DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this fami... See more...

Aliases for DDX27 Gene

Aliases for DDX27 Gene

  • DEAD-Box Helicase 27 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 27 2 3
  • Probable ATP-Dependent RNA Helicase DDX27 3 4
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 27 2 3
  • DEAD Box Protein 27 3 4
  • RHLP 3 4
  • Deficiency Of Ribosomal Subunits Protein 1 Homolog 3
  • RNA Helicase-Like Protein 3
  • EC 3.6.4.13 4
  • DJ686N3.1 3
  • EC 3.6.1 54
  • HSPC259 3
  • CPERP-F 4
  • PP3241 3
  • Drs1p 3
  • DRS1 3

External Ids for DDX27 Gene

Previous GeneCards Identifiers for DDX27 Gene

  • GC20P047564
  • GC20P048474
  • GC20P048521
  • GC20P047269
  • GC20P047835
  • GC20P044584

Summaries for DDX27 Gene

Entrez Gene Summary for DDX27 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. [provided by RefSeq, Jan 2017]

GeneCards Summary for DDX27 Gene

DDX27 (DEAD-Box Helicase 27) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is DDX23.

UniProtKB/Swiss-Prot Summary for DDX27 Gene

  • Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA (PubMed:25825154).

Gene Wiki entry for DDX27 Gene

Additional gene information for DDX27 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DDX27 Gene

Genomics for DDX27 Gene

GeneHancer (GH) Regulatory Elements for DDX27 Gene

Promoters and enhancers for DDX27 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DDX27 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DDX27 gene promoter:
  • AP-1
  • ATF6
  • c-Fos
  • c-Jun
  • GR
  • GR-alpha
  • GR-beta
  • HNF-4alpha1
  • HNF-4alpha2
  • SEF-1 (1)

Genomic Locations for DDX27 Gene

Genomic Locations for DDX27 Gene
chr20:49,219,295-49,244,077
(GRCh38/hg38)
Size:
24,783 bases
Orientation:
Plus strand
chr20:47,835,832-47,860,614
(GRCh37/hg19)
Size:
24,783 bases
Orientation:
Plus strand

Genomic View for DDX27 Gene

Genes around DDX27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX27 Gene

Proteins for DDX27 Gene

  • Protein details for DDX27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GQ7-DDX27_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX27
    Protein Accession:
    Q96GQ7
    Secondary Accessions:
    • A0AVB6
    • B7ZLY1
    • Q5VXM7
    • Q8WYG4
    • Q969N7
    • Q96F57
    • Q96L97
    • Q9BWY9
    • Q9BXF0
    • Q9H990
    • Q9NWU3
    • Q9P0C2
    • Q9UGD6

    Protein attributes for DDX27 Gene

    Size:
    796 amino acids
    Molecular mass:
    89835 Da
    Quaternary structure:
    • Associates with PeBoW complex, composed of BOP1, PES1 and WDR12 (PubMed:25825154). Interacts directly with BOP1 and PES1 (PubMed:25825154).
    SequenceCaution:
    • Sequence=AAF28937.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAF28937.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=AAG22482.1; Type=Frameshift; Positions=208, 427, 434, 532; Evidence={ECO:0000305}; Sequence=AAH16060.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91284.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14343.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for DDX27 Gene

Selected DME Specific Peptides for DDX27 Gene

Q96GQ7:
  • RVGRTAR
  • VAARGLDI
  • GRSVSLVGE
  • DEADRML
  • IQKACIP
  • GTGKTAAF
  • GRTARAGR
  • LVATDVAARGL
  • YVHRVGRT
  • TPGRLID
  • RQTMLFSAT
  • LVPTREL
  • LFSATMT
  • GKTAAFALP
  • IATPGRL
  • TDVAARGLD

Post-translational modifications for DDX27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX27 Gene

Domains & Families for DDX27 Gene

Gene Families for DDX27 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DDX27 Gene

GenScript: Design optimal peptide antigens:
  • DEAD box polypeptide 27 (B3GQE6_HUMAN)
  • DEAD box protein 27 (DDX27_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96GQ7

UniProtKB/Swiss-Prot:

DDX27_HUMAN :
  • The C-terminal domain regulates nucleolar localization (PubMed:25825154).
  • Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
Domain:
  • The C-terminal domain regulates nucleolar localization (PubMed:25825154).
Family:
  • Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
genes like me logo Genes that share domains with DDX27: view

Function for DDX27 Gene

Molecular function for DDX27 Gene

UniProtKB/Swiss-Prot Function:
Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA (PubMed:25825154).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;.

Enzyme Numbers (IUBMB) for DDX27 Gene

Phenotypes From GWAS Catalog for DDX27 Gene

Gene Ontology (GO) - Molecular Function for DDX27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA,HDA 21873635
GO:0003724 RNA helicase activity IEA --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 25825154
genes like me logo Genes that share ontologies with DDX27: view
genes like me logo Genes that share phenotypes with DDX27: view

Animal Models for DDX27 Gene

MGI Knock Outs for DDX27:
  • Ddx27 Ddx27<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for DDX27 Gene

miRTarBase miRNAs that target DDX27

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX27

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DDX27 Gene

Localization for DDX27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX27 Gene

Nucleus, nucleolus. Chromosome. Note=Associates with 60S and 90S pre-ribosomal particles (PubMed:25825154). {ECO:0000269 PubMed:25825154}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX27 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DDX27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA,IDA 20813266
GO:0005730 nucleolus IDA,IEA 25825154
genes like me logo Genes that share ontologies with DDX27: view

Pathways & Interactions for DDX27 Gene

PathCards logo

SuperPathways for DDX27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IMP 25825154
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with DDX27: view

No data available for Pathways by source and SIGNOR curated interactions for DDX27 Gene

Drugs & Compounds for DDX27 Gene

(3) Drugs for DDX27 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for DDX27 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with DDX27: view

Transcripts for DDX27 Gene

mRNA/cDNA for DDX27 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX27

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX27 Gene

No ASD Table

Relevant External Links for DDX27 Gene

GeneLoc Exon Structure for
DDX27
ECgene alternative splicing isoforms for
DDX27

Expression for DDX27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX27 Gene

Protein differential expression in normal tissues from HIPED for DDX27 Gene

This gene is overexpressed in Lung (50.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX27 Gene



Protein tissue co-expression partners for DDX27 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX27 Gene:

DDX27

SOURCE GeneReport for Unigene cluster for DDX27 Gene:

Hs.65234

Evidence on tissue expression from TISSUES for DDX27 Gene

  • Nervous system(4.8)
  • Skin(4.5)
  • Liver(4.4)
  • Muscle(4.3)
  • Blood(4.2)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with DDX27: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX27 Gene

Orthologs for DDX27 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX27 33 32
  • 99.46 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DDX27 33 32
  • 91.99 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DDX27 33 32
  • 91.55 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDX27 33
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx27 17 33 32
  • 87.94 (n)
rat
(Rattus norvegicus)
Mammalia Ddx27 32
  • 87.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DDX27 33
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDX27 33 32
  • 74.73 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDX27 33
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx27 32
  • 70.14 (n)
Str.11808 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.29976 32
zebrafish
(Danio rerio)
Actinopterygii ddx27 33 32 32
  • 70.2 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4514 32
fruit fly
(Drosophila melanogaster)
Insecta Rs1 33 34 32
  • 62.45 (n)
OneToOne
Dbp45A 34
  • 32 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011084 32
  • 59.29 (n)
worm
(Caenorhabditis elegans)
Secernentea Y71G12B.8 33 34 32
  • 55.36 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DRS1 35 33
  • 33 (a)
rice
(Oryza sativa)
Liliopsida Os.27674 32
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8743 33
  • 60 (a)
OneToOne
Species where no ortholog for DDX27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX27 Gene

ENSEMBL:
Gene Tree for DDX27 (if available)
TreeFam:
Gene Tree for DDX27 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DDX27: view image

Paralogs for DDX27 Gene

(13) SIMAP similar genes for DDX27 Gene using alignment to 3 proteins:

  • DDX27_HUMAN
  • B3GQE6_HUMAN
  • Q3MI07_HUMAN
genes like me logo Genes that share paralogs with DDX27: view

Variants for DDX27 Gene

Sequence variations from dbSNP and Humsavar for DDX27 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000097641 -- 49,229,324(+) C/T intron_variant
rs1000213839 -- 49,242,248(+) C/T intron_variant
rs1000230241 -- 49,238,301(+) G/A/C intron_variant
rs1000376657 -- 49,244,196(+) G/A downstream_transcript_variant
rs1000406975 -- 49,229,183(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DDX27 Gene

Variant ID Type Subtype PubMed ID
nsv1064443 CNV gain 25217958
nsv1067146 CNV loss 25217958

Variation tolerance for DDX27 Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.80; 94.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DDX27 Gene

Human Gene Mutation Database (HGMD)
DDX27
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX27

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX27 Gene

Disorders for DDX27 Gene

Additional Disease Information for DDX27

No disorders were found for DDX27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX27 Gene

Publications for DDX27 Gene

  1. DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex. (PMID: 25825154) Kellner M … Eick D (Experimental cell research 2015) 3 4 56
  2. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S … Rappsilber J (Cell 2010) 3 4 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 56

Products for DDX27 Gene

Sources for DDX27 Gene