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This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. Th... See more...
Aliases for DDR2 Gene
Aliases for DDR2 Gene
- Discoidin Domain Receptor Tyrosine Kinase 2 2 3 5
- Discoidin Domain-Containing Receptor Tyrosine Kinase 2 3 4
- Discoidin Domain Receptor Family, Member 2 2 3
- Discoidin Domain-Containing Receptor 2 3 4
- Receptor Protein-Tyrosine Kinase TKT 3 4
- CD167 Antigen-Like Family Member B 3 4
- Tyrosine-Protein Kinase TYRO10 3 4
- Discoidin Domain Receptor 2 3 4
- EC 2.7.10.1 4 52
- NTRKR3 3 4
External Ids for DDR2 Gene
- HGNC: 2731
- Entrez Gene: 4921
- Ensembl: ENSG00000162733
- OMIM: 191311
- UniProtKB: Q16832
Previous HGNC Symbols for DDR2 Gene
- TYRO10
- NTRKR3
Previous GeneCards Identifiers for DDR2 Gene
- GC01P160237
- GC01P158253
- GC01P159297
- GC01P159789
- GC01P159333
- GC01P160868
- GC01P162601
- GC01P133847
Summaries for DDR2 Gene
-
This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. [provided by RefSeq, Aug 2017]
GeneCards Summary for DDR2 Gene
DDR2 (Discoidin Domain Receptor Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with DDR2 include Spondylometaepiphyseal Dysplasia, Short Limb-Hand Type and Warburg-Cinotti Syndrome. Among its related pathways are ERK Signaling and Nanog in Mammalian ESC Pluripotency. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DDR1.
UniProtKB/Swiss-Prot Summary for DDR2 Gene
-
Tyrosine kinase involved in the regulation of tissues remodeling (PubMed:30449416). It functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
Additional gene information for DDR2 Gene
- Monarch Initiative
- Search for DDR2 at DataMed
- Search for DDR2 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DDR2 Gene
Genomics for DDR2 Gene
GeneHancer (GH) Regulatory Elements for DDR2 Gene
Promoters and enhancers for DDR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DDR2 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DDR2
- Top Transcription factor binding sites by QIAGEN in the DDR2 gene promoter:
-
- aMEF-2
- Evi-1
- Hlf
- HNF-3beta
- MEF-2A
- Nkx2-5
- p53
- SREBP-1a
- SREBP-1b
- SREBP-1c
Genomic Locations for DDR2 Gene
Genomic Locations for DDR2 Gene
- chr1:162,631,265-162,787,405
- (GRCh38/hg38)
- Size:
- 156,141 bases
- Orientation:
- Plus strand
- chr1:162,601,163-162,757,190
- (GRCh37/hg19)
- Size:
- 156,028 bases
- Orientation:
- Plus strand
Genomic View for DDR2 Gene
Genes around DDR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q23.3 by HGNC
- 1q23.3 by Entrez Gene
- 1q23.3 by Ensembl
DDR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DDR2 Gene
Proteins for DDR2 Gene
-
Protein details for DDR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16832-DDR2_HUMAN
- Recommended name:
- Discoidin domain-containing receptor 2
- Protein Accession:
- Q16832
- Q7Z730
Protein attributes for DDR2 Gene
- Size:
- 855 amino acids
- Molecular mass:
- 96736 Da
- Quaternary structure:
-
- Binds hydroxyproline-rich sequence motifs in fibrillar, glycosylated collagen, such as the GQOGVMGFO motif, where O stands for hydroxyproline. Interacts with SRC. Interacts (tyrosine phosphorylated) with SHC1.
Protein Expression for DDR2 Gene
Selected DME Specific Peptides for DDR2 Gene
- Q16832:
-
- YSGDYYR
- YMENGDLNQFL
- HRDLATRN
- FVHRDLATRNC
- DPLCMIT
- VWPGYDYVGW
- GEFFRDQGRQ
- ILIGCLVAII
- LVGTQGRHAGG
- GDGAWCP
- KNARNDFLKE
- QGRAVLPIRWM
- FVHRDLA
- LQGVTGGNTY
- SDVWAFGVT
Post-translational modifications for DDR2 Gene
- N-glycosylated.
- Tyrosine phosphorylated in response to collagen binding. Phosphorylated by SRC; this is required for activation and subsequent autophosphorylation on additional tyrosine residues.
-
Glycosylation at Asn121, Asn213, Asn261, Asn280, and Asn372
- NX_Q16832 (NX_Q16832-1)
- Modification sites at PhosphoSitePlus
Other Protein References for DDR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ DDR2 Antibody
- NSJ Bioreagents DDR2 Antibody
-
Creative Biolabs
- Afuco™ Anti-Human DDR2 ADCC Therapeutic Antibody, ADCC Enhanced
- Anti-Human DDR2 Therapeutic Antibody (9M57)
- Anti-Human DDR2 Therapeutic Antibody Fab Fragment (9M57)
- Anti-Human DDR2 Therapeutic Antibody (9M58)
- Anti-Human DDR2 Therapeutic Antibody Fab Fragment (9M58)
- Anti-Human DDR2 Therapeutic Antibody
- Recombinant Mouse Anti-Human DDR2 Antibody (clone 4C22F5)
- Hi-Affi™ Recombinant Rabbit Anti-DDR2 Monoclonal Antibody (DS954AB)
- Mouse Anti-DDR2 Monoclnal Antibody (3B11E4)
- Rabbit Anti-DDR2 Monoclnal Antibody (EPR5179(2))
-
Custom Antibody ServicesOriGene Antibodies for DDR2
- Novus Biologicals Antibodies for DDR2
-
Abcam antibodies for DDR2
- Invitrogen Antibodies for DDR2 (AFLGC-DDR2)
-
Santa Cruz Biotechnology (SCBT) Antibodies for DDR2
- Sino Biological Antibodies for DDR2
Protein Products
-
Creative Biomart
- Recombinant Human DDR2
- Recombinant Human DDR2 cell lysate (DDR2-1033HCL)
- Recombinant Human DDR2, His & GST tagged
- Recombinant Human DDR2, None tagged
- Recombinant Human DDR2 cell lysate (DDR2-001HCL)
- Recombinant Human DDR2, GST-tagged
- Recombinant Human DDR2, Fc tagged
- Recombinant Human DDR2, His tagged
- Recombinant Human DDR2 Protein, DDK/His-tagged
- Recombinant Human DDR2 Protein, MYC/DDK-tagged
- Recombinant Human DDR2 protein, His & T7-tagged
- Recombinant Human DDR2 Protein, GST-His-tagged
- Recombinant Human DDR2 Protein, DDK-tagged
- Recombinant Human DDR2 protein, Flag-tagged, Biotinylated
- Search Origene for MassSpec and Protein Over-expression Lysates for DDR2
- Origene Custom Protein Services for DDR2
- Sino Biological Recombinant Proteins for DDR2
- Sino Biological Cell Lysates for DDR2
- ProSpec Recombinant Proteins for DDR2
-
Abcam proteins for DDR2
Assay Products
- Aviva Systems Biology DDR2 ELISA Kit (Human) (OKEH04200) and DDR2 ELISA Kit (Human) (OKCD07031)
Domains & Families for DDR2 Gene
Gene Families for DDR2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Disease related genes
- Enzymes
- FDA approved drug targets
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for DDR2 Gene
- Blocks:
-
- Tyrosine protein kinase, active site
- Coagulation factor 5/8 type C domain (FA58C)
- Receptor tyrosine kinase, class II
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DDR2 Gene
- GenScript: Design optimal peptide antigens:
-
- Tyrosine-protein kinase TYRO10 (DDR2_HUMAN)
- Discoidin domain receptor tyrosine kinase 2 (Q5T241_HUMAN)
- Discoidin domain receptor tyrosine kinase 2 (Q5T242_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q16832UniProtKB/Swiss-Prot:
DDR2_HUMAN :- Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Function for DDR2 Gene
Molecular function for DDR2 Gene
- UniProtKB/Swiss-Prot Function:
- Tyrosine kinase involved in the regulation of tissues remodeling (PubMed:30449416). It functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255 PROSITE-ProRule:PRU10028, ECO:0000269 PubMed:16186108, ECO:0000269 PubMed:20004161};.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Present in an inactive state in the absence of collagen binding and phosphorylation by SRC. Tyrosine phosphorylation enhances the affinity for ATP and the catalytic activity.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated during osteoblast differentiation (in vitro). Up-regulated in cartilage from osteoarthritis patients.
- GENATLAS Biochemistry:
- discoidin domain recptor family,member 2,expressed in heart and lung
Enzyme Numbers (IUBMB) for DDR2 Gene
Phenotypes From GWAS Catalog for DDR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004713 | protein tyrosine kinase activity | IEA | -- |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IDA,TAS | 20004161 |
| GO:0005515 | protein binding | IPI | 17703188 |
| GO:0005518 | collagen binding | IDA,IBA | 20004161 |
Phenotypes for DDR2 Gene
- MGI mutant phenotypes for DDR2:
-
inferred from 8 alleles
- cardiovascular system phenotype
- limbs/digits/tail phenotype
- vision/eye phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- no phenotypic analysis
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- craniofacial phenotype
- reproductive system phenotype
- skeleton phenotype
- adipose tissue phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for DDR2:
-
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased viability in esophageal squamous lineage
- Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection
- Decreased cella89culturea89derived Hepatitis C virus (HCVcc; Luca89Jc1) infection
- Increased cell migration
- Decreased cell migration
- Increased cell viability after pRB stimulation
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Increased viability
- Increased transferrin (TF) endocytosis
Animal Models for DDR2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DDR2 - Select products 50% OFF >
- * DDR2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * DDR2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for DDR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DDR2
- genomics-online: gRNA clones - Search for available DDR2 gRNA products
- Overview of 162 available DDR2 gene related products
-
Recommended
-
Santa Cruz Biotechnology (SCBT) CRISPR for DDR2
miRNA for DDR2 Gene
- miRTarBase miRNAs that target DDR2
-
- hsa-mir-21-5p (MIRT030671)
- hsa-mir-943 (MIRT497448)
- hsa-mir-4439 (MIRT497449)
- hsa-mir-3136-5p (MIRT497450)
- hsa-mir-5189-3p (MIRT497451)
- hsa-mir-6857-3p (MIRT497452)
- hsa-mir-6855-3p (MIRT497453)
- hsa-mir-4513 (MIRT497454)
- hsa-mir-4637 (MIRT497455)
- hsa-mir-520e (MIRT497456)
- hsa-mir-520d-3p (MIRT497457)
- hsa-mir-520c-3p (MIRT497458)
- hsa-mir-520b (MIRT497459)
- hsa-mir-520a-3p (MIRT497460)
- hsa-mir-373-3p (MIRT497461)
- hsa-mir-372-3p (MIRT497462)
- hsa-mir-302e (MIRT497463)
- hsa-mir-302d-3p (MIRT497464)
- hsa-mir-302c-3p (MIRT497465)
- hsa-mir-302b-3p (MIRT497466)
- hsa-mir-302a-3p (MIRT497467)
- hsa-mir-519c-3p (MIRT497468)
- hsa-mir-519b-3p (MIRT497469)
- hsa-mir-519a-3p (MIRT497470)
- hsa-mir-618 (MIRT497471)
- hsa-mir-6826-3p (MIRT659136)
- hsa-mir-3928-3p (MIRT659137)
- hsa-mir-302a-5p (MIRT659138)
- hsa-mir-6859-5p (MIRT659139)
- hsa-mir-3125 (MIRT659140)
- hsa-mir-3916 (MIRT659141)
- hsa-mir-3119 (MIRT659142)
- hsa-mir-645 (MIRT659143)
- hsa-mir-6749-3p (MIRT668753)
- hsa-mir-6792-3p (MIRT668754)
- hsa-mir-6883-3p (MIRT668755)
- hsa-mir-4691-5p (MIRT668756)
- hsa-mir-7976 (MIRT668757)
- hsa-mir-6759-3p (MIRT668758)
- hsa-mir-4732-3p (MIRT668759)
- hsa-mir-454-5p (MIRT668760)
- hsa-mir-6756-3p (MIRT668761)
- hsa-mir-4704-3p (MIRT668762)
- hsa-mir-506-5p (MIRT668763)
- hsa-mir-892c-5p (MIRT668764)
- hsa-mir-129-2-3p (MIRT668765)
- hsa-mir-129-1-3p (MIRT668766)
- hsa-mir-6779-3p (MIRT668767)
- hsa-mir-4687-5p (MIRT668768)
- hsa-mir-1183 (MIRT735884)
- hsa-mir-2053 (MIRT738840)
- hsa-mir-3152-3p (MIRT740370)
- hsa-mir-4474-5p (MIRT745013)
- hsa-mir-520f-5p (MIRT750246)
- hsa-mir-548a-3p (MIRT750463)
- hsa-mir-548ar-3p (MIRT750580)
- hsa-mir-548az-3p (MIRT750643)
- hsa-mir-548e-3p (MIRT750696)
- hsa-mir-548f-3p (MIRT750706)
- hsa-mir-548g-3p (MIRT750719)
- hsa-mir-5582-3p (MIRT750942)
- hsa-mir-569 (MIRT751329)
- hsa-mir-633 (MIRT752660)
- hsa-mir-6817-3p (MIRT756824)
- hsa-mir-6873-3p (MIRT758048)
- hsa-mir-6895-3p (MIRT758793)
- hsa-mir-7110-3p (MIRT758966)
- hsa-mir-8066 (MIRT760069)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DDR2
- Browse OriGene Inhibitory RNA Products For DDR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDR2
- genomics-online: shRNA clones - Search for available DDR2 shRNA products
- Overview of 162 available DDR2 gene related products
-
Recommended
Clone Products
- Applied Biological Materials (abm): Clones for DDR2 - Select products 50% OFF >
- * DDR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * DDR2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- RC402797
- RC402798
- RC402799
- RC208745
- RC211389
- RC600062
- RG208745
- RG211389
- MR222870
- MG222870
- RR211892
- RC208745L3
- RC208745L3V
- RC208745L4
- RC208745L4V
- RC211389L1
- RC211389L1V
- RC211389L2
- RC211389L2V
- RC211389L3
- RC211389L3V
- RC211389L4
- RC211389L4V
- MR222870L3
- MR222870L3V
- MR222870L4
- MR222870L4V
- RR211892L3
- RR211892L3V
- RR211892L4
- RR211892L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DDR2
- Addgene plasmids for DDR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DDR2
- genomics-online: cdna clones - Search for available DDR2 CDNA products
- Overview of 162 available DDR2 gene related products
-
Recommended
- orf clones - Search for available DDR2 ORF products
- Overview of 162 available DDR2 gene related products
-
Recommended
Cell Line Products
-
Horizon Cell Lines for DDR2
No data available for Transcription Factor Targets and HOMER Transcription for DDR2 Gene
Localization for DDR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DDR2 Gene
- Cell membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 4 |
| extracellular | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| mitochondrion | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| peroxisome | 0 |
- Plasma membrane (3)
- Actin filaments (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IBA,TAS | 21873635 |
| GO:0005925 | focal adhesion | HDA | 21423176 |
| GO:0015629 | actin cytoskeleton | IDA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for DDR2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
|
| 2 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
| 3 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.61
Nanog in Mammalian ESC Pluripotency
.61
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
| 4 | Actin Nucleation by ARP-WASP Complex |
Actin Nucleation and Branching
.66
Actin Nucleation by ARP-WASP Complex
.66
|
CDC42 Pathway
.41
|
| 5 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
|
Activation of PKA through GPCR
.71
|
Pathways by source for DDR2 Gene
1 BioSystems pathway for DDR2 Gene
2 Reactome pathways for DDR2 Gene
1 R&D Systems pathway for DDR2 Gene
29 Qiagen pathways for DDR2 Gene
- 14-3-3 Induced Intracellular Signaling
- Actin Nucleation and Branching
- Actin Nucleation by ARP-WASP Complex
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
2 Cell Signaling Technology pathways for DDR2 Gene
Interacting Proteins for DDR2 Gene
Selected Interacting proteins:
Q16832-DDR2_HUMAN
ENSP00000356899
for DDR2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for DDR2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001503 | ossification | IEA | -- |
| GO:0003416 | endochondral bone growth | ISS | -- |
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0007155 | cell adhesion | TAS | 9659899 |
| GO:0007165 | signal transduction | TAS | 9659899 |
Drugs & Compounds for DDR2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| regorafenib | Approved | Pharma | inhibitor, Target | Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | |
| Tyrosine | Approved, Investigational | Nutra | 985 | |||
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| Dasatinib | Approved, Investigational | Pharma | Inhibition, inhibitor | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 319 | |
| Sorafenib | Approved, Investigational | Pharma | inhibitors, inhibitor | Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 771 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
Drug Products
-
Creative Biomart
- Recombinant Human DDR2
- Recombinant Human DDR2 cell lysate (DDR2-1033HCL)
- Recombinant Human DDR2, His & GST tagged
- Recombinant Human DDR2, None tagged
- Recombinant Human DDR2 cell lysate (DDR2-001HCL)
- Recombinant Human DDR2, GST-tagged
- Recombinant Human DDR2, Fc tagged
- Recombinant Human DDR2, His tagged
- Recombinant Human DDR2 Protein, DDK/His-tagged
- Recombinant Human DDR2 Protein, MYC/DDK-tagged
- Recombinant Human DDR2 protein, His & T7-tagged
- Recombinant Human DDR2 Protein, GST-His-tagged
- Recombinant Human DDR2 Protein, DDK-tagged
- Recombinant Human DDR2 protein, Flag-tagged, Biotinylated
Transcripts for DDR2 Gene
mRNA/cDNA for DDR2 Gene
- 4 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000367921 10086 bps (ENST00000367921.8)
- ENST00000367922 10160 bps (ENST00000367922.7)
- ENST00000415555 718 bps (ENST00000415555.5)
- ENST00000433757 693 bps (ENST00000433757.1)
- ENST00000446985 2998 bps (ENST00000446985.6)
- 2 RNACentral transcripts :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DDR2 - Select products 50% OFF >
- * DDR2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * DDR2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for DDR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DDR2
- genomics-online: gRNA clones - Search for available DDR2 gRNA products
- Overview of 162 available DDR2 gene related products
-
Recommended
-
Santa Cruz Biotechnology (SCBT) CRISPR for DDR2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DDR2
- Browse OriGene Inhibitory RNA Products For DDR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDR2
- genomics-online: shRNA clones - Search for available DDR2 shRNA products
- Overview of 162 available DDR2 gene related products
-
Recommended
Clone Products
- Applied Biological Materials (abm): Clones for DDR2 - Select products 50% OFF >
- * DDR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * DDR2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- RC402797
- RC402798
- RC402799
- RC208745
- RC211389
- RC600062
- RG208745
- RG211389
- MR222870
- MG222870
- RR211892
- RC208745L3
- RC208745L3V
- RC208745L4
- RC208745L4V
- RC211389L1
- RC211389L1V
- RC211389L2
- RC211389L2V
- RC211389L3
- RC211389L3V
- RC211389L4
- RC211389L4V
- MR222870L3
- MR222870L3V
- MR222870L4
- MR222870L4V
- RR211892L3
- RR211892L3V
- RR211892L4
- RR211892L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DDR2
- Addgene plasmids for DDR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DDR2
- genomics-online: cdna clones - Search for available DDR2 CDNA products
- Overview of 162 available DDR2 gene related products
-
Recommended
- orf clones - Search for available DDR2 ORF products
- Overview of 162 available DDR2 gene related products
-
Recommended
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: |
Relevant External Links for DDR2 Gene
- GeneLoc Exon Structure for
- DDR2
Expression for DDR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Fibroblasts
- Mature Cardiac Fibroblasts Myocardium
- Cardiac Fibroblasts Myocardium
- Fibroblasts (family)
- Cardiac fibroblasts
- Detroit 551
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
- Metanephros
-
Heart (Cardiovascular System)
- Mature Cardiac Fibroblasts Myocardium
- Cardiac Fibroblasts Myocardium
- Cardiac fibroblasts
- Intermediate Mesoderm (Gastrulation Derivatives)
- Dermis (Integumentary System)
- Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for DDR2 Gene
This gene is overexpressed in Adrenal Gland (x4.5).
This gene is overexpressed in Adrenal (26.4), Colon (11.8), Rectum (8.3), and Urinary Bladder (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDR2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DDR2
SOURCE GeneReport for Unigene cluster for DDR2 Gene:
Hs.275757mRNA Expression by UniProt/SwissProt for DDR2 Gene:
Q16832-DDR2_HUMAN
Tissue specificity:
Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney.
Evidence on tissue expression from TISSUES for DDR2 Gene
- Heart(4.5)
- Skin(4.5)
- Nervous system(3.4)
- Lung(2.4)
- Muscle(2.2)
- Bone(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for DDR2 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cheek
- chin
- eye
- eyelid
- face
- forehead
- head
- jaw
- mandible
- maxilla
- meninges
- mouth
- neck
- nose
- skull
Thorax:
- chest wall
- clavicle
- lung
- rib
- rib cage
- scapula
- sternum
- trachea
Pelvis:
- pelvis
Limb:
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- thigh
- tibia
- toe
- ulna
- upper limb
General:
- skin
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for DDR2
-
OriGene qPCR primer pairs and template standards for DDR2
- genomics-online: primer clones - Search for available DDR2 Primer products
- Overview of 162 available DDR2 gene related products
-
Recommended
Gene Expression Assay Products
Orthologs for DDR2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DDR2 31 30 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | DDR2 31 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | DDR2 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | DDR2 31 30 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ddr2 17 31 30 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ddr2 30 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | DDR2 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DDR2 30 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | DDR2 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100497889 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ddr2a 31 30 |
|
OneToMany | |
| ddr2b 31 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Ddr 31 30 |
|
ManyToMany | |
| CG34380 31 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | ddr-2 31 30 |
|
OneToMany | |
| F11D5.3a 32 |
|
|
|||
| F11D5.3b 32 |
|
|
|||
| C25F6.4 32 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1149 31 |
|
OneToMany |
- Species where no ortholog for DDR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for DDR2 Gene
- ENSEMBL:
- Gene Tree for DDR2 (if available)
- TreeFam:
- Gene Tree for DDR2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DDR2: view image
Paralogs for DDR2 Gene
Paralogs for DDR2 Gene
- DDR1 5
- NTRK3 5
- MUSK 5
- INSR 5
- IGF1R 5
- KDR 5
- TIE1 5
- AXL 5
- FGFR2 5
- NTRK2 5
- INSRR 5
- EPHA3 5
- EPHA5 5
- EPHB1 5
- PDGFRB 5
- FLT4 5
- EPHA1 5
- TYRO3 5
- FLT1 5
- EPHA7 5
- NTRK1 5
- ERBB3 5
- FGFR4 5
- EGFR 5
- EPHA2 5
- ERBB2 5
- ROR2 5
- CSF1R 5
- FGFR1 5
- EPHA6 5
- MERTK 5
- TEK 5
- EPHA4 5
- ALK 5
- EPHB2 5
- RET 5
- EPHB3 5
- MET 5
- KIT 5
- ROS1 5
- FGFR3 5
- MST1R 5
- ROR1 5
- EPHA8 5
- PDGFRA 5
- ERBB4 5
- EPHB4 5
- LTK 5
- FLT3 5
- EPHA10 5
- EPHB6 5
- RYK 5
- ENSG00000282278 5
- LMTK2 5
(5) SIMAP similar genes for DDR2 Gene using alignment to 5 proteins:
- DDR2_HUMAN
- H0Y570_HUMAN
- Q5T241_HUMAN
- Q5T244_HUMAN
- Q5T245_HUMAN
Variants for DDR2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DDR2 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 12316 | Pathogenic: Spondylometaepiphyseal dysplasia short limb-hand type | 162,776,371(+) | G/A | SPLICE_DONOR_VARIANT | |
| 587431 | Uncertain Significance: Spondylometaepiphyseal dysplasia short limb-hand type | 162,755,246(+) | A/T | MISSENSE_VARIANT | |
| rs1057519789 | Likely Pathogenic: Non-small cell lung cancer; Squamous cell lung carcinoma | 162,775,707(+) | A/T | MISSENSE_VARIANT | |
| rs1057519790 | Likely Pathogenic: Non-small cell lung cancer; Squamous cell lung carcinoma | 162,778,617(+) | G/T | MISSENSE_VARIANT | |
| rs115169993 | Benign: Non-small cell lung cancer; Squamous cell lung carcinoma; not specified | 162,772,032(+) | G/A | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3387297 | CNV | insertion | 20981092 |
| esv3587752 | CNV | loss | 21293372 |
| nsv1120073 | OTHER | inversion | 24896259 |
| nsv1122414 | CNV | deletion | 24896259 |
| nsv3299 | CNV | insertion | 18451855 |
| nsv478620 | CNV | novel sequence insertion | 20440878 |
| nsv516482 | CNV | gain+loss | 19592680 |
Residual Variation Intolerance Score:
19.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.28;
40.84% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DDR2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDR2 Gene
Disorders for DDR2 Gene
(20) MalaCards diseases for DDR2 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spondylometaepiphyseal dysplasia, short limb-hand type |
|
|
| warburg-cinotti syndrome |
|
|
| squamous cell carcinoma |
|
|
| lung cancer |
|
|
| lung large cell carcinoma |
|
|
Search DDR2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
DDR2_HUMAN- Spondyloepimetaphyseal dysplasia short limb-hand type (SEMD-SL) [MIM:271665]: A bone disease characterized by short-limbed dwarfism, a narrow chest with pectus excavatum, brachydactyly in the hands and feet, a characteristic craniofacial appearance and premature calcifications. The radiological findings are distinctive and comprise short long bones throughout the skeleton with striking epiphyses that are stippled, flattened and fragmented and flared, irregular metaphyses. Platyspondyly in the spine with wide intervertebral spaces is observed and some vertebral bodies are pear-shaped with central humps, anterior protrusions and posterior scalloping. {ECO:0000269 PubMed:19110212, ECO:0000269 PubMed:20223752, ECO:0000269 PubMed:26463668}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Warburg-Cinotti syndrome (WRCN) [MIM:618175]: An autosomal dominant disease characterized by progressive corneal neovascularization, keloid formation, chronic skin ulcers, wasting of subcutaneous tissue, flexion contractures of the fingers, and acro-osteolysis. {ECO:0000269 PubMed:30449416}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for DDR2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for DDR2 Gene
Publications for DDR2 Gene
- Trafficking defects and loss of ligand binding are the underlying causes of all reported DDR2 missense mutations found in SMED-SL patients. (PMID: 20223752) Ali BR … Leitinger B (Human molecular genetics 2010) 3 4 23 54
- Mutations in DDR2 gene cause SMED with short limbs and abnormal calcifications. (PMID: 19110212) Bargal R … Raas-Rothschild A (American journal of human genetics 2009) 3 4 23 54
- Crystallographic insight into collagen recognition by discoidin domain receptor 2. (PMID: 20004161) Carafoli F … Hohenester E (Structure (London, England : 1993) 2009) 3 4 23 54
- Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen. (PMID: 18201965) Konitsiotis AD … Leitinger B (The Journal of biological chemistry 2008) 3 4 23 54
- Structural basis of the collagen-binding mode of discoidin domain receptor 2. (PMID: 17703188) Ichikawa O … Shimada I (The EMBO journal 2007) 3 4 23 54
ExternalLinks
Products for DDR2 Gene
- View all 16 R&D Systems DDR2 (DDR2) Products
- View all R&D Systems DDR2 (DDR2) Proteins and Enzymes
- View all 12 R&D Systems DDR2 (DDR2) Primary Antibodies
- View all 2 R&D Systems DDR2 (DDR2) ELISAs
- View all R&D Systems DDR2 (DDR2) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom DDR2 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for DDR2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for DDR2
- Origene Custom Protein Services for DDR2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DDR2
- Browse OriGene Inhibitory RNA Products For DDR2
- OriGene qPCR primer pairs for DDR2
- OriGene qPCR primer pairs and template standards for DDR2
- OriGene CRISPR knockouts for DDR2
- RC402797
- RC402798
- RC402799
- RC208745
- RC211389
- RC600062
- RG208745
- RG211389
- MR222870
- MG222870
- RR211892
- RC208745L3
- RC208745L3V
- RC208745L4
- RC208745L4V
- RC211389L1
- RC211389L1V
- RC211389L2
- RC211389L2V
- RC211389L3
- RC211389L3V
- RC211389L4
- RC211389L4V
- MR222870L3
- MR222870L3V
- MR222870L4
- MR222870L4V
- RR211892L3
- RR211892L3V
- RR211892L4
- RR211892L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DDR2
- Sino Biological Human cDNA Clone for DDR2
- Sino Biological Recombinant Proteins for DDR2
- Sino Biological Cell Lysates for DDR2
- Sino Biological Antibodies for DDR2
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for DDR2
- Novus Biologicals proteins and lysates for DDR2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for DDR2
- Abcam proteins for DDR2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Addgene plasmids for DDR2
- antibodies-online: Show 71 available DDR2 Antibodies ranked by validation data
- Compare Top DDR2 Antibodies
- antibodies-online: Show 16 available DDR2 Elisa Kits ranked by validation data
- Compare Top DDR2 Elisa Kits
- Quality Products: