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Aliases for DDX18 Gene

Aliases for DDX18 Gene

  • DEAD-Box Helicase 18 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 18 (Myc-Regulated) 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 18 2 3
  • Myc-Regulated DEAD Box Protein 3 4
  • DEAD Box Protein 18 3 4
  • MrDb 3 4
  • ATP-Dependent RNA Helicase DDX18 3
  • EC 4
  • CPERP-D 4
  • Has1 3

External Ids for DDX18 Gene

Previous GeneCards Identifiers for DDX18 Gene

  • GC02P115777
  • GC02P116493
  • GC02P118479
  • GC02P118667
  • GC02P118288
  • GC02P118572
  • GC02P110899
  • GC02P117837
  • GC02P117843
  • GC02P117849
  • GC02P117851
  • GC02P117853
  • GC02P117855
  • GC02P117857
  • GC02P117860

Summaries for DDX18 Gene

Entrez Gene Summary for DDX18 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it is activated by Myc protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX18 Gene

DDX18 (DEAD-Box Helicase 18) is a Protein Coding gene. Among its related pathways are Validated targets of C-MYC transcriptional activation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity.

UniProtKB/Swiss-Prot for DDX18 Gene

  • Probable RNA-dependent helicase.

Additional gene information for DDX18 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX18 Gene

Genomics for DDX18 Gene

GeneHancer (GH) Regulatory Elements for DDX18 Gene

Promoters and enhancers for DDX18 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J117813 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 683.5 +0.6 555 3.5 CLOCK DMAP1 YY1 SLC30A9 E2F8 ZNF143 NFYC SSRP1 RCOR2 NBN DDX18 CCDC93 LOC102723413 HTR5BP GC02P117863
GH02J118084 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.5 +273.2 273223 6.3 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A FEZF1 INSIG2 DDX18 CCDC93 HTR5BP RN7SL111P
GH02J117978 Enhancer 1.1 FANTOM5 Ensembl ENCODE 7.7 +166.1 166129 3.6 STAT1 HLF CEBPB CEBPG EP300 ZKSCAN1 SP1 JUND GATA3 POLR2A CCDC93 HTR5BP DDX18 GC02M117974 GC02M117973 LOC102723413
GH02J117835 Promoter/Enhancer 1.2 Ensembl ENCODE 6.3 +21.5 21546 1.3 CTCF TFAP4 ARID4B MAX SIN3A ZNF48 RAD21 ZNF205 YY1 GATAD1 CCDC93 LOC102723413 DDX18 GC02P117863 ENSG00000236255 HTR5BP
GH02J118121 Enhancer 1.1 Ensembl ENCODE dbSUPER 6.7 +309.0 309020 3.4 ELF3 JUN RAD21 NFYB RCOR1 ATF7 FOSL2 IKZF2 TCF7L2 RFX1 GC02M118122 INSIG2 DDX18 HTR5BP GC02P118132
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DDX18 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DDX18 gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • Chx10
  • AREB6
  • Egr-1
  • COMP1
  • Pax-2a
  • Pax-2
  • Pax-2b
  • c-Fos

Genomic Locations for DDX18 Gene

Genomic Locations for DDX18 Gene
17,730 bases
Plus strand
17,730 bases
Plus strand

Genomic View for DDX18 Gene

Genes around DDX18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX18 Gene

Proteins for DDX18 Gene

  • Protein details for DDX18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ATP-dependent RNA helicase DDX18
    Protein Accession:
    Secondary Accessions:
    • Q6GTZ9
    • Q6IAU4
    • Q92732
    • Q9BQB7

    Protein attributes for DDX18 Gene

    670 amino acids
    Molecular mass:
    75407 Da
    Quaternary structure:
    • Interacts with NOL8; the interaction is RNA-dependent.
    • Sequence=CAA67295.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DDX18 Gene

neXtProt entry for DDX18 Gene

Post-translational modifications for DDX18 Gene

  • Ubiquitination at posLast=571571 and Lys195
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DDX18 Gene

Domains & Families for DDX18 Gene

Gene Families for DDX18 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DDX18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
  • Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
genes like me logo Genes that share domains with DDX18: view

Function for DDX18 Gene

Molecular function for DDX18 Gene

UniProtKB/Swiss-Prot Function:
Probable RNA-dependent helicase.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.

Enzyme Numbers (IUBMB) for DDX18 Gene

Phenotypes From GWAS Catalog for DDX18 Gene

Gene Ontology (GO) - Molecular Function for DDX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA,IEA 22658674
GO:0004004 ATP-dependent RNA helicase activity TAS 8861962
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 16963496
genes like me logo Genes that share ontologies with DDX18: view
genes like me logo Genes that share phenotypes with DDX18: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX18 Gene

Localization for DDX18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX18 Gene

Nucleus, nucleolus. Chromosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX18 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DDX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA,IDA 20813266
GO:0005730 nucleolus IDA,IEA 16963496
GO:0005737 cytoplasm IBA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with DDX18: view

Pathways & Interactions for DDX18 Gene

genes like me logo Genes that share pathways with DDX18: view

Pathways by source for DDX18 Gene

1 BioSystems pathway for DDX18 Gene

Gene Ontology (GO) - Biological Process for DDX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010501 RNA secondary structure unwinding IBA --
GO:0071392 cellular response to estradiol stimulus IEA --
genes like me logo Genes that share ontologies with DDX18: view

No data available for SIGNOR curated interactions for DDX18 Gene

Drugs & Compounds for DDX18 Gene

(3) Drugs for DDX18 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(2) Additional Compounds for DDX18 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with DDX18: view

Transcripts for DDX18 Gene

mRNA/cDNA for DDX18 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(427) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DDX18 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 18:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX18 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP2: -
SP3: -

Relevant External Links for DDX18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX18 Gene

This gene is overexpressed in Lung (9.0), Tlymphocyte (8.9), Peripheral blood mononuclear cells (8.3), and CD8 Tcells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX18 Gene

Protein tissue co-expression partners for DDX18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX18 Gene:


SOURCE GeneReport for Unigene cluster for DDX18 Gene:


Evidence on tissue expression from TISSUES for DDX18 Gene

  • Liver(4.5)
  • Nervous system(4.3)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with DDX18: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX18 Gene

Orthologs for DDX18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DDX18 34 33
  • 99.15 (n)
(Bos Taurus)
Mammalia -- 34
  • 90 (a)
-- 34
  • 89 (a)
DDX18 33
  • 88.19 (n)
(Canis familiaris)
Mammalia DDX18 34 33
  • 88.24 (n)
(Monodelphis domestica)
Mammalia DDX18 34
  • 84 (a)
(Mus musculus)
Mammalia Ddx18 16 34 33
  • 83.56 (n)
(Rattus norvegicus)
Mammalia Ddx18 33
  • 81.89 (n)
(Gallus gallus)
Aves DDX18 34 33
  • 73.67 (n)
(Anolis carolinensis)
Reptilia DDX18 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx18 33
  • 67.82 (n)
Str.2227 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23801 33
(Danio rerio)
Actinopterygii ddx18 34 33
  • 66.67 (n)
sbcb155 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1047 33
fruit fly
(Drosophila melanogaster)
Insecta pit 34 35 33
  • 67.99 (n)
CG9630 35
  • 38 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008601 33
  • 63.22 (n)
(Caenorhabditis elegans)
Secernentea B0511.6 34 35 33
  • 61.57 (n)
ZK512.2 35
  • 30 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR333C 33
  • 62.3 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A09669g 33
  • 61.92 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAS1 36 34 33
  • 61.63 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G18600 33
  • 59.68 (n)
(Oryza sativa)
Liliopsida Os06g0535100 33
  • 60.16 (n)
Os.5799 33
(Triticum aestivum)
Liliopsida Ta.6315 33
(Hordeum vulgare)
Liliopsida Hv.831 33
(Zea mays)
Liliopsida Zm.4304 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 70 (a)
Cin.4575 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes has1 33
  • 62.99 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09349 33
  • 60.04 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4575 33
Species where no ortholog for DDX18 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DDX18 Gene

Gene Tree for DDX18 (if available)
Gene Tree for DDX18 (if available)
Evolutionary constrained regions (ECRs) for DDX18: view image

Paralogs for DDX18 Gene

(16) SIMAP similar genes for DDX18 Gene using alignment to 4 proteins:

  • H7C452_HUMAN
  • Q4ZG72_HUMAN
  • Q53TI6_HUMAN
genes like me logo Genes that share paralogs with DDX18: view

No data available for Paralogs for DDX18 Gene

Variants for DDX18 Gene

Sequence variations from dbSNP and Humsavar for DDX18 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
VAR_035841 A breast cancer sample p.Gly41Arg
rs1000195747 -- 117,814,966(+) C/T intron_variant
rs1000632763 -- 117,814,725(+) G/T 5_prime_UTR_variant
rs1000878206 -- 117,831,647(+) C/T 3_prime_UTR_variant
rs1001248303 -- 117,831,399(+) C/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for DDX18 Gene

Variant ID Type Subtype PubMed ID
nsv2889 CNV insertion 18451855
nsv961874 CNV duplication 23825009
nsv961875 CNV duplication 23825009
nsv999434 CNV gain 25217958

Variation tolerance for DDX18 Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.43; 94.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DDX18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX18 Gene

Disorders for DDX18 Gene

Additional Disease Information for DDX18

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DDX18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX18 Gene

Publications for DDX18 Gene

  1. Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo. (PMID: 8861962) Grandori C … Eisenman RN (The EMBO journal 1996) 2 3 4 58
  2. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S … Rappsilber J (Cell 2010) 3 4 58
  3. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. (PMID: 20689807) Wang X … Bell DA (PloS one 2010) 3 44 58
  4. Cellular studies of MrDb (DDX18). (PMID: 18351129) Dubaele S … Chène P (Oncology research 2007) 3 22 58
  5. NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. (PMID: 16963496) Sekiguchi T … Nishimoto T (Nucleic acids research 2006) 3 4 58

Products for DDX18 Gene

Sources for DDX18 Gene

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