DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this fami... See more...

Aliases for DDX18 Gene

Aliases for DDX18 Gene

  • DEAD-Box Helicase 18 2 3 5
  • MrDb 2 3 4
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 18 (Myc-Regulated) 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 18 2 3
  • ATP-Dependent RNA Helicase DDX18 3 4
  • Myc-Regulated DEAD Box Protein 3 4
  • DEAD Box Protein 18 3 4
  • Has1 2 3
  • EC 3.6.4.13 4
  • EC 3.6.1 50
  • CPERP-D 4
  • DDX18 5

External Ids for DDX18 Gene

Previous GeneCards Identifiers for DDX18 Gene

  • GC02P115777
  • GC02P116493
  • GC02P118479
  • GC02P118667
  • GC02P118288
  • GC02P118572
  • GC02P110899
  • GC02P117837
  • GC02P117843
  • GC02P117867
  • GC02P117869
  • GC02P117871
  • GC02P117875
  • GC02P117849
  • GC02P117851
  • GC02P117853
  • GC02P117855
  • GC02P117857
  • GC02P117860
  • GC02P117862
  • GC02P117864
  • GC02P117878
  • GC02P117887

Summaries for DDX18 Gene

Entrez Gene Summary for DDX18 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it is activated by Myc protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX18 Gene

DDX18 (DEAD-Box Helicase 18) is a Protein Coding gene. Diseases associated with DDX18 include Sennetsu Fever. Among its related pathways are Validated targets of C-MYC transcriptional activation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DDX10.

UniProtKB/Swiss-Prot Summary for DDX18 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DDX18 Gene

Genomics for DDX18 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DDX18 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DDX18 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DDX18

Top Transcription factor binding sites by QIAGEN in the DDX18 gene promoter:
  • AREB6
  • c-Fos
  • Chx10
  • COMP1
  • Egr-1
  • Pax-2
  • Pax-2a
  • Pax-2b
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for DDX18 Gene

Latest Assembly
chr2:117,814,691-117,832,377
(GRCh38/hg38)
Size:
17,687 bases
Orientation:
Plus strand

Previous Assembly
chr2:118,572,267-118,589,953
(GRCh37/hg19 by Entrez Gene)
Size:
17,687 bases
Orientation:
Plus strand

chr2:118,572,226-118,589,955
(GRCh37/hg19 by Ensembl)
Size:
17,730 bases
Orientation:
Plus strand

Genomic View for DDX18 Gene

Genes around DDX18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX18 Gene

Proteins for DDX18 Gene

  • Protein details for DDX18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVP1-DDX18_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX18
    Protein Accession:
    Q9NVP1
    Secondary Accessions:
    • Q6GTZ9
    • Q6IAU4
    • Q92732
    • Q9BQB7

    Protein attributes for DDX18 Gene

    Size:
    670 amino acids
    Molecular mass:
    75407 Da
    Quaternary structure:
    • Interacts with NOL8; the interaction is RNA-dependent.
    SequenceCaution:
    • Sequence=CAA67295.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DDX18 Gene

neXtProt entry for DDX18 Gene

Selected DME Specific Peptides for DDX18 Gene

Q9NVP1:
  • RVGRTAR
  • VAARGLDI
  • KRTTTFF
  • KVEDLARISL
  • CTDVAARG
  • GVLKELM
  • TGSGKTLA
  • AARGLDIP
  • AKTGSGKT
  • FLIPAVE
  • ELGFLRYLK
  • MLFSATQT
  • PRNGTGV
  • DEADRIL
  • LEQGYVVC
  • TPGRLLD
  • SPTRELA
  • LVIDEAD
  • RQTMLFSAT
  • NYIDLPV
  • IIVATPGR
  • VATPGRL
  • YIHRVGR
  • TDVAARGLD

Post-translational modifications for DDX18 Gene

  • Ubiquitination at Lys195 and Lys571
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX18 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DDX18 Gene

Gene Families for DDX18 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DDX18 Gene

Suggested Antigen Peptide Sequences for DDX18 Gene

GenScript: Design optimal peptide antigens:
  • Myc-regulated DEAD box protein (DDX18_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NVP1

UniProtKB/Swiss-Prot:

DDX18_HUMAN :
  • Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
Family:
  • Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
genes like me logo Genes that share domains with DDX18: view

Function for DDX18 Gene

Molecular function for DDX18 Gene

UniProtKB/Swiss-Prot Function:
Probable RNA-dependent helicase.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;.

Enzyme Numbers (IUBMB) for DDX18 Gene

Phenotypes From GWAS Catalog for DDX18 Gene

Gene Ontology (GO) - Molecular Function for DDX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003724 RNA helicase activity TAS,IEA --
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with DDX18: view
genes like me logo Genes that share phenotypes with DDX18: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX18

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX18 Gene

Localization for DDX18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX18 Gene

Nucleus, nucleolus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX18 gene
Compartment Confidence
nucleus 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitotic chromosome (4)
  • Nucleoli (4)
  • Nucleoli rim (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DDX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA,IDA 20813266
GO:0005730 nucleolus IBA,IDA 16963496
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with DDX18: view

Pathways & Interactions for DDX18 Gene

genes like me logo Genes that share pathways with DDX18: view

Pathways by source for DDX18 Gene

1 BioSystems pathway for DDX18 Gene

Gene Ontology (GO) - Biological Process for DDX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA 21873635
GO:0071392 cellular response to estradiol stimulus IEA --
genes like me logo Genes that share ontologies with DDX18: view

No data available for SIGNOR curated interactions for DDX18 Gene

Drugs & Compounds for DDX18 Gene

(3) Drugs for DDX18 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phosphate Experimental Pharma 0
ATP Investigational Nutra 0

(2) Additional Compounds for DDX18 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
genes like me logo Genes that share compounds with DDX18: view

Transcripts for DDX18 Gene

mRNA/cDNA for DDX18 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX18

Alternative Splicing Database (ASD) splice patterns (SP) for DDX18 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1:
SP2: -
SP3: -
SP4:

Relevant External Links for DDX18 Gene

GeneLoc Exon Structure for
DDX18

Expression for DDX18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DDX18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX18 Gene

This gene is overexpressed in Lung (9.0), Tlymphocyte (8.9), Peripheral blood mononuclear cells (8.3), and CD8 Tcells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX18 Gene



Protein tissue co-expression partners for DDX18 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DDX18

SOURCE GeneReport for Unigene cluster for DDX18 Gene:

Hs.744922

Evidence on tissue expression from TISSUES for DDX18 Gene

  • Liver(4.6)
  • Nervous system(4.5)
  • Blood(4.3)
  • Kidney(2)
genes like me logo Genes that share expression patterns with DDX18: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX18 Gene

Orthologs for DDX18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX18 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DDX18 29 30
  • 99.15 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 30
  • 90 (a)
OneToMany
-- 30
  • 89 (a)
OneToMany
DDX18 29
  • 88.19 (n)
Dog
(Canis familiaris)
Mammalia DDX18 29 30
  • 88.24 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DDX18 30
  • 84 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Ddx18 29 16 30
  • 83.56 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ddx18 29
  • 81.89 (n)
Chicken
(Gallus gallus)
Aves DDX18 29 30
  • 73.67 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DDX18 30
  • 76 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ddx18 29
  • 67.82 (n)
Str.2227 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.23801 29
Zebrafish
(Danio rerio)
Actinopterygii ddx18 29 30
  • 66.67 (n)
OneToOne
sbcb155 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1047 29
Fruit Fly
(Drosophila melanogaster)
Insecta pit 29 30 31
  • 67.99 (n)
OneToOne
CG9630 31
  • 38 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008601 29
  • 63.22 (n)
Worm
(Caenorhabditis elegans)
Secernentea B0511.6 29 30 31
  • 61.57 (n)
OneToOne
ZK512.2 31
  • 30 (a)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGR333C 29
  • 62.3 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A09669g 29
  • 61.92 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAS1 29 30 32
  • 61.63 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT3G18600 29
  • 59.68 (n)
Rice
(Oryza sativa)
Liliopsida Os06g0535100 29
  • 60.16 (n)
Os.5799 29
Barley
(Hordeum vulgare)
Liliopsida Hv.831 29
Wheat
(Triticum aestivum)
Liliopsida Ta.6315 29
Corn
(Zea mays)
Liliopsida Zm.4304 29
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 70 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes has1 29
  • 62.99 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU09349 29
  • 60.04 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.4575 29
Species where no ortholog for DDX18 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DDX18 Gene

ENSEMBL:
Gene Tree for DDX18 (if available)
TreeFam:
Gene Tree for DDX18 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DDX18: view image
Alliance of Genome Resources:
Additional Orthologs for DDX18

Paralogs for DDX18 Gene

(16) SIMAP similar genes for DDX18 Gene using alignment to 4 proteins:

  • DDX18_HUMAN
  • H7C452_HUMAN
  • Q4ZG72_HUMAN
  • Q53TI6_HUMAN
genes like me logo Genes that share paralogs with DDX18: view

Variants for DDX18 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DDX18 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs137859195 Benign: not provided 117,826,298(+) C/G
NM_006773.4(DDX18):c.1551C>G (p.Ala517=)
SYNONYMOUS
rs138396618 Benign: not provided 117,821,760(+) C/G
NM_006773.4(DDX18):c.751+10C>G
INTRON
rs147371946 Benign: not provided 117,819,702(+) G/A
NM_006773.4(DDX18):c.424G>A (p.Glu142Lys)
MISSENSE
rs34228045 Benign: not provided 117,829,456(+) C/T
NM_006773.4(DDX18):c.1860C>T (p.Phe620=)
SYNONYMOUS
rs61732821 Benign: not provided 117,825,035(+) T/C
NM_006773.4(DDX18):c.1302T>C (p.Ser434=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DDX18 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DDX18 Gene

Variant ID Type Subtype PubMed ID
nsv2889 CNV insertion 18451855
nsv961874 CNV duplication 23825009
nsv961875 CNV duplication 23825009
nsv999434 CNV gain 25217958

Variation tolerance for DDX18 Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.43; 94.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DDX18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX18
Leiden Open Variation Database (LOVD)
DDX18

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX18 Gene

Disorders for DDX18 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DDX18 Gene - From: COP

Disorder Aliases PubMed IDs
sennetsu fever
  • sennetsu ehrlichiosis
- elite association - COSMIC cancer census association via MalaCards
Search DDX18 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DDX18

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with DDX18: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DDX18 Gene

Publications for DDX18 Gene

  1. Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo. (PMID: 8861962) Grandori C … Eisenman RN (The EMBO journal 1996) 2 3 4
  2. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S … Rappsilber J (Cell 2010) 3 4
  3. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. (PMID: 20689807) Wang X … Bell DA (PloS one 2010) 3 40
  4. Cellular studies of MrDb (DDX18). (PMID: 18351129) Dubaele S … Chène P (Oncology research 2007) 3 22
  5. NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. (PMID: 16963496) Sekiguchi T … Nishimoto T (Nucleic acids research 2006) 3 4

Products for DDX18 Gene

Sources for DDX18 Gene