Aliases for DDX3X Gene
Aliases for DDX3X Gene
External Ids for DDX3X Gene
- HGNC: 2745
- Entrez Gene: 1654
- Ensembl: ENSG00000215301
- OMIM: 300160
- UniProtKB: O00571
Previous HGNC Symbols for DDX3X Gene
- DDX3
Previous GeneCards Identifiers for DDX3X Gene
- GC0XP040037
- GC0XP040223
- GC0XP040948
- GC0XP041077
- GC0XP041192
- GC0XP038924
Summaries for DDX3X Gene
-
The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
GeneCards Summary for DDX3X Gene
DDX3X (DEAD-Box Helicase 3 X-Linked) is a Protein Coding gene. Diseases associated with DDX3X include Mental Retardation, X-Linked 102 and Corpus Callosum, Agenesis Of, With Facial Anomalies And Robin Sequence. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Translational Control. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is DDX3Y.
UniProtKB/Swiss-Prot for DDX3X Gene
-
Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5-single-stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can enhance transcription from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found associated with the E-cadherin promoter and can down-regulate transcription from the promoter. Involved in regulation of translation initiation. Proposed to be involved in positive regulation of translation such as of cyclin E1/CCNE1 mRNA and specifically of mRNAs containing complex secondary structures in their 5UTRs; these functions seem to require RNA helicase activity. Specifically promotes translation of a subset of viral and cellular mRNAs carrying a 5proximal stem-loop structure in their 5UTRs and cooperates with the eIF4F complex. Proposed to act prior to 43S ribosomal scanning and to locally destabilize these RNA structures to allow recognition of the mRNA cap or loading onto the 40S subunit. After association with 40S ribosomal subunits seems to be involved in the functional assembly of 80S ribosomes; the function seems to cover translation of mRNAs with structured and non-structured 5UTRs and is independent of RNA helicase activity. Also proposed to inhibit cap-dependent translation by competetive interaction with EIF4E which can block the EIF4E:EIF4G complex formation. Proposed to be involved in stress response and stress granule assembly; the function is independent of RNA helicase activity and seems to involve association with EIF4E. May be involved in nuclear export of specific mRNAs but not in bulk mRNA export via interactions with XPO1 and NXF1. Also associates with polyadenylated mRNAs independently of NXF1. Associates with spliced mRNAs in an exon junction complex (EJC)-dependent manner and seems not to be directly involved in splicing. May be involved in nuclear mRNA export by association with DDX5 and regulating its nuclear location. Involved in innate immune signaling promoting the production of type I interferon (IFN-alpha and IFN-beta); proposed to act as viral RNA sensor, signaling intermediate and transcriptional coactivator. Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, plays a role of scaffolding adapter that links IKBKE and IRF3 and coordinates their activation. Also found associated with IFNB promoters; the function is independent of IRF3. Can bind to viral RNAs and via association with MAVS/IPS1 and DDX58/RIG-I is thought to induce signaling in early stages of infection. Involved in regulation of apoptosis. May be required for activation of the intrinsic but inhibit activation of the extrinsic apoptotic pathway. Acts as an antiapoptotic protein through association with GSK3A/B and BIRC2 in an apoptosis antagonizing signaling complex; activation of death receptors promotes caspase-dependent cleavage of BIRC2 and DDX3X and relieves the inhibition. May be involved in mitotic chromosome segregation. Is an allosteric activator of CSNK1E, it stimulates CSNK1E-mediated phosphorylation of DVL2 and is involved in the positive regulation of canonical Wnt signaling (PubMed:23413191).
-
(Microbial infection) Appears to be a prime target for viral manipulations. Hepatitis B virus (HBV) polymerase and possibly vaccinia virus (VACV) protein K7 inhibit IFNB induction probably by dissociating DDX3X from TBK1 or IKBKE. Is involved in hepatitis C virus (HCV) replication; the function may involve the association with HCV core protein. HCV core protein inhibits the IPS1-dependent function in viral RNA sensing and may switch the function from a INFB inducing to a HCV replication mode. Involved in HIV-1 replication. Acts as a cofactor for XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs.
Additional gene information for DDX3X Gene
- Monarch Initiative
- Search for DDX3X at DataMed
- Search for DDX3X at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX3X Gene
Genomics for DDX3X Gene
GeneHancer (GH) Regulatory Elements for DDX3X Gene
Promoters and enhancers for DDX3X Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around DDX3X on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DDX3X gene promoter:
-
- Sp1
- p53
- deltaCREB
- CREB
- SREBP-1a
- SREBP-1b
- SREBP-1c
- CHOP-10
- C/EBPalpha
Regulatory Element Products
Genomic Locations for DDX3X Gene
Genomic Locations for DDX3X Gene
- chrX:41,333,284-41,364,472
- (GRCh38/hg38)
- Size:
- 31,189 bases
- Orientation:
- Plus strand
- chrX:41,192,651-41,223,725
- (GRCh37/hg19)
- Size:
- 31,075 bases
- Orientation:
- Plus strand
Genomic View for DDX3X Gene
Genes around DDX3X on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp11.4 by Entrez Gene
- Xp11.4 by HGNC
- Xp11.4 by Ensembl
DDX3X Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DDX3X Gene
Proteins for DDX3X Gene
-
Protein details for DDX3X Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00571-DDX3X_HUMAN
- Recommended name:
- ATP-dependent RNA helicase DDX3X
- Protein Accession:
- O00571
- A8K538
- B4E3E8
- O15536
Protein attributes for DDX3X Gene
- Size:
- 662 amino acids
- Molecular mass:
- 73243 Da
- Quaternary structure:
-
- Binds RNA as a monomer at low DDX3X concentrations and as a dimer at high DDX3X concentrations (PubMed:27546789). Interacts with XPO1, TDRD3, PABPC1, NXF1, EIF3C, MAVS, DDX58 and NCAPH (PubMed:15507209, PubMed:18632687, PubMed:18596238, PubMed:20127681, PubMed:21170385, PubMed:21730191, PubMed:21883093, PubMed:22323517, PubMed:22872150). Interacts with DDX5; the interaction is regulated by the phosphorylation status of both proteins (PubMed:22034099). Interacts with EIF4E; DDX3X competes with EIF4G1/EIF4G3 for interaction with EIF4E (PubMed:17667941, PubMed:21883093). Interacts with IKBKE; the interaction is direct, found to be induced upon virus infection (PubMed:20375222, PubMed:20657822, PubMed:23478265). Interacts (when phosphorylated at Ser-102) with IRF3; the interaction allows the phosphorylation and activation of IRF3 by IKBKE (PubMed:23478265). Interacts with TBK1 (PubMed:20375222). Associates with the eukaryotic translation initiation factor 3 (eIF-3) complex (PubMed:18628297). Associates with the 40S ribosome (PubMed:22323517). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1 (PubMed:19029303). Interacts with SP1 (PubMed:16818630). Interacts with GSK3A, GSK3B and TNFRSF10B (PubMed:18846110). Interacts with HCV core protein (PubMed:10329544). Interacts with vaccinia virus (VACV) protein K7 (PubMed:18636090, PubMed:19913487). Found in a complex with HIV-1 Rev and XPO1 (PubMed:15507209). Interacts with CSNK1E; the interaction enhances CSNK1E recruitement to DVL2 (PubMed:23413191). Interacts with DHX33; the interaction is independent of RNA (PubMed:26100019).
Three dimensional structures from OCA and Proteopedia for DDX3X Gene
Protein Expression for DDX3X Gene
Post-translational modifications for DDX3X Gene
- Phosphorylated by TBK1; the phosphorylation is required to synergize with TBK1 in IFNB induction. Phosphorylated by IKBKE at Ser-102 after ssRNA viral infection; enhances the induction of INFB promoter by IRF3. The cytoplasmic form is highly phosphorylated in the G1/S phase and much lower phosphorylated in G2/M.
- Ubiquitination at Lys554 and posLast=5555
- Modification sites at PhosphoSitePlus
Other Protein References for DDX3X Gene
- ENSEMBL proteins:
-
- ENSP00000495377
- ENSP00000494952
- ENSP00000487224
- ENSP00000487626
- ENSP00000480647
- ENSP00000496222
- ENSP00000496524
- ENSP00000486720
- ENSP00000494040
- ENSP00000478443
- ENSP00000392494
- ENSP00000494518
- ENSP00000496356
- ENSP00000496257
- ENSP00000496052
- ENSP00000493819
- ENSP00000382840
- ENSP00000494905
- ENSP00000496043
- ENSP00000486443
- ENSP00000486516
- ENSP00000486514
- ENSP00000493687
- ENSP00000479790
- ENSP00000496076
- ENSP00000486306
- ENSP00000495264
- ENSP00000493997
- ENSP00000493795
- ENSP00000414281
- ENSP00000494767
- ENSP00000496663
- ENSP00000494887
- ENSP00000494588
- ENSP00000487062
- ENSP00000493976
- ENSP00000493475
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for DDX3X
- Novus Biologicals Antibodies for DDX3X
-
Abcam antibodies for DDX3X
- Invitrogen Antibodies for DDX3X (AFLGC-DDX3X)
- antibodies-online: Search results for 221 available DDX3X Antibodies ranked by validation data
- Compare Top DDX3X Antibodies
-
Recommended
- 179 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 7 FACS Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 63 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 83 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- GeneTex DDX3X Antibody for DDX3X
-
Santa Cruz Biotechnology (SCBT) Antibodies for DDX3X
- Sino Biological Antibodies for DDX3X
Protein Products
-
OriGene Purified Proteins for DDX3X
- Search Origene for MassSpec and Protein Over-expression Lysates for DDX3X
- Origene Custom Protein Services for DDX3X
- Search GeneTex for Proteins for DDX3X
-
Abcam proteins for DDX3X
Assay Products
No data available for DME Specific Peptides for DDX3X Gene
Domains & Families for DDX3X Gene
Gene Families for DDX3X Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
- Transporters
Protein Domains for DDX3X Gene
Suggested Antigen Peptide Sequences for DDX3X Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ55031, highly similar to ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (B4DLA0_HUMAN)
- cDNA FLJ60675, highly similar to ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (B4DLU5_HUMAN)
- cDNA FLJ52848, highly similar to ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (B4E3C4_HUMAN)
- cDNA FLJ60399, highly similar to ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (B4E3E8_HUMAN)
- ATP-dependent RNA helicase DDX3X (B5BTY4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O00571- Family:
-
- Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
Function for DDX3X Gene
Molecular function for DDX3X Gene
- UniProtKB/Swiss-Prot Function:
- Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5-single-stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can enhance transcription from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found associated with the E-cadherin promoter and can down-regulate transcription from the promoter. Involved in regulation of translation initiation. Proposed to be involved in positive regulation of translation such as of cyclin E1/CCNE1 mRNA and specifically of mRNAs containing complex secondary structures in their 5UTRs; these functions seem to require RNA helicase activity. Specifically promotes translation of a subset of viral and cellular mRNAs carrying a 5proximal stem-loop structure in their 5UTRs and cooperates with the eIF4F complex. Proposed to act prior to 43S ribosomal scanning and to locally destabilize these RNA structures to allow recognition of the mRNA cap or loading onto the 40S subunit. After association with 40S ribosomal subunits seems to be involved in the functional assembly of 80S ribosomes; the function seems to cover translation of mRNAs with structured and non-structured 5UTRs and is independent of RNA helicase activity. Also proposed to inhibit cap-dependent translation by competetive interaction with EIF4E which can block the EIF4E:EIF4G complex formation. Proposed to be involved in stress response and stress granule assembly; the function is independent of RNA helicase activity and seems to involve association with EIF4E. May be involved in nuclear export of specific mRNAs but not in bulk mRNA export via interactions with XPO1 and NXF1. Also associates with polyadenylated mRNAs independently of NXF1. Associates with spliced mRNAs in an exon junction complex (EJC)-dependent manner and seems not to be directly involved in splicing. May be involved in nuclear mRNA export by association with DDX5 and regulating its nuclear location. Involved in innate immune signaling promoting the production of type I interferon (IFN-alpha and IFN-beta); proposed to act as viral RNA sensor, signaling intermediate and transcriptional coactivator. Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, plays a role of scaffolding adapter that links IKBKE and IRF3 and coordinates their activation. Also found associated with IFNB promoters; the function is independent of IRF3. Can bind to viral RNAs and via association with MAVS/IPS1 and DDX58/RIG-I is thought to induce signaling in early stages of infection. Involved in regulation of apoptosis. May be required for activation of the intrinsic but inhibit activation of the extrinsic apoptotic pathway. Acts as an antiapoptotic protein through association with GSK3A/B and BIRC2 in an apoptosis antagonizing signaling complex; activation of death receptors promotes caspase-dependent cleavage of BIRC2 and DDX3X and relieves the inhibition. May be involved in mitotic chromosome segregation. Is an allosteric activator of CSNK1E, it stimulates CSNK1E-mediated phosphorylation of DVL2 and is involved in the positive regulation of canonical Wnt signaling (PubMed:23413191).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Appears to be a prime target for viral manipulations. Hepatitis B virus (HBV) polymerase and possibly vaccinia virus (VACV) protein K7 inhibit IFNB induction probably by dissociating DDX3X from TBK1 or IKBKE. Is involved in hepatitis C virus (HCV) replication; the function may involve the association with HCV core protein. HCV core protein inhibits the IPS1-dependent function in viral RNA sensing and may switch the function from a INFB inducing to a HCV replication mode. Involved in HIV-1 replication. Acts as a cofactor for XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + H(2)O = ADP + phosphate.
- UniProtKB/Swiss-Prot Induction:
- Regulated by the cell cycle. Maximally expressed din the cytoplasm uring G1/S phase and decreased expression during G2/M phase.
Enzyme Numbers (IUBMB) for DDX3X Gene
Phenotypes From GWAS Catalog for DDX3X Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA,IDA | 21589879 |
| GO:0003723 | RNA binding | IDA,IEA | 21589879 |
| GO:0003924 | GTPase activity | IDA | 10074132 |
| GO:0004003 | ATP-dependent DNA helicase activity | IDA | 21589879 |
Phenotypes for DDX3X Gene
- MGI mutant phenotypes for DDX3X:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for DDX3X:
-
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Increased transcriptional activity
- Decreased HIV-LTR-beta-galactosidase protein expression
- Increased circadian period length
- Decreased p24 protein expression
- Decreased viability
- no effect
- Decreased Aire reporter expression
- Increased vaccinia virus (VACV) infection
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- shRNA abundance <= 50%
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
Animal Models for DDX3X Gene
- MGI Knock Outs for DDX3X:
-
- Ddx3x Ddx3x<tm1.2Lyou>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DDX3X
-
CRISPR Products
-
OriGene CRISPR knockouts for DDX3X
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DDX3X
- genomics-online: gRNA clones - Search results for 107 available DDX3X gene related products
- Overview of 107 available DDX3X gene related products
- Applied Biological Materials CRISPR for DDX3X
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DDX3X
- GenScript: Design CRISPR guide RNA sequences for DDX3X
miRNA for DDX3X Gene
- miRTarBase miRNAs that target DDX3X
-
- hsa-mir-192-5p (MIRT004132)
- hsa-mir-421 (MIRT016125)
- hsa-mir-124-3p (MIRT022863)
- hsa-mir-215-5p (MIRT024813)
- hsa-mir-181a-5p (MIRT025200)
- hsa-mir-26b-5p (MIRT029833)
- hsa-mir-21-5p (MIRT030902)
- hsa-mir-16-5p (MIRT031843)
- hsa-mir-505-5p (MIRT037942)
- hsa-mir-130b-5p (MIRT038287)
- hsa-mir-629-3p (MIRT039582)
- hsa-mir-92b-3p (MIRT040544)
- hsa-mir-99a-5p (MIRT048615)
- hsa-mir-1304-5p (MIRT478235)
- hsa-mir-106a-3p (MIRT478236)
- hsa-mir-6858-5p (MIRT478237)
- hsa-mir-4689 (MIRT478238)
- hsa-mir-1224-5p (MIRT478239)
- hsa-mir-3915 (MIRT478240)
- hsa-mir-653-3p (MIRT478241)
- hsa-mir-1227-3p (MIRT478242)
- hsa-mir-3605-5p (MIRT478243)
- hsa-mir-3679-5p (MIRT478244)
- hsa-mir-1185-5p (MIRT478245)
- hsa-mir-6776-3p (MIRT478246)
- hsa-mir-455-5p (MIRT478247)
- hsa-mir-181d-5p (MIRT478248)
- hsa-mir-181c-5p (MIRT478249)
- hsa-mir-181b-5p (MIRT478250)
- hsa-mir-4262 (MIRT478251)
- hsa-mir-1257 (MIRT478252)
- hsa-mir-4304 (MIRT478253)
- hsa-mir-596 (MIRT478254)
- hsa-mir-4797-5p (MIRT478255)
- hsa-mir-8066 (MIRT478256)
- hsa-mir-4524b-5p (MIRT502626)
- hsa-mir-4524a-5p (MIRT502627)
- hsa-mir-8067 (MIRT502628)
- hsa-mir-6508-5p (MIRT502629)
- hsa-mir-646 (MIRT502630)
- hsa-mir-545-3p (MIRT502631)
- hsa-mir-548p (MIRT502632)
- hsa-mir-548l (MIRT502633)
- hsa-mir-7844-5p (MIRT502634)
- hsa-mir-548n (MIRT502635)
- hsa-mir-5582-3p (MIRT502636)
- hsa-mir-548f-3p (MIRT502637)
- hsa-mir-548e-3p (MIRT502638)
- hsa-mir-548az-3p (MIRT502639)
- hsa-mir-548ar-3p (MIRT502640)
- hsa-mir-548a-3p (MIRT502641)
- hsa-mir-503-5p (MIRT502642)
- hsa-mir-15a-5p (MIRT502643)
- hsa-mir-6838-5p (MIRT502644)
- hsa-mir-497-5p (MIRT502645)
- hsa-mir-424-5p (MIRT502646)
- hsa-mir-195-5p (MIRT502647)
- hsa-mir-15b-5p (MIRT502648)
- hsa-mir-4440 (MIRT507581)
- hsa-mir-5680 (MIRT507582)
- hsa-mir-651-5p (MIRT507583)
- hsa-mir-4325 (MIRT507584)
- hsa-mir-7703 (MIRT507585)
- hsa-mir-4496 (MIRT507586)
- hsa-mir-25-3p (MIRT507587)
- hsa-mir-32-5p (MIRT507588)
- hsa-mir-363-3p (MIRT507589)
- hsa-mir-92a-3p (MIRT507590)
- hsa-mir-367-3p (MIRT507591)
- hsa-mir-129-5p (MIRT507592)
- hsa-mir-3191-5p (MIRT513938)
- hsa-mir-5585-5p (MIRT513939)
- hsa-mir-4680-3p (MIRT513940)
- hsa-mir-5187-3p (MIRT513941)
- hsa-mir-4427 (MIRT513942)
- hsa-mir-3921 (MIRT513943)
- hsa-mir-4653-5p (MIRT513944)
- hsa-mir-301b-5p (MIRT513945)
- hsa-mir-301a-5p (MIRT513946)
- hsa-mir-146a-3p (MIRT513947)
- hsa-mir-95-5p (MIRT513948)
- hsa-mir-19b-3p (MIRT513949)
- hsa-mir-19a-3p (MIRT513950)
- hsa-mir-3115 (MIRT538127)
- hsa-mir-1468-3p (MIRT538128)
- hsa-mir-5571-5p (MIRT538129)
- hsa-mir-548at-5p (MIRT538130)
- hsa-mir-4465 (MIRT541349)
- hsa-mir-26a-5p (MIRT541350)
- hsa-mir-1297 (MIRT541351)
- hsa-mir-505-3p (MIRT541352)
- hsa-mir-7159-5p (MIRT541353)
- hsa-mir-6513-3p (MIRT541354)
- hsa-mir-4272 (MIRT541355)
- hsa-mir-433-5p (MIRT541356)
- hsa-mir-543 (MIRT541357)
- hsa-mir-199b-5p (MIRT541358)
- hsa-mir-199a-5p (MIRT541359)
- hsa-mir-6504-3p (MIRT548584)
- hsa-mir-4659b-3p (MIRT548585)
- hsa-mir-4659a-3p (MIRT548586)
- hsa-mir-6875-3p (MIRT548587)
- hsa-mir-4282 (MIRT548588)
- hsa-mir-190a-3p (MIRT558429)
- hsa-mir-4512 (MIRT558430)
- hsa-mir-641 (MIRT558431)
- hsa-mir-3617-5p (MIRT558432)
- hsa-mir-337-3p (MIRT558433)
- hsa-mir-202-5p (MIRT558434)
- hsa-let-7c-3p (MIRT567806)
- hsa-mir-3163 (MIRT567807)
- hsa-mir-624-3p (MIRT567808)
- hsa-mir-4999-3p (MIRT572154)
- hsa-mir-216b-3p (MIRT572155)
- hsa-mir-5011-5p (MIRT572156)
- hsa-mir-410-3p (MIRT572157)
- hsa-mir-1277-5p (MIRT572158)
- hsa-mir-342-3p (MIRT572159)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DDX3X
- Browse OriGene Inhibitory RNA Products For DDX3X
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX3X
- genomics-online: shRNA clones - Search results for 107 available DDX3X gene related products
- Overview of 107 available DDX3X gene related products
Clone Products
-
OriGene ORF clones in human for DDX3X
- RC204171
- RC204171L1
- RC204171L2
- RC204171L3
- RC204171L4
- RC230863
- RC230863L1
- RC230863L2
- RC230863L3
- RC230863L4
- RC231353
- RC231353L1
- RC231353L2
- RC231353L3
- RC231353L4
- RC504171
- RG204171
- RG230863
- RG231353
- RC204171L1V
- RC204171L2V
- RC204171L3V
- RC204171L4V
- RC230863L1V
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- RC231353L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DDX3X
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- Applied Biological Materials Clones for DDX3X
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DDX3X
No data available for Transcription Factor Targets and HOMER Transcription for DDX3X Gene
Localization for DDX3X Gene
Subcellular locations from UniProtKB/Swiss-Prot for DDX3X Gene
- Nucleus speckle. Cytoplasm. Mitochondrion outer membrane. Note=Located predominantly in nuclear speckles and, at low levels, throughout the cytoplasm. Located to the outer side of nuclear pore complexes (NPC). Shuttles between the nucleus and the cytoplasm in a XPO1 and may be also in a NFX1-dependent manner. Associated with polyadenylated mRNAs in the cytoplasm and the nucleus. Predominantly located in nucleus during G(0) phase and in the cytoplasm during G1/S phase.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
- Cytosol (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | IDA | 10074132 |
| GO:0005730 | nucleolus | IBA | -- |
| GO:0005737 | cytoplasm | IMP | 10074132 |
| GO:0005739 | mitochondrion | IEA | -- |
Pathways & Interactions for DDX3X Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | ||
| 3 | Kaposi's sarcoma-associated herpesvirus infection |
.33
|
|
| 4 | Viral carcinogenesis | ||
| 5 | DNA Damage | ||
Pathways by source for DDX3X Gene
1 GeneTex pathway for DDX3X Gene
1 BioSystems pathway for DDX3X Gene
3 Reactome pathways for DDX3X Gene
3 KEGG pathways for DDX3X Gene
2 Cell Signaling Technology pathways for DDX3X Gene
Interacting Proteins for DDX3X Gene
Selected Interacting proteins:
O00571-DDX3X_HUMAN
ENSP00000382840
for DDX3X Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for DDX3X
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002376 | immune system process | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006413 | translational initiation | IMP | 26100019 |
| GO:0006417 | regulation of translation | IEA | -- |
Drugs & Compounds for DDX3X Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
Drug Products
Transcripts for DDX3X Gene
mRNA/cDNA for DDX3X Gene
- (7) REFSEQ mRNAs :
- (17) Additional mRNA sequences :
- (564) Selected AceView cDNA sequences:
- (69) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000644876 6907 bps
- ENST00000610559 553 bps (uc064ypz.1)
- ENST00000629496 5036 bps (uc033eaf.2)
- ENST00000629785 3457 bps (uc064yqc.1)
- ENST00000630255 3289 bps (uc064yqd.1)
Unigene Clusters for DDX3X Gene
CRISPR Products
-
OriGene CRISPR knockouts for DDX3X
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DDX3X
- genomics-online: gRNA clones - Search results for 107 available DDX3X gene related products
- Overview of 107 available DDX3X gene related products
- Applied Biological Materials CRISPR for DDX3X
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DDX3X
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miRNA Products
Inhibitory RNA Products
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- Browse OriGene Inhibitory RNA Products For DDX3X
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- genomics-online: shRNA clones - Search results for 107 available DDX3X gene related products
- Overview of 107 available DDX3X gene related products
Clone Products
-
OriGene ORF clones in human for DDX3X
- RC204171
- RC204171L1
- RC204171L2
- RC204171L3
- RC204171L4
- RC230863
- RC230863L1
- RC230863L2
- RC230863L3
- RC230863L4
- RC231353
- RC231353L1
- RC231353L2
- RC231353L3
- RC231353L4
- RC504171
- RG204171
- RG230863
- RG231353
- RC204171L1V
- RC204171L2V
- RC204171L3V
- RC204171L4V
- RC230863L1V
- RC230863L2V
- RC230863L3V
- RC230863L4V
- RC231353L1V
- RC231353L2V
- RC231353L3V
- RC231353L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DDX3X
- Sino Biological Human cDNA Clone for DDX3X
- Addgene plasmids for DDX3X
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DDX3X
- Applied Biological Materials Clones for DDX3X
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for DDX3X Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Thymus (Hematopoietic System)
- Lung (Respiratory System)
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Blood (Cardiovascular System)
- Double Negative 2 Thymocytes Thymus
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
-
Heart (Cardiovascular System)
- Cardiac Crescent Cells Cardiac Crescent
- Neural Tube (Nervous System)
- Kidney (Urinary System)
This gene is overexpressed in Bone marrow stromal cell (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX3X Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DDX3X Gene:
DDX3XSOURCE GeneReport for Unigene cluster for DDX3X Gene:
Hs.743263Evidence on tissue expression from TISSUES for DDX3X Gene
- Nervous system(5)
- Liver(4.6)
- Skin(4.4)
- Lung(3.1)
- Intestine(2.8)
- Lymph node(2.2)
- Blood(2.1)
- Bone marrow(2.1)
- Eye(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX3X Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- nervous
- skeletal muscle
Regions:
Head and neck:
- brain
- head
Primer Products
-
OriGene qPCR primer pairs for DDX3X
-
OriGene qPCR primer pairs and template standards for DDX3X
- genomics-online: primer clones - Search results for 107 available DDX3X gene related products
- Overview of 107 available DDX3X gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX3X Gene
Orthologs for DDX3X Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | D1Pas1 34 |
|
OneToMany | |
| Ddx3x 16 34 33 |
|
||||
| dog (Canis familiaris) |
Mammalia | DDX3X 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | DDX3X 34 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DDX3X 34 33 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ddx3x 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pl10 34 |
|
ManyToMany | |
| ddx3 34 |
|
ManyToMany | |||
| -- 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10835 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | bel 34 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | laf-1 34 33 |
|
ManyToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | DED1 34 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT3G58570 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7412 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os07g0202100 33 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.10750 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.10226 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| Cin.3988 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3988 33 |
|
- Species where no ortholog for DDX3X was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rat (Rattus norvegicus)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for DDX3X Gene
- ENSEMBL:
- Gene Tree for DDX3X (if available)
- TreeFam:
- Gene Tree for DDX3X (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DDX3X: view image
Paralogs for DDX3X Gene
(11) SIMAP similar genes for DDX3X Gene using alignment to 4 proteins:
- DDX3X_HUMAN
- B4DLA0_HUMAN
- B4E3C4_HUMAN
- B5BTY4_HUMAN
Pseudogenes.org Pseudogenes for DDX3X Gene
Variants for DDX3X Gene
| SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1057518707 | retardation, X-linked 102 (MRX102) [MIM:300958], pathogenic, Mental retardation, X-linked 102 | 41,345,206(+) | G/A | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
| rs1057519430 | retardation, X-linked 102 (MRX102) [MIM:300958], pathogenic, Mental retardation, X-linked 102 | 41,346,946(+) | C/T | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
| rs1057519431 | pathogenic, Mental retardation, X-linked 102 | 41,341,522(+) | AAA/AAAA | 5_prime_UTR_variant, coding_sequence_variant, frameshift, genic_downstream_transcript_variant, non_coding_transcript_variant | |
| rs1057519446 | pathogenic, Mental retardation, X-linked 102 | 41,342,572(+) | G/C/T | 5_prime_UTR_variant, coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
| rs752738546 | pathogenic, Mental retardation, X-linked 102 | 41,343,802(+) | G/A/T | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant, stop_gained |
Residual Variation Intolerance Score:
19.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.08;
1.81% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DDX3X Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX3X Gene
Disorders for DDX3X Gene
(10) MalaCards diseases for DDX3X Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mental retardation, x-linked 102 |
|
|
| corpus callosum, agenesis of, with facial anomalies and robin sequence |
|
|
| precursor t-cell acute lymphoblastic leukemia |
|
|
| lymphocytic choriomeningitis |
|
|
| childhood medulloblastoma |
|
|
Search DDX3X in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
DDX3X_HUMAN- Mental retardation, X-linked 102 (MRX102) [MIM:300958]: A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. MRX102 features include mild to severe intellectual disability, hypotonia, movement disorders, behavior problems, corpus callosum hypoplasia, and epilepsy. Additionally, patients manifest variable non-neurologic features such as joint hyperlaxity, skin pigmentary abnormalities, cleft lip and/or palate, hearing and visual impairment, and precocious puberty. {ECO:0000269 PubMed:26235985}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for DDX3X
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for DDX3X Gene
Publications for DDX3X Gene
- DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential. (PMID: 20127681) Oshiumi H … Seya T (European journal of immunology 2010) 3 4 22 58
- Expression, purification, crystallization and preliminary X-ray diffraction analysis of the DDX3 RNA helicase domain. (PMID: 17401195) Rodamilans B … Montoya G (Acta crystallographica. Section F, Structural biology and crystallization communications 2007) 3 4 22 58
- DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control. (PMID: 16301996) Chang PC … Wu Lee YH (Oncogene 2006) 3 4 22 58
- Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function. (PMID: 15507209) Yedavalli VS … Jeang KT (Cell 2004) 3 4 22 58
- Hepatitis C virus core protein interacts with a human DEAD box protein DDX3. (PMID: 10329544) Owsianka AM … Patel AH (Virology 1999) 3 4 22 58
Products for DDX3X Gene
- Browse R&D Systems for Antibodies
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- RC204171
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- antibodies-online: Search results for 221 available DDX3X Antibodies ranked by validation data
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- Recommended
- 179 WB Antibodies (anti-human)
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- 3 IHC (p) Antibodies (anti-human)
- 63 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
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- 83 WB Antibodies (anti-mouse)
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- 2 IHC (p) Antibodies (anti-mouse)
- antibodies-online: Search results for 3 available DDX3X Elisa Kits ranked by validation data
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- antibodies-online: Search results for 5 available DDX3X Proteins ranked by validation data
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- GeneTex DDX3X Antibody for DDX3X
- Search GeneTex for Proteins for DDX3X
- Santa Cruz Biotechnology (SCBT) Antibodies for DDX3X
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- genomics-online: cdna clones - Search results for 107 available DDX3X gene related products
- Overview of 107 available DDX3X gene related products
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Sources for DDX3X Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS