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Aliases for DDX25 Gene

Aliases for DDX25 Gene

  • DEAD-Box Helicase 25 2 3 5
  • Gonadotropin-Regulated Testicular RNA Helicase 2 3 4
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 25 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 25 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 25 2 3
  • ATP-Dependent RNA Helicase DDX25 3 4
  • DEAD Box Protein 25 3 4
  • GRTH 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • EC 3.6.4.13 4
  • EC 3.6.1 56

External Ids for DDX25 Gene

Previous GeneCards Identifiers for DDX25 Gene

  • GC11P127774
  • GC11P127287
  • GC11P125806
  • GC11P125312
  • GC11P125279
  • GC11P121716
  • GC11P125773

Summaries for DDX25 Gene

Entrez Gene Summary for DDX25 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain testicular functions related to steroidogenesis and spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX25 Gene

DDX25 (DEAD-Box Helicase 25) is a Protein Coding gene. Diseases associated with DDX25 include Hydrolethalus Syndrome 1. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is ENSG00000260537.

UniProtKB/Swiss-Prot for DDX25 Gene

  • ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity).

Additional gene information for DDX25 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX25 Gene

Genomics for DDX25 Gene

GeneHancer (GH) Regulatory Elements for DDX25 Gene

Promoters and enhancers for DDX25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J125901 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 653.9 -0.1 -147 2.8 ELF3 SIX5 NKRF POLR2A GTF2F1 ZNF384 SP1 CREM PRDM1 IKZF1 DDX25 PUS3 ENSG00000254790 ENSG00000254694 FAM118B RPUSD4 PIR36090 ENSG00000255027
GH11J125568 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 8.5 -333.7 -333715 3.3 SP1 ZFX ELF3 CC2D1A MNT SIX5 ZNF148 NKRF POLR2A MLLT1 EI24 FEZ1 STT3A CHEK1 MSANTD2 DDX25 PUS3 RNU6-1156P STT3A-AS1
GH11J125591 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 7.5 -310.6 -310566 3.2 SP1 CC2D1A ZFX ELF3 MNT CBFA2T2 NKRF POLR2A MLLT1 GTF2F1 STT3A FEZ1 STT3A-AS1 ENSG00000255062 CHEK1 MSANTD2 TMEM218 ENSG00000254509 ENSG00000254694 EI24
GH11J125874 Promoter 1.5 EPDnew Ensembl 10.5 -29.1 -29147 0.8 IKZF1 ATF1 CTCF TRIM22 SAP130 SMC3 GATA3 MNT RAD21 ZNF654 ENSG00000260209 PATE2 PUS3 DDX25 PATE4 CHEK1
GH11J125800 Enhancer 0.4 FANTOM5 38.7 -103.0 -102969 0.4 ZNF507 REST DDX25 ENSG00000254694 MSANTD2 CHEK1 PATE4 HYLS1 PATE1 PATE2 PATE3 GC11P125812
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DDX25 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DDX25 gene promoter:
  • CBF(2)
  • CBF-B
  • E47
  • Pax-2
  • Pax-2a
  • Pax-6
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • TBP

Genomic Locations for DDX25 Gene

Genomic Locations for DDX25 Gene
chr11:125,903,348-125,943,702
(GRCh38/hg38)
Size:
40,355 bases
Orientation:
Plus strand
chr11:125,773,271-125,793,158
(GRCh37/hg19)
Size:
19,888 bases
Orientation:
Plus strand

Genomic View for DDX25 Gene

Genes around DDX25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX25 Gene

Proteins for DDX25 Gene

  • Protein details for DDX25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHL0-DDX25_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX25
    Protein Accession:
    Q9UHL0
    Secondary Accessions:
    • B2R6Z0
    • Q5XVN2
    • Q86W81
    • Q8IYP1

    Protein attributes for DDX25 Gene

    Size:
    483 amino acids
    Molecular mass:
    54692 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DDX25 Gene

    Alternative splice isoforms for DDX25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX25 Gene

Selected DME Specific Peptides for DDX25 Gene

Q9UHL0:
  • KVLITTN
  • IGTPGTVLDWC
  • DVVDLAANSLLNKLI
  • FVLDEAD
  • ITIGQAIIFCQTRRNAKWLTVEM
  • HRIGRTGR
  • GTGKTAAF
  • YLHRIGR
  • SPLYSVK
  • YAMGFNRPSKIQE
  • ALPMMLA
  • QALCNIYG
  • CQMLLFSATFEDSVW
  • TTNVCARGIDV
  • PDPNVIKL

Post-translational modifications for DDX25 Gene

  • Phosphorylated on threonine residues. The phosphorylated form is found in the cytoplasm but not in the nucleus (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DDX25 Gene

Gene Families for DDX25 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for DDX25 Gene

GenScript: Design optimal peptide antigens:
  • DDX25 (B4YF11_HUMAN)
  • Gonadotropin-regulated testicular RNA helicase (DDX25_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UHL0

UniProtKB/Swiss-Prot:

DDX25_HUMAN :
  • Belongs to the DEAD box helicase family.
Family:
  • Belongs to the DEAD box helicase family.
genes like me logo Genes that share domains with DDX25: view

Function for DDX25 Gene

Molecular function for DDX25 Gene

UniProtKB/Swiss-Prot Function:
ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;.
UniProtKB/Swiss-Prot Induction:
Up-regulated at transcriptional level by chorionic gonadotropin via cyclic AMP-induced androgen formation in the Leydig cell.

Enzyme Numbers (IUBMB) for DDX25 Gene

Phenotypes From GWAS Catalog for DDX25 Gene

Gene Ontology (GO) - Molecular Function for DDX25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0004004 ATP-dependent RNA helicase activity IEA,ISS --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding ISS,IEA --
genes like me logo Genes that share ontologies with DDX25: view
genes like me logo Genes that share phenotypes with DDX25: view

Animal Models for DDX25 Gene

MGI Knock Outs for DDX25:

Animal Model Products

CRISPR Products

miRNA for DDX25 Gene

miRTarBase miRNAs that target DDX25

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX25

Clone Products

  • Applied Biological Materials (abm): Clones for DDX25 - Now 50% OFF >
  • * DDX25 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * DDX25 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DDX25 Gene

Localization for DDX25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX25 Gene

Cytoplasm. Nucleus. Note=Detected in both cytoplasm and nucleus of testicular cells. Also detected in chromatoid bodies of round spermatids (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX25 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for DDX25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0033391 chromatoid body IEA,ISS --
genes like me logo Genes that share ontologies with DDX25: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DDX25 Gene

Pathways & Interactions for DDX25 Gene

PathCards logo

SuperPathways for DDX25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006406 mRNA export from nucleus ISS,IEA --
GO:0006417 regulation of translation ISS --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0007286 spermatid development IEA,ISS --
genes like me logo Genes that share ontologies with DDX25: view

No data available for Pathways by source and SIGNOR curated interactions for DDX25 Gene

Drugs & Compounds for DDX25 Gene

(4) Drugs for DDX25 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for DDX25 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with DDX25: view

Transcripts for DDX25 Gene

mRNA/cDNA for DDX25 Gene

Unigene Clusters for DDX25 Gene

DEAD (Asp-Glu-Ala-Asp) box helicase 25:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX25

Clone Products

  • Applied Biological Materials (abm): Clones for DDX25 - Now 50% OFF >
  • * DDX25 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * DDX25 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for DDX25 Gene

No ASD Table

Relevant External Links for DDX25 Gene

GeneLoc Exon Structure for
DDX25
ECgene alternative splicing isoforms for
DDX25

Expression for DDX25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DDX25 Gene

This gene is overexpressed in Testis (x9.9), Brain - Cortex (x4.1), and Brain - Frontal Cortex (BA9) (x4.0).

Protein differential expression in normal tissues from HIPED for DDX25 Gene

This gene is overexpressed in Testis (59.8) and Heart (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX25 Gene



Protein tissue co-expression partners for DDX25 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX25 Gene:

DDX25

SOURCE GeneReport for Unigene cluster for DDX25 Gene:

Hs.420263

mRNA Expression by UniProt/SwissProt for DDX25 Gene:

Q9UHL0-DDX25_HUMAN
Tissue specificity: Highly expressed in the Leydig and germ cells of the testis and weakly expressed in the pituitary and hypothalamus.

Evidence on tissue expression from TISSUES for DDX25 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with DDX25: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX25 Gene

Orthologs for DDX25 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDX25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX25 35 34
  • 99.72 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DDX25 35 34
  • 90.97 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDX25 35
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDX25 35 34
  • 89.03 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx25 17 35 34
  • 87.65 (n)
rat
(Rattus norvegicus)
Mammalia Ddx25 34
  • 87.51 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DDX25 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDX25 35 34
  • 68.16 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDX25 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx25 34
  • 66.29 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:193690 35
  • 60 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Dbp80 35 36
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T07D4.4a 36
  • 48 (a)
T07D4.4b 36
  • 48 (a)
T07D4.4c 36
  • 48 (a)
ddx-19 35
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP5 35
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8406 35
  • 55 (a)
OneToMany
Species where no ortholog for DDX25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX25 Gene

ENSEMBL:
Gene Tree for DDX25 (if available)
TreeFam:
Gene Tree for DDX25 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DDX25: view image

Paralogs for DDX25 Gene

(16) SIMAP similar genes for DDX25 Gene using alignment to 6 proteins:

  • DDX25_HUMAN
  • B4YF11_HUMAN
  • E9PR46_HUMAN
  • H0YD26_HUMAN
  • J3QL17_HUMAN
  • J3QRJ6_HUMAN

Pseudogenes.org Pseudogenes for DDX25 Gene

genes like me logo Genes that share paralogs with DDX25: view

Variants for DDX25 Gene

Sequence variations from dbSNP and Humsavar for DDX25 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000030391 -- 125,905,970(+) C/T intron_variant
rs1000478233 -- 125,918,533(+) T/C intron_variant
rs1000594025 -- 125,912,401(+) T/C intron_variant
rs1000750411 -- 125,915,537(+) A/C intron_variant
rs1000774965 -- 125,906,742(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DDX25 Gene

Variant ID Type Subtype PubMed ID
dgv248n67 CNV gain 20364138
esv32964 CNV gain+loss 17666407
nsv535 CNV deletion 18451855
nsv556525 CNV gain 21841781

Variation tolerance for DDX25 Gene

Residual Variation Intolerance Score: 21.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DDX25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX25
Human Gene Mutation Database (HGMD)
DDX25

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX25 Gene

Disorders for DDX25 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DDX25 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
hydrolethalus syndrome 1
  • hls1
- elite association - COSMIC cancer census association via MalaCards
Search DDX25 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DDX25

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DDX25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DDX25 Gene

Publications for DDX25 Gene

  1. A novel gonadotropin-regulated testicular RNA helicase. A new member of the dead-box family. (PMID: 10608860) Tang PZ … Dufau ML (The Journal of biological chemistry 1999) 2 3 4 23 58
  2. Polymorphism of the GRTH/DDX25 gene in normal and infertile Japanese men: a missense mutation associated with loss of GRTH phosphorylation. (PMID: 17848414) Tsai-Morris CH … Dufau ML (Molecular human reproduction 2007) 3 23 45 58
  3. Single nucleotide polymorphisms of the gonadotrophin-regulated testicular helicase (GRTH) gene may be associated with the human spermatogenesis impairment. (PMID: 16293649) A Z … Zhang W (Human reproduction (Oxford, England) 2006) 3 23 45 58
  4. Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25): a multifunctional protein essential for spermatogenesis. (PMID: 19875492) Tsai-Morris CH … Dufau ML (Journal of andrology 2010) 3 23 58
  5. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston KI … Carrell DT (Human reproduction (Oxford, England) 2010) 3 45 58

Products for DDX25 Gene

Sources for DDX25 Gene

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