Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that... See more...

Aliases for DDR1 Gene

Aliases for DDR1 Gene

  • Discoidin Domain Receptor Tyrosine Kinase 1 2 3 5
  • Epithelial Discoidin Domain-Containing Receptor 1 3 4
  • CD167 Antigen-Like Family Member A 3 4
  • Protein-Tyrosine Kinase RTK-6 3 4
  • Mammary Carcinoma Kinase 10 3 4
  • Tyrosine-Protein Kinase CAK 3 4
  • Cell Adhesion Kinase 3 4
  • Tyrosine Kinase DDR 3 4
  • EC 2.7.10.1 4 52
  • EDDR1 3 4
  • NTRK4 3 4
  • PTK3A 3 4
  • HGK2 3 4
  • RTK6 3 4
  • TRKE 3 4
  • CAK 3 4
  • NEP 3 4
  • Neurotrophic Tyrosine Kinase, Receptor, Type 4 3
  • Discoidin Domain Receptor Family, Member 1 2
  • Epithelial Discoidin Domain Receptor 1 4
  • Discoidin Receptor Tyrosine Kinase 4
  • PTK3A Protein Tyrosine Kinase 3A 3
  • Neuroepithelial Tyrosine Kinase 3
  • Protein-Tyrosine Kinase 3A 4
  • CD167a Antigen 4
  • EC 2.7.10 52
  • MCK-10 4
  • CD167 3
  • MCK10 3
  • TRK E 4
  • PTK3 3
  • DDR 3

External Ids for DDR1 Gene

Previous HGNC Symbols for DDR1 Gene

  • NTRK4
  • PTK3A
  • NEP
  • CAK
  • EDDR1

Previous GeneCards Identifiers for DDR1 Gene

  • GC06P030907
  • GC06P030619
  • GC06P030959
  • GC06P030960
  • GC06P030631
  • GC06P030848
  • GC06P030653
  • GC06P030879
  • GC06P032288
  • GC06P032478
  • GC06P032585
  • GC06P031003
  • GC06P031004
  • GC06P031073
  • GC06P031219
  • GC06P031426
  • GC06P032067

Summaries for DDR1 Gene

Entrez Gene Summary for DDR1 Gene

  • Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for DDR1 Gene

DDR1 (Discoidin Domain Receptor Tyrosine Kinase 1) is a Protein Coding gene. Diseases associated with DDR1 include Breast Cancer and Meninges Sarcoma. Among its related pathways are ERK Signaling and Nanog in Mammalian ESC Pluripotency. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DDR2.

UniProtKB/Swiss-Prot Summary for DDR1 Gene

  • Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

Gene Wiki entry for DDR1 Gene

Additional gene information for DDR1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DDR1 Gene

Genomics for DDR1 Gene

GeneHancer (GH) Regulatory Elements for DDR1 Gene

Promoters and enhancers for DDR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J030879 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 509.6 +8.0 7962 9.2 HNRNPK ZNF217 EP300 SIN3A POLR2G JUND FOS TEAD4 ZFX ZNF10 DDR1 lnc-GTF2H4-5 VARS2 PSORS1C1 HLA-C GNL1 PSORS1C3 SFTA2 HCG18 IER3
GH06J030875 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 509.8 +0.4 399 3.5 RXRA CTCF USF1 JUND ZBTB10 AFF1 TARDBP REST MEF2C ZBTB25 DDR1 DDR1-DT VARS2 ABCF1 VARS1 GTF2H4 MDC1 IER3 NFKBIL1 PSORS1C2
GH06J030826 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 31.7 -47.1 -47140 5.5 CTCF TCF12 POLR2G JUND TEAD4 FOS ZBTB11 AFF1 REST ZBTB25 LINC00243 DDR1 VARS2 IER3 HLA-C DDR1-DT FLOT1 MUCL3 ATP6V1G2 HCG21
GH06J030816 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 32.1 -56.5 -56548 6.5 FOXK2 ZNF217 CTCF ZSCAN5C GTF2E2 EP300 KDM6A CLOCK TCF7 FOXA1 lnc-DDR1-4 IER3 DDR1 PPP1R18 LINC00243 FLOT1 VARS2 DDR1-DT MUCL3 ABCF1
GH06J030810 Enhancer 1.2 ENCODE dbSUPER 31.7 -63.2 -63184 5.9 USF1 SP1 JUND FOS EP300 ZBTB10 ZBTB11 AFF1 TARDBP REST DDR1 MDC1 DDX39B IER3 LSM2 NFKBIL1 LY6G5B ENSG00000230521 ZNRD1 DHX16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DDR1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DDR1

Top Transcription factor binding sites by QIAGEN in the DDR1 gene promoter:
  • STAT3

Genomic Locations for DDR1 Gene

Genomic Locations for DDR1 Gene
chr6:30,876,421-30,900,156
(GRCh38/hg38)
Size:
23,736 bases
Orientation:
Plus strand
chr6:30,844,198-30,867,933
(GRCh37/hg19)
Size:
23,736 bases
Orientation:
Plus strand

Genomic View for DDR1 Gene

Genes around DDR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for DDR1 Gene

  • Protein details for DDR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08345-DDR1_HUMAN
    Recommended name:
    Epithelial discoidin domain-containing receptor 1
    Protein Accession:
    Q08345
    Secondary Accessions:
    • B5A975
    • B5A976
    • B7Z2K0
    • Q14196
    • Q16562
    • Q2L6H3
    • Q4LE50
    • Q5ST11
    • Q5ST12
    • Q6NSK4
    • Q9UD35
    • Q9UD36
    • Q9UD37
    • Q9UD86
    • Q9UDL2

    Protein attributes for DDR1 Gene

    Size:
    913 amino acids
    Molecular mass:
    101128 Da
    Quaternary structure:
    • Homodimer. Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms a tripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen. Interacts (tyrosine phosphorylated) with SHC1. Interacts with SRC. Interacts with MYH9. Interacts with CDH1. Interacts with PTPN11. Interacts with NCK2.
    Miscellaneous:
    • [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    SequenceCaution:
    • Sequence=ACF47649.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=BAE06103.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DDR1 Gene

    Alternative splice isoforms for DDR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDR1 Gene

Selected DME Specific Peptides for DDR1 Gene

Q08345:
  • YMENGDLNQFL
  • HRDLATRN
  • FVHRDLATRNC
  • DPLCMIT
  • PPRGPGPP
  • VWPGYDYVGW
  • GEFFRDQGRQ
  • ILIGCLVAII
  • LVGTQGRHAGG
  • GDGAWCP
  • KNARNDFLKE
  • GYVEMEFEFDRLR
  • QGRAVLPIRWM
  • FVHRDLA
  • SDVWAFGVT
  • LQGVTGGNTY

Post-translational modifications for DDR1 Gene

  • Autophosphorylated in response to fibrillar collagen binding.
  • Glycosylation of Asn-211, but apparently not of Asn-260 or Asn-394, prevents autophosphorylation from occurring in the absence of collagen.
  • Glycosylation at Asn211, Asn260, Asn370, and Asn394
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for DDR1
  • Boster Bio Antibodies for DDR1

Domains & Families for DDR1 Gene

Gene Families for DDR1 Gene

Protein Domains for DDR1 Gene

Blocks:
  • Tyrosine protein kinase, active site
  • Coagulation factor 5/8 type C domain (FA58C)
  • Receptor tyrosine kinase, class II
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DDR1 Gene

GenScript: Design optimal peptide antigens:
  • Discoidin domain receptor family, member 1 (A2ABL3_HUMAN)
  • Discoidin domain receptor family, member 1 (A2ABL4_HUMAN)
  • Discoidin domain receptor family, member 1 (A2ABM8_HUMAN)
  • cDNA FLJ56035, highly similar to Epithelial discoidin domain-containing receptor 1 (EC 2.7.10.1) (B7Z2K0_HUMAN)
  • cDNA FLJ54797, highly similar to Epithelial discoidin domain-containing receptor 1 (EC 2.7.10.1) (B7Z3A2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q08345

UniProtKB/Swiss-Prot:

DDR1_HUMAN :
  • The Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand or substrates.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Domain:
  • The Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand or substrates.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
genes like me logo Genes that share domains with DDR1: view

Function for DDR1 Gene

Molecular function for DDR1 Gene

UniProtKB/Swiss-Prot Function:
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the multi-targeted cancer drugs imatinib and ponatinib.
GENATLAS Biochemistry:
discoidin domains receptor family,member 1

Enzyme Numbers (IUBMB) for DDR1 Gene

Phenotypes From GWAS Catalog for DDR1 Gene

Gene Ontology (GO) - Molecular Function for DDR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity TAS,IBA 21873635
GO:0005515 protein binding IPI 16337946
GO:0005518 collagen binding IBA,IMP 12065315
genes like me logo Genes that share ontologies with DDR1: view
genes like me logo Genes that share phenotypes with DDR1: view

Animal Models for DDR1 Gene

MGI Knock Outs for DDR1:
  • Ddr1 Ddr1<tm1Lex>
  • Ddr1 Ddr1<tm1Wfv>
  • Ddr1 Ddr1<tm1b(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for DDR1

Clone Products

  • Addgene plasmids for DDR1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DDR1 Gene

Localization for DDR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDR1 Gene

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.
[Isoform 2]: Cell membrane; Single-pass type I membrane protein.
[Isoform 3]: Secreted.
[Isoform 4]: Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDR1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
mitochondrion 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DDR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space HDA 16502470
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA,TAS 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DDR1: view

Pathways & Interactions for DDR1 Gene

PathCards logo

SuperPathways for DDR1 Gene

SuperPathway Contained pathways
1 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
.38
2 ERK Signaling
.61
.61
.58
.51
.49
3 Nanog in Mammalian ESC Pluripotency
.61
.61
.59
.48
4 Actin Nucleation by ARP-WASP Complex
.66
.66
.41
5 p53 Signaling
.44
genes like me logo Genes that share pathways with DDR1: view

Pathways by source for DDR1 Gene

1 Sino Biological pathway for DDR1 Gene
30 Qiagen pathways for DDR1 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
1 Cell Signaling Technology pathway for DDR1 Gene

SIGNOR curated interactions for DDR1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for DDR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0001952 regulation of cell-matrix adhesion IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007155 cell adhesion TAS 8302582
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with DDR1: view

Drugs & Compounds for DDR1 Gene

(8) Drugs for DDR1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
imatinib Approved Pharma Target, antagonist, inhibitor Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 0
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
DDR1-IN-1 Pharma 0

(5) Additional Compounds for DDR1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
N-desmethylimatinib
  • CGP74588

(1) ApexBio Compounds for DDR1 Gene

Compound Action Cas Number
DDR1-IN-1 1449685-96-4
genes like me logo Genes that share compounds with DDR1: view

Drug Products

Transcripts for DDR1 Gene

mRNA/cDNA for DDR1 Gene

9 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
58 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for DDR1

Alternative Splicing Database (ASD) splice patterns (SP) for DDR1 Gene

No ASD Table

Relevant External Links for DDR1 Gene

GeneLoc Exon Structure for
DDR1

Expression for DDR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DDR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDR1 Gene

This gene is overexpressed in Lung (38.3), Milk (15.1), and Monocytes (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDR1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DDR1

SOURCE GeneReport for Unigene cluster for DDR1 Gene:

Hs.631988

mRNA Expression by UniProt/SwissProt for DDR1 Gene:

Q08345-DDR1_HUMAN
Tissue specificity: Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin.

Evidence on tissue expression from TISSUES for DDR1 Gene

  • Nervous system(5)
  • Lung(4.4)
  • Blood(4.3)
  • Muscle(4.3)
  • Skin(4.3)
  • Pancreas(3)
  • Kidney(2.6)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with DDR1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDR1 Gene

Orthologs for DDR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DDR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDR1 31 30
  • 99.78 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DDR1 31 30
  • 91.41 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DDR1 31 30
  • 91.25 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 90 (a)
OneToMany
-- 31
  • 82 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ddr1 17 31 30
  • 88.08 (n)
rat
(Rattus norvegicus)
Mammalia Ddr1 30
  • 87.6 (n)
oppossum
(Monodelphis domestica)
Mammalia DDR1 31
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF2H4 31
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia DDR1 31
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddr1 30
  • 62.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC69083 30
zebrafish
(Danio rerio)
Actinopterygii ddr1 31 30
  • 64.42 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ddr 31
  • 28 (a)
ManyToMany
CG34380 31
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ddr-2 31
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1149 31
  • 39 (a)
OneToMany
Species where no ortholog for DDR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDR1 Gene

ENSEMBL:
Gene Tree for DDR1 (if available)
TreeFam:
Gene Tree for DDR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DDR1: view image

Paralogs for DDR1 Gene

(55) SIMAP similar genes for DDR1 Gene using alignment to 34 proteins:

  • DDR1_HUMAN
  • A2ABL0_HUMAN
  • A2ABL2_HUMAN
  • A2ABM8_HUMAN
  • D6R9C4_HUMAN
  • D6RAJ3_HUMAN
  • D6RB35_HUMAN
  • D6RB82_HUMAN
  • D6RBU7_HUMAN
  • D6RGW5_HUMAN
  • E7EN94_HUMAN
  • E7ENJ2_HUMAN
  • E7EPH4_HUMAN
  • E7EPN2_HUMAN
  • E7EQ23_HUMAN
  • E7EQ30_HUMAN
  • E7ERI6_HUMAN
  • E7ERN0_HUMAN
  • E7ES06_HUMAN
  • E7ESR9_HUMAN
  • E7ETI3_HUMAN
  • E7ETX3_HUMAN
  • E7EUD5_HUMAN
  • E7EUP7_HUMAN
  • E7EVT1_HUMAN
  • E7EVW6_HUMAN
  • E7EX99_HUMAN
  • E7EXB0_HUMAN
  • H0Y717_HUMAN
  • H0Y9F4_HUMAN
  • H0YAH6_HUMAN
  • Q6ZNR9_HUMAN
  • Q96T61_HUMAN
  • Q96T62_HUMAN