view

Transcripts for DDX6 Gene

mRNA/cDNA for DDX6 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for DDX6

Alternative Splicing Database (ASD) splice patterns (SP) for DDX6 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - -
SP2: - - - - - - -
SP3:
SP4: - - - - - - - -
SP5: - - -
SP6: - - -
SP7:

Relevant External Links for DDX6 Gene

GeneLoc Exon Structure for
DDX6
ECgene alternative splicing isoforms for
DDX6

Expression for DDX6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX6 Gene

Protein differential expression in normal tissues from HIPED for DDX6 Gene

This gene is overexpressed in Lymph node (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX6 Gene



Protein tissue co-expression partners for DDX6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX6 Gene:

DDX6

SOURCE GeneReport for Unigene cluster for DDX6 Gene:

Hs.408461

mRNA Expression by UniProt/SwissProt for DDX6 Gene:

P26196-DDX6_HUMAN
Tissue specificity: Abundantly expressed in most tissues.

Evidence on tissue expression from TISSUES for DDX6 Gene

  • Lung(4.3)
  • Skin(4.2)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with DDX6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX6 Gene

Orthologs for DDX6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX6 33 32
  • 100 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDX6 33
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX6 33
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX6 33 32
  • 98 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DDX6 33 32
  • 97.99 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx6 32
  • 94.48 (n)
mouse
(Mus musculus)
Mammalia Ddx6 17 33 32
  • 93.58 (n)
chicken
(Gallus gallus)
Aves DDX6 33 32
  • 91.22 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDX6 33
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx6 32
  • 85.21 (n)
Str.1861 32
African clawed frog
(Xenopus laevis)
Amphibia P54H 32
zebrafish
(Danio rerio)
Actinopterygii ddx6 33 32
  • 76.9 (n)
OneToOne
wufk48d07 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9736 32
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009135 32
  • 67.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta me31B 33 34 32
  • 67.08 (n)
OneToOne
Dhh1 34
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea cgh-1 33 32
  • 64.48 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DHH1 33 32
  • 64.09 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR197W 32
  • 62.2 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C16599g 32
  • 60.68 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RH8 32
  • 67.08 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.12384 32
soybean
(Glycine max)
eudicotyledons Gma.10855 32
rice
(Oryza sativa)
Liliopsida Os04g0533000 32
  • 65.91 (n)
Os.2594 32
barley
(Hordeum vulgare)
Liliopsida Hv.6031 32
wheat
(Triticum aestivum)
Liliopsida Ta.7626 32
corn
(Zea mays)
Liliopsida Zm.12922 32
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ste13 32
  • 65.67 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06149 32
  • 63.43 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.11700 32
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11700 32
Species where no ortholog for DDX6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DDX6 Gene

ENSEMBL:
Gene Tree for DDX6 (if available)
TreeFam:
Gene Tree for DDX6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DDX6: view image

Paralogs for DDX6 Gene

Variants for DDX6 Gene

Sequence variations from dbSNP and Humsavar for DDX6 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000024449 -- 118,771,907(-) A/G intron_variant
rs1000110169 -- 118,752,803(-) T/C intron_variant
rs1000138908 -- 118,783,362(-) T/C intron_variant
rs1000190010 -- 118,774,452(-) T/G intron_variant
rs1000284713 -- 118,774,727(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DDX6 Gene

Variant ID Type Subtype PubMed ID
esv2673492 CNV deletion 23128226
esv2762946 CNV gain 21179565
nsv1134179 CNV deletion 24896259
nsv832283 CNV loss 17160897

Variation tolerance for DDX6 Gene

Residual Variation Intolerance Score: 26.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DDX6 Gene

Human Gene Mutation Database (HGMD)
DDX6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX6 Gene

Disorders for DDX6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DDX6 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
nodal marginal zone lymphoma
  • mucosa-associated lymphoid tissue lymphoma
embryonal testis carcinoma
  • embryonal carcinoma of testis
- elite association - COSMIC cancer census association via MalaCards
Search DDX6 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DDX6_HUMAN
  • Note=A chromosomal aberration involving DDX6 may be a cause of hematopoietic tumors such as B-cell lymphomas. Translocation t(11;14)(q23;q32).

Additional Disease Information for DDX6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DDX6: view

No data available for Genatlas for DDX6 Gene

Publications for DDX6 Gene

  1. Crystallization and X-ray analysis of the N-terminal core domain of a tumour-associated human DEAD-box RNA helicase, rck/p54. (PMID: 14684915) Matsui T … Tanaka N (Acta crystallographica. Section D, Biological crystallography 2004) 3 4 23 56
  2. RNA helicase p54 (DDX6) is a shuttling protein involved in nuclear assembly of stored mRNP particles. (PMID: 11839790) Smillie DA … Sommerville J (Journal of cell science 2002) 2 3 23 56
  3. Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3. (PMID: 1579499) Lu D … Yunis JJ (Nucleic acids research 1992) 2 3 4 56
  4. Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins. (PMID: 26184334) Bish R … Vogel C (Biomolecules 2015) 3 4 56
  5. The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function. (PMID: 23125361) Loedige I … Filipowicz W (Nucleic acids research 2013) 3 4 56

Products for DDX6 Gene