This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012] See more...

Aliases for DDX6 Gene

Aliases for DDX6 Gene

  • DEAD-Box Helicase 6 2 3 5
  • RCK 2 3 4
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 6 (RNA Helicase, 54kD) 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 6 2 3
  • Probable ATP-Dependent RNA Helicase DDX6 3 4
  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 6 2 3
  • ATP-Dependent RNA Helicase P54 3 4
  • DEAD Box Protein 6 3 4
  • Oncogene RCK 3 4
  • Rck/P54 2 3
  • HLR2 3 4
  • EC 3.6.4.13 4
  • DEAD Box-6 3
  • EC 3.6.1 50
  • IDDILF 3
  • DDX6 5
  • P54 3

External Ids for DDX6 Gene

Previous HGNC Symbols for DDX6 Gene

  • HLR2

Previous GeneCards Identifiers for DDX6 Gene

  • GC11M120959
  • GC11M120132
  • GC11M118654
  • GC11M118160
  • GC11M118162
  • GC11M118125
  • GC11M114556
  • GC11M118619

Summaries for DDX6 Gene

Entrez Gene Summary for DDX6 Gene

  • This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]

GeneCards Summary for DDX6 Gene

DDX6 (DEAD-Box Helicase 6) is a Protein Coding gene. Diseases associated with DDX6 include Intellectual Developmental Disorder With Impaired Language And Dysmorphic Facies and Non-Specific Syndromic Intellectual Disability. Among its related pathways are Deadenylation-dependent mRNA decay and Translational Control. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein domain specific binding. An important paralog of this gene is DDX46.

UniProtKB/Swiss-Prot Summary for DDX6 Gene

  • Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (PubMed:25995375, PubMed:27342281, PubMed:31422817). Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:27342281). In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573).

Gene Wiki entry for DDX6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DDX6 Gene

Genomics for DDX6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DDX6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DDX6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DDX6

Top Transcription factor binding sites by QIAGEN in the DDX6 gene promoter:
  • AP-1
  • c-Fos
  • CREB
  • deltaCREB
  • FOXO3
  • FOXO3a
  • FOXO3b
  • MAZR
  • Pax-5
  • Pbx1a

Genomic Locations for DDX6 Gene

Latest Assembly
chr11:118,747,763-118,791,696
(GRCh38/hg38)
Size:
43,934 bases
Orientation:
Minus strand

Previous Assembly
chr11:118,618,472-118,661,873
(GRCh37/hg19 by Entrez Gene)
Size:
43,402 bases
Orientation:
Minus strand

chr11:118,620,034-118,661,858
(GRCh37/hg19 by Ensembl)
Size:
41,825 bases
Orientation:
Minus strand

Genomic View for DDX6 Gene

Genes around DDX6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX6 Gene

Proteins for DDX6 Gene

  • Protein details for DDX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26196-DDX6_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX6
    Protein Accession:
    P26196
    Secondary Accessions:
    • Q5D048

    Protein attributes for DDX6 Gene

    Size:
    483 amino acids
    Molecular mass:
    54417 Da
    Quaternary structure:
    • Interacts with LSM14A, LSM14B, EIF4ENIF1/4E-T, PATL1, EDC3 and EDC4 (PubMed:26027925, PubMed:31422817, PubMed:27342281, PubMed:28216671, PubMed:32354837, PubMed:26489469, PubMed:29510985). Forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS (PubMed:16364915, PubMed:19285948). Interacts with LIMD1, WTIP and AJUBA (PubMed:20616046). Interacts with APOBEC3G in an RNA-dependent manner (PubMed:16699599). Interacts with RC3H1 (By similarity). Interacts with ATXN2L (PubMed:23209657). Interacts with MCRIP1 (PubMed:26184334). Interacts with MCRIP2 (PubMed:26184334). Interacts with NUFIP2 (PubMed:26184334). Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (PubMed:23125361).

    Three dimensional structures from OCA and Proteopedia for DDX6 Gene

neXtProt entry for DDX6 Gene

Selected DME Specific Peptides for DDX6 Gene

P26196:
  • LLMGIFE
  • PSPIQEE
  • RNRVFHDFRNG
  • PYEINLM
  • GVTQYYA
  • IDKSLYV
  • LGYSCFYIHAKM
  • GAYLIPLLERLDLKKD
  • GRDILARAKNGTGK
  • TKGNEFEDY
  • DEADKLLS
  • QAVNVVINFDFP
  • HRIGRSGRFG
  • VPTRELA
  • GPGGGGTQ
  • NQSIIFCNS
  • VIATPGR
  • RVELLAKKI
  • YLHRIGR
  • TPGRILDL
  • TLPKNRQILLYSATFPLSVQKFM
  • EKPSPIQ
  • HCLNTLF
  • AETYLHR
  • LGTEIKPIP
  • TTGGTNLR
  • LYVAEYHSE
  • LRDDIMRL
  • GHLGLAINLI
  • SSQNGQLRGP
  • PTRELALQ

Post-translational modifications for DDX6 Gene

Domains & Families for DDX6 Gene

Gene Families for DDX6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for DDX6 Gene

Suggested Antigen Peptide Sequences for DDX6 Gene

GenScript: Design optimal peptide antigens:
  • Oncogene RCK (DDX6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P26196

UniProtKB/Swiss-Prot:

DDX6_HUMAN :
  • Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
Family:
  • Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
genes like me logo Genes that share domains with DDX6: view

Function for DDX6 Gene

Molecular function for DDX6 Gene

UniProtKB/Swiss-Prot Function:
Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (PubMed:25995375, PubMed:27342281, PubMed:31422817). Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:27342281). In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence={ECO:0000305|PubMed:27342281};.
GENATLAS Biochemistry:
DEAD/H box protein 6,proliferation associated nuclear antigen p68,with homology to Drosophila oocyte specific helicase ME31,overexpressed in colorectal adenocarcinomas

Enzyme Numbers (IUBMB) for DDX6 Gene

Phenotypes From GWAS Catalog for DDX6 Gene

Gene Ontology (GO) - Molecular Function for DDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003724 RNA helicase activity IEA --
GO:0003729 mRNA binding IBA 21873635
genes like me logo Genes that share ontologies with DDX6: view
genes like me logo Genes that share phenotypes with DDX6: view

Human Phenotype Ontology for DDX6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

miRNA for DDX6 Gene

miRTarBase miRNAs that target DDX6

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX6

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DDX6 Gene

Localization for DDX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX6 Gene

Cytoplasm, P-body. Cytoplasm. Nucleus. Note=Imported in the nucleus via interaction with EIF4ENIF1/4E-T via a piggy-back mechanism (PubMed:28216671). Upon cellular stress, relocalizes to stress granules (PubMed:26184334). {ECO:0000269 PubMed:26184334, ECO:0000269 PubMed:28216671}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX6 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
mitochondrion 3
extracellular 2
plasma membrane 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000792 heterochromatin IEA --
GO:0000932 P-body IMP 22022269
GO:0001520 outer dense fiber IEA --
GO:0005634 nucleus IEA,IDA 26184334
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with DDX6: view

Pathways & Interactions for DDX6 Gene

genes like me logo Genes that share pathways with DDX6: view

Pathways by source for DDX6 Gene

1 KEGG pathway for DDX6 Gene
1 Cell Signaling Technology pathway for DDX6 Gene

SIGNOR curated interactions for DDX6 Gene

Other effect:

Gene Ontology (GO) - Biological Process for DDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEA --
GO:0017148 negative regulation of translation IDA 27342281
GO:0019074 viral RNA genome packaging IMP 22022269
GO:0019827 stem cell population maintenance IEA --
GO:0033962 cytoplasmic mRNA processing body assembly IMP 25995375
genes like me logo Genes that share ontologies with DDX6: view

Drugs & Compounds for DDX6 Gene

(4) Drugs for DDX6 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
D-tartaric acid Experimental Pharma Target 0
Phosphate Experimental Pharma 0
ATP Investigational Nutra 0

(1) Additional Compounds for DDX6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
genes like me logo Genes that share compounds with DDX6: view

Transcripts for DDX6 Gene

mRNA/cDNA for DDX6 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX6

Alternative Splicing Database (ASD) splice patterns (SP) for DDX6 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - -
SP2: - - - - - - -
SP3:
SP4: - - - - - - - -
SP5: - - -
SP6: - - -
SP7:

Relevant External Links for DDX6 Gene

GeneLoc Exon Structure for
DDX6

Expression for DDX6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DDX6 Gene

Protein differential expression in normal tissues from HIPED for DDX6 Gene

This gene is overexpressed in Lymph node (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX6 Gene



Protein tissue co-expression partners for DDX6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DDX6

SOURCE GeneReport for Unigene cluster for DDX6 Gene:

Hs.408461

mRNA Expression by UniProt/SwissProt for DDX6 Gene:

P26196-DDX6_HUMAN
Tissue specificity: Abundantly expressed in most tissues.

Evidence on tissue expression from TISSUES for DDX6 Gene

  • Skin(4.5)
  • Lung(4.4)
  • Nervous system(3)
  • Kidney(2.6)
  • Spleen(2.5)
  • Muscle(2.3)
  • Liver(2.3)
  • Heart(2.3)
  • Intestine(2.2)
  • Blood(2.2)
  • Bone marrow(2.1)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with DDX6: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX6 Gene

Orthologs for DDX6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DDX6 29 30
  • 100 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DDX6 30
  • 100 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DDX6 30
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia DDX6 29 30
  • 98 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DDX6 29 30
  • 97.99 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ddx6 29
  • 94.48 (n)
Mouse
(Mus musculus)
Mammalia Ddx6 29 16 30
  • 93.58 (n)
OneToOne
Chicken
(Gallus gallus)
Aves DDX6 29 30
  • 91.22 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DDX6 30
  • 96 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ddx6 29
  • 85.21 (n)
Str.1861 29
African clawed frog
(Xenopus laevis)
Amphibia P54H 29
Zebrafish
(Danio rerio)
Actinopterygii ddx6 29 30
  • 76.9 (n)
OneToOne
wufk48d07 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9736 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009135 29
  • 67.49 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta me31B 29 30 31
  • 67.08 (n)
OneToOne
Dhh1 31
  • 33 (a)
Worm
(Caenorhabditis elegans)
Secernentea cgh-1 29 30
  • 64.48 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DHH1 29 30
  • 64.09 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ACR197W 29
  • 62.2 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C16599g 29
  • 60.68 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons RH8 29
  • 67.08 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.12384 29
Soybean
(Glycine max)
eudicotyledons Gma.10855 29
Rice
(Oryza sativa)
Liliopsida Os04g0533000 29
  • 65.91 (n)
Os.2594 29
Barley
(Hordeum vulgare)
Liliopsida Hv.6031 29
Wheat
(Triticum aestivum)
Liliopsida Ta.7626 29
Corn
(Zea mays)
Liliopsida Zm.12922 29
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ste13 29
  • 65.67 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU06149 29
  • 63.43 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.11700 29
Species where no ortholog for DDX6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DDX6 Gene

ENSEMBL:
Gene Tree for DDX6 (if available)
TreeFam:
Gene Tree for DDX6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DDX6: view image
Alliance of Genome Resources:
Additional Orthologs for DDX6

Paralogs for DDX6 Gene

Variants for DDX6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DDX6 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
932661 Pathogenic: not provided 118,755,491(-) C/T
NM_004397.6(DDX6):c.1187G>A (p.Arg396Gln)
MISSENSE
rs1591885290 Pathogenic: Intellectual developmental disorder with impaired language and dysmorphic facies 118,756,262(-) G/A
NM_004397.6(DDX6):c.1172C>T (p.Thr391Ile)
MISSENSE
rs1591885297 Pathogenic: Intellectual developmental disorder with impaired language and dysmorphic facies 118,756,263(-) T/G
NM_004397.6(DDX6):c.1171A>C (p.Thr391Pro)
MISSENSE
rs1591885305 Pathogenic: Intellectual developmental disorder with impaired language and dysmorphic facies 118,756,266(-) A/G
NM_004397.6(DDX6):c.1168T>C (p.Cys390Arg)
MISSENSE
rs1591885383 Pathogenic: Intellectual developmental disorder with impaired language and dysmorphic facies 118,756,316(-) C/T
NM_004397.6(DDX6):c.1118G>A (p.Arg373Gln)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DDX6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DDX6 Gene

Variant ID Type Subtype PubMed ID
esv2673492 CNV deletion 23128226
esv2762946 CNV gain 21179565
nsv1134179 CNV deletion 24896259
nsv832283 CNV loss 17160897

Variation tolerance for DDX6 Gene

Residual Variation Intolerance Score: 26.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DDX6 Gene

Human Gene Mutation Database (HGMD)
DDX6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX6
Leiden Open Variation Database (LOVD)
DDX6

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX6 Gene

Disorders for DDX6 Gene

MalaCards: The human disease database

(5) MalaCards diseases for DDX6 Gene - From: OMI, CVR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search DDX6 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DDX6_HUMAN
  • Intellectual developmental disorder with impaired language and dysmorphic facies (IDDILF) [MIM:618653]: An autosomal dominant disorder characterized by intellectual disability, developmental delay, impaired language development, and dysmorphic features including telecanthus, epicanthus, arched eyebrows and low-set ears. Additional features include feeding difficulties, mild cardiac or genitourinary defects, and distal skeletal anomalies. {ECO:0000269 PubMed:31422817}. Note=The disease is caused by variants affecting the gene represented in this entry.
  • Note=A chromosomal aberration involving DDX6 may be a cause of hematopoietic tumors such as B-cell lymphomas. Translocation t(11;14)(q23;q32).

Additional Disease Information for DDX6

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with DDX6: view

No data available for Genatlas for DDX6 Gene

Publications for DDX6 Gene

  1. Rare De Novo Missense Variants in RNA Helicase DDX6 Cause Intellectual Disability and Dysmorphic Features and Lead to P-Body Defects and RNA Dysregulation. (PMID: 31422817) Balak C … Piton A (American journal of human genetics 2019) 3 4 72
  2. Crystallization and X-ray analysis of the N-terminal core domain of a tumour-associated human DEAD-box RNA helicase, rck/p54. (PMID: 14684915) Matsui T … Tanaka N (Acta crystallographica. Section D, Biological crystallography 2004) 3 4 22
  3. RNA helicase p54 (DDX6) is a shuttling protein involved in nuclear assembly of stored mRNP particles. (PMID: 11839790) Smillie DA … Sommerville J (Journal of cell science 2002) 2 3 22
  4. Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3. (PMID: 1579499) Lu D … Yunis JJ (Nucleic acids research 1992) 2 3 4
  5. Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes. (PMID: 29510985) Brandmann T … Jinek M (The EMBO journal 2018) 3 4

Products for DDX6 Gene

Sources for DDX6 Gene