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DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain testicular functions related to steroidogenesis and spermatogenesis. [provided by RefSeq, Jul 2008]
DDX25 (DEAD-Box Helicase 25) is a Protein Coding gene. Diseases associated with DDX25 include Male Infertility. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is ENSG00000260537.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003723 | RNA binding | IBA | 21873635 |
GO:0003724 | RNA helicase activity | IEA,ISS | -- |
GO:0004386 | helicase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA,ISS | -- |
GO:0005737 | cytoplasm | ISS | -- |
GO:0010494 | cytoplasmic stress granule | IBA | 21873635 |
GO:0033391 | chromatoid body | IEA,ISS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006406 | mRNA export from nucleus | IEA,ISS | -- |
GO:0006417 | regulation of translation | ISS | -- |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0007283 | spermatogenesis | IEA | -- |
GO:0007286 | spermatid development | IEA,ISS | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
58-64-0 |
|
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DDX25 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DDX25 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | DDX25 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DDX25 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ddx25 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ddx25 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | DDX25 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DDX25 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DDX25 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ddx25 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | zgc:193690 31 |
|
ManyToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Dbp80 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | T07D4.4a 32 |
|
|
|
T07D4.4b 32 |
|
|
|||
T07D4.4c 32 |
|
|
|||
ddx-19 31 |
|
OneToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | DBP5 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8406 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs116333528 | Benign: not provided | 125,910,358(+) |
C/T NM_013264.5(DDX25):c.508-6C>T |
INTRON | |
rs34007659 | Benign: not provided | 125,908,410(+) |
C/T NM_013264.5(DDX25):c.414C>T (p.Asn138=) |
SYNONYMOUS |
Disorder | Aliases | PubMed IDs |
---|---|---|
male infertility |
|
|