Aliases for DDX6 Gene
External Ids for DDX6 Gene
Previous HGNC Symbols for DDX6 Gene
Previous GeneCards Identifiers for DDX6 Gene
This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]
GeneCards Summary for DDX6 Gene
DDX6 (DEAD-Box Helicase 6) is a Protein Coding gene. Diseases associated with DDX6 include Nodal Marginal Zone Lymphoma and Embryonal Testis Carcinoma. Among its related pathways are Deadenylation-dependent mRNA decay and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein domain specific binding. An important paralog of this gene is DDX3X.
UniProtKB/Swiss-Prot Summary for DDX6 Gene
In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573).