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DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. [provided by RefSeq, Jul 2008]
DDX20 (DEAD-Box Helicase 20) is a Protein Coding gene. Diseases associated with DDX20 include Spinal Muscular Atrophy and Muscular Atrophy. Among its related pathways are Transport of the SLBP independent Mature mRNA and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DDX10.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003723 | RNA binding | IBA | 21873635 |
GO:0003724 | RNA helicase activity | TAS,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | TAS | 10383418 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | TAS,IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
GO:0005856 | cytoskeleton | TAS | 10383418 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Transport of the SLBP independent Mature mRNA |
.55
|
|
2 | RNA transport | ||
3 | Macrophage Differentiation and Growth Inhibition by METS |
Macrophage Differentiation and Growth Inhibition by METS
.30
|
|
4 | Gene Expression |
.48
|
|
5 | mRNA Splicing - Major Pathway |
.41
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA,IDA | 12007404 |
GO:0000244 | spliceosomal tri-snRNP complex assembly | TAS | 10601333 |
GO:0000387 | spliceosomal snRNP assembly | IBA,TAS | -- |
GO:0006396 | RNA processing | TAS | 10601333 |
GO:0006397 | mRNA processing | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DDX20 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DDX20 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DDX20 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ddx20 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ddx20 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | DDX20 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | DDX20 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DDX20 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DDX20 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ddx20 30 |
|
||
Str.10125 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | ddx20 30 31 |
|
OneToOne | |
wufc03g10 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Dhh1 32 |
|
|
|
Gem3 31 |
|
OneToOne | |||
Worm (Caenorhabditis elegans) |
Secernentea | T06A10.1 32 |
|
|
|
mel-46 31 |
|
OneToOne | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SUB2 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
spinal muscular atrophy |
|
|
muscular atrophy |
|
|