Aliases for DDOST Gene
- Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Non-Catalytic Subunit 2 3 5
- Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 48 KDa Subunit 3 4
- Oligosaccharyl Transferase 48 KDa Subunit 3 4
- Advanced Glycation End-Product Receptor 1 2 3
- Oligosaccharyltransferase Subunit 48 2 3
- OST48 3 4
- Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit (Non-Catalytic) 3
- Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase 2
- Dolichyl-Diphosphooligosaccharide-Protein Glycotransferase 3
- Advanced Glycation Endproduct Receptor 1 3
- Oligosaccharyltransferase 48 KDa Subunit 3
External Ids for DDOST Gene
Previous GeneCards Identifiers for DDOST Gene
This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008]
GeneCards Summary for DDOST Gene
DDOST (Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Non-Catalytic Subunit) is a Protein Coding gene. Diseases associated with DDOST include Congenital Disorder Of Glycosylation, Type Ir and Congenital Disorder Of Glycosylation, Type In. Among its related pathways are AGE/RAGE pathway and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include dolichyl-diphosphooligosaccharide-protein glycotransferase activity and oligosaccharyl transferase activity.
UniProtKB/Swiss-Prot for DDOST Gene
Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for the assembly of both SST3A- and SS3B-containing OST complexes. Required for efficient N-glycosylation.
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (PubMed:22467853).