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This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Bas... See more...
Aliases for DDX23 Gene
Aliases for DDX23 Gene
External Ids for DDX23 Gene
- HGNC: 17347
- Entrez Gene: 9416
- Ensembl: ENSG00000174243
- OMIM: 612172
- UniProtKB: Q9BUQ8
Previous GeneCards Identifiers for DDX23 Gene
- GC12M048940
- GC12M047509
- GC12M049223
- GC12M046256
Summaries for DDX23 Gene
-
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for DDX23 Gene
DDX23 (DEAD-Box Helicase 23) is a Protein Coding gene. Diseases associated with DDX23 include Distal Hereditary Motor Neuronopathy Type 2 and Spinal Muscular Atrophy, Type I. Among its related pathways are mRNA Splicing - Minor Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DDX46.
UniProtKB/Swiss-Prot Summary for DDX23 Gene
-
Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation (PubMed:18425142). Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779).
Additional gene information for DDX23 Gene
- HGNC(17347)
- Entrez Gene(9416)
- Ensembl(ENSG00000174243)
- OMIM(612172)
- UniProtKB(Q9BUQ8)
- Open Targets Platform(ENSG00000174243)
- Search for DDX23 at DataMed
- Search for DDX23 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DDX23 Gene
Genomics for DDX23 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DDX23 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DDX23 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DDX23
- Top Transcription factor binding sites by QIAGEN in the DDX23 gene promoter:
-
- CBF(2)
- CBF-A
- CBF-B
- CP1A
- Egr-4
- NF-Y
- NF-YA
- NF-YB
- POU2F1
- POU2F1c
Genomic Locations for DDX23 Gene
Genomic Locations for DDX23 Gene
- chr12:48,829,756-48,852,842
- (GRCh38/hg38)
- Size:
- 23,087 bases
- Orientation:
- Minus strand
- chr12:49,223,539-49,246,625
- (GRCh37/hg19)
- Size:
- 23,087 bases
- Orientation:
- Minus strand
Genomic View for DDX23 Gene
Genes around DDX23 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.12 by HGNC
- 12q13.12 by Entrez Gene
- 12q13.12 by Ensembl
DDX23 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DDX23 Gene
Proteins for DDX23 Gene
-
Protein details for DDX23 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BUQ8-DDX23_HUMAN
- Recommended name:
- Probable ATP-dependent RNA helicase DDX23
- Protein Accession:
- Q9BUQ8
- B2R600
- B4DH15
- O43188
Protein attributes for DDX23 Gene
- Size:
- 820 amino acids
- Molecular mass:
- 95583 Da
- Quaternary structure:
-
- The phosphorylated form (by SRPK2) is a component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39 (PubMed:16723661, PubMed:9409622). Identified in the spliceosome C complex (PubMed:11991638). Interacts with ERBB4 (PubMed:20858735). Interacts with ERCC6 (PubMed:26030138).
Three dimensional structures from OCA and Proteopedia for DDX23 Gene
Protein Expression for DDX23 Gene
Selected DME Specific Peptides for DDX23 Gene
- Q9BUQ8:
-
- PTRELAQQ
- VLDEADRM
- VSMVVNYD
- AETGSGKT
- HRIGRTGR
- VIATPGR
- DEADRMID
- GVAITFL
- LAPTREL
- TGSGKTAAF
- TPGRLID
- GRTGRAG
- APTRELA
- IATPGRL
- YIHRIGR
Post-translational modifications for DDX23 Gene
- In vitro phosphorylated by CLK1 and U1 snRNP-associated protein kinase (PubMed:9409622). Phosphorylated by SRPK2 and this phosphorylation is required for its association with the tri-snRNP (U4/U6-U5 tri-small nuclear ribonucleoproteins) and subsequent spliceosomal B complex formation (PubMed:18425142). May be phosphorylated by SRPK2 on Ser residues in the SR domain; the phosphorylation is required for the removal of inappropriate R-loops during transcription (PubMed:28076779).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for DDX23 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for DDX23
- Novus Biologicals Antibodies for DDX23
-
Abcam antibodies for DDX23
- Invitrogen Antibodies for DDX23 (AFLGC-Ddx23)
-
Biorbyt antibodies for DDX23
Protein Products
-
OriGene Purified Proteins for DDX23
- Search Origene for MassSpec and Protein Over-expression Lysates for DDX23
- Origene Custom Protein Services for DDX23
-
Signalway Proteins for DDX23
Domains & Families for DDX23 Gene
Gene Families for DDX23 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for DDX23 Gene
- InterPro:
- Blocks:
-
- ATP-dependent helicase, DEAD-box
- ProtoNet:
Suggested Antigen Peptide Sequences for DDX23 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ54028, highly similar to Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (B4DH15_HUMAN)
- U5-100kD (DDX23_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9BUQ8- Family:
-
- Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Function for DDX23 Gene
Molecular function for DDX23 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation (PubMed:18425142). Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;.
Enzyme Numbers (IUBMB) for DDX23 Gene
Phenotypes From GWAS Catalog for DDX23 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | IBA | 21873635 |
| GO:0003724 | RNA helicase activity | TAS | 9409622 |
| GO:0004386 | NOT helicase activity | IDA | 9539711 |
Phenotypes for DDX23 Gene
- MGI mutant phenotypes for DDX23:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DDX23:
-
- no effect
- Decreased vaccinia virus (VACV) infection
- Negative genetic interaction between BLM-/- and BLM+/+
- Increased IL-8 secretion
- shRNA abundance <= 25%
- Reduced mammosphere formation
- Decreased shRNA abundance
- Decreased vesicular stomatitis virus (VSV) infection
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased viability in ovarian lineage
- Decreased HIV-1 infection
Animal Model Products
-
Taconic Biosciences Mouse Models for DDX23
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DDX23 - Select products 50% OFF >
- * DDX23 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DDX23
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DDX23
-
Santa Cruz Biotechnology (SCBT) CRISPR for DDX23
miRNA for DDX23 Gene
- miRTarBase miRNAs that target DDX23
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DDX23
- Browse OriGene Inhibitory RNA Products For DDX23
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX23
Clone Products
- Applied Biological Materials (abm): Clones for DDX23 - Select products 50% OFF >
- * DDX23 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for DDX23
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DDX23
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX23 Gene
Localization for DDX23 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DDX23 Gene
- Nucleus. Chromosome. Note=During transcription, accumulates at chromatin loci where unscheduled R-loops form and colocalizes with paused 'Ser-5'-phosphorlyated POLR2A/RNA polymerase II and kinase SRPK2. {ECO:0000269 PubMed:28076779}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 4 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| cytosol | 1 |
- Nucleoli (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | IDA | 28076779 |
| GO:0005634 | nucleus | TAS,IDA | 28076779 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005681 | spliceosomal complex | IEA | -- |
| GO:0005682 | U5 snRNP | IDA | 9539711 |
Pathways & Interactions for DDX23 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.47
|
| 2 | Gene Expression |
.48
|
|
| 3 | mRNA Splicing - Minor Pathway | ||
Pathways by source for DDX23 Gene
5 Reactome pathways for DDX23 Gene
1 KEGG pathway for DDX23 Gene
Interacting Proteins for DDX23 Gene
Selected Interacting proteins:
Q9BUQ8-DDX23_HUMAN
ENSP00000310723
for DDX23 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for DDX23
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000354 | cis assembly of pre-catalytic spliceosome | IC | 9539711 |
| GO:0000375 | RNA splicing, via transesterification reactions | TAS | 9409622 |
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0008380 | RNA splicing | TAS | 9409622 |
No data available for SIGNOR curated interactions for DDX23 Gene
Drugs & Compounds for DDX23 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Transcripts for DDX23 Gene
mRNA/cDNA for DDX23 Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000308025 3256 nts (view in UCSC)
- ENST00000550834 869 nts (view in UCSC)
- ENST00000551331 706 nts (view in UCSC)
- ENST00000549795 579 nts (view in UCSC)
- ENST00000547842 554 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DDX23 - Select products 50% OFF >
- * DDX23 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DDX23
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DDX23
-
Santa Cruz Biotechnology (SCBT) CRISPR for DDX23
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DDX23
- Browse OriGene Inhibitory RNA Products For DDX23
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX23
Clone Products
- Applied Biological Materials (abm): Clones for DDX23 - Select products 50% OFF >
- * DDX23 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for DDX23
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DDX23
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21a | · | 21b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||
| SP3: | |||||||||||||||||||||
| SP4: | |||||||||||||||||||||
| SP5: | |||||||||||||||||||||
| SP6: | |||||||||||||||||||||
| SP7: | |||||||||||||||||||||
| SP8: | |||||||||||||||||||||
| SP9: | |||||||||||||||||||||
| SP10: | |||||||||||||||||||||
| SP11: | |||||||||||||||||||||
| SP12: | - | ||||||||||||||||||||
| SP13: | - |
Relevant External Links for DDX23 Gene
- GeneLoc Exon Structure for
- DDX23
Expression for DDX23 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epiblast (Early Embryonic Tissues)
- Epiblast Cells Epiblast
-
Spleen (Hematopoietic System)
-
Thymus (Hematopoietic System)
This gene is overexpressed in Peripheral blood mononuclear cells (14.1) and CD8 Tcells (8.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX23 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DDX23
SOURCE GeneReport for Unigene cluster for DDX23 Gene:
Hs.130098Evidence on tissue expression from TISSUES for DDX23 Gene
- Nervous system(5)
- Lung(4.7)
- Skin(2.6)
- Intestine(2.5)
- Pancreas(2)
Primer Products
-
OriGene qPCR primer pairs for DDX23
-
OriGene qPCR primer pairs and template standards for DDX23
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX23 Gene
Orthologs for DDX23 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Chimpanzee (Pan troglodytes) |
Mammalia | DDX23 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | DDX23 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | DDX23 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | DDX23 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ddx23 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ddx23 30 |
|
||
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| DDX23 30 |
|
||||
| Lizard (Anolis carolinensis) |
Reptilia | DDX23 31 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.24773 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ddx23 30 31 |
|
OneToOne | |
| wufi39b12 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG10333 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007825 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | ddx-23 30 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PRP28 31 33 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT2G33730 30 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.3548 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os03g0708600 30 |
|
||
| Os.3228 30 |
|
||||
| Barley (Hordeum vulgare) |
Liliopsida | Hv.2391 30 |
|
||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.3307 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU02803 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | prp28 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.11344 30 |
|
- Species where no ortholog for DDX23 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
Evolution for DDX23 Gene
- ENSEMBL:
- Gene Tree for DDX23 (if available)
- TreeFam:
- Gene Tree for DDX23 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DDX23: view image
Paralogs for DDX23 Gene
Paralogs for DDX23 Gene
- DDX46 5
- DDX3X 5
- DDX59 5
- DDX3Y 5
- DDX41 5
- DDX47 5
- DDX43 5
- DDX17 5
- DDX5 5
- DDX4 5
- DDX53 5
- DDX27 5
- DDX49 5
- DDX42 5
- DDX54 5
- DDX52 5
- DDX50 5
- DDX21 5
- DDX18 5
- DDX31 5
- DDX24 5
- DDX51 5
- EIF4A2 5
- DDX10 5
- DDX39B 5
- DDX55 5
- DDX28 5
- DDX39A 5
- DDX19B 5
- DDX19A 5
- ENSG00000260537 5
- EIF4A1 5
- DDX6 5
- DDX20 5
- DDX25 5
- EIF4A3 5
- DDX56 5
- DDX1 5
(11) SIMAP similar genes for DDX23 Gene using alignment to 6 proteins:
- DDX23_HUMAN
- B4DH15_HUMAN
- F8VVA2_HUMAN
- F8W1J5_HUMAN
- H0YI52_HUMAN
- H0YIL9_HUMAN
Pseudogenes.org Pseudogenes for DDX23 Gene
Variants for DDX23 Gene
Residual Variation Intolerance Score:
2.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.57;
12.25% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DDX23 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DDX23
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX23 Gene
Disorders for DDX23 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| distal hereditary motor neuronopathy type 2 |
|
|
| spinal muscular atrophy, type i |
|
|
Search DDX23 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DDX23
No data available for UniProtKB/Swiss-Prot and Genatlas for DDX23 Gene
Publications for DDX23 Gene
- The human U5 snRNP-specific 100-kD protein is an RS domain-containing, putative RNA helicase with significant homology to the yeast splicing factor Prp28p. (PMID: 9409622) Teigelkamp S … Lührmann R (RNA (New York, N.Y.) 1997) 2 3 4 23
- Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome. (PMID: 18425142) Mathew R … Lührmann R (Nature structural & molecular biology 2008) 3 4 23
- The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro. (PMID: 9539711) Laggerbauer B … Lührmann R (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 23
- Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation. (PMID: 28076779) Sridhara SC … de Almeida SF (Cell reports 2017) 3 4
- Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics. (PMID: 26030138) Nicolai S … Proietti-De-Santis L (PloS one 2015) 3 4
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