DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this fami... See more...

Aliases for DDX10 Gene

Aliases for DDX10 Gene

  • DEAD-Box Helicase 10 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 10 (RNA Helicase) 2 3
  • Probable ATP-Dependent RNA Helicase DDX10 3 4
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 10 2 3
  • DEAD Box Protein 10 3 4
  • DDX10-NUP98 Fusion Protein Type 2 3
  • EC 3.6.4.13 4
  • EC 3.6.1 52
  • HRH-J8 3
  • Dbp4 3

External Ids for DDX10 Gene

Previous GeneCards Identifiers for DDX10 Gene

  • GC11P110792
  • GC11P109988
  • GC11P108073
  • GC11P108041
  • GC11P104461

Summaries for DDX10 Gene

Entrez Gene Summary for DDX10 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX10 Gene

DDX10 (DEAD-Box Helicase 10) is a Protein Coding gene. Diseases associated with DDX10 include Myelodysplastic Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is DDX18.

UniProtKB/Swiss-Prot Summary for DDX10 Gene

Gene Wiki entry for DDX10 Gene

Additional gene information for DDX10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DDX10 Gene

Genomics for DDX10 Gene

GeneHancer (GH) Regulatory Elements for DDX10 Gene

Promoters and enhancers for DDX10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J108663 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 506.2 +0.3 264 2.6 FOXK2 ZBTB40 SIN3A NRF1 POLR2G USF1 SP1 PHF8 JUND POLR2A DDX10 piR-45874-044
GH11J108666 Enhancer 0.4 ENCODE 500.7 +1.7 1726 0 RBM25 SRF CTCF KDM1A PRDM10 DDX10 piR-45874-044
GH11J108008 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 -655.0 -655027 3.6 EP300 CTCF SIN3A USF1 POLR2G SP1 PHF8 ZFX ZNF10 ZIC2 CUL5 ENSG00000288012 NONHSAG009537.2 NPAT DDX10 ACAT1 piR-33614-046
GH11J108120 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.1 -543.1 -543144 2.6 HNRNPK CTCF NRF1 USF1 POLR2G SP1 NCOR1 PHF8 ZFX ZIC2 ACAT1 ENSG00000255467 DDX10 POGLUT3 piR-41206
GH11J108465 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.1 -197.9 -197900 3.1 ZBTB40 ZNF217 EP300 SIN3A POLR2G SP1 GTF2E2 PHF8 JUND PHB2 C11orf65 hsa-miR-5095-078 POGLUT3 DDX10 ACAT1 piR-61240-062
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DDX10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DDX10

Top Transcription factor binding sites by QIAGEN in the DDX10 gene promoter:
  • CREB
  • deltaCREB
  • E47
  • FOXD3
  • GATA-1
  • Nkx2-5
  • Pax-5
  • POU2F1
  • POU2F1a
  • Tal-1

Genomic Locations for DDX10 Gene

Genomic Locations for DDX10 Gene
chr11:108,665,025-108,940,930
(GRCh38/hg38)
Size:
275,906 bases
Orientation:
Plus strand
chr11:108,535,752-108,811,657
(GRCh37/hg19)
Size:
275,906 bases
Orientation:
Plus strand

Genomic View for DDX10 Gene

Genes around DDX10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX10 Gene

Proteins for DDX10 Gene

  • Protein details for DDX10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13206-DDX10_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX10
    Protein Accession:
    Q13206
    Secondary Accessions:
    • B2RCQ3
    • Q5BJD8

    Protein attributes for DDX10 Gene

    Size:
    875 amino acids
    Molecular mass:
    100888 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DDX10 Gene

neXtProt entry for DDX10 Gene

Selected DME Specific Peptides for DDX10 Gene

Q13206:
  • DLARLSL
  • GKDVLGAA
  • TGSGKTLA
  • AKTGSGKT
  • DEADRIL
  • IISPTREL
  • SPTRELA
  • LVLDEADR
  • RQTLLFSAT
  • ARGLDFPA

Post-translational modifications for DDX10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DDX10 Gene

Gene Families for DDX10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DDX10 Gene

Suggested Antigen Peptide Sequences for DDX10 Gene

GenScript: Design optimal peptide antigens:
  • DEAD box protein 10 (DDX10_HUMAN)
  • DDX10 protein (Q86VR6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13206

UniProtKB/Swiss-Prot:

DDX10_HUMAN :
  • The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
  • Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.
Domain:
  • The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Family:
  • Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.
genes like me logo Genes that share domains with DDX10: view

Function for DDX10 Gene

Molecular function for DDX10 Gene

UniProtKB/Swiss-Prot Function:
Putative ATP-dependent RNA helicase.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;.
GENATLAS Biochemistry:
DEAD/H box protein 10,ubiquitously expressed,fused with NUP98 in de novo or therapy related myeloid maligancies with inv 11(p15-q22)

Enzyme Numbers (IUBMB) for DDX10 Gene

Phenotypes From GWAS Catalog for DDX10 Gene

Gene Ontology (GO) - Molecular Function for DDX10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IBA 21873635
GO:0003724 RNA helicase activity IEA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX10: view
genes like me logo Genes that share phenotypes with DDX10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DDX10

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX10 Gene

Localization for DDX10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX10 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DDX10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with DDX10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DDX10 Gene

Pathways & Interactions for DDX10 Gene

PathCards logo

SuperPathways for DDX10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IBA 21873635
GO:0097065 anterior head development IEA --
genes like me logo Genes that share ontologies with DDX10: view

No data available for Pathways by source and SIGNOR curated interactions for DDX10 Gene

Drugs & Compounds for DDX10 Gene

(3) Drugs for DDX10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for DDX10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with DDX10: view

Transcripts for DDX10 Gene

mRNA/cDNA for DDX10 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX10 Gene

No ASD Table

Relevant External Links for DDX10 Gene

GeneLoc Exon Structure for
DDX10

Expression for DDX10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DDX10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX10 Gene

This gene is overexpressed in Lung (10.9), Testis (6.9), Blymphocyte (6.7), Fetal heart (6.5), Frontal cortex (6.2), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX10 Gene



Protein tissue co-expression partners for DDX10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DDX10

SOURCE GeneReport for Unigene cluster for DDX10 Gene:

Hs.591931

mRNA Expression by UniProt/SwissProt for DDX10 Gene:

Q13206-DDX10_HUMAN
Tissue specificity: High in testis but widely expressed.

Evidence on tissue expression from TISSUES for DDX10 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with DDX10: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX10 Gene

Orthologs for DDX10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX10 31 30
  • 99.43 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DDX10 31 30
  • 89.45 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DDX10 31 30
  • 89.32 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx10 30
  • 86.44 (n)
mouse
(Mus musculus)
Mammalia Ddx10 17 31 30
  • 86.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DDX10 31
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDX10 31
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDX10 31 30
  • 70.59 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDX10 31
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx10 30
  • 66.06 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14681 30
zebrafish
(Danio rerio)
Actinopterygii ddx10 31 30
  • 64.87 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001057 30
  • 57.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5800 31 32 30
  • 53.46 (n)
OneToOne
CG9630 32
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea Y23H5B.6 31 32 30
  • 54.22 (n)
OneToOne
ZK512.2 32
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HCA4 33 31
  • 40 (a)
rice
(Oryza sativa)
Liliopsida Os.24708 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 52 (a)
OneToOne
Cin.10849 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10849 30
Species where no ortholog for DDX10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX10 Gene

ENSEMBL:
Gene Tree for DDX10 (if available)
TreeFam:
Gene Tree for DDX10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DDX10: view image

Paralogs for DDX10 Gene

(15) SIMAP similar genes for DDX10 Gene using alignment to 3 proteins:

  • DDX10_HUMAN
  • E9PIF2_HUMAN
  • Q86VR6_HUMAN

Pseudogenes.org Pseudogenes for DDX10 Gene

genes like me logo Genes that share paralogs with DDX10: view

Variants for DDX10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DDX10 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
777859 Likely Benign: not provided 108,665,284(+) C/G MISSENSE_VARIANT
790363 Benign: not provided 108,679,558(+) T/C SYNONYMOUS_VARIANT
790364 Benign: not provided 108,723,060(+) C/T SYNONYMOUS_VARIANT
rs116953461 Benign: not specified 108,715,890(+) A/G MISSENSE_VARIANT
VAR_035840 A breast cancer sample p.Leu566Val

Additional dbSNP identifiers (rs#s) for DDX10 Gene

Structural Variations from Database of Genomic Variants (DGV) for DDX10 Gene

Variant ID Type Subtype PubMed ID
esv23672 CNV loss 19812545
esv2660905 CNV deletion 23128226
esv2673710 CNV deletion 23128226
esv2675797 CNV deletion 23128226
esv2761707 CNV loss 21179565
esv3579905 CNV loss 25503493
esv3627681 CNV gain 21293372
esv3627682 CNV gain 21293372
esv3627683 CNV loss 21293372
esv3627684 CNV loss 21293372
esv3627685 CNV loss 21293372
esv3627686 CNV gain 21293372
esv3627688 CNV gain 21293372
esv3627689 CNV loss 21293372
esv3627690 CNV loss 21293372
nsv1145569 CNV deletion 24896259
nsv39083 CNV deletion 16902084
nsv826084 CNV gain 20364138
nsv832264 CNV gain+loss 17160897
nsv930473 CNV insertion 23359205
nsv972070 CNV duplication 23825009
nsv972071 CNV duplication 23825009

Variation tolerance for DDX10 Gene

Residual Variation Intolerance Score: 38.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DDX10 Gene

Human Gene Mutation Database (HGMD)
DDX10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX10 Gene

Disorders for DDX10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DDX10 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myelodysplastic syndrome
  • mds
- elite association - COSMIC cancer census association via MalaCards
Search DDX10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DDX10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DDX10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DDX10 Gene

Publications for DDX10 Gene

  1. A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23. (PMID: 8660968) Savitsky K … Rotman G (Genomics 1996) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Fusion of the nucleoporin gene, NUP98, and the putative RNA helicase gene, DDX10, by inversion 11 (p15q22) chromosome translocation in a patient with etoposide-related myelodysplastic syndrome. (PMID: 10830185) Nakao K … Ohki M (Internal medicine (Tokyo, Japan) 2000) 3 23 54
  4. The inv(11)(p15q22) chromosome translocation of therapy-related myelodysplasia with NUP98-DDX10 and DDX10-NUP98 fusion transcripts. (PMID: 10222653) Ikeda T … Takahara J (International journal of hematology 1999) 3 23 54
  5. The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10. (PMID: 9166830) Arai Y … Ohki M (Blood 1997) 3 23 54

Products for DDX10 Gene

Sources for DDX10 Gene