DDX21 Gene (Protein Coding)

DExD-Box Helicase 21

GC10P068956
GIFtS:
38
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this fami... See more...

Aliases for DDX21 Gene

Aliases for DDX21 Gene

  • DExD-Box Helicase 21 2 3 5
  • Nucleolar RNA Helicase 2 2 3 4
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 21 2 3
  • Nucleolar RNA Helicase Gu 3 4
  • Nucleolar RNA Helicase II 3 4
  • DEAD-Box Helicase 21 2 3
  • DEAD Box Protein 21 3 4
  • RH-II/GU 2 3
  • RH II/Gu 3 4
  • Gu-Alpha 3 4
  • GURDB 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 21 3
  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 21 3
  • RNA Helicase II/Gu Alpha 3
  • EC 3.6.4.13 4
  • Gu Protein 3
  • RH-II/GuA 3
  • EC 3.6.1 51
  • DDX21 5
  • GUA 3

External Ids for DDX21 Gene

Previous GeneCards Identifiers for DDX21 Gene

  • GC10P069527
  • GC10P069802
  • GC10P070608
  • GC10P070060
  • GC10P070385
  • GC10P070715
  • GC10P064717

Summaries for DDX21 Gene

Entrez Gene Summary for DDX21 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX21 Gene

DDX21 (DExD-Box Helicase 21) is a Protein Coding gene. Diseases associated with DDX21 include Stomach Disease and Cone-Rod Dystrophy 19. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is DDX50.

UniProtKB/Swiss-Prot Summary for DDX21 Gene

  • RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity).

Gene Wiki entry for DDX21 Gene

Additional gene information for DDX21 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DDX21 Gene

Genomics for DDX21 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for DDX21 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DDX21 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DDX21

Top Transcription factor binding sites by QIAGEN in the DDX21 gene promoter:
  • ATF-2
  • CRE-BP1
  • E47
  • Evi-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • Hand1
  • HNF-3beta
  • Ik-3
  • STAT5A

Genomic Locations for DDX21 Gene

Genomic Locations for DDX21 Gene
chr10:68,956,131-68,985,069
(GRCh38/hg38)
Size:
28,939 bases
Orientation:
Plus strand
chr10:70,715,884-70,744,829
(GRCh37/hg19)
Size:
28,946 bases
Orientation:
Plus strand

Genomic View for DDX21 Gene

Genes around DDX21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX21 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DDX21 Gene

Proteins for DDX21 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DDX21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR30-DDX21_HUMAN
    Recommended name:
    Nucleolar RNA helicase 2
    Protein Accession:
    Q9NR30
    Secondary Accessions:
    • B2RDL0
    • Q13436
    • Q5VX41
    • Q68D35

    Protein attributes for DDX21 Gene

    Size:
    783 amino acids
    Molecular mass:
    87344 Da
    Quaternary structure:
    • Homodimer; homodimerizes via its N-terminus. Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1; this complex exists in resting cells with or without poly(I:C) RNA ligand stimulation. Interacts (via C-terminus) with TICAM1 (via TIR domain). Interacts with DHX36 (via C-terminus); this interaction serves as bridges to TICAM1. Interacts (via C-terminus) with DDX1 (via B30.2/SPRY domain); this interaction serves as bridges to TICAM1. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Interacts with C1QBP. Interacts with JUN. Interacts with WDR46 (By similarity). Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Interacts with C1QBP. Interacts with JUN (PubMed:11823437, PubMed:18180292). Interacts with WDR46 (PubMed:23848194). Interacts with MCM3AP isoform GANP (PubMed:23652018). Interacts with WDR43 (By similarity).
    SequenceCaution:
    • Sequence=AAB02546.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • Autoantibodies against DDX21 are found in patients with watermelon stomach disease, which is characterized by prominent stripes of ectatic vascular tissue in the stomach similar to stripes on a watermelon.

    Three dimensional structures from OCA and Proteopedia for DDX21 Gene

    Alternative splice isoforms for DDX21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX21 Gene

Protein Expression for DDX21 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for DDX21 Gene

Q9NR30:
  • VAARGLDI
  • NGKLDLT
  • VGTPGRI
  • HVVLDEVDQMLD
  • YIHRSGRT
  • ILVGTPGR
  • AARGLDIP
  • SFAIPLIE
  • LAPTREL
  • GRTGRAG
  • VAKKYMKS
  • PKPKKMKK
  • TNVAARGLD
  • APTRELA
  • DSEDNPQTLLFSATCP
  • EQKEGAFSNF

Post-translational modifications for DDX21 Gene

  • Acetylation by CREBBP/CBP inhibits the helicase activity (PubMed:28790157). Deacetylation by SIRT7 promotes the helicase activity and overcomes R-loop-mediated stalling of RNA polymerases (PubMed:28790157).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX21 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for DDX21

Domains & Families for DDX21 Gene

Gene Families for DDX21 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DDX21 Gene

InterPro:
Blocks:
  • ATP-dependent helicase, DEAD-box
  • GUCT
ProtoNet:

Suggested Antigen Peptide Sequences for DDX21 Gene

GenScript: Design optimal peptide antigens:
  • RH II/Gu (DDX21_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NR30

UniProtKB/Swiss-Prot:

DDX21_HUMAN :
  • The helicase and foldase activities reside in two separate domains, the helicase in the N-terminus and the foldase in the C-terminus.
  • Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.
Domain:
  • The helicase and foldase activities reside in two separate domains, the helicase in the N-terminus and the foldase in the C-terminus.
  • The 3 X 5 AA repeats seem to be critical for the RNA folding activity.
Family:
  • Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.
genes like me logo Genes that share domains with DDX21: view

Function for DDX21 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for DDX21 Gene

UniProtKB/Swiss-Prot Function:
RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence={ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Acetylation inhibits the helicase activity.

Enzyme Numbers (IUBMB) for DDX21 Gene

Phenotypes From GWAS Catalog for DDX21 Gene

Gene Ontology (GO) - Molecular Function for DDX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA 21873635
GO:0003724 RNA helicase activity TAS,IMP 25470060
GO:0003725 double-stranded RNA binding IEA --
genes like me logo Genes that share ontologies with DDX21: view
genes like me logo Genes that share phenotypes with DDX21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX21

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX21 Gene

Localization for DDX21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX21 Gene

Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytosol. Mitochondrion. Note=Present both in nucleolus and nucleoplasm. Interaction with JUN promotes translocation from the nucleolus to the nucleoplasm (PubMed:11823437, PubMed:18180292). Interaction with WDR46 is required for localization to the nucleolus (PubMed:23848194). Colocalizes in the cytosol with DDX1, DHX36 and TICAM1. The multi-helicase-TICAM1 complex may translocate to the mitochondria upon poly(I:C) RNA ligand stimulation (By similarity). {ECO:0000250 UniProtKB:Q9JIK5, ECO:0000269 PubMed:11823437, ECO:0000269 PubMed:18180292, ECO:0000269 PubMed:23848194}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX21 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 4
plasma membrane 2
extracellular 2
cytoskeleton 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DDX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus TAS,IDA 28790157
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with DDX21: view

Pathways & Interactions for DDX21 Gene

genes like me logo Genes that share pathways with DDX21: view

SIGNOR curated interactions for DDX21 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for DDX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation HDA 16210410
GO:0002376 immune system process IEA --
GO:0002735 positive regulation of myeloid dendritic cell cytokine production IEA --
GO:0006364 rRNA processing IEA --
GO:0006366 transcription by RNA polymerase II IMP 25470060
genes like me logo Genes that share ontologies with DDX21: view

Drugs & Compounds for DDX21 Gene

Products:

  1. Drug

(3) Drugs for DDX21 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for DDX21 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with DDX21: view

Transcripts for DDX21 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for DDX21 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX21

Alternative Splicing Database (ASD) splice patterns (SP) for DDX21 Gene

No ASD Table

Relevant External Links for DDX21 Gene

GeneLoc Exon Structure for
DDX21

Expression for DDX21 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DDX21 Gene

mRNA expression in normal human tissues for DDX21 Gene
mRNA expression by GTEx for DDX21 GenemRNA expression by BioGPS for DDX21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX21 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.0), Tlymphocyte (6.3), and Stomach (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX21 Gene



Protein tissue co-expression partners for DDX21 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DDX21

SOURCE GeneReport for Unigene cluster for DDX21 Gene:

Hs.223141

Evidence on tissue expression from TISSUES for DDX21 Gene

  • Liver(4.8)
  • Intestine(4.6)
  • Blood(4.6)
  • Muscle(4.5)
  • Nervous system(3.7)
  • Skin(3.7)
  • Kidney(2.8)
  • Spleen(2.8)
  • Bone marrow(2.8)
  • Lung(2.7)
  • Heart(2.7)
  • Lymph node(2.5)
  • Stomach(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with DDX21: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX21 Gene

Orthologs for DDX21 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX21 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia DDX21 30 31
  • 99.83 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia DDX21 30 31
  • 89.34 (n)
 OneToMany
-- 31
  • 75 (a)
 OneToMany
Dog
(Canis familiaris)
 Mammalia DDX21 30 31
  • 89.31 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Ddx21 30 17 31
  • 86.07 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Ddx21 30
  • 83.83 (n)
Oppossum
(Monodelphis domestica)
 Mammalia DDX21 31
  • 71 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia DDX21 31
  • 66 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves DDX50 30
  • 70.39 (n)
-- 31
  • 67 (a)
 ManyToMany
-- 31
  • 65 (a)
 ManyToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 61 (a)
 OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia ddx21 30
  • 63.18 (n)
Zebrafish
(Danio rerio)
 Actinopterygii ddx21 30 31
  • 64.37 (n)
 OneToMany
-- 30
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes TIF2 31
  • 32 (a)
 ManyToMany
TIF1 31
  • 32 (a)
 ManyToMany
DBP3 31
  • 29 (a)
 ManyToMany
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons PRH75 30
  • 49.35 (n)
Rice
(Oryza sativa)
 Liliopsida Os09g0520700 30
  • 51.24 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.2984 31
  • 50 (a)
 OneToMany
Species where no ortholog for DDX21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DDX21 Gene

ENSEMBL:
Gene Tree for DDX21 (if available)
TreeFam:
Gene Tree for DDX21 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DDX21: view image

Paralogs for DDX21 Gene

Paralogs for DDX21 Gene

(8) SIMAP similar genes for DDX21 Gene using alignment to 2 proteins:

  • DDX21_HUMAN
  • Q3SWU7_HUMAN
genes like me logo Genes that share paralogs with DDX21: view

Variants for DDX21 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DDX21 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
707856 Benign: not provided 68,978,961(+) T/C SYNONYMOUS_VARIANT
710606 Benign: not provided 68,963,354(+) A/G MISSENSE_VARIANT
rs1235513038 Uncertain Significance: not provided 68,962,118(+) A/C MISSENSE_VARIANT
rs1554840242 Uncertain Significance: not provided 68,963,355(+) G/C MISSENSE_VARIANT
rs17556220 - p.Thr27Ile

Additional dbSNP identifiers (rs#s) for DDX21 Gene

Structural Variations from Database of Genomic Variants (DGV) for DDX21 Gene

Variant ID Type Subtype PubMed ID
nsv519999 CNV loss 19592680
nsv831907 CNV gain 17160897
nsv948053 CNV duplication 23825009

Variation tolerance for DDX21 Gene

Residual Variation Intolerance Score: 39.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DDX21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX21

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX21 Gene

Disorders for DDX21 Gene

MalaCards: The human disease database

(5) MalaCards diseases for DDX21 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
stomach disease
  • gastric disease
cone-rod dystrophy 19
  • cord19
contractural arachnodactyly, congenital
  • cca
neurodermatitis
distal arthrogryposis
  • freeman-sheldon syndrome
- elite association - COSMIC cancer census association via MalaCards
Search DDX21 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DDX21

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with DDX21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DDX21 Gene

Publications for DDX21 Gene

  1. c-Jun supports ribosomal RNA processing and nucleolar localization of RNA helicase DDX21. (PMID: 18180292) Holmström TH … Westermarck J (The Journal of biological chemistry 2008) 2 3 4
  2. A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease. (PMID: 8614622) Valdez BC … Busch H (Nucleic acids research 1996) 2 3 4
  3. SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability. (PMID: 28790157) Song C … Grummt I (Genes & development 2017) 3 4
  4. A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. (PMID: 28431233) Treiber T … Meister G (Molecular cell 2017) 3 4
  5. RNA helicase DDX21 coordinates transcription and ribosomal RNA processing. (PMID: 25470060) Calo E … Wysocka J (Nature 2015) 3 4

ExternalLinks

View latest publications for DDX21 gene in Mastermind

Products for DDX21 Gene

  • Signalway Proteins for DDX21

Sources for DDX21 Gene