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DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008]
DDX24 (DEAD-Box Helicase 24) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DDX18.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003723 | RNA binding | IEA,HDA | 22658674 |
GO:0003724 | RNA helicase activity | NAS | 10936056 |
GO:0004386 | helicase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005730 | nucleolus | IDA | -- |
GO:0016020 | membrane | HDA | 19946888 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016070 | RNA metabolic process | NAS | 10936056 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
58-64-0 |
|
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | · | 12c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP8: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DDX24 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DDX24 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DDX24 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ddx24 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ddx24 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | DDX24 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | DDX24 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DDX24 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DDX24 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ddx24 30 |
|
||
Str.14965 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | LOC398446 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC553462 30 |
|
||
ddx24 31 |
|
OneToOne | |||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2533 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG9143 30 31 32 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010702 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | F55F8.2 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MAK5 31 33 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3498 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs35413935 | - |
p.Glu316Lys |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv34067 | CNV | loss | 18971310 |
esv3581391 | CNV | loss | 25503493 |
esv3635373 | CNV | gain | 21293372 |
No disorders were found for DDX24 Gene.