DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this fami... See more...

Aliases for DDX24 Gene

Aliases for DDX24 Gene

  • DEAD-Box Helicase 24 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 24 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 24 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 24 2 3
  • ATP-Dependent RNA Helicase DDX24 3 4
  • DEAD Box Protein 24 3 4
  • S. Cerevisiae CHL1-Like Helicase 3
  • EC 3.6.4.13 4
  • EC 3.6.1 51
  • DDX24 5

External Ids for DDX24 Gene

Previous GeneCards Identifiers for DDX24 Gene

  • GC14M092024
  • GC14M088333
  • GC14M092507
  • GC14M093587
  • GC14M094517
  • GC14M074697

Summaries for DDX24 Gene

Entrez Gene Summary for DDX24 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX24 Gene

DDX24 (DEAD-Box Helicase 24) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DDX18.

UniProtKB/Swiss-Prot Summary for DDX24 Gene

Gene Wiki entry for DDX24 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DDX24 Gene

Genomics for DDX24 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DDX24 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DDX24 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DDX24

Top Transcription factor binding sites by QIAGEN in the DDX24 gene promoter:
  • c-Rel
  • CUTL1
  • E47
  • HOXA9
  • HOXA9B
  • LCR-F1
  • Meis-1
  • Meis-1a
  • STAT1
  • Tal-1beta

Genomic Locations for DDX24 Gene

Latest Assembly
chr14:94,048,287-94,081,212
(GRCh38/hg38)
Size:
32,926 bases
Orientation:
Minus strand

Previous Assembly
chr14:94,514,633-94,547,548
(GRCh37/hg19 by Entrez Gene)
Size:
32,916 bases
Orientation:
Minus strand

chr14:94,517,266-94,547,591
(GRCh37/hg19 by Ensembl)
Size:
30,326 bases
Orientation:
Minus strand

Genomic View for DDX24 Gene

Genes around DDX24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX24 Gene

Proteins for DDX24 Gene

  • Protein details for DDX24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZR7-DDX24_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX24
    Protein Accession:
    Q9GZR7
    Secondary Accessions:
    • E7EMJ4
    • Q4V9L5

    Protein attributes for DDX24 Gene

    Size:
    859 amino acids
    Molecular mass:
    96332 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDX24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX24 Gene

Selected DME Specific Peptides for DDX24 Gene

Q9GZR7:
  • VAARGLDI
  • VQHVIHYQVPRT
  • HRSGRTARA
  • TGSGKTLA
  • AARGLDIP
  • VLTPTREL
  • TPTRELA
  • AETGSGKT
  • LVFANSI
  • TRELAVQ
  • VATPGRL
  • IVVATPGR
  • TDVAARGLD

Post-translational modifications for DDX24 Gene

  • Ubiquitination at Lys195, Lys429, Lys541, and Lys601
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX24 Gene

Domains & Families for DDX24 Gene

Gene Families for DDX24 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DDX24 Gene

Suggested Antigen Peptide Sequences for DDX24 Gene

GenScript: Design optimal peptide antigens:
  • DEAD box protein 24 (DDX24_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9GZR7

UniProtKB/Swiss-Prot:

DDX24_HUMAN :
  • Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
Family:
  • Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
genes like me logo Genes that share domains with DDX24: view

Function for DDX24 Gene

Molecular function for DDX24 Gene

UniProtKB/Swiss-Prot Function:
ATP-dependent RNA helicase.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;.

Enzyme Numbers (IUBMB) for DDX24 Gene

Phenotypes From GWAS Catalog for DDX24 Gene

Gene Ontology (GO) - Molecular Function for DDX24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003724 RNA helicase activity NAS 10936056
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with DDX24: view
genes like me logo Genes that share phenotypes with DDX24: view

Animal Models for research

  • Taconic Biosciences Mouse Models for DDX24

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX24

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX24 Gene

Localization for DDX24 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX24 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
mitochondrion 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DDX24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with DDX24: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DDX24 Gene

Pathways & Interactions for DDX24 Gene

PathCards logo

SuperPathways for DDX24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016070 RNA metabolic process NAS 10936056
genes like me logo Genes that share ontologies with DDX24: view

No data available for Pathways by source and SIGNOR curated interactions for DDX24 Gene

Drugs & Compounds for DDX24 Gene

(3) Drugs for DDX24 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phosphate Experimental Pharma 0
ATP Investigational Nutra 0

(1) Additional Compounds for DDX24 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
genes like me logo Genes that share compounds with DDX24: view

Transcripts for DDX24 Gene

mRNA/cDNA for DDX24 Gene

1 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX24

Alternative Splicing Database (ASD) splice patterns (SP) for DDX24 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
SP1: - -
SP2: - -
SP3:
SP4: - -
SP5:
SP6: -
SP7: -
SP8:

Relevant External Links for DDX24 Gene

GeneLoc Exon Structure for
DDX24

Expression for DDX24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DDX24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX24 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.7) and Tlymphocyte (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX24 Gene



Protein tissue co-expression partners for DDX24 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DDX24

SOURCE GeneReport for Unigene cluster for DDX24 Gene:

Hs.510328

mRNA Expression by UniProt/SwissProt for DDX24 Gene:

Q9GZR7-DDX24_HUMAN
Tissue specificity: Ubiquitous. Most abundant in heart and brain, but with lowest levels in thymus and small intestine.

Evidence on tissue expression from TISSUES for DDX24 Gene

  • Nervous system(4.9)
  • Liver(4.8)
  • Intestine(4.6)
  • Lung(4)
  • Skin(3.8)
  • Pancreas(3.6)
  • Kidney(3.5)
  • Eye(2.9)
  • Stomach(2.9)
  • Heart(2.8)
  • Spleen(2.5)
  • Blood(2.3)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with DDX24: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX24 Gene

Orthologs for DDX24 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDX24 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DDX24 30 31
  • 99.26 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DDX24 30 31
  • 86.76 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DDX24 30 31
  • 85.56 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ddx24 30
  • 82.25 (n)
Mouse
(Mus musculus)
Mammalia Ddx24 30 17 31
  • 81.75 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DDX24 31
  • 62 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DDX24 31
  • 60 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DDX24 30 31
  • 63.01 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DDX24 31
  • 59 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ddx24 30
  • 60.35 (n)
Str.14965 30
African clawed frog
(Xenopus laevis)
Amphibia LOC398446 30
Zebrafish
(Danio rerio)
Actinopterygii LOC553462 30
  • 62.3 (n)
ddx24 31
  • 48 (a)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2533 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG9143 30 31 32
  • 57.41 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010702 30
  • 51.33 (n)
Worm
(Caenorhabditis elegans)
Secernentea F55F8.2 30 31
  • 50.53 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAK5 31 33
  • 29 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3498 31
  • 41 (a)
OneToOne
Species where no ortholog for DDX24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DDX24 Gene

ENSEMBL:
Gene Tree for DDX24 (if available)
TreeFam:
Gene Tree for DDX24 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DDX24: view image

Paralogs for DDX24 Gene

(4) SIMAP similar genes for DDX24 Gene using alignment to 3 proteins:

  • DDX24_HUMAN
  • F5GYL3_HUMAN
  • G3V529_HUMAN

Pseudogenes.org Pseudogenes for DDX24 Gene

genes like me logo Genes that share paralogs with DDX24: view

Variants for DDX24 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DDX24 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs35413935 - p.Glu316Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DDX24 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DDX24 Gene

Variant ID Type Subtype PubMed ID
esv34067 CNV loss 18971310
esv3581391 CNV loss 25503493
esv3635373 CNV gain 21293372

Variation tolerance for DDX24 Gene

Residual Variation Intolerance Score: 80.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.05; 60.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DDX24 Gene

Human Gene Mutation Database (HGMD)
DDX24
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX24

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX24 Gene

Disorders for DDX24 Gene

Additional Disease Information for DDX24

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for DDX24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX24 Gene

Publications for DDX24 Gene

  1. Cloning and characterization of human DDX24 and mouse Ddx24, two novel putative DEAD-Box proteins, and mapping DDX24 to human chromosome 14q32. (PMID: 10936056) Zhao Y … Zhao S (Genomics 2000) 2 3 4
  2. The requirement of the DEAD-box protein DDX24 for the packaging of human immunodeficiency virus type 1 RNA. (PMID: 18289627) Ma J … Liang C (Virology 2008) 2 3
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for DDX24 Gene

Sources for DDX24 Gene