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Aliases for DDX50 Gene

Aliases for DDX50 Gene

  • DExD-Box Helicase 50 2 3 5
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 50 2 3
  • DEAD-Box Helicase 50 2 3
  • DEAD Box Protein 50 3 4
  • Gu-Beta 3 4
  • Malignant Cell Derived RNA Helicase 3
  • ATP-Dependent RNA Helicase DDX50 3
  • RNA Helicase II/Gu Beta 3
  • Nucleolar Protein GU2 3
  • Nucleolar Protein Gu2 4
  • EC 4
  • RH-II/GuB 3
  • Mcdrh 3
  • GU2 3
  • GUB 3

External Ids for DDX50 Gene

Previous GeneCards Identifiers for DDX50 Gene

  • GC10P070553
  • GC10P070005
  • GC10P070331
  • GC10P070661
  • GC10P064662

Summaries for DDX50 Gene

Entrez Gene Summary for DDX50 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. This gene and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. This gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX50 Gene

DDX50 (DExD-Box Helicase 50) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is DDX21.

Gene Wiki entry for DDX50 Gene

Additional gene information for DDX50 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX50 Gene

Genomics for DDX50 Gene

GeneHancer (GH) Regulatory Elements for DDX50 Gene

Promoters and enhancers for DDX50 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J068899 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 673.3 +2.1 2077 3.4 CLOCK FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D SSRP1 DDX50 PIR62040 RPL26P27 CCAR1 MIR1254-1 DDX21 KIF1BP GC10M068913 RNU6-571P
GH10J068897 Enhancer 0.9 Ensembl ENCODE 650.7 -1.4 -1371 0.4 CTCF NFATC3 ARNT ARID4B MAX ERF CEBPG ZNF384 RAD21 ZNF335 DDX50 PIR62943
GH10J069179 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 102 +281.7 281687 3.3 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SUPV3L1 CCAR1 DDX50 TYSND1 HNRNPH3 DDX21 SAR1A RPL26P27 VPS26A HKDC1
GH10J068954 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 62.9 +57.5 57537 3.8 MLX DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC DDX21 DDX50 CCAR1 HERC4 HNRNPH3 KIF1BP RPL26P27 VPS26A STOX1 GC10P068966
GH10J068327 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 54.3 -566.7 -566702 9.1 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 HNRNPH3 PBLD HERC4 DDX50 CCAR1 SIRT1 DNA2 RPL26P27 TET1 RPS3AP38
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DDX50 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DDX50 gene promoter:
  • POU3F2
  • p53
  • HOXA9B
  • HOXA9
  • Meis-1
  • Meis-1a
  • MAZR
  • N-Myc
  • MEF-2A
  • aMEF-2

Genomic Locations for DDX50 Gene

Genomic Locations for DDX50 Gene
47,876 bases
Plus strand
45,570 bases
Plus strand

Genomic View for DDX50 Gene

Genes around DDX50 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX50 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX50 Gene

Proteins for DDX50 Gene

  • Protein details for DDX50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ATP-dependent RNA helicase DDX50
    Protein Accession:
    Secondary Accessions:
    • Q5VX37
    • Q8WV76
    • Q9BWI8

    Protein attributes for DDX50 Gene

    737 amino acids
    Molecular mass:
    82565 Da
    Quaternary structure:
    • Interacts with C1QBP.

    Three dimensional structures from OCA and Proteopedia for DDX50 Gene

neXtProt entry for DDX50 Gene

Post-translational modifications for DDX50 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DDX50 Gene

Domains & Families for DDX50 Gene

Gene Families for DDX50 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DDX50 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.
  • Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.
genes like me logo Genes that share domains with DDX50: view

Function for DDX50 Gene

Molecular function for DDX50 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.

Enzyme Numbers (IUBMB) for DDX50 Gene

Phenotypes From GWAS Catalog for DDX50 Gene

Gene Ontology (GO) - Molecular Function for DDX50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA,IEA 22658674
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX50: view
genes like me logo Genes that share phenotypes with DDX50: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DDX50

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX50

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX50 Gene

Localization for DDX50 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX50 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX50 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DDX50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with DDX50: view

Pathways & Interactions for DDX50 Gene

SuperPathways for DDX50 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX50: view

No data available for Pathways by source and SIGNOR curated interactions for DDX50 Gene

Drugs & Compounds for DDX50 Gene

(3) Drugs for DDX50 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for DDX50 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with DDX50: view

Transcripts for DDX50 Gene

Unigene Clusters for DDX50 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 50:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX50

Alternative Splicing Database (ASD) splice patterns (SP) for DDX50 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP2: -
SP5: - -

Relevant External Links for DDX50 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX50 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX50 Gene

Protein differential expression in normal tissues from HIPED for DDX50 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.9) and Stomach (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX50 Gene

Protein tissue co-expression partners for DDX50 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX50 Gene:


SOURCE GeneReport for Unigene cluster for DDX50 Gene:


Evidence on tissue expression from TISSUES for DDX50 Gene

  • Eye(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with DDX50: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX50 Gene

Orthologs for DDX50 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX50 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DDX50 34 33
  • 99.91 (n)
(Canis familiaris)
Mammalia DDX50 34 33
  • 95.65 (n)
(Bos Taurus)
Mammalia DDX50 34 33
  • 94.84 (n)
(Mus musculus)
Mammalia Ddx50 16 34 33
  • 92.74 (n)
(Rattus norvegicus)
Mammalia Ddx50 33
  • 92.3 (n)
(Monodelphis domestica)
Mammalia DDX50 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia DDX50 34
  • 57 (a)
(Gallus gallus)
Aves -- 34
  • 63 (a)
-- 34
  • 61 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6015 33
(Danio rerio)
Actinopterygii ddx21 34
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF1 34
  • 32 (a)
TIF2 34
  • 32 (a)
DBP3 34
  • 31 (a)
MRH4 36
thale cress
(Arabidopsis thaliana)
eudicotyledons emb1138 33
  • 49.73 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7087 33
(Oryza sativa)
Liliopsida Os03g0827700 33
  • 51.26 (n)
(Zea mays)
Liliopsida Zm.12927 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2984 34
  • 47 (a)
Species where no ortholog for DDX50 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDX50 Gene

Gene Tree for DDX50 (if available)
Gene Tree for DDX50 (if available)
Evolutionary constrained regions (ECRs) for DDX50: view image

Paralogs for DDX50 Gene

Paralogs for DDX50 Gene

(6) SIMAP similar genes for DDX50 Gene using alignment to 3 proteins:

  • S4R3G6_HUMAN
  • S4R3V4_HUMAN Pseudogenes for DDX50 Gene

genes like me logo Genes that share paralogs with DDX50: view

Variants for DDX50 Gene

Sequence variations from dbSNP and Humsavar for DDX50 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs374203626 uncertain-significance, Malignant tumor of prostate 68,906,745(+) C/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000080014 -- 68,951,512(+) A/T genic_downstream_transcript_variant, intron_variant
rs1000116265 -- 68,905,386(+) C/A intron_variant
rs1000124757 -- 68,952,523(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000169298 -- 68,912,131(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DDX50 Gene

Variant ID Type Subtype PubMed ID
esv2579637 CNV insertion 19546169
nsv519999 CNV loss 19592680
nsv831907 CNV gain 17160897

Variation tolerance for DDX50 Gene

Residual Variation Intolerance Score: 13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DDX50 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX50 Gene

Disorders for DDX50 Gene

Additional Disease Information for DDX50

No disorders were found for DDX50 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX50 Gene

Publications for DDX50 Gene

  1. Genomic structure of newly identified paralogue of RNA helicase II/Gu: detection of pseudogenes and multiple alternatively spliced mRNAs. (PMID: 11891046) Valdez BC … Sequitin AM (Gene 2002) 2 3 4 22 58
  2. Solution structure of the GUCT domain from human RNA helicase II/Gu beta reveals the RRM fold, but implausible RNA interactions. (PMID: 18615715) Ohnishi S … Yokoyama S (Proteins 2009) 3 4 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for DDX50 Gene

Sources for DDX50 Gene

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