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This gene encodes a member of protein family containing a characteristic Asp-Glu-Ala-Asp (DEAD) motif. These proteins are putative RNA helicases, and may be involved in a range of nuclear processes including translational initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Multiple alternatively spliced transcript variants have been found for this gene. Pseudogenes have been identified on chromosomes 1 and 12. [provided by RefSeq, Feb 2016]
DDX55 (DEAD-Box Helicase 55) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is DDX27.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003723 | RNA binding | IEA,HDA | 22658674 |
GO:0003724 | RNA helicase activity | IEA | -- |
GO:0004386 | helicase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005730 | nucleolus | IBA,IDA | -- |
GO:0005829 | cytosol | IDA | -- |
GO:0016020 | membrane | HDA | 19946888 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
58-64-0 |
|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: |
ExUns: | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c |
---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||
SP2: | |||||||||
SP3: | |||||||||
SP4: | |||||||||
SP5: | |||||||||
SP6: | - | ||||||||
SP7: | |||||||||
SP8: | |||||||||
SP9: | - | - | |||||||
SP10: | |||||||||
SP11: | |||||||||
SP12: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DDX55 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | DDX55 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DDX55 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | DDX55 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DDX55 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ddx55 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ddx55 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DDX55 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DDX55 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ddx55 30 |
|
||
Str.10301 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.6290 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ddx55 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.14198 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001223 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG9630 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | ZK512.2 31 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E14367g 30 |
|
||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AGL004C 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SPB4 30 31 33 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT5G05450 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os01g0164500 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.10429 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7893 31 |
|
OneToOne | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU03380 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPBC24C6.02 30 |
|
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs10773019 | - |
p.Asn556Ser |
|||
rs11057306 | - |
p.Asn264Ser |
|||
rs17881657 | - |
p.Val101Leu |
|||
rs17886035 | - |
p.Glu154Gly |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1566n100 | CNV | gain | 25217958 |
dgv524e212 | CNV | loss | 25503493 |
esv3385376 | CNV | insertion | 20981092 |
nsv1042181 | CNV | gain | 25217958 |
No disorders were found for DDX55 Gene.