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Aliases for DDX17 Gene

Aliases for DDX17 Gene

  • DEAD-Box Helicase 17 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 17 (72kD) 2 3
  • Probable ATP-Dependent RNA Helicase DDX17 3 4
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 17 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 17 2 3
  • RNA-Dependent Helicase P72 3 4
  • DEAD Box Protein P72 3 4
  • DEAD Box Protein P82 3 4
  • DEAD Box Protein 17 4
  • EC 3.6.4.13 4
  • EC 3.6.1 56
  • RH70 3
  • P72 3

External Ids for DDX17 Gene

Previous GeneCards Identifiers for DDX17 Gene

  • GC22M035496
  • GC22M037122
  • GC22M037124
  • GC22M037203
  • GC22M038879
  • GC22M021845

Summaries for DDX17 Gene

Entrez Gene Summary for DDX17 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species, but not by dsDNA. This protein, and that encoded by DDX5 gene, are more closely related to each other than to any other member of the DEAD box family. This gene can encode multiple isoforms due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) start codon. [provided by RefSeq, Apr 2011]

GeneCards Summary for DDX17 Gene

DDX17 (DEAD-Box Helicase 17) is a Protein Coding gene. Diseases associated with DDX17 include Retinitis Pigmentosa 54 and Retinitis Pigmentosa 30. Among its related pathways are GPCR Pathway and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is DDX5.

UniProtKB/Swiss-Prot for DDX17 Gene

  • As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). Affects NFAT5 and histone macro-H2A.1/H2AFY alternative splicing in a CDK9-dependent manner (PubMed:26209609, PubMed:22266867). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784). Binds pri-microRNAs on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (PubMed:24581491). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153). May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701). Enhances NFAT5 transcriptional activity (PubMed:22266867). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:20663877, PubMed:19995069). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766). Coactivates MMP7 transcription (PubMed:17226766). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:24275493, PubMed:20406972, PubMed:20663877, PubMed:19995069). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637).

Gene Wiki entry for DDX17 Gene

Additional gene information for DDX17 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX17 Gene

Genomics for DDX17 Gene

GeneHancer (GH) Regulatory Elements for DDX17 Gene

Promoters and enhancers for DDX17 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DDX17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DDX17 gene promoter:
  • ATF-2
  • c-Jun
  • TBP

Genomic Locations for DDX17 Gene

Genomic Locations for DDX17 Gene
chr22:38,483,438-38,507,660
(GRCh38/hg38)
Size:
24,223 bases
Orientation:
Minus strand
chr22:38,879,443-38,903,665
(GRCh37/hg19)
Size:
24,223 bases
Orientation:
Minus strand

Genomic View for DDX17 Gene

Genes around DDX17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX17 Gene

Proteins for DDX17 Gene

  • Protein details for DDX17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92841-DDX17_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX17
    Protein Accession:
    Q92841
    Secondary Accessions:
    • B1AHM0
    • H3BLZ8
    • Q69YT1
    • Q6ICD6

    Protein attributes for DDX17 Gene

    Size:
    729 amino acids
    Molecular mass:
    80272 Da
    Quaternary structure:
    • Interacts with DDX5 in an RNA-independent manner (PubMed:12595555, PubMed:19995069). Interacts with CDK9 transcription elongation complex under basal conditions. Following cell stimulation with poly(I:C), a synthetic double-stranded RNA mimicking viral infection, the interaction with CDK9 is decreased (PubMed:26209609). Interacts with ESR1 in an estrogen-independent manner (PubMed:19718048, PubMed:20663877). Interacts with HNRNPH1; this interaction is important for the regulation of alternative splicing on G-quadruplex structures (PubMed:24910439). At high, but not low, cell density, interacts with DROSHA and DGCR8, the core components of the microprocessor complex involved in the maturation of primary microRNAs (pri-miRNAs) into pre-miRNAs. The interaction with DGCR8 is reduced during mitosis (PubMed:24589731, PubMed:24581491). At low, but not high, cell density, interacts with YAP1 and with its paralog, WWTR1/TAZ. Interactions with DROSHA and YAP1 are mutually exclusive (PubMed:24581491). In vitro, the pre-miRNA processing activity of the DDX17-containing microprocessor complex is weaker than that of the DROSHA/DGCR8 microprocessor complex devoid of DDX17 (PubMed:15531877). Interacts with UPF3B (PubMed:23788676). Interacts with NFAT5; this interaction leads to DDX17 recruitment to LNC2 and S100A4 promoters and NFAT5-mediated DDX17-enhanced transactivation (PubMed:22266867). Interacts with HDAC1, HDAC2 and HDAC3; this interaction with HDAC1 and HDAC3, but not HDAC2, depends upon DDX17 acetylation (PubMed:15298701, PubMed:20663877). Interacts with ZC3HAV1 (via N-terminal domain) in an RNA-independent manner. Interacts with EXOSC3/RRP40 and EXOSC5/RRP46; this interaction may be indirect and mediated by ZC3HAV1-binding (PubMed:18334637). Interacts with EP300; this interaction leads to acetylation at lysine residues (PubMed:17226766, PubMed:19995069). Interacts with CREBBP/CBP and KAT2B/P/CAF (PubMed:17226766). Directly interacts with CTNNB1 (PubMed:17699760). Interacts with MYOD1 (PubMed:17011493). Interacts with TP53 (PubMed:15660129). Interacts with DCP1A in an RNA-independent manner. Interacts with DCP2 in an RNA-dependent manner (PubMed:21876179). Interacts with DHX36; this interaction occurs in a RNA-dependent manner (PubMed:18279852).

    Alternative splice isoforms for DDX17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX17 Gene

Selected DME Specific Peptides for DDX17 Gene

Q92841:
  • EDYVHRIGRT
  • MRRDGWPAM
  • DMGFEPQ
  • YGGAPKG
  • DEADRML
  • VASRGLD
  • PTRELAQQ
  • TGSGKTLA
  • VLDEADRM
  • TDVASRG
  • QLAEDFL
  • KKFGNPGE
  • LPAIVHIN
  • AQTGSGKT
  • FVETKRRCD
  • GKTLAYL
  • FEKNFYVE
  • LAPTREL
  • HRIGRTAR
  • LELSANHNILQIVDVC
  • TPGRLID
  • ILIATDVA
  • LVLDEADR
  • MWSATWPK
  • QIRPDRQT
  • IHGDKSQ
  • SATWPKEV
  • APTRELA
  • GPQIRDL
  • GKTNLRR
  • IATPGRL
  • KSQPERD
  • PKFEKNFY
  • EANQAINPKL

Post-translational modifications for DDX17 Gene

  • Sumoylation significantly increases stability. It also promotes interaction specifically with HDAC1 (but not HDAC2, nor HDAC3) and strongly stimulates ESR1 and TP53 coactivation.
  • Acetylation at lysine residues stabilizes the protein, stimulates interaction with HDAC1 and HDAC3, but not HDAC2, and represses ESR1 and TP53 coactivation activity.
  • Ubiquitination at posLast=436436, isoforms=4, 2, 3373, isoforms=4, 2, 353, posLast=449449, posLast=389389, posLast=4242, posLast=190190, posLast=5050, and posLast=468468
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX17 Gene

Domains & Families for DDX17 Gene

Gene Families for DDX17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for DDX17 Gene

GenScript: Design optimal peptide antigens:
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 (B1AHM1_HUMAN)
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 (B1AHM2_HUMAN)
  • RNA-dependent helicase p72 (DDX17_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92841

UniProtKB/Swiss-Prot:

DDX17_HUMAN :
  • Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
Family:
  • Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
genes like me logo Genes that share domains with DDX17: view

Function for DDX17 Gene

Molecular function for DDX17 Gene

UniProtKB/Swiss-Prot Function:
As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). Affects NFAT5 and histone macro-H2A.1/H2AFY alternative splicing in a CDK9-dependent manner (PubMed:26209609, PubMed:22266867). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784). Binds pri-microRNAs on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (PubMed:24581491). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153). May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701). Enhances NFAT5 transcriptional activity (PubMed:22266867). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:20663877, PubMed:19995069). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766). Coactivates MMP7 transcription (PubMed:17226766). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:24275493, PubMed:20406972, PubMed:20663877, PubMed:19995069). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=170 uM for ATP {ECO:0000269 PubMed:8871553};
GENATLAS Biochemistry:
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72kD)

Enzyme Numbers (IUBMB) for DDX17 Gene

Phenotypes From GWAS Catalog for DDX17 Gene

Gene Ontology (GO) - Molecular Function for DDX17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003713 transcription coactivator activity IDA 17226766
GO:0003723 RNA binding TAS,HDA 22658674
GO:0003724 RNA helicase activity TAS 8871553
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with DDX17: view
genes like me logo Genes that share phenotypes with DDX17: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for DDX17 - Now 50% OFF >
  • * DDX17 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * DDX17 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for DDX17

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX17 Gene

Localization for DDX17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX17 Gene

Nucleus. Nucleus, nucleolus. Cytoplasm, cytosol. Note=In the course of bunyavirus infection, relocalizes from the nucleus to the cytosol where it binds viral RNA to antagonize replication. {ECO:0000269 PubMed:25126784}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX17 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DDX17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IDA 24910439
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with DDX17: view

Pathways & Interactions for DDX17 Gene

PathCards logo

SuperPathways for DDX17 Gene

genes like me logo Genes that share pathways with DDX17: view

Pathways by source for DDX17 Gene

1 BioSystems pathway for DDX17 Gene
1 Qiagen pathway for DDX17 Gene

Gene Ontology (GO) - Biological Process for DDX17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000380 alternative mRNA splicing, via spliceosome IMP 24275493
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IMP 23022728
GO:0001837 epithelial to mesenchymal transition IMP 24910439
GO:0002376 immune system process IEA --
GO:0006357 regulation of transcription by RNA polymerase II IMP 24275493
genes like me logo Genes that share ontologies with DDX17: view

No data available for SIGNOR curated interactions for DDX17 Gene

Drugs & Compounds for DDX17 Gene

(3) Drugs for DDX17 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for DDX17 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with DDX17: view

Transcripts for DDX17 Gene

Unigene Clusters for DDX17 Gene

DEAD (Asp-Glu-Ala-Asp) box helicase 17:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for DDX17 - Now 50% OFF >
  • * DDX17 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * DDX17 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for DDX17

Alternative Splicing Database (ASD) splice patterns (SP) for DDX17 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c
SP1: - - - - - -
SP2: - - - - - -
SP3: - -
SP4: -
SP5: - - - - -
SP6:
SP7:
SP8:

Relevant External Links for DDX17 Gene

GeneLoc Exon Structure for
DDX17
ECgene alternative splicing isoforms for
DDX17

Expression for DDX17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX17 Gene

Protein differential expression in normal tissues from HIPED for DDX17 Gene

This gene is overexpressed in Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX17 Gene



Protein tissue co-expression partners for DDX17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX17 Gene:

DDX17

SOURCE GeneReport for Unigene cluster for DDX17 Gene:

Hs.528305

mRNA Expression by UniProt/SwissProt for DDX17 Gene:

Q92841-DDX17_HUMAN
Tissue specificity: Widely expressed (PubMed:8871553). Low expression, if any, in normal colonic epithelial cells (at protein level). Levels tend to increase during colon cancer progression, from very low in benign hyperplastic polyps to very high in tubular and villous adenomas (PubMed:17699760).

Evidence on tissue expression from TISSUES for DDX17 Gene

  • Nervous system(5)
  • Skin(4.8)
  • Liver(4.6)
  • Lung(4.4)
  • Intestine(4)
  • Eye(3.9)
  • Blood(3.8)
  • Kidney(3.8)
  • Pancreas(3.5)
  • Stomach(3.1)
  • Bone(2.8)
  • Heart(2.8)
  • Muscle(2.4)
  • Thyroid gland(2.4)
  • Lymph node(2.3)
  • Spleen(2.3)
  • Gall bladder(2.2)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with DDX17: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX17 Gene

Orthologs for DDX17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX17 34 35
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia DDX17 34 35
  • 95.3 (n)
oppossum
(Monodelphis domestica)
Mammalia DDX17 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX17 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDX17 34 35
  • 94.87 (n)
mouse
(Mus musculus)
Mammalia Ddx17 17 34 35
  • 90.15 (n)
chicken
(Gallus gallus)
Aves DDX17 34 35
  • 79.42 (n)
lizard
(Anolis carolinensis)
Reptilia DDX17 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx17 34
  • 73.96 (n)
zebrafish
(Danio rerio)
Actinopterygii DDX17 35
  • 73 (a)
OneToOne
LOC556764 34
  • 69.93 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10077 36 35
  • 67 (a)
Rm62 36 35
  • 65 (a)
CG10777 36 35
  • 59 (a)
CG14443 36
  • 32 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005652 34
  • 61.95 (n)
worm
(Caenorhabditis elegans)
Secernentea F58E10.3 36 34
  • 59.56 (n)
ddx-17 35
  • 52 (a)
OneToMany
F58G11.2 36
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP2 35
  • 55 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.6121 34
corn
(Zea mays)
Liliopsida Zm.5411 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1847 34
sea squirt
(Ciona savignyi)
Ascidiacea Cin.1847 34
Species where no ortholog for DDX17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX17 Gene

ENSEMBL:
Gene Tree for DDX17 (if available)
TreeFam:
Gene Tree for DDX17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DDX17: view image

Paralogs for DDX17 Gene

(25) SIMAP similar genes for DDX17 Gene using alignment to 4 proteins:

  • DDX17_HUMAN
  • C9JMU5_HUMAN
  • G5E9L5_HUMAN
  • H3BLZ8_HUMAN
genes like me logo Genes that share paralogs with DDX17: view

Variants for DDX17 Gene

Sequence variations from dbSNP and Humsavar for DDX17 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000072115 -- 38,501,663(-) T/C intron_variant
rs1000411664 -- 38,483,710(-) C/T 3_prime_UTR_variant
rs1000427810 -- 38,489,668(-) C/A intron_variant
rs1000502419 -- 38,495,595(-) GTACA/GTACAGTACA intron_variant
rs1000507383 -- 38,501,484(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DDX17 Gene

Variant ID Type Subtype PubMed ID
nsv834195 CNV loss 17160897

Variation tolerance for DDX17 Gene

Residual Variation Intolerance Score: 9.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DDX17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX17

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX17 Gene

Disorders for DDX17 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DDX17 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 54
  • rp54
retinitis pigmentosa 30
  • rp30
- elite association - COSMIC cancer census association via MalaCards
Search DDX17 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DDX17

genes like me logo Genes that share disorders with DDX17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DDX17 Gene

Publications for DDX17 Gene

  1. Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF. (PMID: 17226766) Shin S … Janknecht R (Journal of cellular biochemistry 2007) 2 3 4 23 58
  2. p72: a human nuclear DEAD box protein highly related to p68. (PMID: 8871553) Lamm GM … Lamond AI (Nucleic acids research 1996) 2 3 4 23 58
  3. Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential. (PMID: 19995069) Mooney SM … Janknecht R (Biochemistry 2010) 3 4 23 58
  4. The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer. (PMID: 19718048) Wortham NC … Fuller-Pace FV (Oncogene 2009) 3 4 23 58
  5. Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU. (PMID: 18279852) Iwamoto F … Nagamine Y (Experimental cell research 2008) 3 4 23 58

Products for DDX17 Gene

Sources for DDX17 Gene