Aliases for DDX6 Gene
External Ids for DDX6 Gene
Previous HGNC Symbols for DDX6 Gene
Previous GeneCards Identifiers for DDX6 Gene
This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]
GeneCards Summary for DDX6 Gene
DDX6 (DEAD-Box Helicase 6) is a Protein Coding gene. Diseases associated with DDX6 include Nodal Marginal Zone Lymphoma and Embryonal Testis Carcinoma. Among its related pathways are Translational Control and Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein domain specific binding.
UniProtKB/Swiss-Prot for DDX6 Gene
In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573).