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DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]
DDX21 (DExD-Box Helicase 21) is a Protein Coding gene. Diseases associated with DDX21 include Stomach Disease and Cone-Rod Dystrophy 19. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is DDX50.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003723 | RNA binding | IBA | 21873635 |
GO:0003724 | RNA helicase activity | TAS,IMP | 25470060 |
GO:0003725 | double-stranded RNA binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005730 | nucleolus | TAS,IDA | 28790157 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005739 | mitochondrion | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
2 | Gene Expression |
.48
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001649 | osteoblast differentiation | HDA | 16210410 |
GO:0002376 | immune system process | IEA | -- |
GO:0002735 | positive regulation of myeloid dendritic cell cytokine production | IEA | -- |
GO:0006364 | rRNA processing | IEA | -- |
GO:0006366 | transcription by RNA polymerase II | IMP | 25470060 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DDX21 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DDX21 30 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | DDX21 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ddx21 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ddx21 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | DDX21 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | DDX21 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DDX50 30 |
|
||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ddx21 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ddx21 30 31 |
|
OneToMany | |
-- 30 |
|
||||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TIF2 31 |
|
ManyToMany | |
TIF1 31 |
|
ManyToMany | |||
DBP3 31 |
|
ManyToMany | |||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | PRH75 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os09g0520700 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2984 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
707856 | Benign: not provided | 68,978,961(+) | T/C | SYNONYMOUS_VARIANT | |
710606 | Benign: not provided | 68,963,354(+) | A/G | MISSENSE_VARIANT | |
rs1235513038 | Uncertain Significance: not provided | 68,962,118(+) | A/C | MISSENSE_VARIANT | |
rs1554840242 | Uncertain Significance: not provided | 68,963,355(+) | G/C | MISSENSE_VARIANT | |
rs17556220 | - | p.Thr27Ile |
Disorder | Aliases | PubMed IDs |
---|---|---|
stomach disease |
|
|
cone-rod dystrophy 19 |
|
|
contractural arachnodactyly, congenital |
|
|
neurodermatitis |
|
|
distal arthrogryposis |
|
|