Aliases for DDX3Y Gene
External Ids for DDX3Y Gene
Previous HGNC Symbols for DDX3Y Gene
Previous GeneCards Identifiers for DDX3Y Gene
The protein encoded by this gene is a member of the DEAD-box RNA helicase family, characterized by nine conserved motifs, included the conserved Asp-Glu-Ala-Asp (DEAD) motif. These motifs are thought to be involved in ATP binding, hydrolysis, RNA binding, and in the formation of intramolecular interactions. This protein shares high similarity to DDX3X, on the X chromosome, but a deletion of this gene is not complemented by DDX3X. Mutations in this gene result in male infertility, a reduction in germ cell numbers, and can result in Sertoli-cell only sydrome. Pseudogenes sharing similarity to both this gene and the DDX3X paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
GeneCards Summary for DDX3Y Gene
DDX3Y (DEAD-Box Helicase 3 Y-Linked) is a Protein Coding gene. Diseases associated with DDX3Y include Spermatogenic Failure, Y-Linked, 2 and Partial Deletion Of Y. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DDX3X.
UniProtKB/Swiss-Prot Summary for DDX3Y Gene
Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity).