This gene encodes a member of protein family containing a characteristic Asp-Glu-Ala-Asp (DEAD) motif. These proteins are putative RNA helicases, and may be involved in a range of nuclear processes including translational initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Multiple alternatively spliced transcript variants have been found for ... See more...

Aliases for DDX55 Gene

Aliases for DDX55 Gene

  • DEAD-Box Helicase 55 2 3 5
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 55 2 3
  • ATP-Dependent RNA Helicase DDX55 3 4
  • DEAD Box Protein 55 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • EC 3.6.4.13 4
  • KIAA1595 4
  • EC 3.6.1 52

External Ids for DDX55 Gene

Previous GeneCards Identifiers for DDX55 Gene

  • GC12P123810
  • GC12P122439
  • GC12P122611
  • GC12P124086
  • GC12P121048

Summaries for DDX55 Gene

Entrez Gene Summary for DDX55 Gene

  • This gene encodes a member of protein family containing a characteristic Asp-Glu-Ala-Asp (DEAD) motif. These proteins are putative RNA helicases, and may be involved in a range of nuclear processes including translational initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Multiple alternatively spliced transcript variants have been found for this gene. Pseudogenes have been identified on chromosomes 1 and 12. [provided by RefSeq, Feb 2016]

GeneCards Summary for DDX55 Gene

DDX55 (DEAD-Box Helicase 55) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is DDX10.

UniProtKB/Swiss-Prot Summary for DDX55 Gene

Additional gene information for DDX55 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DDX55 Gene

Genomics for DDX55 Gene

GeneHancer (GH) Regulatory Elements for DDX55 Gene

Promoters and enhancers for DDX55 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DDX55 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DDX55

Top Transcription factor binding sites by QIAGEN in the DDX55 gene promoter:
  • FOXL1
  • FOXO1
  • FOXO1a
  • FOXO3
  • FOXO3a
  • FOXO3b
  • MIF-1
  • MRF-2
  • SRY
  • STAT5B

Genomic Locations for DDX55 Gene

Genomic Locations for DDX55 Gene
chr12:123,602,077-123,620,943
(GRCh38/hg38)
Size:
18,867 bases
Orientation:
Plus strand
chr12:124,086,624-124,105,488
(GRCh37/hg19)
Size:
18,865 bases
Orientation:
Plus strand

Genomic View for DDX55 Gene

Genes around DDX55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX55 Gene

Proteins for DDX55 Gene

  • Protein details for DDX55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHQ9-DDX55_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX55
    Protein Accession:
    Q8NHQ9
    Secondary Accessions:
    • Q658L6
    • Q8IYH0
    • Q9HCH7

    Protein attributes for DDX55 Gene

    Size:
    600 amino acids
    Molecular mass:
    68547 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDX55 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX55 Gene

Selected DME Specific Peptides for DDX55 Gene

Q8NHQ9:
  • QAYAKHECNLIFR
  • DEADRLL
  • GLRNPVR
  • TGSGKTLA
  • TPTRELA
  • VLVLDEAD
  • LVLDEADR
  • AVTGSGKT
  • LVFFSTCACVEY
  • IIVATPGR
  • GILVCTDV
  • VATPGRL
  • EILLRREEK
  • NQLVHFL
  • PTRELAIQ
  • RRTGLFSA
  • KIREKQR

Post-translational modifications for DDX55 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DDX55 Gene

Gene Families for DDX55 Gene

Protein Domains for DDX55 Gene

Suggested Antigen Peptide Sequences for DDX55 Gene

GenScript: Design optimal peptide antigens:
  • DEAD box protein 55 (DDX55_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NHQ9

UniProtKB/Swiss-Prot:

DDX55_HUMAN :
  • The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
  • Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Domain:
  • The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Family:
  • Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
genes like me logo Genes that share domains with DDX55: view

Function for DDX55 Gene

Molecular function for DDX55 Gene

UniProtKB/Swiss-Prot Function:
Probable ATP-binding RNA helicase.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;.

Enzyme Numbers (IUBMB) for DDX55 Gene

Phenotypes From GWAS Catalog for DDX55 Gene

Gene Ontology (GO) - Molecular Function for DDX55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA 21873635
GO:0003724 RNA helicase activity IEA --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DDX55: view
genes like me logo Genes that share phenotypes with DDX55: view

Animal Models for DDX55 Gene

MGI Knock Outs for DDX55:
  • Ddx55 Ddx55<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DDX55 Gene

Localization for DDX55 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX55 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DDX55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA,IBA --
GO:0005829 cytosol IDA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with DDX55: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DDX55 Gene

Pathways & Interactions for DDX55 Gene

PathCards logo

SuperPathways for DDX55 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX55 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DDX55 Gene

Drugs & Compounds for DDX55 Gene

(3) Drugs for DDX55 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for DDX55 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with DDX55: view

Transcripts for DDX55 Gene

mRNA/cDNA for DDX55 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX55 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^
SP1: - - -
SP2:
SP3: - - -
SP4: - - - - - -
SP5:
SP6:
SP7: - - - - -
SP8:
SP9: - -
SP10: - - -
SP11: -
SP12:

ExUns: 12a · 12b ^ 13a · 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12:

Relevant External Links for DDX55 Gene

GeneLoc Exon Structure for
DDX55

Expression for DDX55 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DDX55 Gene

Protein differential expression in normal tissues from HIPED for DDX55 Gene

This gene is overexpressed in Lung (47.4) and Cerebrospinal fluid (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX55 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DDX55

SOURCE GeneReport for Unigene cluster for DDX55 Gene:

Hs.286173

Evidence on tissue expression from TISSUES for DDX55 Gene

  • Stomach(4.2)
genes like me logo Genes that share expression patterns with DDX55: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX55 Gene

Orthologs for DDX55 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX55 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX55 31 30
  • 99.72 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX55 31
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX55 31 30
  • 89.54 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDX55 31
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDX55 31 30
  • 88.94 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx55 30
  • 85.92 (n)
mouse
(Mus musculus)
Mammalia Ddx55 17 31 30
  • 85.75 (n)
chicken
(Gallus gallus)
Aves DDX55 31 30
  • 77.36 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDX55 31
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx55 30
  • 72.32 (n)
Str.10301 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.6290 30
zebrafish
(Danio rerio)
Actinopterygii ddx55 31 30 30
  • 69.03 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14198 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001223 30
  • 56.24 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9630 31 30
  • 54.48 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK512.2 31
  • 36 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E14367g 30
  • 50.54 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL004C 30
  • 49.93 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPB4 33 31 30
  • 49.76 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G05450 30
  • 52.94 (n)
rice
(Oryza sativa)
Liliopsida Os01g0164500 30
  • 52.19 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.10429 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7893 31
  • 52 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU03380 30
  • 51.18 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC24C6.02 30
  • 47.56 (n)
Species where no ortholog for DDX55 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DDX55 Gene

ENSEMBL:
Gene Tree for DDX55 (if available)
TreeFam:
Gene Tree for DDX55 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DDX55: view image

Paralogs for DDX55 Gene

(12) SIMAP similar genes for DDX55 Gene using alignment to 6 proteins:

  • DDX55_HUMAN
  • E7EX41_HUMAN
  • F5H2I2_HUMAN
  • F5H5U2_HUMAN
  • F5H735_HUMAN
  • Q8IYH0_HUMAN

Pseudogenes.org Pseudogenes for DDX55 Gene

genes like me logo Genes that share paralogs with DDX55: view

Variants for DDX55 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DDX55 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs10773019 - p.Asn556Ser
rs11057306 - p.Asn264Ser
rs17881657 - p.Val101Leu
rs17886035 - p.Glu154Gly

Additional dbSNP identifiers (rs#s) for DDX55 Gene

Structural Variations from Database of Genomic Variants (DGV) for DDX55 Gene

Variant ID Type Subtype PubMed ID
dgv1566n100 CNV gain 25217958
dgv524e212 CNV loss 25503493
esv3385376 CNV insertion 20981092
nsv1042181 CNV gain 25217958

Variation tolerance for DDX55 Gene

Residual Variation Intolerance Score: 32.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.21; 88.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DDX55 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX55

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX55 Gene

Disorders for DDX55 Gene

Additional Disease Information for DDX55

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DDX55 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX55 Gene

Publications for DDX55 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. ATG5 is required for B cell polarization and presentation of particulate antigens. (PMID: 30196744) Arbogast F … Gros F (Autophagy 2019) 3 54
  4. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 54
  5. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 54

Products for DDX55 Gene

Sources for DDX55 Gene