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This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
DDX23 (DEAD-Box Helicase 23) is a Protein Coding gene. Diseases associated with DDX23 include Distal Hereditary Motor Neuronopathy Type 2 and Spinal Muscular Atrophy, Type I. Among its related pathways are mRNA Splicing - Minor Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DDX46.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003723 | RNA binding | IBA | 21873635 |
GO:0003724 | RNA helicase activity | TAS | 9409622 |
GO:0004386 | NOT helicase activity | IDA | 9539711 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000785 | chromatin | IDA | 28076779 |
GO:0005634 | nucleus | TAS,IDA | 28076779 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005681 | spliceosomal complex | IEA | -- |
GO:0005682 | U5 snRNP | IDA | 9539711 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | mRNA Splicing - Major Pathway |
.79
|
.47
|
2 | Gene Expression |
.48
|
|
3 | mRNA Splicing - Minor Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000354 | cis assembly of pre-catalytic spliceosome | IC | 9539711 |
GO:0000375 | RNA splicing, via transesterification reactions | TAS | 9409622 |
GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
GO:0006397 | mRNA processing | IEA | -- |
GO:0008380 | RNA splicing | TAS | 9409622 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: |
ExUns: | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21a | · | 21b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||
SP2: | - | - | |||||||||||||||||||
SP3: | |||||||||||||||||||||
SP4: | |||||||||||||||||||||
SP5: | |||||||||||||||||||||
SP6: | |||||||||||||||||||||
SP7: | |||||||||||||||||||||
SP8: | |||||||||||||||||||||
SP9: | |||||||||||||||||||||
SP10: | |||||||||||||||||||||
SP11: | |||||||||||||||||||||
SP12: | - | ||||||||||||||||||||
SP13: | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Chimpanzee (Pan troglodytes) |
Mammalia | DDX23 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | DDX23 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DDX23 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DDX23 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ddx23 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ddx23 30 |
|
||
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
DDX23 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | DDX23 31 |
|
OneToOne | |
African clawed frog (Xenopus laevis) |
Amphibia | Xl.24773 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ddx23 30 31 |
|
OneToOne | |
wufi39b12 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG10333 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007825 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | ddx-23 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PRP28 31 33 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT2G33730 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.3548 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os03g0708600 30 |
|
||
Os.3228 30 |
|
||||
Barley (Hordeum vulgare) |
Liliopsida | Hv.2391 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.3307 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU02803 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | prp28 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.11344 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
distal hereditary motor neuronopathy type 2 |
|
|
spinal muscular atrophy, type i |
|
|