Aliases for DDX41 Gene
External Ids for DDX41 Gene
Previous GeneCards Identifiers for DDX41 Gene
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD box protein family and interacts with several spliceosomal proteins. In addition, the encoded protein may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. [provided by RefSeq, Jan 2017]
GeneCards Summary for DDX41 Gene
DDX41 (DEAD-Box Helicase 41) is a Protein Coding gene. Diseases associated with DDX41 include Myeloproliferative/Lymphoproliferative Neoplasms, Familial and Bone Marrow Failure Syndrome 1. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Innate Immune System. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DDX42.
UniProtKB/Swiss-Prot Summary for DDX41 Gene
Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing.