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Aliases for DDI1 Gene

Aliases for DDI1 Gene

  • DNA Damage Inducible 1 Homolog 1 2 3 5
  • DDI1, DNA-Damage Inducible 1, Homolog 1 (S. Cerevisiae) 2
  • DNA-Damage Inducible 1 Homolog 1 (S. Cerevisiae) 2
  • DDI1, DNA-Damage Inducible 1, Homolog 1 3
  • DNA-Damage Inducible 1 Homolog 1 2
  • DNA-Damage Inducible Protein 1 3
  • Protein DDI1 Homolog 1 3
  • EC 3.4.23.- 4

External Ids for DDI1 Gene

Previous GeneCards Identifiers for DDI1 Gene

  • GC00U915586
  • GC11P103412
  • GC11U900686
  • GC11P103907
  • GC11P099836

Summaries for DDI1 Gene

GeneCards Summary for DDI1 Gene

DDI1 (DNA Damage Inducible 1 Homolog 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is DDI2.

UniProtKB/Swiss-Prot for DDI1 Gene

  • Probable aspartic protease.

Additional gene information for DDI1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDI1 Gene

Genomics for DDI1 Gene

GeneHancer (GH) Regulatory Elements for DDI1 Gene

Promoters and enhancers for DDI1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J104034 Enhancer 0.2 ENCODE 650.7 -1.5 -1459 0.3 DDI1 ENSG00000255548 PDGFD
GH11J104366 Enhancer 0.4 FANTOM5 20 +329.6 329646 0.4 NRF1 DDI1 MIR7641-1 PIR31145
GH11J103958 Enhancer 0.7 ENCODE 11.1 -77.4 -77395 1.1 PKNOX1 BACH1 EBF1 BMI1 BATF RELA NFATC1 ATF7 FOSL2 BCLAF1 DDI1 PDGFD ENSG00000255548
GH11J104074 Enhancer 0.6 Ensembl ENCODE 11.2 +37.6 37620 0.4 POLR2A ZSCAN29 SPI1 DDI1 PDGFD
GH11J103987 Enhancer 0.5 ENCODE 10.9 -48.3 -48287 2 CTCF FOXP2 FOS MAFK ENSG00000255548 DDI1 PDGFD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DDI1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DDI1 gene promoter:
  • RREB-1
  • AML1a
  • MyoD
  • deltaCREB
  • CREB
  • Tal-1beta
  • ITF-2
  • Cdc5
  • HNF-3beta

Genomic Locations for DDI1 Gene

Genomic Locations for DDI1 Gene
chr11:104,036,580-104,039,194
(GRCh38/hg38)
Size:
2,615 bases
Orientation:
Plus strand
chr11:103,907,308-103,909,922
(GRCh37/hg19)
Size:
2,615 bases
Orientation:
Plus strand

Genomic View for DDI1 Gene

Genes around DDI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDI1 Gene

Proteins for DDI1 Gene

  • Protein details for DDI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTU0-DDI1_HUMAN
    Recommended name:
    Protein DDI1 homolog 1
    Protein Accession:
    Q8WTU0
    Secondary Accessions:
    • Q7Z4U6
    • Q8WTS3

    Protein attributes for DDI1 Gene

    Size:
    396 amino acids
    Molecular mass:
    44124 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DDI1 Gene

neXtProt entry for DDI1 Gene

Post-translational modifications for DDI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDI1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DDI1 Gene

Domains & Families for DDI1 Gene

Gene Families for DDI1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DDI1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WTU0

UniProtKB/Swiss-Prot:

DDI1_HUMAN :
  • Belongs to the DDI1 family.
Family:
  • Belongs to the DDI1 family.
genes like me logo Genes that share domains with DDI1: view

Function for DDI1 Gene

Molecular function for DDI1 Gene

UniProtKB/Swiss-Prot Function:
Probable aspartic protease.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the proteinase inhibitors amprenavir, indinavir, lopinavir, isovaleryl pepstatin, ritonavir and saquinavir.

Enzyme Numbers (IUBMB) for DDI1 Gene

Gene Ontology (GO) - Molecular Function for DDI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004190 aspartic-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 21516116
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DDI1: view
genes like me logo Genes that share phenotypes with DDI1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDI1

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DDI1 Gene

Localization for DDI1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDI1 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DDI1 Gene

Pathways & Interactions for DDI1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with DDI1: view

No data available for Pathways by source and SIGNOR curated interactions for DDI1 Gene

Drugs & Compounds for DDI1 Gene

No Compound Related Data Available

Transcripts for DDI1 Gene

mRNA/cDNA for DDI1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DDI1 Gene

DNA-damage inducible 1 homolog 1 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDI1

Alternative Splicing Database (ASD) splice patterns (SP) for DDI1 Gene

No ASD Table

Relevant External Links for DDI1 Gene

GeneLoc Exon Structure for
DDI1
ECgene alternative splicing isoforms for
DDI1

Expression for DDI1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDI1 Gene

This gene is overexpressed in Bone marrow stromal cell (45.9), Peripheral blood mononuclear cells (17.1), and Testis (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DDI1 Gene



Protein tissue co-expression partners for DDI1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DDI1 Gene:

DDI1

SOURCE GeneReport for Unigene cluster for DDI1 Gene:

Hs.591941

Evidence on tissue expression from TISSUES for DDI1 Gene

  • Adrenal gland(5)
  • Blood(5)
  • Eye(5)
  • Gall bladder(5)
  • Heart(5)
  • Intestine(5)
  • Kidney(5)
  • Liver(5)
  • Lung(5)
  • Pancreas(5)
  • Nervous system(5)
genes like me logo Genes that share expression patterns with DDI1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDI1 Gene

Orthologs for DDI1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDI1 33
  • 98.98 (n)
dog
(Canis familiaris)
Mammalia DDI1 34 33
  • 80.96 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ddi1 16 34 33
  • 80.54 (n)
rat
(Rattus norvegicus)
Mammalia Ddi1 33
  • 80.05 (n)
cow
(Bos Taurus)
Mammalia DDI1 34 33
  • 78.63 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDI1 34
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta rngo 34
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C01G5.6 34
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DDI1 34
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9741 34
  • 41 (a)
OneToMany
Species where no ortholog for DDI1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for DDI1 Gene

ENSEMBL:
Gene Tree for DDI1 (if available)
TreeFam:
Gene Tree for DDI1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DDI1: view image

Paralogs for DDI1 Gene

Paralogs for DDI1 Gene

(1) SIMAP similar genes for DDI1 Gene using alignment to 1 proteins:

  • DDI1_HUMAN
genes like me logo Genes that share paralogs with DDI1: view

Variants for DDI1 Gene

Sequence variations from dbSNP and Humsavar for DDI1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000987835 -- 104,037,027(+) G/A coding_sequence_variant, missense_variant
rs1001438638 -- 104,036,680(+) C/A/T 5_prime_UTR_variant
rs1002223509 -- 104,036,466(+) T/C upstream_transcript_variant
rs1002998066 -- 104,034,767(+) C/T upstream_transcript_variant
rs1003303067 -- 104,039,431(+) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DDI1 Gene

Variant ID Type Subtype PubMed ID
esv2750977 CNV gain 17911159
esv2760322 CNV loss 21179565
nsv1043976 CNV gain 25217958

Variation tolerance for DDI1 Gene

Residual Variation Intolerance Score: 81.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DDI1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDI1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDI1 Gene

Disorders for DDI1 Gene

Additional Disease Information for DDI1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DDI1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDI1 Gene

Publications for DDI1 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for DDI1 Gene

Sources for DDI1 Gene

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