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Aliases for DDX12P Gene

Aliases for DDX12P Gene

  • DEAD/H-Box Helicase 12, Pseudogene 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 12, Pseudogene 2 3
  • CHL1-Related Protein 2 3 4
  • DEAD/H Box Protein 12 3 4
  • HCHLR2 3 4
  • DDX12 3 4
  • CHLR2 3 4
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 12 (CHL1-Like Helicase Homolog, S. Cerevisiae) 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 12 (S.Cerevisiae CHL1-Like Helicase) 2
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 12 2
  • CHL1-Like Helicase Homolog 2 (S. Cerevisiae) 2
  • Probable ATP-Dependent RNA Helicase DDX12 3
  • Putative ATP-Dependent RNA Helicase DDX12 4
  • CHL1-Like Helicase Homolog 2 3
  • DEAD/H Box-12 3
  • EC 3.6.1.23 56
  • EC 3.6.4.13 4
  • EC 3.6.1.7 56
  • EC 3.6.1 56

External Ids for DDX12P Gene

Previous HGNC Symbols for DDX12P Gene

  • DDX12

Previous GeneCards Identifiers for DDX12P Gene

  • GC12M009571
  • GC12M009572
  • GC12M009720
  • GC12M010042
  • GC12M010237
  • GC12M010476

Summaries for DDX12P Gene

GeneCards Summary for DDX12P Gene

DDX12P (DEAD/H-Box Helicase 12, Pseudogene) is a Pseudogene. Gene Ontology (GO) annotations related to this gene include RNA binding and ATP-dependent DNA helicase activity.

UniProtKB/Swiss-Prot for DDX12P Gene

  • DNA helicase involved in cellular proliferation. Probably required for maintaining the chromosome segregation (By similarity).

Additional gene information for DDX12P Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX12P Gene

Genomics for DDX12P Gene

GeneHancer (GH) Regulatory Elements for DDX12P Gene

Promoters and enhancers for DDX12P Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DDX12P on UCSC Golden Path with GeneCards custom track

Genomic Locations for DDX12P Gene

Genomic Locations for DDX12P Gene
chr12:9,417,691-9,448,229
(GRCh38/hg38)
Size:
30,539 bases
Orientation:
Minus strand
chr12:9,570,287-9,600,825
(GRCh37/hg19)
Size:
30,539 bases
Orientation:
Minus strand

Genomic View for DDX12P Gene

Genes around DDX12P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX12P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX12P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX12P Gene

Proteins for DDX12P Gene

  • Protein details for DDX12P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92771-DDX12_HUMAN
    Recommended name:
    Putative ATP-dependent RNA helicase DDX12
    Protein Accession:
    Q92771

    Protein attributes for DDX12P Gene

    Size:
    950 amino acids
    Molecular mass:
    106006 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DDX12P Gene

Selected DME Specific Peptides for DDX12P Gene

Q92771:
  • INDFLFQSQ
  • SRTHSQL
  • RKKIFQEPK
  • DNINLFKVQRY
  • VGGKMSE
  • VGMPFPN
  • LPYQMLL
  • MLLHAATRQAAGIRLQ
  • AVNQSIGR
  • FLAALTTANQDGRVI
  • SEGINFSD
  • PFPNIRSA
  • EAGKIGI
  • KRLKAKNLMY
  • SCGHVIP
  • AGGTMQP
  • LGRCVVMVGMP
  • IGRAIRH
  • YGKRLKA
  • RLVSLGSRQ
  • KQILYLLEKFVAVLGGN
  • TQSLSQTG
  • AQLVVLP
  • IDEAHNL
  • LVLAEYESDEE
  • SRKLFGFTE
  • FVQKKEERDLV
  • ESPTGTGK
  • CPFYNHEQM

Post-translational modifications for DDX12P Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DDX12P Gene

Gene Families for DDX12P Gene

Suggested Antigen Peptide Sequences for DDX12P Gene

GenScript: Design optimal peptide antigens:
  • DEAD/H box protein 12 (DDX12_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92771

UniProtKB/Swiss-Prot:

DDX12_HUMAN :
  • Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
genes like me logo Genes that share domains with DDX12P: view

Function for DDX12P Gene

Molecular function for DDX12P Gene

UniProtKB/Swiss-Prot Function:
DNA helicase involved in cellular proliferation. Probably required for maintaining the chromosome segregation (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;.

Enzyme Numbers (IUBMB) for DDX12P Gene

Phenotypes From GWAS Catalog for DDX12P Gene

Gene Ontology (GO) - Molecular Function for DDX12P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0004003 ATP-dependent DNA helicase activity IBA 21873635
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX12P: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DDX12P Gene

Localization for DDX12P Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX12P Gene

Gene Ontology (GO) - Cellular Components for DDX12P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with DDX12P: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for DDX12P Gene

Pathways & Interactions for DDX12P Gene

PathCards logo

SuperPathways for DDX12P Gene

No Data Available

Interacting Proteins for DDX12P Gene

Selected Interacting proteins: Q92771-DDX12_HUMAN for DDX12P Gene via IID

Gene Ontology (GO) - Biological Process for DDX12P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process IEA --
GO:0032508 DNA duplex unwinding IBA 21873635
GO:0034085 establishment of sister chromatid cohesion IBA 21873635
genes like me logo Genes that share ontologies with DDX12P: view

No data available for Pathways by source and SIGNOR curated interactions for DDX12P Gene

Drugs & Compounds for DDX12P Gene

(3) Drugs for DDX12P Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for DDX12P Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with DDX12P: view

Transcripts for DDX12P Gene

mRNA/cDNA for DDX12P Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for DDX12P Gene

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX12P Gene

No ASD Table

Relevant External Links for DDX12P Gene

GeneLoc Exon Structure for
DDX12P
ECgene alternative splicing isoforms for
DDX12P

Expression for DDX12P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX12P Gene

NURSA nuclear receptor signaling pathways regulating expression of DDX12P Gene:

DDX12P

SOURCE GeneReport for Unigene cluster for DDX12P Gene:

Hs.504688

mRNA Expression by UniProt/SwissProt for DDX12P Gene:

Q92771-DDX12_HUMAN
Tissue specificity: Only expressed in proliferating tissues.
genes like me logo Genes that share expression patterns with DDX12P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX12P Gene

Orthologs for DDX12P Gene

Evolution for DDX12P Gene

ENSEMBL:
Gene Tree for DDX12P (if available)
TreeFam:
Gene Tree for DDX12P (if available)

No data available for Orthologs for DDX12P Gene

Paralogs for DDX12P Gene

(3) SIMAP similar genes for DDX12P Gene using alignment to 1 proteins:

  • DDX12_HUMAN
genes like me logo Genes that share paralogs with DDX12P: view

No data available for Paralogs for DDX12P Gene

Variants for DDX12P Gene

Sequence variations from dbSNP and Humsavar for DDX12P Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000036198 -- 9,448,898(-) A/C/G upstream_transcript_variant
rs1000377675 -- 9,430,535(-) A/G intron_variant
rs1000715437 -- 9,423,678(-) G/A intron_variant
rs1000768130 -- 9,423,844(-) T/C intron_variant
rs1000996183 -- 9,434,831(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DDX12P Gene

Variant ID Type Subtype PubMed ID
dgv2344n54 CNV gain 21841781
dgv761n106 OTHER inversion 24896259
esv2568009 CNV loss 19546169
esv2759878 CNV gain+loss 17122850
esv2760270 CNV gain+loss 21179565
esv2760977 CNV loss 21179565
esv3580099 CNV loss 25503493
esv3628503 CNV loss 21293372
esv3628504 CNV gain 21293372
esv3628505 CNV gain 21293372
nsv1035958 CNV gain 25217958
nsv1050161 CNV loss 25217958
nsv1051530 CNV gain 25217958
nsv1128662 CNV duplication 24896259
nsv1141210 CNV duplication 24896259
nsv1159969 CNV duplication 26073780
nsv428271 CNV gain 18775914
nsv508665 CNV deletion 20534489
nsv509454 CNV insertion 20534489
nsv557367 CNV loss 21841781
nsv557368 CNV loss 21841781
nsv557385 CNV loss 21841781
nsv557387 CNV gain 21841781
nsv7228 OTHER inversion 18451855
nsv8907 CNV gain 18304495
nsv952799 CNV deletion 24416366
nsv975443 CNV duplication 23825009
nsv983275 CNV duplication 23825009

Additional Variant Information for DDX12P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX12P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for DDX12P Gene

Disorders for DDX12P Gene

Additional Disease Information for DDX12P

No disorders were found for DDX12P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX12P Gene

Publications for DDX12P Gene

  1. Characterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1. (PMID: 9013641) Amann J … Lahti JM (The Journal of biological chemistry 1997) 3 4 58
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58
  3. Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation. (PMID: 17611414) Inoue A … Lahti JM (Cell cycle (Georgetown, Tex.) 2007) 23 58
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4 58
  5. Lineage-specific gene duplication and loss in human and great ape evolution. (PMID: 15252450) Fortna A … Sikela JM (PLoS biology 2004) 3 58

Products for DDX12P Gene

Sources for DDX12P Gene

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