Aliases for DDX39A Gene
External Ids for DDX39A Gene
Previous HGNC Symbols for DDX39A Gene
Previous GeneCards Identifiers for DDX39A Gene
This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is thought to play a role in the prognosis of patients with gastrointestinal stromal tumors. A pseudogene of this gene is present on chromosome 13. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
GeneCards Summary for DDX39A Gene
DDX39A (DExD-Box Helicase 39A) is a Protein Coding gene. Diseases associated with DDX39A include Gastrointestinal Stromal Tumor and Inflammatory Bowel Disease 6. Among its related pathways are RNA Polymerase II Transcription Termination and Transport of Mature Transcript to Cytoplasm. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is DDX39B.
UniProtKB/Swiss-Prot for DDX39A Gene
Isoform 1: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus.