Aliases for DDAH2 Gene
External Ids for DDAH2 Gene
Previous GeneCards Identifiers for DDAH2 Gene
This gene encodes a dimethylarginine dimethylaminohydrolase. The encoded enzyme functions in nitric oxide generation by regulating the cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. The protein may be localized to the mitochondria. Alternative splicing resulting in multiple transcript variants. [provided by RefSeq, Dec 2014]
GeneCards Summary for DDAH2 Gene
DDAH2 (Dimethylarginine Dimethylaminohydrolase 2) is a Protein Coding gene. Diseases associated with DDAH2 include Chronic Kidney Disease and Pre-Eclampsia. Among its related pathways are eNOS activation and regulation and Metabolism. Gene Ontology (GO) annotations related to this gene include amino acid binding and dimethylargininase activity. An important paralog of this gene is DDAH1.
UniProtKB/Swiss-Prot Summary for DDAH2 Gene
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.