This gene is a member of the intracellular phospholipase A1 gene family. The protein encoded by this gene preferentially hydrolyzes phosphatidic acid. It is a cytosolic protein with some mitochondrial localization, and is thought to be involved in the regulation of mitochondrial dynamics. Overexpression of this gene causes fragmentation of the tubular structures in mitochondria... See more...

Aliases for DDHD1 Gene

Aliases for DDHD1 Gene

  • DDHD Domain Containing 1 2 3 5
  • Phosphatidic Acid-Preferring Phospholipase A1 Homolog 3 4
  • Spastic Paraplegia 28 (Autosomal Recessive) 2 3
  • Phospholipase DDHD1 3 4
  • PA-PLA1 3 4
  • Phosphatidic Acid-Preferring Phospholipase A1-Like Protein 3
  • Phosphatidic Acid-Preferring Phospholipase A1 2
  • DDHD Domain-Containing Protein 1 4
  • EC 3.1.1.- 4
  • KIAA1705 4
  • PAPLA1 3
  • SPG28 3

External Ids for DDHD1 Gene

Previous HGNC Symbols for DDHD1 Gene

  • SPG28

Previous GeneCards Identifiers for DDHD1 Gene

  • GC14M047308
  • GC14M051502
  • GC14M052582
  • GC14M053510
  • GC14M033666

Summaries for DDHD1 Gene

Entrez Gene Summary for DDHD1 Gene

  • This gene is a member of the intracellular phospholipase A1 gene family. The protein encoded by this gene preferentially hydrolyzes phosphatidic acid. It is a cytosolic protein with some mitochondrial localization, and is thought to be involved in the regulation of mitochondrial dynamics. Overexpression of this gene causes fragmentation of the tubular structures in mitochondria, while depletion of the gene results in mitochondrial tubule elongation. Deletion of this gene in male mice caused fertility defects, resulting from disruption in the organization of the mitochondria during spermiogenesis. In humans, mutations in this gene have been associated with hereditary spastic paraplegia (HSP), also known as Strumpell-Lorrain disease, or, familial spastic paraparesis (FSP). This inherited disorder is characterized by progressive weakness and spasticity of the legs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

GeneCards Summary for DDHD1 Gene

DDHD1 (DDHD Domain Containing 1) is a Protein Coding gene. Diseases associated with DDHD1 include Spastic Paraplegia 28, Autosomal Recessive and Paraplegia. Among its related pathways are Acyl chain remodelling of PE and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is SEC23IP.

UniProtKB/Swiss-Prot Summary for DDHD1 Gene

  • Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity (PubMed:22922100). Required for the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:17428803).

Additional gene information for DDHD1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DDHD1 Gene

Genomics for DDHD1 Gene

GeneHancer (GH) Regulatory Elements for DDHD1 Gene

Promoters and enhancers for DDHD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J053148 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +1.8 1776 6.1 ZNF217 SIN3A POLR2G PHF8 ZFX EP300 POLR2A ZBTB10 ZBTB11 ZBTB26 LOC101927620 DDHD1 lnc-FERMT2-6 piR-37586-017
GH14J053126 Enhancer 0.5 ENCODE 18.4 +26.2 26216 1.6 ZBTB40 MEF2C ZNF384 MEF2B ATF4 BHLHE40 MAX ZBTB33 MEF2A RAD51 LOC101927620 DDHD1 ERO1A piR-37586-017 piR-38537-022 lnc-FERMT2-6
GH14J053117 Enhancer 0.6 Ensembl ENCODE 12.5 +35.4 35427 1.4 FOXA2 CTCF FOXA1 DDHD1 piR-38537-022 piR-37586-017 lnc-FERMT2-6
GH14J052917 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 3.7 +234.2 234239 3.7 ZSCAN5C ZNF10 FOXA2 OSR2 NR2F2 BCL11A WT1 CEBPB MEF2B ZBTB11 lnc-FERMT2-2 ERO1A STYX LOC101927620 DDHD1 piR-50443-113 FERMT2 ENSG00000285664 LOC105370500
GH14J053161 Enhancer 0.7 FANTOM5 7 -8.6 -8632 0.2 CBFB ARNT SPI1 TBP ATF2 TBX21 JUNB MTA3 TCF7 HLF lnc-DDHD1-3 DDHD1 lnc-DDHD1-1 LOC101927620
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DDHD1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DDHD1

Top Transcription factor binding sites by QIAGEN in the DDHD1 gene promoter:
  • AhR
  • Arnt
  • c-Ets-1
  • c-Myb
  • Egr-4
  • FOXJ2
  • FOXJ2 (long isoform)
  • ITF-2
  • Pax-2b
  • Tal-1beta

Genomic Locations for DDHD1 Gene

Genomic Locations for DDHD1 Gene
chr14:53,036,740-53,153,328
(GRCh38/hg38)
Size:
116,589 bases
Orientation:
Minus strand
chr14:53,503,458-53,620,046
(GRCh37/hg19)
Size:
116,589 bases
Orientation:
Minus strand

Genomic View for DDHD1 Gene

Genes around DDHD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDHD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDHD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDHD1 Gene

Proteins for DDHD1 Gene

  • Protein details for DDHD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEL9-DDHD1_HUMAN
    Recommended name:
    Phospholipase DDHD1
    Protein Accession:
    Q8NEL9
    Secondary Accessions:
    • G5E9D1
    • Q8WVH3
    • Q96LL2
    • Q9C0F8

    Protein attributes for DDHD1 Gene

    Size:
    900 amino acids
    Molecular mass:
    100435 Da
    Quaternary structure:
    • Forms homooligomers and, to a much smaller extent, heterooligomers with DDHD2 (PubMed:22922100). Interacts with SEC23A and SEC24C (PubMed:17428803).
    SequenceCaution:
    • Sequence=BAB21796.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAB71679.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for DDHD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDHD1 Gene

Post-translational modifications for DDHD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DDHD1 Gene

Domains & Families for DDHD1 Gene

Gene Families for DDHD1 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DDHD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DDHD1 Gene

GenScript: Design optimal peptide antigens:
  • Phosphatidic acid-preferring phospholipase A1 splice variant 2 (D3K5P3_HUMAN)
  • Phosphatidic acid-preferring phospholipase A1 homolog (DDHD1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NEL9

UniProtKB/Swiss-Prot:

DDHD1_HUMAN :
  • Belongs to the PA-PLA1 family.
Family:
  • Belongs to the PA-PLA1 family.
genes like me logo Genes that share domains with DDHD1: view

Function for DDHD1 Gene

Molecular function for DDHD1 Gene

UniProtKB/Swiss-Prot Function:
Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity (PubMed:22922100). Required for the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:17428803).

Enzyme Numbers (IUBMB) for DDHD1 Gene

Phenotypes From GWAS Catalog for DDHD1 Gene

Gene Ontology (GO) - Molecular Function for DDHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity IBA 21873635
GO:0005515 protein binding IPI 17428803
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DDHD1: view
genes like me logo Genes that share phenotypes with DDHD1: view

Human Phenotype Ontology for DDHD1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DDHD1 Gene

MGI Knock Outs for DDHD1:
  • Ddhd1 Ddhd1<tm1a(KOMP)Wtsi>
  • Ddhd1 Ddhd1<tm1b(KOMP)Katn>

Animal Model Products

CRISPR Products

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for DDHD1 Gene

Localization for DDHD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDHD1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDHD1 gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DDHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DDHD1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DDHD1 Gene

Pathways & Interactions for DDHD1 Gene

genes like me logo Genes that share pathways with DDHD1: view

Gene Ontology (GO) - Biological Process for DDHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0016042 lipid catabolic process IEA --
GO:0090141 positive regulation of mitochondrial fission IDA 24599962
genes like me logo Genes that share ontologies with DDHD1: view

No data available for SIGNOR curated interactions for DDHD1 Gene

Drugs & Compounds for DDHD1 Gene

(1) Drugs for DDHD1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Warfarin Approved Pharma 593

(12) Additional Compounds for DDHD1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PA(16:0/16:0)
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphate
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphoric acid
  • Dipalmitoyl phosphatidic acid
  • PA(32:0)
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1N7)
  • PA(16:0/18:1W7)
PA(16:0/18:1(9Z))
  • (2R)-1-(Palmitoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol 3-phosphate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • PA(16:0/18:1)
PA(16:0/18:2(9Z,12Z))
  • 1-16:0-2-18:2-Phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • 16:0-18:2-PA
  • 2-Linoleoyl-1-palmitoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
PA(16:0e/18:0)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with DDHD1: view

Transcripts for DDHD1 Gene

mRNA/cDNA for DDHD1 Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDHD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for DDHD1 Gene

GeneLoc Exon Structure for
DDHD1

Expression for DDHD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DDHD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDHD1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (32.1) and Urinary Bladder (21.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDHD1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DDHD1

SOURCE GeneReport for Unigene cluster for DDHD1 Gene:

Hs.125525

mRNA Expression by UniProt/SwissProt for DDHD1 Gene:

Q8NEL9-DDHD1_HUMAN
Tissue specificity: Highly expressed in testis. Also expressed in brain, spleen and lung. Only expressed in cerebellum in fetal brain.

Evidence on tissue expression from TISSUES for DDHD1 Gene

  • Nervous system(4.7)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DDHD1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • head
Thorax:
  • lung
  • rib
  • rib cage
Pelvis:
  • pelvis
Limb:
  • foot
  • lower limb
General:
  • peripheral nerve
  • peripheral nervous system
  • spinal column
  • spinal cord
  • vertebrae
genes like me logo Genes that share expression patterns with DDHD1: view

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for DDHD1 Gene

Orthologs for DDHD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDHD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDHD1 31 30
  • 99.81 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DDHD1 31 30
  • 91.16 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DDHD1 31 30
  • 90.86 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ddhd1 17 31 30
  • 86.59 (n)
rat
(Rattus norvegicus)
Mammalia Ddhd1 30
  • 85.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DDHD1 31
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDHD1 31
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDHD1 31 30
  • 79.67 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDHD1 31
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddhd1 30
  • 75.82 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7818 30
zebrafish
(Danio rerio)
Actinopterygii LOC562868 30
  • 64.65 (n)
ddhd1a 31
  • 58 (a)
OneToMany
ddhd1b 31
  • 56 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ipla-1 31 30
  • 45.93 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 31
  • 14 (a)
OneToMany
Species where no ortholog for DDHD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDHD1 Gene

ENSEMBL:
Gene Tree for DDHD1 (if available)
TreeFam:
Gene Tree for DDHD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DDHD1: view image

Paralogs for DDHD1 Gene

Paralogs for DDHD1 Gene

(1) SIMAP similar genes for DDHD1 Gene using alignment to 2 proteins:

  • DDHD1_HUMAN
  • G3V2P6_HUMAN
genes like me logo Genes that share paralogs with DDHD1: view

Variants for DDHD1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DDHD1 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
639067 Uncertain Significance: Spastic paraplegia 28, autosomal recessive 53,152,762(-) T/TGCCGCCGCCGCCG INFRAME_INSERTION
641826 Uncertain Significance: Spastic paraplegia 28, autosomal recessive 53,058,589(-) A/G MISSENSE_VARIANT
648556 Uncertain Significance: Spastic paraplegia 28, autosomal recessive 53,152,833(-) T/C MISSENSE_VARIANT
648690 Uncertain Significance: Spastic paraplegia 28, autosomal recessive 53,091,935(-) G/A INTRON_VARIANT
650977 Uncertain Significance: Spastic paraplegia 28, autosomal recessive 53,152,287(-) C/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for DDHD1 Gene

Structural Variations from Database of Genomic Variants (DGV) for DDHD1 Gene

Variant ID Type Subtype PubMed ID
esv3379514 CNV insertion 20981092
esv988662 CNV deletion 20482838
nsv1116027 CNV deletion 24896259
nsv832797 CNV gain 17160897

Variation tolerance for DDHD1 Gene

Residual Variation Intolerance Score: 14.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.42; 71.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DDHD1 Gene

Human Gene Mutation Database (HGMD)
DDHD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDHD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDHD1 Gene

Disorders for DDHD1 Gene

MalaCards: The human disease database

(21) MalaCards diseases for DDHD1 Gene - From: OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spastic paraplegia 28, autosomal recessive
  • spg28
paraplegia
  • paraplegia, lower
spastic paraparesis
spastic paraplegia 54, autosomal recessive
  • spg54
hereditary spastic paraplegia
  • spastic paraplegia 3, autosomal dominant
- elite association - COSMIC cancer census association via MalaCards
Search DDHD1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DDHD1_HUMAN
  • Spastic paraplegia 28, autosomal recessive (SPG28) [MIM:609340]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Some SPG28 patients also have distal sensory impairment. {ECO:0000269 PubMed:23176821}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for DDHD1

genes like me logo Genes that share disorders with DDHD1: view

No data available for Genatlas for DDHD1 Gene

Publications for DDHD1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 54
  2. Cloning of a phosphatidic acid-preferring phospholipase A1 from bovine testis. (PMID: 9488669) Higgs HN … Glomset JA (The Journal of biological chemistry 1998) 3 4 23 54
  3. Alteration of fatty-acid-metabolizing enzymes affects mitochondrial form and function in hereditary spastic paraplegia. (PMID: 23176821) Tesson C … Stevanin G (American journal of human genetics 2012) 3 4 54
  4. Generation of lysophosphatidylinositol by DDHD domain containing 1 (DDHD1): Possible involvement of phospholipase D/phosphatidic acid in the activation of DDHD1. (PMID: 20359546) Yamashita A … Sugiura T (Biochimica et biophysica acta 2010) 2 3 54
  5. Mammalian Sec16/p250 plays a role in membrane traffic from the endoplasmic reticulum. (PMID: 17428803) Iinuma T … Tani K (The Journal of biological chemistry 2007) 3 4 54

Products for DDHD1 Gene

Sources for DDHD1 Gene