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DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this fami... See more...
Aliases for DDX11 Gene
Aliases for DDX11 Gene
- DEAD/H-Box Helicase 11 2 3 5
- CHLR1 2 3 4
- CHL1 2 3 4
- KRG2 2 3 4
- Keratinocyte Growth Factor-Regulated Gene 2 Protein 3 4
- DEAD/H (Asp-Glu-Ala-Asp/His) Box Helicase 11 2 3
- ATP-Dependent DNA Helicase DDX11 3 4
- CHL1-Related Protein 1 3 4
- HCHLR1 3 4
- KRG-2 3 4
- WABS 2 3
- DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 11 (CHL1-Like Helicase Homolog, S. Cerevisiae) 3
- DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 11 (S.Cerevisiae CHL1-Like Helicase) 2
- DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 11 2
- CHL1-Like Helicase Homolog (S. Cerevisiae) 2
- Probable ATP-Dependent DNA Helicase DDX11 3
- Probable ATP-Dependent RNA Helicase DDX11 3
- CHL1-Related Helicase Gene-1 3
- CHL1-Like Helicase Homolog 3
- DEAD/H Box Protein 11 3
- DEAD/H-Box Protein 11 4
- EC 3.6.1.23 51
- EC 3.6.4.12 4
- EC 3.6.1.7 51
- EC 3.6.1 51
- DDX11 5
- ChlR1 2
External Ids for DDX11 Gene
- HGNC: 2736
- Entrez Gene: 1663
- Ensembl: ENSG00000013573
- OMIM: 601150
- UniProtKB: Q96FC9
Previous GeneCards Identifiers for DDX11 Gene
- GC12P031609
- GC12P031250
- GC12P031127
- GC12P031118
- GC12P030992
- GC12P031226
Summaries for DDX11 Gene
-
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for DDX11 Gene
DDX11 (DEAD/H-Box Helicase 11) is a Protein Coding gene. Diseases associated with DDX11 include Warsaw Breakage Syndrome and Roberts Syndrome. Among its related pathways are Unfolded Protein Response (UPR) and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and double-stranded DNA binding. An important paralog of this gene is BRIP1.
UniProtKB/Swiss-Prot Summary for DDX11 Gene
-
DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis (PubMed:10648783, PubMed:21854770, PubMed:23797032, PubMed:26089203, PubMed:26503245). Its double-stranded DNA helicase activity requires either a minimal 5'-single-stranded tail length of approximately 15 nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of a partial duplex DNA structure for helicase loading and translocation along DNA in a 5' to 3' direction (PubMed:18499658, PubMed:22102414). The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended up to 500 bp by the replication protein A (RPA) or the cohesion CTF18-replication factor C (Ctf18-RFC) complex activities (PubMed:18499658). Shows also ATPase- and helicase activities on substrates that mimic key DNA intermediates of replication, repair and homologous recombination reactions, including forked duplex, anti-parallel G-quadruplex and three-stranded D-loop DNA molecules (PubMed:22102414, PubMed:26503245). Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during DNA replication recovery from DNA damage (PubMed:23797032). Recruited with TIMELESS factor upon DNA-replication stress response at DNA replication fork to preserve replication fork progression, and hence ensure DNA replication fidelity (PubMed:26503245). Cooperates also with TIMELESS factor during DNA replication to regulate proper sister chromatid cohesion and mitotic chromosome segregation (PubMed:17105772, PubMed:18499658, PubMed:20124417, PubMed:23116066, PubMed:23797032). Stimulates 5'-single-stranded DNA flap endonuclease activity of FEN1 in an ATP- and helicase-independent manner; and hence it may contribute in Okazaki fragment processing at DNA replication fork during lagging strand DNA synthesis (PubMed:18499658). Its ability to function at DNA replication fork is modulated by its binding to long non-coding RNA (lncRNA) cohesion regulator non-coding RNA DDX11-AS1/CONCR, which is able to increase both DDX11 ATPase activity and binding to DNA replicating regions (PubMed:27477908). Plays also a role in heterochromatin organization (PubMed:21854770). Involved in rRNA transcription activation through binding to active hypomethylated rDNA gene loci by recruiting UBTF and the RNA polymerase Pol I transcriptional machinery (PubMed:26089203). Plays a role in embryonic development and prevention of aneuploidy (By similarity). Involved in melanoma cell proliferation and survival (PubMed:23116066). Associates with chromatin at DNA replication fork regions (PubMed:27477908). Binds to single- and double-stranded DNAs (PubMed:9013641, PubMed:18499658, PubMed:22102414).
-
(Microbial infection) Required for bovine papillomavirus type 1 regulatory protein E2 loading onto mitotic chromosomes during DNA replication for the viral genome to be maintained and segregated.
Additional gene information for DDX11 Gene
- HGNC(2736)
- Entrez Gene(1663)
- Ensembl(ENSG00000013573)
- OMIM(601150)
- UniProtKB(Q96FC9)
- Open Targets Platform(ENSG00000013573)
- Monarch Initiative
- Search for DDX11 at DataMed
- Search for DDX11 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DDX11 Gene
Genomics for DDX11 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DDX11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DDX11 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DDX11
- Top Transcription factor binding sites by QIAGEN in the DDX11 gene promoter:
-
- AP-1
- Bach1
- c-Fos
- c-Jun
- FosB
- Fra-1
- JunB
Genomic Locations for DDX11 Gene
Genomic Locations for DDX11 Gene
- chr12:31,073,860-31,104,799
- (GRCh38/hg38)
- Size:
- 30,940 bases
- Orientation:
- Plus strand
- chr12:31,226,779-31,257,725
- (GRCh37/hg19)
- Size:
- 30,947 bases
- Orientation:
- Plus strand
Genomic View for DDX11 Gene
Genes around DDX11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p11.21 by HGNC
- 12p11.21 by Entrez Gene
- 12p11.21 by Ensembl
DDX11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DDX11 Gene
Proteins for DDX11 Gene
-
Protein details for DDX11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96FC9-DDX11_HUMAN
- Recommended name:
- ATP-dependent DNA helicase DDX11
- Protein Accession:
- Q96FC9
- Q13333
- Q86VQ4
- Q86W62
- Q92498
- Q92770
- Q92998
- Q92999
Protein attributes for DDX11 Gene
- Size:
- 970 amino acids
- Molecular mass:
- 108313 Da
- Cofactor:
- Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
- Quaternary structure:
-
- Associates with the CTF18-RFC complex (PubMed:18499658). Associates with a cohesin complex composed of RAD21, SMC1 proteins and SMC3 (PubMed:17105772). Interacts with CHTF18 (PubMed:18499658). Interacts with DSCC1 (PubMed:18499658). Interacts with FEN1; this interaction is direct and increases flap endonuclease activity of FEN1 (PubMed:18499658). Interacts with PCNA (PubMed:18499658). Interacts with POLR1A and UBTF (PubMed:26089203). Interacts with RAD21, SMC1 proteins and SMC3 (PubMed:17105772). Interacts with RFC2 (PubMed:18499658). Interacts with TIMELESS; this interaction increases recruitment of both proteins onto chromatin in response to replication stress induction by hydroxyurea (PubMed:20124417, PubMed:26503245).
- (Microbial infection) Interacts with bovine papillomavirus type 1 regulatory protein E2; this interaction stimulates the recruitment of E2 onto mitotic chromosomes.
- SequenceCaution:
-
- Sequence=CAA67895.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA67895.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for DDX11 Gene
Selected DME Specific Peptides for DDX11 Gene
- Q96FC9:
-
- INDFLFQSQ
- SRTHSQL
- RKKIFQEPK
- DNINLFKVQRY
- VGGKMSE
- VGMPFPN
- MLLHAATRQAAGIRLQ
- LPYQMLL
- FLAALTTANQDGRVI
- SEGINFSD
- PFPNIRSA
- EAGKIGI
- KRLKAKNLMY
- SCGHVIP
- AGGTMQP
- LGRCVVMVGMP
- YGKRLKA
- RLVSLGSRQ
- KQILYLLEKFVAVLGGN
- TQSLSQTG
- AQLVVLP
- IDEAHNL
- LVLAEYESDEE
- SRKLFGFTE
- FVQKKEERDLV
- ESPTGTGK
- CPFYNHEQM
Post-translational modifications for DDX11 Gene
Other Protein References for DDX11 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_005253388.1
- XP_005253390.1
- XP_006719113.1
- XP_011518894.1
- XP_011518897.1
- XP_011518899.1
- XP_016874407.1
- XP_016874408.1
- XP_016874409.1
- XP_016874410.1
- XP_016874411.1
- XP_016874412.1
- XP_016874413.1
- XP_016874414.1
- XP_016874415.1
- XP_016874416.1
- XP_016874417.1
- XP_016874418.1
- XP_016874419.1
- XP_016874420.1
- XP_016874421.1
- XP_016874422.1
- XP_016874423.1
- XP_016874424.1
- XP_016874425.1
- XP_016874426.1
- XP_016874427.1
- XP_016874428.1
- NP_001244073.1
- NP_001244074.1
- NP_004390.3
- NP_085911.2
- NP_689651.1
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for DDX11
- Novus Biologicals Antibodies for DDX11
-
Abcam antibodies for DDX11
- Invitrogen Antibodies for DDX11 (AFLGC-DDX11)
-
Boster Bio Antibodies for DDX11
-
Santa Cruz Biotechnology (SCBT) Antibodies for DDX11
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for DDX11
- Origene Custom Protein Services for DDX11
-
Signalway Proteins for DDX11
-
Abcam proteins for DDX11
Assay Products
- antibodies-online: Show 12 available DDX11 Elisa Kits ranked by validation data
- Compare Top DDX11 Elisa Kits
-
Quality Products:
Domains & Families for DDX11 Gene
Gene Families for DDX11 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for DDX11 Gene
- InterPro:
- Blocks:
-
- ATP-dependent helicase, DEAH-box
- ProtoNet:
Suggested Antigen Peptide Sequences for DDX11 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ60129, highly similar to Probable ATP-dependent RNA helicase DDX11 (EC 3.6.1.-) (B4DMS8_HUMAN)
- Keratinocyte growth factor-regulated gene 2 protein (DDX11_HUMAN)
- DDX11 protein (Q2NKM7_HUMAN)
- Helicase (Q7KYX3_HUMAN)
- CHL1 protein (Q93000_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96FC9UniProtKB/Swiss-Prot:
DDX11_HUMAN :- Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
- Family:
-
- Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
Function for DDX11 Gene
Molecular function for DDX11 Gene
- UniProtKB/Swiss-Prot Function:
- DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis (PubMed:10648783, PubMed:21854770, PubMed:23797032, PubMed:26089203, PubMed:26503245). Its double-stranded DNA helicase activity requires either a minimal 5'-single-stranded tail length of approximately 15 nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of a partial duplex DNA structure for helicase loading and translocation along DNA in a 5' to 3' direction (PubMed:18499658, PubMed:22102414). The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended up to 500 bp by the replication protein A (RPA) or the cohesion CTF18-replication factor C (Ctf18-RFC) complex activities (PubMed:18499658). Shows also ATPase- and helicase activities on substrates that mimic key DNA intermediates of replication, repair and homologous recombination reactions, including forked duplex, anti-parallel G-quadruplex and three-stranded D-loop DNA molecules (PubMed:22102414, PubMed:26503245). Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during DNA replication recovery from DNA damage (PubMed:23797032). Recruited with TIMELESS factor upon DNA-replication stress response at DNA replication fork to preserve replication fork progression, and hence ensure DNA replication fidelity (PubMed:26503245). Cooperates also with TIMELESS factor during DNA replication to regulate proper sister chromatid cohesion and mitotic chromosome segregation (PubMed:17105772, PubMed:18499658, PubMed:20124417, PubMed:23116066, PubMed:23797032). Stimulates 5'-single-stranded DNA flap endonuclease activity of FEN1 in an ATP- and helicase-independent manner; and hence it may contribute in Okazaki fragment processing at DNA replication fork during lagging strand DNA synthesis (PubMed:18499658). Its ability to function at DNA replication fork is modulated by its binding to long non-coding RNA (lncRNA) cohesion regulator non-coding RNA DDX11-AS1/CONCR, which is able to increase both DDX11 ATPase activity and binding to DNA replicating regions (PubMed:27477908). Plays also a role in heterochromatin organization (PubMed:21854770). Involved in rRNA transcription activation through binding to active hypomethylated rDNA gene loci by recruiting UBTF and the RNA polymerase Pol I transcriptional machinery (PubMed:26089203). Plays a role in embryonic development and prevention of aneuploidy (By similarity). Involved in melanoma cell proliferation and survival (PubMed:23116066). Associates with chromatin at DNA replication fork regions (PubMed:27477908). Binds to single- and double-stranded DNAs (PubMed:9013641, PubMed:18499658, PubMed:22102414).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Required for bovine papillomavirus type 1 regulatory protein E2 loading onto mitotic chromosomes during DNA replication for the viral genome to be maintained and segregated.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000269|PubMed:10648783, ECO:0000269|PubMed:18499658, ECO:0000269|PubMed:22102414, ECO:0000269|PubMed:26089203, ECO:0000269|PubMed:27477908};.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by serum (at protein level) (PubMed:26089203). Up-regulated by fibroblast growth factor FGF7 (PubMed:8798685). Expressed in keratinocyte growth factor-stimulated cells but not in EGF and IL1-beta-treated keratinocytes (PubMed:8798685). Up-regulated with progression from noninvasive to invasive melanoma (PubMed:23116066).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- ATPase activity is stimulated by high magnesium salt levels (up to a 0.1 M), and potassium salts (glutamate, chloride or acetate) are more effective than the corresponding sodium salts (PubMed:10648783, PubMed:18499658). ATPase activity is enhanced by the long non-coding RNA (lncRNA) cohesion regulator noncoding RNA (CONCR) (PubMed:27477908). Double-stranded DNA helicase activity is maximal with magnesium ions at low concentrations (0.5-1 mM) whereas is markedly inhibited at higher levels (5 mM and above) (PubMed:10648783, PubMed:18499658). Double-stranded DNA helicase activity is stimulated by 25-50 mM potassium acetate, stimulated to a lesser extent by 25 mM of ammonium acetate, and markedly inhibited by sodium acetate (PubMed:18499658).
- GENATLAS Biochemistry:
- DEAD/H box protein 11,yeast Chl1 related-helicase gene 1,putative regulator of chromosome segregation and transmission
Enzyme Numbers (IUBMB) for DDX11 Gene
Phenotypes From GWAS Catalog for DDX11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IDA | 26503245 |
| GO:0003678 | DNA helicase activity | IEA,IDA | 18499658 |
| GO:0003682 | chromatin binding | IMP | 20124417 |
Phenotypes for DDX11 Gene
- MGI mutant phenotypes for DDX11:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for DDX11:
Animal Models for DDX11 Gene
- MGI Knock Outs for DDX11:
-
- Ddx11 Ddx11<tm1Jiml>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DDX11 - Select products 50% OFF >
- * DDX11 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DDX11
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DDX11
-
Santa Cruz Biotechnology (SCBT) CRISPR for DDX11
miRNA for DDX11 Gene
- miRTarBase miRNAs that target DDX11
-
- hsa-miR-744-5p (MIRT037623)
- hsa-miR-615-3p (MIRT040191)
- hsa-miR-324-5p (MIRT043115)
- hsa-miR-4504 (MIRT461747)
- hsa-miR-6780b-5p (MIRT461748)
- hsa-miR-4725-3p (MIRT461749)
- hsa-miR-4271 (MIRT461750)
- hsa-miR-5196-5p (MIRT461751)
- hsa-miR-4747-5p (MIRT461752)
- hsa-miR-765 (MIRT461753)
- hsa-miR-4533 (MIRT461754)
- hsa-miR-3664-3p (MIRT461755)
- hsa-miR-873-5p (MIRT461756)
- hsa-miR-6783-5p (MIRT461757)
- hsa-miR-4779 (MIRT461758)
- hsa-miR-6876-5p (MIRT461759)
- hsa-miR-4476 (MIRT461760)
- hsa-miR-6891-5p (MIRT461761)
- hsa-miR-510-5p (MIRT461762)
- hsa-miR-3173-3p (MIRT461763)
- mmu-miR-5101 (MIRT587463)
- mmu-miR-684 (MIRT587464)
- mmu-miR-1896 (MIRT587465)
- mmu-miR-212-5p (MIRT587466)
- mmu-miR-1983 (MIRT602517)
- mmu-miR-412-3p (MIRT602518)
- mmu-miR-3105-3p (MIRT605784)
- mmu-miR-105 (MIRT605785)
- mmu-miR-302d-3p (MIRT605786)
- mmu-miR-291a-3p (MIRT605787)
- mmu-miR-302b-3p (MIRT605788)
- mmu-miR-302a-3p (MIRT605789)
- mmu-miR-294-3p (MIRT605790)
- mmu-miR-295-3p (MIRT605791)
- hsa-miR-1281 (MIRT736984)
- hsa-miR-1286 (MIRT737045)
- hsa-miR-2682-3p (MIRT739407)
- hsa-miR-3653-3p (MIRT741905)
- hsa-miR-3658 (MIRT741940)
- hsa-miR-541-3p (MIRT750364)
- hsa-miR-654-5p (MIRT753435)
- hsa-miR-6721-5p (MIRT753787)
- hsa-miR-6781-3p (MIRT755668)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DDX11
- Browse OriGene Inhibitory RNA Products For DDX11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX11
Clone Products
- Applied Biological Materials (abm): Clones for DDX11 - Select products 50% OFF >
- * DDX11 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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- Sino Biological Human cDNA Clone for DDX11
- Addgene plasmids for DDX11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DDX11
No data available for Transcription Factor Targets and HOMER Transcription for DDX11 Gene
Localization for DDX11 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DDX11 Gene
- Nucleus. Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle pole. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=During the early stages of mitosis, localizes to condensed chromatin and is released from the chromatin with progression to metaphase. Also localizes to the spindle poles throughout mitosis and at the midbody at later stages of mitosis (metaphase to telophase) (PubMed:17105772). In interphase, colocalizes with nucleolin in the nucleolus (PubMed:26089203). {ECO:0000269 PubMed:17105772, ECO:0000269 PubMed:26089203}.
- Chromosome. Note=(Microbial infection) Colocalizes with bovine papillomavirus type 1 regulatory protein E2 on mitotic chromosomes at early stages of mitosis. {ECO:0000269 PubMed:17189189}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| extracellular | 4 |
| plasma membrane | 3 |
| mitochondrion | 1 |
| cytosol | 1 |
| peroxisome | 0 |
- Centrosome (3)
- Nucleoli fibrillar center (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IDA | 17105772 |
| GO:0000922 | spindle pole | IEA,IDA | 17105772 |
| GO:0001650 | fibrillar center | IDA | -- |
| GO:0005634 | colocalizes_with nucleus | IEA,IDA | 17189189 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
Pathways & Interactions for DDX11 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Unfolded Protein Response (UPR) | ||
| 2 | Metabolism of proteins | ||
Pathways by source for DDX11 Gene
4 Reactome pathways for DDX11 Gene
Interacting Proteins for DDX11 Gene
GPS-Prot Interaction Network for DDX11
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006139 | nucleobase-containing compound metabolic process | IEA | -- |
| GO:0006260 | DNA replication | IEA | -- |
| GO:0006281 | DNA repair | IEA | -- |
| GO:0006974 | cellular response to DNA damage stimulus | IMP | 23797032 |
| GO:0007062 | sister chromatid cohesion | IDA | 17105772 |
No data available for SIGNOR curated interactions for DDX11 Gene
Drugs & Compounds for DDX11 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Transcripts for DDX11 Gene
mRNA/cDNA for DDX11 Gene
- 6 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 30 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000542838 3920 nts (view in UCSC)
- ENST00000542129 1561 nts (view in UCSC)
- ENST00000228264 3717 nts (view in UCSC)
- ENST00000438391 1135 nts (view in UCSC)
- ENST00000435753 4182 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DDX11 - Select products 50% OFF >
- * DDX11 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DDX11
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DDX11
-
Santa Cruz Biotechnology (SCBT) CRISPR for DDX11
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DDX11
- Browse OriGene Inhibitory RNA Products For DDX11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX11
Clone Products
- Applied Biological Materials (abm): Clones for DDX11 - Select products 50% OFF >
- * DDX11 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for DDX11
- Addgene plasmids for DDX11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DDX11
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ |
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| ExUns: | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 |
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Relevant External Links for DDX11 Gene
- GeneLoc Exon Structure for
- DDX11
Expression for DDX11 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Thymus (Hematopoietic System)
- Double Negative 2 Thymocytes Thymus
-
Blood (Cardiovascular System)
- Double Negative 2 Thymocytes Thymus
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX11 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DDX11
SOURCE GeneReport for Unigene cluster for DDX11 Gene:
Hs.443960mRNA Expression by UniProt/SwissProt for DDX11 Gene:
Q96FC9-DDX11_HUMAN
Tissue specificity:
Expressed in melanoma cells. Not detected in epidermal melanocytes of normal skin (at protein level) (PubMed:23116066). Highly expressed in spleen, B-cells, thymus, testis, ovary, small intestine and pancreas (PubMed:9013641). Very low expression seen in brain (PubMed:9013641). Expressed in dividing cells and/or cells undergoing high levels of recombination (PubMed:9013641). No expression detected in cells signaled to terminally differentiate (PubMed:9013641). Expressed weakly in keratinocytes (PubMed:8798685).
Evidence on tissue expression from TISSUES for DDX11 Gene
- Skin(4.3)
- Nervous system(3.9)
- Lung(2.6)
- Intestine(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX11 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- forehead
- head
- inner ear
- jaw
- lip
- mandible
- maxilla
- mouth
- outer ear
- skull
Thorax:
- heart
- lung
Limb:
- foot
- hand
- lower limb
- toe
- upper limb
General:
- blood
- blood vessel
- peripheral nervous system
- skin
Primer Products
-
OriGene qPCR primer pairs for DDX11
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for DDX11 Gene
Orthologs for DDX11 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | DDX11 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | DDX11 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ddx11 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | LOC506293 30 |
|
||
| DDX11 31 |
|
OneToOne | |||
| Mouse (Mus musculus) |
Mammalia | Ddx11 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | DDX11 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | DDX11 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | DDX11 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | DDX11 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ddx11 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ddx11 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG11403 30 31 |
|
OneToOne | |
| EG:33C11.2 32 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001537 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | chl-1 30 31 |
|
OneToOne | |
| M03C11.2 32 |
|
|
|||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F27181g 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AGL010W 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CHL1 30 31 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G79890 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU11409 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | chl1 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for DDX11 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for DDX11 Gene
- ENSEMBL:
- Gene Tree for DDX11 (if available)
- TreeFam:
- Gene Tree for DDX11 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DDX11: view image
Paralogs for DDX11 Gene
(7) SIMAP similar genes for DDX11 Gene using alignment to 14 proteins:
- DDX11_HUMAN
- B4DMS8_HUMAN
- C9K0E8_HUMAN
- F5GXJ8_HUMAN
- F5GXL6_HUMAN
- F5GYY1_HUMAN
- F5H235_HUMAN
- F5H2V9_HUMAN
- F6WZM0_HUMAN
- H0YFY8_HUMAN
- H0YGL4_HUMAN
- H0YGX9_HUMAN
- Q2NKM7_HUMAN
- R4GNE1_HUMAN
Pseudogenes.org Pseudogenes for DDX11 Gene
Variants for DDX11 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DDX11 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 638411 | Pathogenic: Warsaw breakage syndrome | 31,103,021(+) | G/T | SPLICE_DONOR_VARIANT | |
| 708407 | Benign: not provided | 31,083,815(+) | G/A | SYNONYMOUS_VARIANT | |
| 708543 | Benign: not provided | 31,103,372(+) | T/C | MISSENSE_VARIANT,SYNONYMOUS_VARIANT | |
| 710450 | Benign: not provided | 31,093,332(+) | C/T | INTRON_VARIANT | |
| 710969 | Likely Benign: not provided | 31,096,738(+) | G/A | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.45;
85.72% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DDX11 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX11 Gene
Disorders for DDX11 Gene
(14) MalaCards diseases for DDX11 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| warsaw breakage syndrome |
|
|
| roberts syndrome |
|
|
| warsaw syndrome |
|
|
| chronic atrial and intestinal dysrhythmia |
|
|
| fanconi anemia, complementation group j |
|
|
Search DDX11 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
DDX11_HUMAN- Warsaw breakage syndrome (WBRS) [MIM:613398]: A syndrome characterized by severe microcephaly, pre- and postnatal growth retardation, facial dysmorphism and abnormal skin pigmentation. Additional features include high arched palate, coloboma of the right optic disk, deafness, ventricular septal defect, toes and fingers abnormalities. At cellular level, drug-induced chromosomal breakage, a feature of Fanconi anemia, and sister chromatid cohesion defects, a feature of Roberts syndrome, coexist. {ECO:0000269 PubMed:20137776, ECO:0000269 PubMed:23033317, ECO:0000269 PubMed:26089203}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for DDX11
No data available for Genatlas for DDX11 Gene
Publications for DDX11 Gene
- Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1. (PMID: 18499658) Farina A … Hurwitz J (The Journal of biological chemistry 2008) 3 4 23
- Characterization of the enzymatic activity of hChlR1, a novel human DNA helicase. (PMID: 10648783) Hirota Y … Lahti JM (Nucleic acids research 2000) 3 4 23
- Characterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1. (PMID: 9013641) Amann J … Lahti JM (The Journal of biological chemistry 1997) 3 4 23
- The human homologue of the yeast CHL1 gene is a novel keratinocyte growth factor-regulated gene. (PMID: 8798685) Frank S … Werner S (The Journal of biological chemistry 1996) 3 4 23
- Tim/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathway. (PMID: 26503245) Calì F … Pisani FM (Nucleic acids research 2016) 3 4
ExternalLinks
Products for DDX11 Gene
- Custom Antibody ServicesOriGene Antibodies for DDX11
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for DDX11
- Origene Custom Protein Services for DDX11
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DDX11
- Browse OriGene Inhibitory RNA Products For DDX11
- OriGene qPCR primer pairs for DDX11
- OriGene CRISPR knockouts for DDX11
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DDX11
- Sino Biological Human cDNA Clone for DDX11
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for DDX11
- Novus Biologicals proteins and lysates for DDX11
- Browse Antibodies
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- Invitrogen Antibodies for DDX11 (AFLGC-DDX11)
- VectorBuilder Custom and pre-made DNA vectors for DDX11 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for DDX11 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for DDX11 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for DDX11 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for DDX11
- Addgene plasmids for DDX11
- antibodies-online: Show 21 available DDX11 Antibodies ranked by validation data
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- antibodies-online: Show 12 available DDX11 Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Show 4 available DDX11 Proteins ranked by validation data
- Compare Top DDX11 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for DDX11
- Search Santa Cruz Biotechnology (SCBT) for DDX11 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DDX11
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DDX11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DDX11
- Search GeneCopoeia for miRNA 3'UTR Target clone products for DDX11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX11
- Boster Bio Antibodies for DDX11
- Browse Boster Bio ELISA Kits
- Signalway Proteins for DDX11
Sources for DDX11 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB