Aliases for DDX21 Gene
Aliases for DDX21 Gene
External Ids for DDX21 Gene
- HGNC: 2744
- Entrez Gene: 9188
- Ensembl: ENSG00000165732
- OMIM: 606357
- UniProtKB: Q9NR30
Previous GeneCards Identifiers for DDX21 Gene
- GC10P069527
- GC10P069802
- GC10P070608
- GC10P070060
- GC10P070385
- GC10P070715
- GC10P064717
Summaries for DDX21 Gene
-
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]
GeneCards Summary for DDX21 Gene
DDX21 (DExD-Box Helicase 21) is a Protein Coding gene. Diseases associated with DDX21 include Stomach Disease and Cerebral Creatine Deficiency Syndrome 3. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is DDX50.
UniProtKB/Swiss-Prot for DDX21 Gene
-
RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at Ser-77 (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX21 Gene
Genomics for DDX21 Gene
GeneHancer (GH) Regulatory Elements for DDX21 Gene
Promoters and enhancers for DDX21 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DDX21 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for DDX21 Gene
Genomic Locations for DDX21 Gene
- chr10:68,956,123-68,985,073
- (GRCh38/hg38)
- Size:
- 28,951 bases
- Orientation:
- Plus strand
- chr10:70,715,884-70,744,829
- (GRCh37/hg19)
Genomic View for DDX21 Gene
Genes around DDX21 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q22.1 by Entrez Gene
- 10q22.1 by HGNC
- 10q22.1 by Ensembl
DDX21 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DDX21 Gene
Proteins for DDX21 Gene
-
Protein details for DDX21 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NR30-DDX21_HUMAN
- Recommended name:
- Nucleolar RNA helicase 2
- Protein Accession:
- Q9NR30
- B2RDL0
- Q13436
- Q5VX41
- Q68D35
Protein attributes for DDX21 Gene
- Size:
- 783 amino acids
- Molecular mass:
- 87344 Da
- Quaternary structure:
-
- Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Interacts with C1QBP. Interacts with JUN (PubMed:11823437, PubMed:18180292). Interacts with WDR46 (PubMed:23848194).
- Miscellaneous:
-
- Autoantibodies against DDX21 are found in patients with watermelon stomach disease, which is characterized by prominent stripes of ectatic vascular tissue in the stomach similar to stripes on a watermelon.
- SequenceCaution:
-
- Sequence=AAB02546.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for DDX21 Gene
Post-translational modifications for DDX21 Gene
Other Protein References for DDX21 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for DDX21
- Invitrogen Antibodies for DDX21
- GeneTex DDX21 Antibody for DDX21
-
Boster Bio Antibodies for DDX21
-
Santa Cruz Biotechnology (SCBT) Antibodies for DDX21
Protein Products
-
OriGene Purified Proteins for DDX21
- Search Origene for MassSpec and Protein Over-expression Lysates for DDX21
- Origene Custom Protein Services for DDX21
- antibodies-online: Search results for 5 available DDX21 Proteins ranked by validation data
- Compare Top DDX21 Proteins
-
Quality Products:
- Search GeneTex for Proteins for DDX21
Assay Products
No data available for DME Specific Peptides for DDX21 Gene
Domains & Families for DDX21 Gene
Gene Families for DDX21 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for DDX21 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for DDX21 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NR30UniProtKB/Swiss-Prot:
DDX21_HUMAN :- The helicase and foldase activities reside in two separate domains, the helicase in the N-terminus and the foldase in the C-terminus.
- Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.
- Domain:
-
- The helicase and foldase activities reside in two separate domains, the helicase in the N-terminus and the foldase in the C-terminus.
- The 3 X 5 AA repeats seem to be critical for the RNA folding activity.
- Family:
-
- Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.
Function for DDX21 Gene
Molecular function for DDX21 Gene
- UniProtKB/Swiss-Prot Function:
- RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at Ser-77 (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233).
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + H(2)O = ADP + phosphate.
Enzyme Numbers (IUBMB) for DDX21 Gene
Phenotypes From GWAS Catalog for DDX21 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0003725 | double-stranded RNA binding | IEA | -- |
| GO:0004004 | ATP-dependent RNA helicase activity | TAS,IMP | 25470060 |
| GO:0004386 | helicase activity | IEA | -- |
Phenotypes for DDX21 Gene
- MGI mutant phenotypes for DDX21:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DDX21:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased G1 DNA content
- Increased shRNA abundance (Z-score > 2)
- Decreased ionizing radiation sensitivity
- Decreased shRNA abundance
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Synthetic lethal with Ras
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- shRNA abundance <= 50%
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DDX21
-
CRISPR Products
-
OriGene CRISPR knockouts for DDX21
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DDX21
- genomics-online: gRNA clones - Search results for 118 available DDX21 gene related products
- Overview of 118 available DDX21 gene related products
- Applied Biological Materials CRISPR for DDX21
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DDX21
- GenScript: Design CRISPR guide RNA sequences for DDX21
miRNA for DDX21 Gene
- miRTarBase miRNAs that target DDX21
-
- hsa-mir-193b-3p (MIRT016482)
- hsa-mir-29c-3p (MIRT020395)
- hsa-mir-34a-5p (MIRT025491)
- hsa-mir-16-5p (MIRT031736)
- hsa-let-7b-5p (MIRT032414)
- hsa-mir-877-3p (MIRT036938)
- hsa-mir-423-5p (MIRT038053)
- hsa-mir-331-3p (MIRT043386)
- hsa-mir-186-5p (MIRT045036)
- hsa-mir-222-3p (MIRT046685)
- hsa-mir-100-5p (MIRT048581)
- hsa-mir-340-5p (MIRT573966)
- hsa-mir-4772-5p (MIRT573967)
- hsa-mir-383-5p (MIRT573968)
- hsa-mir-548ax (MIRT573969)
- hsa-mir-3185 (MIRT573970)
- hsa-mir-548ao-5p (MIRT573971)
- hsa-mir-4502 (MIRT573972)
- hsa-mir-1245b-3p (MIRT573973)
- hsa-mir-95-5p (MIRT573974)
- hsa-mir-5590-3p (MIRT573975)
- hsa-mir-142-5p (MIRT573976)
- hsa-mir-802 (MIRT573977)
- hsa-mir-580-5p (MIRT573978)
- hsa-mir-3646 (MIRT573979)
- hsa-mir-1252-3p (MIRT573980)
- hsa-mir-561-3p (MIRT573981)
- hsa-mir-548at-5p (MIRT573982)
- hsa-mir-548f-3p (MIRT573983)
- hsa-mir-548e-3p (MIRT573984)
- hsa-mir-548az-3p (MIRT573985)
- hsa-mir-548ar-3p (MIRT573986)
- hsa-mir-548a-3p (MIRT573987)
- hsa-mir-548x-3p (MIRT573988)
- hsa-mir-548j-3p (MIRT573989)
- hsa-mir-548aq-3p (MIRT573990)
- hsa-mir-548am-3p (MIRT573991)
- hsa-mir-548aj-3p (MIRT573992)
- hsa-mir-548ah-3p (MIRT573993)
- hsa-mir-548ae-3p (MIRT573994)
- hsa-mir-2681-5p (MIRT784329)
- hsa-mir-3908 (MIRT785421)
- hsa-mir-526b-5p (MIRT787361)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DDX21
- Browse OriGene Inhibitory RNA Products For DDX21
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX21
- genomics-online: shRNA clones - Search results for 118 available DDX21 gene related products
- Overview of 118 available DDX21 gene related products
Clone Products
- Sino Biological Human cDNA Clone for DDX21
- VectorBuilder custom plasmid, inducible vectors for DDX21
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DDX21
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DDX21
- Applied Biological Materials Clones for DDX21
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX21 Gene
Localization for DDX21 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DDX21 Gene
- Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Present both in nucleolus and nucleoplasm. Interaction with JUN promotes translocation from the nucleolus to the nucleoplasm (PubMed:11823437, PubMed:18180292). Interaction with WDR46 is required for localization to the nucleolus (PubMed:23848194). {ECO:0000269 PubMed:11823437, ECO:0000269 PubMed:18180292, ECO:0000269 PubMed:23848194}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| mitochondrion | 1 |
- Nucleoli (4)
- Nucleus (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005730 | nucleolus | IDA,TAS | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0016020 | membrane | HDA | 16210410 |
Pathways & Interactions for DDX21 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 2 | Gene Expression |
.48
|
|
Pathways by source for DDX21 Gene
Interacting Proteins for DDX21 Gene
Selected Interacting proteins:
Q9NR30-DDX21_HUMAN
ENSP00000346120
for DDX21 Gene via
IID
MINT
UniProtKB
STRING
GPS-Prot Interaction Network for DDX21
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001649 | osteoblast differentiation | HDA | 16210410 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006364 | rRNA processing | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | IMP | 25470060 |
| GO:0009615 | response to virus | IEA | -- |
No data available for SIGNOR curated interactions for DDX21 Gene
Drugs & Compounds for DDX21 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
Transcripts for DDX21 Gene
mRNA/cDNA for DDX21 Gene
- (650) Selected AceView cDNA sequences:
- (11) Additional mRNA sequences :
- (4) REFSEQ mRNAs :
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000354185 4711 bps (uc001jov.3)
- ENST00000620315 4829 bps (uc001jow.3)
Unigene Clusters for DDX21 Gene
- DEAD (Asp-Glu-Ala-Asp) box helicase 21:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for DDX21
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DDX21
- genomics-online: gRNA clones - Search results for 118 available DDX21 gene related products
- Overview of 118 available DDX21 gene related products
- Applied Biological Materials CRISPR for DDX21
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DDX21
- GenScript: Design CRISPR guide RNA sequences for DDX21
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DDX21
- Browse OriGene Inhibitory RNA Products For DDX21
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX21
- genomics-online: shRNA clones - Search results for 118 available DDX21 gene related products
- Overview of 118 available DDX21 gene related products
Clone Products
- Sino Biological Human cDNA Clone for DDX21
- VectorBuilder custom plasmid, inducible vectors for DDX21
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DDX21
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DDX21
- Applied Biological Materials Clones for DDX21
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for DDX21 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Intermediate Mesoderm (Gastrulation Derivatives)
- Neural Tube (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Ovary (Reproductive System)
- Blood (Hematopoietic System)
This gene is overexpressed in Peripheral blood mononuclear cells (21.0), Tlymphocyte (6.3), and Stomach (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX21 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DDX21 Gene:
DDX21SOURCE GeneReport for Unigene cluster for DDX21 Gene:
Hs.223141Evidence on tissue expression from TISSUES for DDX21 Gene
- Liver(4.8)
- Intestine(4.4)
- Muscle(4.4)
- Nervous system(3.4)
- Skin(3.2)
- Lung(2.5)
- Kidney(2.4)
- Spleen(2.4)
- Blood(2.3)
- Bone marrow(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for DDX21
-
OriGene qPCR primer pairs for DDX21
- genomics-online: primer clones - Search results for 118 available DDX21 gene related products
- Overview of 118 available DDX21 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX21 Gene
Orthologs for DDX21 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DDX21 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | DDX21 34 33 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | DDX21 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ddx21 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ddx21 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DDX21 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | DDX21 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DDX50 33 |
|
||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ddx21 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ddx21 34 33 |
|
OneToMany | |
| -- 33 |
|
||||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TIF2 34 |
|
ManyToMany | |
| TIF1 34 |
|
ManyToMany | |||
| DBP3 34 |
|
ManyToMany | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | PRH75 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os09g0520700 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2984 34 |
|
OneToMany |
- Species where no ortholog for DDX21 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for DDX21 Gene
- ENSEMBL:
- Gene Tree for DDX21 (if available)
- TreeFam:
- Gene Tree for DDX21 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DDX21: view image
Paralogs for DDX21 Gene
Variants for DDX21 Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000029965 | -- | 68,957,702(+) | G/A | intron_variant | |
| rs1000051705 | -- | 68,964,445(+) | A/G | intron_variant | |
| rs1000322128 | -- | 68,964,218(+) | T/A | intron_variant | |
| rs1000376753 | -- | 68,969,652(+) | C/T | intron_variant | |
| rs1000567999 | -- | 68,984,471(+) | C/G | 3_prime_UTR_variant |
Residual Variation Intolerance Score:
39.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.10;
38.40% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DDX21 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DDX21
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX21 Gene
Disorders for DDX21 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| stomach disease |
|
|
| cerebral creatine deficiency syndrome 3 |
|
|
| cerebral creatine deficiency syndrome 2 |
|
|
| cerebral creatine deficiency syndrome |
|
|
| breast abscess |
|
|
Search DDX21 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DDX21
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for DDX21 Gene
Publications for DDX21 Gene
- c-Jun supports ribosomal RNA processing and nucleolar localization of RNA helicase DDX21. (PMID: 18180292) Holmström TH … Westermarck J (The Journal of biological chemistry 2008) 2 3 4 58
- A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease. (PMID: 8614622) Valdez BC … Busch H (Nucleic acids research 1996) 2 3 4 58
- A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. (PMID: 28431233) Treiber T … Meister G (Molecular cell 2017) 3 4 58
- The association of late-acting snoRNPs with human pre-ribosomal complexes requires the RNA helicase DDX21. (PMID: 25477391) Sloan KE … Bohnsack MT (Nucleic acids research 2015) 3 4 58
- RNA helicase DDX21 coordinates transcription and ribosomal RNA processing. (PMID: 25470060) Calo E … Wysocka J (Nature 2015) 3 4 58
Products for DDX21 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
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- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for DDX21
- Search Origene for MassSpec and Protein Over-expression Lysates for DDX21
- Origene Custom Protein Services for DDX21
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DDX21
- Browse OriGene Inhibitory RNA Products For DDX21
- OriGene qPCR primer pairs and template standards for DDX21
- OriGene qPCR primer pairs for DDX21
- OriGene CRISPR knockouts for DDX21
- OriGene ORF clones in human for DDX21
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DDX21
- GenScript: Next-day shipping of latest version cDNA ORF clones for DDX21 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for DDX21
- GenScript Custom Assay Services for DDX21
- GenScript Custom overexpressing Cell Line Services for DDX21
- GenScript: Design CRISPR guide RNA sequences for DDX21
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for DDX21
- Sino Biological Human cDNA Clone for DDX21
- Browse Sino Biological Cell Lysates
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- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for DDX21
- Novus Biologicals proteins and lysates for DDX21
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- Browse Lysates
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- VectorBuilder custom plasmid, inducible vectors for DDX21
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DDX21
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 69 available DDX21 Antibodies ranked by validation data
- Compare Top DDX21 Antibodies
- antibodies-online: Search results for available DDX21 related products ranked by validation data
- antibodies-online: Search results for 5 available DDX21 Proteins ranked by validation data
- Compare Top DDX21 Proteins
- Quality Products:
- GeneTex DDX21 Antibody for DDX21
- Search GeneTex for Proteins for DDX21
- Santa Cruz Biotechnology (SCBT) Antibodies for DDX21
- Search Santa Cruz Biotechnology (SCBT) for DDX21 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DDX21
- genomics-online: cdna clones - Search results for 118 available DDX21 gene related products
- Overview of 118 available DDX21 gene related products
- orf clones - Search results for 118 available DDX21 gene related products
- Overview of 118 available DDX21 gene related products
- genomics-online: gRNA clones - Search results for 118 available DDX21 gene related products
- Overview of 118 available DDX21 gene related products
- genomics-online: primer clones - Search results for 118 available DDX21 gene related products
- Overview of 118 available DDX21 gene related products
- genomics-online: shRNA clones - Search results for 118 available DDX21 gene related products
- Overview of 118 available DDX21 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DDX21
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DDX21
- GeneCopoeia miRNA 3'UTR Target clone products for DDX21
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX21
- Boster Bio Antibodies for DDX21
- Browse Boster Bio ELISA Kits
Sources for DDX21 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio