Aliases for DDX19A Gene

Aliases for DDX19A Gene

  • DEAD-Box Helicase 19A 2 3 5
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 19A 2 3
  • ATP-Dependent RNA Helicase DDX19A 3 4
  • DEAD Box Protein 19A 3 4
  • DDX19-Like Protein 3 4
  • DDX19L 3 4
  • DEAD (Asp-Glu-Ala-As) Box Polypeptide 19-Like 2
  • DEAD (Asp-Glu-Ala-As) Box Polypeptide 19A 3
  • DDX19-DDX19L 3
  • RNA Helicase 3
  • EC 3.6.4.13 4
  • EC 3.6.1 52

External Ids for DDX19A Gene

Previous HGNC Symbols for DDX19A Gene

  • DDX19L

Previous GeneCards Identifiers for DDX19A Gene

  • GC16P068940
  • GC16P070380
  • GC16P056213
  • GC16P070299

Summaries for DDX19A Gene

GeneCards Summary for DDX19A Gene

DDX19A (DEAD-Box Helicase 19A) is a Protein Coding gene. Diseases associated with DDX19A include Heavy Chain Disease. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is ENSG00000260537.

UniProtKB/Swiss-Prot Summary for DDX19A Gene

  • ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity).

Additional gene information for DDX19A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DDX19A Gene

Genomics for DDX19A Gene

GeneHancer (GH) Regulatory Elements for DDX19A Gene

Promoters and enhancers for DDX19A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DDX19A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DDX19A

Top Transcription factor binding sites by QIAGEN in the DDX19A gene promoter:
  • ATF-2
  • c-Ets-1
  • c-Myc
  • C/EBPbeta
  • FOXO4
  • Max
  • Meis-1
  • Meis-1a
  • Meis-1b
  • SEF-1 (1)

Genomic Locations for DDX19A Gene

Genomic Locations for DDX19A Gene
chr16:70,346,861-70,373,383
(GRCh38/hg38)
Size:
26,523 bases
Orientation:
Plus strand
chr16:70,380,732-70,407,286
(GRCh37/hg19)
Size:
26,555 bases
Orientation:
Plus strand

Genomic View for DDX19A Gene

Genes around DDX19A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX19A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX19A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX19A Gene

Proteins for DDX19A Gene

  • Protein details for DDX19A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUU7-DD19A_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX19A
    Protein Accession:
    Q9NUU7
    Secondary Accessions:
    • B2RPL0
    • B4DRZ7
    • Q53FM0

    Protein attributes for DDX19A Gene

    Size:
    478 amino acids
    Molecular mass:
    53975 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDX19A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX19A Gene

Selected DME Specific Peptides for DDX19A Gene

Q9NUU7:
  • IGTPGTVLDWC
  • VINFDLP
  • FVLDEAD
  • SVKSFEEL
  • HRIGRTGR
  • ALCNLYG
  • GTGKTAAF
  • EEEKEDRAAQSLLNKLIRSNLVDNTNQVEVLQRDP
  • YLHRIGR
  • SPLYSVK
  • YAMGFNRPSKIQE
  • GHQVALLSGE
  • ALPMMLA
  • CQMLLFSATFEDSVW
  • TTNVCARGIDV
  • PDPNVIKL

Post-translational modifications for DDX19A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DDX19A Gene

Gene Families for DDX19A Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Transporters

Suggested Antigen Peptide Sequences for DDX19A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52463, highly similar to ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (B4DRZ7_HUMAN)
  • DEAD box protein 19A (DD19A_HUMAN)
  • RNA helicase (Q9HBZ9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NUU7

UniProtKB/Swiss-Prot:

DD19A_HUMAN :
  • The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into position for catalysis.
  • Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
Domain:
  • The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into position for catalysis.
Family:
  • Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
genes like me logo Genes that share domains with DDX19A: view

Function for DDX19A Gene

Molecular function for DDX19A Gene

UniProtKB/Swiss-Prot Function:
ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;.

Enzyme Numbers (IUBMB) for DDX19A Gene

Phenotypes From GWAS Catalog for DDX19A Gene

Gene Ontology (GO) - Molecular Function for DDX19A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA 21873635
GO:0003724 RNA helicase activity IEA --
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with DDX19A: view
genes like me logo Genes that share phenotypes with DDX19A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DDX19A

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX19A Gene

Localization for DDX19A Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX19A Gene

Cytoplasm. Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Nuclear pore complex cytoplasmic fibrils.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX19A gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DDX19A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005643 nuclear pore IEA --
GO:0005737 cytoplasm IEA --
GO:0010494 cytoplasmic stress granule IBA 21873635
GO:0016020 membrane IEA,HDA 19946888
genes like me logo Genes that share ontologies with DDX19A: view

Pathways & Interactions for DDX19A Gene

PathCards logo

SuperPathways for DDX19A Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX19A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0015031 protein transport IEA --
GO:0016973 poly(A)+ mRNA export from nucleus IBA 21873635
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with DDX19A: view

No data available for Pathways by source and SIGNOR curated interactions for DDX19A Gene

Drugs & Compounds for DDX19A Gene

(3) Drugs for DDX19A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for DDX19A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with DDX19A: view

Transcripts for DDX19A Gene

mRNA/cDNA for DDX19A Gene

5 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX19A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - - - - - -
SP7:
SP8:

Relevant External Links for DDX19A Gene

GeneLoc Exon Structure for
DDX19A

Expression for DDX19A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DDX19A Gene

Protein differential expression in normal tissues from HIPED for DDX19A Gene

This gene is overexpressed in Lymph node (16.7) and Peripheral blood mononuclear cells (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX19A Gene



Protein tissue co-expression partners for DDX19A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DDX19A

SOURCE GeneReport for Unigene cluster for DDX19A Gene:

Hs.656037

Evidence on tissue expression from TISSUES for DDX19A Gene

  • Nervous system(4.8)
  • Muscle(4.2)
  • Stomach(4.2)
  • Skin(2.5)
genes like me logo Genes that share expression patterns with DDX19A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX19A Gene

Orthologs for DDX19A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX19A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX19A 31 30
  • 99.37 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 31
  • 97 (a)
OneToMany
DDX19A 30
  • 93.17 (n)
-- 31
  • 84 (a)
OneToMany
cow
(Bos Taurus)
Mammalia DDX19A 31 30
  • 92.4 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 92 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ddx19a 30
  • 91 (n)
mouse
(Mus musculus)
Mammalia Ddx19a 17 31 30
  • 90.93 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 87 (a)
OneToMany
-- 31
  • 56 (a)
OneToMany
chicken
(Gallus gallus)
Aves DDX19B 31
  • 92 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ddx19 31
  • 84 (a)
OneToMany
zgc:193690 30
  • 76.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dbp80 31
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ddx-19 31 30
  • 56.7 (n)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR078W 30
  • 57.72 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP5 33 31 30
  • 54.14 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15950g 30
  • 53.85 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons LOS4 30
  • 49.69 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8406 31
  • 59 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC12C2.06 30
  • 54.71 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01160 30
  • 52.04 (n)
Species where no ortholog for DDX19A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DDX19A Gene

ENSEMBL:
Gene Tree for DDX19A (if available)
TreeFam:
Gene Tree for DDX19A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DDX19A: view image

Paralogs for DDX19A Gene

(23) SIMAP similar genes for DDX19A Gene using alignment to 9 proteins:

  • DD19A_HUMAN
  • B4DRZ7_HUMAN
  • H3BP36_HUMAN
  • H3BP50_HUMAN
  • H3BSL8_HUMAN
  • H3BTB3_HUMAN
  • I3L0H8_HUMAN
  • I3L352_HUMAN
  • J3QRH0_HUMAN
genes like me logo Genes that share paralogs with DDX19A: view

Variants for DDX19A Gene

Additional dbSNP identifiers (rs#s) for DDX19A Gene

Structural Variations from Database of Genomic Variants (DGV) for DDX19A Gene

Variant ID Type Subtype PubMed ID
esv2714670 CNV deletion 23290073
esv3638953 CNV loss 21293372
nsv7285 OTHER inversion 18451855
nsv833272 CNV loss 17160897
nsv977995 CNV duplication 23825009

Variation tolerance for DDX19A Gene

Residual Variation Intolerance Score: 29.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DDX19A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX19A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DDX19A Gene

Disorders for DDX19A Gene

MalaCards: The human disease database

(1) MalaCards diseases for DDX19A Gene - From: DISEASES

Disorder Aliases PubMed IDs
heavy chain disease
  • hcd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DDX19A

genes like me logo Genes that share disorders with DDX19A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DDX19A Gene

Publications for DDX19A Gene

  1. DDX19A Senses Viral RNA and Mediates NLRP3-Dependent Inflammasome Activation. (PMID: 26538395) Li J … Weng C (Journal of immunology (Baltimore, Md. : 1950) 2015) 2 3 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. (PMID: 29467282) Heidelberger JB … Beli P (EMBO reports 2018) 3 54
  5. BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression. (PMID: 30463901) Yu L … Engel JD (Genes & development 2018) 3 54

Products for DDX19A Gene

Sources for DDX19A Gene